Go to
JCI Insight
Citations to this article
Yong Lu, … , Jianfei Qian, Qing Yi
Published October 15, 2012
Citation Information: J Clin Invest. 2012;122(11):4160-4171. https://doi.org/10.1172/JCI65459.
Citation Information: J Clin Invest. 2012;122(11):4160-4171. https://doi.org/10.1172/JCI65459.
Abstract
Th9 cells are a subset of CD4+ Th cells that produce the pleiotropic cytokine IL-9. IL-9/Th9 can function as both positive and negative regulators of immune response, but the role of IL-9/Th9 in tumor immunity is unknown. We examined the role of IL-9/Th9 in a model of pulmonary melanoma in mice. Lack of IL-9 enhanced tumor growth, while tumor-specific Th9 cell treatment promoted stronger antitumor responses in both prophylactic and therapeutic models. Th9 cells also elicited strong host antitumor CD8+ CTL responses by promoting Ccl20/Ccr6-dependent recruitment of DCs to the tumor tissues. Subsequent tumor antigen delivery to the draining LN resulted in CD8+ T cell priming. In agreement with this model, Ccr6 deficiency abrogated the Th9 cell–mediated antitumor response. Our data suggest a distinct role for tumor-specific Th9 cells in provoking CD8+ CTL-mediated antitumor immunity and indicate that Th9 cell–based cancer immunotherapy may be a promising therapeutic approach.
Authors
Yong Lu, Sungyoul Hong, Haiyan Li, Jungsun Park, Bangxing Hong, Lijuan Wang, Yuhuan Zheng, Zhiqiang Liu, Jingda Xu, Jin He, Jing Yang, Jianfei Qian, Qing Yi
Total citations by year
Citation information
Citations to this article (186)
| Title and authors | Publication | Year |
|---|---|---|
|
Targeting γc family cytokines with biologics: current status and future prospects
Bick F, Blanchetot C, Lambrecht BN, Schuijs MJ |
mAbs | 2025 |
|
Combination of percutaneous thermal ablation and adoptive Th9 cell transfer therapy for the treatment of non-small cell lung cancer
Hanbo Pan, Yu Tian, Siyu Pei, Wanlin Yang, Yanyang Zhang, Zenan Gu, Hongda Zhu, Ningyuan Zou, Jiaqi Zhang, Long Jiang, Yingjie Hu, Shengping Shen, Kai Wang, Haizhen Jin, Ziming Li, Yanyun Zhang, Yichuan Xiao, Qingquan Luo, Hui Wang, Jia Huang |
Experimental Hematology and Oncology | 2024 |
|
Natural lung-tropic TH9 cells: A sharp weapon for pulmonary metastatic tumor therapy
Tao Chen, Chenxiao Qiao, Yinwang Eloy, Shengdong Wang, Xuehuan Wen, Yixuan Feng, Xiangang Jin, Shumin Li, Yucheng Xue, Hao Zhou, Wenkan Zhang, Xianchang Zeng, Zenan Wang, Hangxiang Sun, Yingyin Shen, Nong Lin, Hengyuan Li, Binghao Li, Zhijian Cai, Zhaoming Ye |
Journal for immunotherapy of cancer | 2024 |
|
Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation
Joulia E, Michieletto MF, Agesta A, Peillex C, Girault V, Le Dorze AL, Peroceschi R, Bucciarelli F, Szelechowski M, Chaubet A, Hakim N, Marrocco R, Lhuillier E, Lebeurrier M, Argüello RJ, Saoudi A, El Costa H, Adoue V, Walzer T, Sarry JE, Dejean AS |
Journal of Experimental Medicine | 2024 |
|
Immune modulation in malignant pleural effusion: from microenvironment to therapeutic implications
Ge S, Zhao Y, Liang J, He Z, Li K, Zhang G, Hua B, Zheng H, Guo Q, Qi R, Shi Z |
Cancer Cell International | 2024 |
|
