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Citations to this article

Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone
Robert L. Jilka, … , A. Michael Parfitt, Stavros C. Manolagas
Robert L. Jilka, … , A. Michael Parfitt, Stavros C. Manolagas
Published August 15, 1999
Citation Information: J Clin Invest. 1999;104(4):439-446. https://doi.org/10.1172/JCI6610.
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Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone

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Abstract

The mass of regenerating tissues, such as bone, is critically dependent on the number of executive cells, which in turn is determined by the rate of replication of progenitors and the life-span of mature cells, reflecting the timing of death by apoptosis. Bone mass can be increased by intermittent parathyroid hormone (PTH) administration, but the mechanism of this phenomenon has remained unknown. We report that daily PTH injections in mice with either normal bone mass or osteopenia due to defective osteoblastogenesis increased bone formation without affecting the generation of new osteoblasts. Instead, PTH increased the life-span of mature osteoblasts by preventing their apoptosis — the fate of the majority of these cells under normal conditions. The antiapoptotic effect of PTH was sufficient to account for the increase in bone mass, and was confirmed in vitro using rodent and human osteoblasts and osteocytes. This evidence provides proof of the basic principle that the work performed by a cell population can be increased by suppression of apoptosis. Moreover, it suggests novel pharmacotherapeutic strategies for osteoporosis and, perhaps, other pathologic conditions in which tissue mass diminution has compromised functional integrity.

Authors

Robert L. Jilka, Robert S. Weinstein, Teresita Bellido, Paula Roberson, A. Michael Parfitt, Stavros C. Manolagas

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1997 1988 Total
Citations: 5 9 14 13 30 25 29 24 38 25 31 26 33 27 53 42 34 38 47 46 42 39 37 25 36 14 3 1 1 787
Citation information
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Citations to this article in year 2008 (38)

