The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.
Andrew J. Holland, Don W. Cleveland
Title and authors | Publication | Year |
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Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics
AM Antao, A Tyagi, KS Kim, S Ramakrishna |
Cancers | 2020 |
Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma
J Zhou, T Wang, T Qiu, Z Chen, X Ma, L Zhang, J Zou |
BMC Cancer | 2020 |
USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA
HY Zhang, BW Liao, ZS Xu, Y Ran, DP Wang, Y Yang, WW Luo, YY Wang, EE Heldwein |
PLoS pathogens | 2020 |