Intratumoral Delivery of Interleukin 9 via Oncolytic Vaccinia Virus Elicits Potent Antitumor Effects in Tumor Models
Ye J, Chen L, Waltermire J, Zhao J, Ren J, Guo Z, Bartlett DL, Liu Z |
Cancers | 2024 |
|
Therapeutic potential of interleukin-21 in cancer
Isvoranu G, Chiritoiu-Butnaru M |
Frontiers in immunology | 2024 |
|
Deciphering CD4+ T cell-mediated responses against cancer
Kirkpatrick C, Lu YC |
Molecular Carcinogenesis | 2024 |
|
The Complex Dysregulations of CD4 T Cell Subtypes in HIV Infection
Tolomeo M, Cascio A |
International journal of molecular sciences | 2024 |
|
Cytokine profile of anti-spike CD4+T cells predicts humoral and CD8+T cell responses after anti-SARS-CoV-2 mRNA vaccination
Benhamouda N, Besbes A, Bauer R, Mabrouk N, Gadouas G, Desaint C, Chevrier L, Lefebvre M, Radenne A, Roelens M, Parfait B, Weiskopf D, Sette A, Gruel N, Courbebaisse M, Appay V, Paul S, Gorochov G, Ropers J, Lebbah S, Lelievre JD, Johannes L, Ulmer J, Lebeaux D, Friedlander G, De Lamballerie X, Ravel P, Kieny MP, Batteux F, Durier C, Launay O, Tartour E |
iScience | 2024 |
|
Differentiation and regulation of CD4(+) T cell subsets in Parkinson's disease.
Sun X, Gu R, Bai J |
Cellular and molecular life sciences : CMLS | 2024 |
|
Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling.
Nakajima T, Kanno T, Ueda Y, Miyako K, Endo T, Yoshida S, Yokoyama S, Asou HK, Yamada K, Ikeda K, Togashi Y, Endo Y |
Cellular & molecular immunology | 2024 |
|
Th17 cell function in cancers: immunosuppressive agents or anti-tumor allies?
Anvar MT, Rashidan K, Arsam N, Rasouli-Saravani A, Yadegari H, Ahmadi A, Asgari Z, Vanan AG, Ghorbaninezhad F, Tahmasebi S |
Cancer cell international | 2024 |
|
Tumor Antigen-Tethered Spiked Virus-Like- Poly(Lactic-Co-Glycolic Acid)-Nanoparticle Vaccine Enhances Antitumor Ability Through Th9 Promotion in Mice
Lin TW, Chou PY, Shen YT, Sheu MT, Chuang KH, Lin SY, Chang CY |
International Journal of Nanomedicine | 2024 |
|
Functional diversity and regulation of IL-9-producing T cells in cancer immunotherapy
Kalim M, Jing R, Guo W, Xing H, Lu Y |
Cancer letters | 2024 |
|
Role and Potential of Different T Helper Cell Subsets in Adoptive Cell Therapy
Andreu-Sanz D, Kobold S |
Cancers | 2023 |
|
The Emerging Role of IL-9 in the Anticancer Effects of Anti-PD-1 Therapy
Vinokurova D, Apetoh L |
Biomolecules | 2023 |
|
Deficiency of the CD155-CD96 immune checkpoint controls IL-9 production in giant cell arteritis
Ohtsuki S, Wang C, Watanabe R, Zhang H, Akiyama M, Bois MC, Maleszewski JJ, Warrington KJ, Berry GJ, Goronzy JJ, Weyand CM |
Cell reports. Medicine | 2023 |
|
JAKing up IL-9 expression in T(H)9 cells.
Muñoz-Paleta O, Licona-Limón P |
Nature Immunology | 2023 |
|
Protein Phosphatase 2A: Role in T Cells and Diseases
Roy S, Batra L |
Journal of Immunology Research | 2023 |
|
Differences in the phenotypes and transcriptomic signatures of chimeric antigen receptor T lymphocytes manufactured via electroporation or lentiviral transfection
Niu A, Zou J, Hu X, Zhang Z, Su L, Wang J, Lu X, Zhang W, Chen W, Zhang X |
Frontiers in immunology | 2023 |
|
T cells in health and disease.
