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Citations to this article

Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone
Robert L. Jilka, … , A. Michael Parfitt, Stavros C. Manolagas
Robert L. Jilka, … , A. Michael Parfitt, Stavros C. Manolagas
Published August 15, 1999
Citation Information: J Clin Invest. 1999;104(4):439-446. https://doi.org/10.1172/JCI6610.
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Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone

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Abstract

The mass of regenerating tissues, such as bone, is critically dependent on the number of executive cells, which in turn is determined by the rate of replication of progenitors and the life-span of mature cells, reflecting the timing of death by apoptosis. Bone mass can be increased by intermittent parathyroid hormone (PTH) administration, but the mechanism of this phenomenon has remained unknown. We report that daily PTH injections in mice with either normal bone mass or osteopenia due to defective osteoblastogenesis increased bone formation without affecting the generation of new osteoblasts. Instead, PTH increased the life-span of mature osteoblasts by preventing their apoptosis — the fate of the majority of these cells under normal conditions. The antiapoptotic effect of PTH was sufficient to account for the increase in bone mass, and was confirmed in vitro using rodent and human osteoblasts and osteocytes. This evidence provides proof of the basic principle that the work performed by a cell population can be increased by suppression of apoptosis. Moreover, it suggests novel pharmacotherapeutic strategies for osteoporosis and, perhaps, other pathologic conditions in which tissue mass diminution has compromised functional integrity.

Authors

Robert L. Jilka, Robert S. Weinstein, Teresita Bellido, Paula Roberson, A. Michael Parfitt, Stavros C. Manolagas

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1997 1988 Total
Citations: 5 9 14 13 30 25 29 24 38 25 31 26 33 27 53 42 34 38 47 46 42 39 37 25 36 14 3 1 1 787
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