Title and authors Publication Year
Building bone to reverse osteoporosis and repair fractures
Sundeep Khosla, Jennifer J. Westendorf, and Merry Jo Oursler
Journal of Clinical Investigation 2008
Control of bone mass and remodeling by PTH receptor signaling in osteocytes
CA O'Brien, LI Plotkin, C Galli, JJ Goellner, AR Gortazar, MR Allen, AG Robling, M Bouxsein, E Schipani, CH Turner, RL Jilka, RS Weinstein, SC Manolagas, T Bellido
PloS one 2008
Regulatory pathways revealing new approaches to the development of anabolic drugs for osteoporosis
TJ Martin, NA Sims, KW Ng
Osteoporosis International 2008
Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation
MJ Christopher, DC Link
Journal of Bone and Mineral Research 2008
Osteoporosis
JJ Westendorf
Osteoporosis International 2008
Osteoporosis
JJ Westendorf
Osteoporosis International 2008
Osteoporosis
JJ Westendorf
Osteoporosis International 2008
Osteoporosis
JJ Westendorf
Osteoporosis International 2008
Osteoporosis
JJ Westendorf
Osteoporosis International 2008
Differentiation and proliferation of periosteal osteoblast progenitors are differentially regulated by estrogens and intermittent parathyroid hormone administration
M Ogita, MT Rached, E Dworakowski, JP Bilezikian, S Kousteni
Endocrinology 2008
Mechanisms of the Anabolic Effects of Teriparatide on Bone: Insight From the Treatment of a Patient With Pycnodysostosis
P Chavassieux, MA Karsdal, T Segovia-Silvestre, AV Neutzsky-Wulff, R Chapurlat, G Boivin, PD Delmas
Journal of Bone and Mineral Research 2008
Bim, Bak, and Bax Regulate Osteoblast Survival
M Liang, G Russell, PA Hulley
Journal of Bone and Mineral Research 2008
Combination Therapy Using Exercise and Pharmaceutical Agents to Optimize Bone Health
RK Fuchs, SJ Warden
Clinical Reviews in Bone and Mineral Metabolism 2008
Formulations for Intermittent Release of Parathyroid Hormone (1-34) and Local Enhancement of Osteoblast Activities
JH Jeon, DA Puleo
Pharmaceutical Development and Technology 2008
IL-6 receptor expression and IL-6 effects change during osteoblast differentiation
Y Li, CM Bäckesjö, LA Haldosén, U Lindgren
Cytokine 2008
The anabolic response to parathyroid hormone is augmented in Rac2 knockout mice
T Kawano, N Troiano, DJ Adams, JJ Wu, B Sun, K Insogna
Endocrinology 2008
Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo
LI Plotkin, V Lezcano, J Thostenson, RS Weinstein, SC Manolagas, T Bellido
Journal of Bone and Mineral Research 2008
Hyperlipidemia impairs osteoanabolic effects of PTH
MS Huang, J Lu, Y Ivanov, AP Sage, W Tseng, LL Demer, Y Tintut
Journal of Bone and Mineral Research 2008
Osteoporosis in men: its pathophysiology and the role of teriparatide in its treatment
C Gagnon, V Li, PR Ebeling
Clinical Interventions in Aging 2008
Cancer treatment-related bone loss: a review and synthesis of the literature
MN Khan, AA Khan
Current oncology (Toronto, Ont.) 2008
Clinical significance of HIV-associated bone loss: when and how to intervene
MT Yin, E Shane, K Anastos
Future HIV Therapy 2008
Influence of host periosteum and recipient bed perforation on the healing of onlay mandibular bone graft: an experimental pilot study in the sheep
WL Adeyemo, T Reuther, W Bloch, Y Korkmaz, JH Fischer, JE Zöller, AC Kuebler
Oral and Maxillofacial Surgery 2008
Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2
V Alonso, AR de Gortázar, JA Ardura, I Andrade-Zapata, MV Alvarez-Arroyo, P Esbrit
Journal of Cellular Physiology 2008
Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption
NA Sims, JH Gooi
Seminars in Cell & Developmental Biology 2008
Effect of progesterone on apoptosis of murine MC3T3-E1 osteoblastic cells
QP Wang, H Xie, LQ Yuan, XH Luo, H Li, D Wang, P Meng, EY Liao
Amino Acids 2008
On the Interpretation of Rat Carcinogenicity Studies for Human PTH(1-34) and Human PTH(1-84)
AH Tashjian, D Goltzman
Journal of Bone and Mineral Research 2008
Bone-forming agents in the management of osteoporosis
A Neuprez, JY Reginster
Best Practice & Research Clinical Endocrinology & Metabolism 2008
Effect of Teriparatide on Early Bone Loss After Kidney Transplantation
D Cejka, T Benesch, C Krestan, P Roschger, K Klaushofer, P Pietschmann, M Haas
American Journal of Transplantation 2008
Species difference exists in the effects of 1α,25(OH)2D3 and its analogue 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 (2MD) on osteoblastic cells
Y Li, CM Bäckesjö, LA Haldosén, U Lindgren
The Journal of Steroid Biochemistry and Molecular Biology 2008
Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion
H Galitzer, I Ben-Dov, V Lavi-Moshayoff, T Naveh-Many, J Silver
Current Opinion in Nephrology and Hypertension 2008
Osteocytes in the pathogenesis of osteoporosis
K Ikeda
Geriatrics & Gerontology International 2008
Teriparatide or Alendronate in Glucocorticoid-Induced Osteoporosis
BL Clarke
Yearbook of Endocrinology 2008
Hypoparathyroidism
D Shoback
New England Journal of Medicine 2008
Human Parathyroid Hormone 1–34 Prevents Bone Loss in Experimental Biliary Cirrhosis in Rats
R Dresner–Pollak, Y Gabet, A Steimatzky, G Hamdani, I Bab, Z Ackerman, M Weinreb
Gastroenterology 2008
Principles of Bone Biology
CJ Rosen, T Niu
Principles of Bone Biology 2008
Studies on the mechanisms of the skeletal anabolic action of endogenous and exogenous parathyroid hormone
D Goltzman
Archives of Biochemistry and Biophysics 2008
Teriparatide in the treatment of osteoporosis
J Stroup, MP Kane, AM Abu-Baker
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2008
Genomics in Endocrinology
S Handwerger, B Aronow
2008

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Referenced in 37 patents
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