Sun L, Su Y, Jiao A, Wang X, Zhang B |
Signal Transduction and Targeted Therapy | 2023 |
|
The Dichotomy of Interleukin-9 Function in the Tumor Microenvironment
Cannon A, Pajulas A, Kaplan MH, Zhang J |
Journal of Interferon & Cytokine Research | 2023 |
|
The world according to IL-9
Pajulas A, Zhang J, Kaplan MH |
Journal of immunology (Baltimore, Md. : 1950) | 2023 |
|
IL-24 is the key effector of Th9 cell-mediated tumor immunotherapy
Chen J, Zhang Y, Zhang H, Zhang M, Dong H, Qin T, Gao S, Wang S |
iScience | 2023 |
|
The role of CD4+ T cells in tumor and chronic viral immune responses
Xie L, Fang J, Yu J, Zhang W, He Z, Ye L, Wang H |
2023 | |
|
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer
Topchyan P, Lin S, Cui W |
Immune Network | 2023 |
|
Transcription Factor Id1 Plays an Essential Role in Th9 Cell Differentiation by Inhibiting Tcf3 and Tcf4
Lee WH, Hong KJ, Li H, Lee GR |
Advanced Science | 2023 |
|
Distinct gene expression signatures comparing latent tuberculosis infection with different routes of Bacillus Calmette-Guérin vaccination.
Silver RF, Xia M, Storer CE, Jarvela JR, Moyer MC, Blazevic A, Stoeckel DA, Rakey EK, Tennant JM, Goll JB, Head RD, Hoft DF |
Nature Communications | 2023 |
|
Proteostasis in T cell aging
Gressler AE, Leng H, Zinecker H, Simon AK |
Seminars in Immunology | 2023 |
|
The Differentially Expressed Genes Responsible for the Development of T Helper 9 Cells From T Helper 2 Cells in Various Disease States: Immuno-Interactomics Study
Khokhar M, Purohit P, Gadwal A, Tomo S, Bajpai NK, Shukla R |
2023 | |
|
Pulmonary interstitial macrophages are required to mediate the pro-tumorigenic effects of IL-9
Yongyao Fu, Jocelyn Wang, Baohua Zhou, Hongyu Gao, Huaxin Zhou, Amanda Fisher, David Omstead, Sabrina Khan, Lei Han, Abigail Pajulas, Jean-Christophe Renauld, Sophie Paczesny, Yunlong Liu, Lei Yang, Robert Tighe, Paula Licona-Limón, Richard Flavell, Shogo Takatsuka, Daisuke Kitamura, Jie Sun, Basar Bilgicer, Catherine Sears, Kai Yang, Mark Kaplan |
Nature Communications | 2022 |
|
Epigenetic Regulation: A Link between Inflammation and Carcinogenesis
B Vezzani, M Carinci, M Previati, S Giacovazzi, M Sala, R Gafà, G Lanza, M Wieckowski, P Pinton, C Giorgi |
Cancers | 2022 |
|
Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy
M Khelil, Y Godet, S Abdeljaoued, C Borg, O Adotévi, R Loyon |
Cancers | 2022 |
|
The Roles of IRF-8 in Regulating IL-9-Mediated Immunologic Mechanisms in the Development of DLBCL: A State-of-the-Art Literature Review
M Cai, N Chen |
Frontiers in Oncology | 2022 |
|
Intravenous Oncolytic Vaccinia Virus Therapy Results in a Differential Immune Response between Cancer Patients
E West, K Scott, E Tidswell, K Bendjama, N Stojkowitz, M Lusky, M Kurzawa, R Prasad, G Toogood, C Ralph, D Anthoney, A Melcher, F Collinson, A Samson |
Cancers | 2022 |
|
Potentiating adoptive cell therapy using synthetic IL-9 receptors
A Kalbasi, M Siurala, L Su, M Tariveranmoshabad, L Picton, P Ravikumar, P Li, J Lin, H Escuin-Ordinas, T Da, S Kremer, A Sun, S Castelli, S Agarwal, J Scholler, D Song, P Rommel, E Radaelli, R Young, W Leonard, A Ribas, C June, K Garcia |
Nature | 2022 |
|
IL-9 Producing Tumor-Infiltrating Lymphocytes and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer
Heim L, Yang Z, Tausche P, Hohenberger K, Chiriac MT, Koelle J, Geppert CI, Kachler K, Miksch S, Graser A, Friedrich J, Kharwadkar R, Rieker RJ, Trufa DI, Sirbu H, Neurath MF, Kaplan MH, Finotto S |
Frontiers in immunology | 2022 |
|
First Characterization of Chicken Interleukin-9
He S, Chen L, Hao X, Yang Y, Shang S |
Frontiers in immunology | 2022 |
|
IRF8: Mechanism of Action and Health Implications.
