Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone
Robert L. Jilka, … , A. Michael Parfitt, Stavros C. Manolagas
Robert L. Jilka, … , A. Michael Parfitt, Stavros C. Manolagas
Published August 15, 1999
Citation Information: J Clin Invest. 1999;104(4):439-446. https://doi.org/10.1172/JCI6610.
View: Text | PDF
Article Article has an altmetric score of 6

Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone

  • Text
  • PDF
Abstract

The mass of regenerating tissues, such as bone, is critically dependent on the number of executive cells, which in turn is determined by the rate of replication of progenitors and the life-span of mature cells, reflecting the timing of death by apoptosis. Bone mass can be increased by intermittent parathyroid hormone (PTH) administration, but the mechanism of this phenomenon has remained unknown. We report that daily PTH injections in mice with either normal bone mass or osteopenia due to defective osteoblastogenesis increased bone formation without affecting the generation of new osteoblasts. Instead, PTH increased the life-span of mature osteoblasts by preventing their apoptosis — the fate of the majority of these cells under normal conditions. The antiapoptotic effect of PTH was sufficient to account for the increase in bone mass, and was confirmed in vitro using rodent and human osteoblasts and osteocytes. This evidence provides proof of the basic principle that the work performed by a cell population can be increased by suppression of apoptosis. Moreover, it suggests novel pharmacotherapeutic strategies for osteoporosis and, perhaps, other pathologic conditions in which tissue mass diminution has compromised functional integrity.

Authors

Robert L. Jilka, Robert S. Weinstein, Teresita Bellido, Paula Roberson, A. Michael Parfitt, Stavros C. Manolagas

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1997 1988 Total
Citations: 5 9 14 13 30 25 29 24 38 25 31 26 33 27 53 42 34 38 47 46 42 39 37 25 36 14 3 1 1 787
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2017 (38)