Moorman HR, Reategui Y, Poschel DB, Liu K |
Cells | 2022 |
|
Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation
Park SA, Lim YJ, Ku WL, Zhang D, Cui K, Tang LY, Chia C, Zanvit P, Chen Z, Jin W, Wang D, Xu J, Liu O, Wang F, Cain A, Guo N, Nakatsukasa H, Wu C, Zhang YE, Zhao K, Chen W |
Nature Communications | 2022 |
|
Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion
Kaminskiy Y, Kuznetsova V, Kudriaeva A, Zmievskaya E, Bulatov E |
Frontiers in immunology | 2022 |
|
IL-1β promotes IL-9-producing Th cell differentiation in IL-2-limiting conditions through the inhibition of BCL6
Canaria DA, Clare MG, Yan B, Campbell CB, Ismaio ZA, Anderson NL, Park S, Dent AL, Kazemian M, Olson MR |
Frontiers in immunology | 2022 |
|
Enhancement of T cell infiltration via tumor-targeted Th9 cell delivery improves the efficacy of antitumor immunotherapy of solid tumors
Chen T, Xue Y, Wang S, Lu J, Zhou H, Zhang W, Zhou Z, Li B, Li Y, Wang Z, Li C, Eloy Y, Sun H, Shen Y, Diarra MD, Ge C, Chai X, Mou H, Lin P, Yu X, Ye Z |
Bioactive Materials | 2022 |
|
PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells.
Gerlach K, Popp V, Wirtz S, Al-Saifi R, Gonzalez Acera M, Atreya R, Dregelies T, Vieth M, Fichtner-Feigl S, McKenzie ANJ, Rosenbauer F, Weigmann B, Neurath MF |
Journal of Crohn's & colitis | 2022 |
|
Distinct T helper cell-mediated antitumor immunity: T helper 2 cells in focus
Silva RC, Lopes MF, Travassos LH |
2022 | |
|
Significant and Conflicting Correlation of IL-9 With Prevotella and Bacteroides in Human Colorectal Cancer
E Niccolai, E Russo, S Baldi, F Ricci, G Nannini, M Pedone, FC Stingo, A Taddei, MN Ringressi, P Bechi, A Mengoni, R Fani, G Bacci, C Fagorzi, C Chiellini, D Prisco, M Ramazzotti, A Amedei |
Frontiers in immunology | 2021 |
|
BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy
S Pei, M Huang, J Huang, X Zhu, H Wang, S Romano, X Deng, Y Wang, Y Luo, S Hao, J Xu, T Yu, Q Zhu, J Yuan, K Shen, Z Liu, G Hu, C Peng, Q Luo, Z Wen, D Dai, Y Xiao |
Journal of Experimental Medicine | 2021 |
|
T Cell Subsets in Graft Versus Host Disease and Graft Versus Tumor
H Jiang, D Fu, A Bidgoli, S Paczesny |
Frontiers in immunology | 2021 |
|
Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells
G Xue, N Zheng, J Fang, G Jin, X Li, G Dotti, Q Yi, Y Lu |
Cancer Cell | 2021 |
|
Engineered Cytokine Signaling to Improve CAR T Cell Effector Function
M Bell, S Gottschalk |
Frontiers in immunology | 2021 |
|
Critical Roles of Balanced T Helper 9 Cells and Regulatory T Cells in Allergic Airway Inflammation and Tumor Immunity
M Huang, J Dong, A Singh |
Journal of Immunology Research | 2021 |
|
Targeting ubiquitin signaling for cancer immunotherapy
X Zhou, SC Sun |
Signal Transduction and Targeted Therapy | 2021 |
|
Interleukin-1 as Innate Mediator of T Cell Immunity
BV Eeckhout, J Tavernier, S Gerlo |
Frontiers in immunology | 2021 |
|
EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells
S Roy, ZA Rizvi, AJ Clarke, F Macdonald, A Pandey, DM Zaiss, AK Simon, A Awasthi |
Nature Communications | 2021 |
|
Harnessing the IL-21-BATF Pathway in the CD8+ T Cell Anti-Tumor Response
P Topchyan, G Xin, Y Chen, S Zheng, R Burns, J Shen, MY Kasmani, M Kudek, N Yang, W Cui |
Cancers | 2021 |
|
Impact of Immunotherapy on CD4 T Cell Phenotypes and Function in Cancer
M Saillard, M Cenerenti, P Romero, C Jandus |
Human vaccines | 2021 |
|
STAT5 Represses a STAT3-Independent Th17-like Program during Th9 Cell Differentiation
DA Canaria, B Yan, MG Clare, Z Zhang, GA Taylor, DL Boone, M Kazemian, MR Olson |
Journal of immunology (Baltimore, Md. : 1950) | 2021 |
|
Antibody-based delivery of interleukin-9 to neovascular structures: Therapeutic evaluation in cancer and arthritis
B Gouyou, T Ongaro, S Cazzamalli, RD Luca, A Kerschenmeyer, P Valet, A Villa, D Neri, M Matasci |
Experimental biology and medicine (Maywood, N.J.) | 2021 |
|
Elimination of acquired resistance to PD-1 blockade via the concurrent depletion of tumour cells and immunosuppressive cells
G Xue, Z Wang, N Zheng, J Fang, C Mao, X Li, G Jin, X Ming, Y Lu |
Nature Biomedical Engineering | 2021 |
|
Irradiated whole‑cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells
J Chen, Y Ding, F Huang, R Lan, Z Wang, W Huang, R Chen, B Wu, L Fu, Y Yang, J Liu, J Hong, W Zhang, L Zhang |
Oncology Letters | 2021 |
|
Interleukin (IL)-9 Supports the Tumor-Promoting Environment of Chronic Lymphocytic Leukemia
L Patrussi, N Capitani, CT Baldari |
Cancers | 2021 |
|
Regulatory Roles of MicroRNA in Shaping T Cell Function, Differentiation and Polarization
Naqvi RA, Manali M, Khan SH, Naqvi AR |
Seminars in cell & developmental biology | 2021 |
|
Immunopathobiology and therapeutic targets related to cytokines in liver diseases
Y He, S Hwang, YA Ahmed, D Feng, N Li, M Ribeiro, F Lafdil, T Kisseleva, G Szabo, B Gao |
Cellular and Molecular Immunology | 2020 |
|
IL-9-producing T cells: potential players in allergy and cancer
P Angkasekwinai, C Dong |
Nature Reviews Immunology | 2020 |
|
HIV persistence in subsets of CD4+ T cells: 50 shades of reservoirs
R Fromentin, N Chomont |
Seminars in Immunology | 2020 |
|
Role of the Immune System and the Circadian Rhythm in the Pathogenesis of Chronic Pancreatitis: Establishing a Personalized Signature for Improving the Effect of Immunotherapies for Chronic Pancreatitis
A Kessler, S Weksler-Zangen, Y Ilan |
Pancreas | 2020 |
|
TNF-a Is a Potent Stimulator of Tc9-Cell Differentiation
S Yang, J Chen, H Zhang, Y Jiang, T Qin, S Gao, Y Yue, S Wang |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2020 |
|
Interleukin-9 Inhibits Lung Metastasis of Melanoma through Stimulating Anti-Tumor M1 Macrophages
Sang Min Park, Van Anh Do-Thi, Jie-Oh Lee, Hayyoung Lee, Young Sang Kim |
Molecules and Cells | 2020 |
|
Th9 Cell Differentiation and Its Dual Effects in Tumor Development
T Chen, J Guo, Z Cai, B Li, L Sun, Y Shen, S Wang, Z Wang, Z Wang, Y Wang, H Zhou, Z Cai, Z Ye |
Frontiers in immunology | 2020 |
|
Interleukin-35 Promotes Th9 Cell Differentiation in IgG4-Related Disorders: Experimental Data and Review of the Literature
J Zhang, M Lian, B Li, L Gao, T Tanaka, Z You, Y Wei, Y Chen, Y Li, Y Li, B Huang, R Tang, Q Wang, Q Miao, Y Peng, J Fang, Z Lian, K Okazaki, X Xiao, W Zhang, X Ma |