Title and authors Publication Year
Parathyroid hormone regulates fates of osteoblast precursors in vivo
Deepak Balani, Noriaki Ono, Henry M Kronenberg
Journal of Clinical Investigation 2017
Comparison of the effects of once-weekly and once-daily rhPTH (1-34) injections on promoting fracture healing in rodents: rhPTH (1-34) PROMOTES FRACTURE HEALING
W Zhang, J Zhu, T Ma, C Liu, B Hai, G Du, H Wang, N Li, H Leng, Y Xu, C Song
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2017
Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation through Induction of Runx2: MURAMYL DIPEPTIDE IS A NOVEL INDUCER OF BONE FORMATION
OJ Park, J Kim, J Yang, CH Yun, SH Han
Journal of Bone and Mineral Research 2017
Heterotrimeric G proteins in the control of parathyroid hormone actions
M Bastepe, S Turan, Q He
Journal of Molecular Endocrinology 2017
Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate
Y Fan, J Hanai, PT Le, R Bi, D Maridas, V DeMambro, CA Figueroa, S Kir, X Zhou, M Mannstadt, R Baron, RT Bronson, MC Horowitz, JY Wu, JP Bilezikian, DW Dempster, CJ Rosen, B Lanske
Cell Metabolism 2017
Parathyroid Hormone Signaling in Osteocytes: PTH SIGNALING IN OSTEOCYTES
MN Wein
JBMR Plus 2017
Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders.
Liu J, Khalil RA
Progress in molecular biology and translational science 2017
Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia.
Chen J, Khalil RA
Progress in molecular biology and translational science 2017
Wnt Signaling in Kidney Development and Disease
Wang Y, Zhou CJ, Liu Y
Progress in molecular biology and translational science 2017
Wnt Signaling in Hematological Malignancies.
Grainger S, Traver D, Willert K
Progress in molecular biology and translational science 2017
Matrix Metalloproteinases in Myocardial Infarction and Heart Failure
DeLeon-Pennell KY, Meschiari CA, Jung M, Lindsey ML
Progress in molecular biology and translational science 2017
Role of cortical bone in hip fracture
J Reeve
BoneKEy Reports 2017
Modeling the Effect of Curvature on the Collective Behavior of Cells Growing New Tissue
MA Alias, PR Buenzli
Biophysical Journal 2017
Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition
A Varela-López, J Ochoa, J Llamas-Elvira, M López-Frías, E Planells, MC Ramirez-Tortosa, C Ramirez-Tortosa, F Giampieri, M Battino, J Quiles
Nutrients 2017
Efficacy of teriparatide in the treatment of nontraumatic osteonecrosis of the femoral head: a retrospective comparative study with alendronate
R Arai, D Takahashi, M Inoue, T Irie, T Asano, T Konno, MA Terkawi, T Onodera, E Kondo, N Iwasaki
BMC musculoskeletal disorders 2017
Feasibility and Efficacy of Autologous Bone Marrow Aspirate Transplantation Combined with Human Parathyroid Hormone 1-34 Administration to Treat Osteonecrosis in a Rabbit Model
T Makihara, T Yoshioka, H Sugaya, K Aoto, H Wada, K Uemura, K Tanaka, H Akaogi, M Yamazaki, H Mishima
Bone Marrow Research 2017
Treatment of postmenopausal osteoporosis: a literature-based algorithm for use in the public health care system
EL Caires, MC Bezerra, AF de Junqueira, SM de Fontenele, SC de Andrade, CB dAlva
Revista Brasileira de Reumatologia (English Edition) 2017
Bone histomorphometry in de novo renal transplant recipients indicates a further decline in bone resorption 1 year posttransplantation
P Evenepoel, GJ Behets, L Viaene, PC D'Haese
Kidney International 2017
CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone
JA Siddiqui, NC Partridge
Frontiers in Endocrinology 2017
Effect of teriparatide (rh-PTH 1–34) versus bisphosphonate on the healing of osteoporotic vertebral compression fracture: A retrospective comparative study
A Iwata, M Kanayama, F Oha, T Hashimoto, N Iwasaki
BMC musculoskeletal disorders 2017
Intermittent parathyroid hormone improve bone microarchitecture of the mandible and femoral head in ovariectomized rats
YJ Chen, SP Wang, FC Cheng, PY Hsu, YF Li, J Wu, HL Huang, MT Tsai, JT Hsu
BMC musculoskeletal disorders 2017
PTH[1-34] improves the effects of core decompression in early-stage steroid-associated osteonecrosis model by enhancing bone repair and revascularization
C Zhou, J Meng, C Zhao, C Ye, H Zhu, B Hu, BC Heng, Y Shen, T Lin, X Yang, Z Shi, W Shen, S Yan, D Miao
PloS one 2017
Influence of Dosing Interval and Administration on the Bone Metabolism, Skeletal Effects, and Clinical Efficacy of Parathyroid Hormone in Treating Osteoporosis: A Narrative Review: DIFFERENTIAL EFFECTS OF PARATHYROID HORMONE REGIMEN
KM Kim, SY Lee, Y Rhee
JBMR Plus 2017
Assessment of the effect of systemic delivery of sclerostin antibodies on Wnt signaling in distraction osteogenesis
MM Alzahrani, AM Makhdom, F Rauch, D Lauzier, M Kotsiopriftis, S Ghadakzadeh, RC Hamdy
Journal of Bone and Mineral Metabolism 2017
Combination of PTH (1-34) with anti-IL17 prevents bone loss by inhibiting IL-17/N-cadherin mediated disruption of PTHR1/LRP-6 interaction
MN Mansoori, P Shukla, D Singh
Bone 2017
The Role of Bone Remodelling in Maintaining and Restoring Bone Health: an Overview
E Raubenheimer, H Miniggio, L Lemmer, W Heerden
Clinical Reviews in Bone and Mineral Metabolism 2017
Bone Lining Cells: Normal Physiology and Role in Response to Anabolic Osteoporosis Treatments
MN Wein
Current Molecular Biology Reports 2017
Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway
SC Tao, T Yuan, BY Rui, ZZ Zhu, SC Guo, CQ Zhang
Theranostics 2017
Parathyroid Hormone Activates Phospholipase C (PLC)-Independent Protein Kinase C Signaling Pathway via Protein Kinase A (PKA)-Dependent Mechanism: A New Defined Signaling Route Would Induce Alternative Consideration to Previous Conceptions
G Tong, Y Meng, S Hao, S Hu, Y He, W Yan, D Yang
Medical science monitor : international medical journal of experimental and clinical research 2017
Multiscale Mechanobiology of Bone Remodeling and Adaptation
P Pivonka
Multiscale Mechanobiology of Bone Remodeling and Adaptation 2017
Osteoblast as a target of anti-osteoporotic treatment
A Corrado, ER Sanpaolo, SD Bello, FP Cantatore
Postgraduate Medicine 2017
Parathyroid Hormone (PTH) Induces Autophagy to Protect Osteocyte Cell Survival from Dexamethasone Damage
L Zhu, J Chen, J Zhang, C Guo, W Fan, Y Wang, Z Yan
Medical science monitor : international medical journal of experimental and clinical research 2017
The Proteasome and Myeloma-Associated Bone Disease
F Accardi, D Toscani, F Costa, F Aversa, N Giuliani
Calcified Tissue International 2017
G protein-coupled receptors as anabolic drug targets in osteoporosis
N Diepenhorst, P Rueda, AE Cook, P Pastoureau, M Sabatini, CJ Langmead
Pharmacology & Therapeutics 2017
Single-dose local administration of teriparatide with a octacalcium phosphate collagen composite enhances bone regeneration in a rodent critical-sized calvarial defect: BONE REGENERATION BY OCP/COL WITH TERIPARATIDE SOLUTION
F Kajii, A Iwai, H Tanaka, K Matsui, T Kawai, S Kamakura
Journal of biomedical materials research. Part B, Applied biomaterials 2017
Periodontal Biology: Stem Cells, Bmp2 Gene, Transcriptional Enhancers, and Use of Sclerostin Antibody and Pth for Treatment of Periodontal Disease and Bone Loss
Stephen E Harris, Michael Rediske, Rebecca Neitzke, Audrey Rakian
Cell, stem cells and regenerative medicine 2017
Parathyroid Hormone Activates Phospholipase C (PLC)-Independent Protein Kinase C Signaling Pathway via Protein Kinase A (PKA)-Dependent Mechanism: A New Defined Signaling Route Would Induce Alternative Consideration to Previous Conceptions.
Tong G, Meng Y, Hao S, Hu S, He Y, Yan W, Yang D
Medical science monitor : international medical journal of experimental and clinical research 2017
Parathyroid Hormone (PTH) Induces Autophagy to Protect Osteocyte Cell Survival from Dexamethasone Damage.
Zhu L, Chen J, Zhang J, Guo C, Fan W, Wang YM, Yan Z
Medical science monitor : international medical journal of experimental and clinical research 2017

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 37 patents
Referenced in 1 clinical guideline sources
221 readers on Mendeley
1 readers on CiteULike
See more details