Clinical Reviews in Allergy & Immunology | 2020 |
|
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
Y Fu, J Wang, G Panangipalli, BJ Ulrich, B Koh, C Xu, R Kharwadkar, X Chu, Y Wang, H Gao, W Wu, J Sun, RS Tepper, B Zhou, SC Janga, K Yang, MH Kaplan |
Nature Communications | 2020 |
|
Intratumoral interleukin-9 delineates a distinct immunogenic class of gastric cancer patients with better prognosis and adjuvant chemotherapeutic response
H Fang, R Li, Y Gu, Y Fei, K Jin, Y Chen, Y Cao, X Liu, K Lv, J Wang, K Yu, C Lin, H Liu, H Li, H He, W Zhang, H Zhang, Z Shen |
OncoImmunology | 2020 |
|
Identification of Interleukin-9 Producing Immune Cells in Endometrial Carcinoma and Establishment of a Prognostic Nomogram
H Tong, H Feng, X Hu, M Wang, Y Song, X Wen, Y Li, X Wan |
Frontiers in immunology | 2020 |
|
Immunomodulatory dynamics of excretory and secretory products on Th9 immune response during Haemonchus contortus infection in goat
MA Memon, MA Naqvi, H Xin, L Meng, MW Hasan, M Haseeb, SA Lakho, K Aimulajiang, Y Bu, L Xu, X Song, X Li, R Yan, SJ Davies |
PLoS neglected tropical diseases | 2020 |
|
Host dysbiosis negatively impacts IL-9-producing T-cell differentiation and antitumour immunity
RR Almeida, R de Souza Vieira, A Castoldi, FF Terra, AC Melo, MC Canesso, L Lemos, M Cipelli, N Rana, MI Hiyane, EL Pearce, F dos Santos Martins, AM de Faria, NO Câmara |
British Journal of Cancer | 2020 |
|
The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4 + T Cell Subsets
P Wang, Q Zhang, L Tan, Y Xu, X Xie, Y Zhao |
Journal of Immunology Research | 2020 |
|
IL-9 and IL-9-producing cells in tumor immunity
J Wan, Y Wu, X Ji, L Huang, W Cai, Z Su, S Wang, H Xu |
Cell Communication and Signaling | 2020 |
|
Proteome analysis revealed the essential functions of protein phosphatase PP2A in the induction of Th9 cells
S Roy, R Goel, S Aggarwal, S Asthana, AK Yadav, A Awasthi |
Scientific Reports | 2020 |
|
Targeting the IL-9 pathway in cancer immunotherapy
N Zheng, Y Lu |
Human Vaccines & Immunotherapeutics | 2020 |
|
Evolution of the immune landscape during progression of pancreatic intraductal papillary mucinous neoplasms to invasive cancer
S Roth, K Zamzow, MM Gaida, M Heikenwälder, C Tjaden, U Hinz, P Bose, CW Michalski, T Hackert |
EBioMedicine | 2020 |
|
Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9
L Liu, E Bi, X Ma, W Xiong, J Qian, L Ye, P Su, Q Wang, L Xiao, M Yang, Y Lu, Q Yi |
Nature Communications | 2020 |
|
In vitro-generated alloantigen-specific Th9 cells mediate antileukemia cytotoxicity in the absence of graft-versus-host disease
T Reisser, D Halbgebauer, J Scheurer, L Wolf, F Leithäuser, N Beyersdorf, P Fischer-Posovszky, KM Debatin, G Strauss |
Leukemia | 2020 |
|
An overview of the tumor microenvironment, from cells to complex networks (Review)
O Farc, V Cristea |
Experimental and therapeutic medicine | 2020 |
|
Fueling Cancer Immunotherapy With Common Gamma Chain Cytokines
CJ Dwyer, HM Knochelmann, AS Smith, MM Wyatt, GO Rivera, DC Arhontoulis, E Bartee, Z Li, MP Rubinstein, CM Paulos |
Frontiers in immunology | 2019 |
|
Butyrate Attenuates Lung Inflammation by Negatively Modulating Th9 Cells
R de Souza Vieira, A Castoldi, PJ Basso, MI Hiyane, NO Câmara, RR Almeida |
Frontiers in immunology | 2019 |
|
ATP Triggers Human Th9 Cell Differentiation via Nitric Oxide-Mediated mTOR-HIF1α Pathway
S Roy, A Awasthi |
Frontiers in immunology | 2019 |
|
B lymphocyte–induced maturation protein 1 controls TH9 cell development, IL-9 production, and allergic inflammation
L Benevides, RS Costa, LA Tavares, M Russo, GA Martins, LL da Silva, LK Arruda, FQ Cunha, V Carregaro, JS Silva |
Journal of Allergy and Clinical Immunology | 2019 |
|
Nod1 Imprints Inflammatory and Carcinogenic Responses toward the Gastric Pathogen Helicobacter pylori
G Suarez, J Romero-Gallo, MB Piazuelo, JC Sierra, AG Delgado, MK Washington, SC Shah, KT Wilson, RM Peek |
Cancer research | 2019 |
|
Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor
D Yan, AO Adeshakin, M Xu, LO Afolabi, G Zhang, YH Chen, X Wan |
Frontiers in immunology | 2019 |
|
TNF-α enhances Th9 cell differentiation and antitumor immunity via TNFR2-dependent pathways
Y Jiang, J Chen, E Bi, Y Zhao, T Qin, Y Wang, A Wang, S Gao, Q Yi, S Wang |
Journal for ImmunoTherapy of Cancer | 2019 |
|
Innate lymphoid cells: A potential link between microbiota and immune responses against cancer
SK Panda, M Colonna |
Seminars in Immunology | 2019 |
|
IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling
G Xue, G Jin, J Fang, Y Lu |
Nature Communications | 2019 |
|
The Role of Interleukin-9 in Cancer
JE Lee, Z Zhu, Q Bai, TJ Brady, H Xiao, MR Wakefield, Y Fang |
Pathology & Oncology Research | 2019 |
|
Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness
M Saeki, T Nishimura, N Kitamura, T Hiroi, A Mori, O Kaminuma |
International journal of molecular sciences | 2019 |
|
Functions of Group 2 Innate Lymphoid Cells in Tumor Microenvironment
J Xiong, H Wang, J He, Q Wang |
Frontiers in immunology | 2019 |
|
Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions
Y Shen, Z Song, X Lu, Z Ma, C Lu, B Zhang, Y Chen, M Duan, L Apetoh, X Li, J Guo, Y Miao, G Zhang, D Yang, Z Cai, J Wang |
Nature Communications | 2019 |
|
IL-9 Exerts Antitumor Effects in Colon Cancer and Transforms the Tumor Microenvironment In Vivo
J Wang, M Sun, H Zhao, Y Huang, D Li, D Mao, Z Zhang, X Zhu, X Dong, X Zhao |
Technology in cancer research & treatment | 2019 |
|
T Helper 9 Cells: A New Player in Immune-Related Diseases
J Chen, L Guan, L Tang, S Liu, Y Zhou, C Chen, Z He, L Xu |
DNA and Cell Biology | 2019 |
|
The dichotomous function of interleukin-9 in cancer diseases
K Gerlach, B Weigmann |
Journal of Molecular Medicine | 2019 |
|
IL-9 Controls Central Nervous System Autoimmunity by Suppressing GM-CSF Production
S Yoshimura, R Thome, S Konno, ER Mari, J Rasouli, D Hwang, A Boehm, Y Li, GX Zhang, B Ciric, A Rostami |
Journal of immunology (Baltimore, Md. : 1950) | 2019 |
|
PIM-2 Protein Kinase Negatively Regulates T Cell Responses in Transplantation and Tumor Immunity
Anusara Daenthanasanmak, Yongxia Wu, Supinya Iamsawat, Hung Nguyen, David Bastian, Mengmeng Zhang, M.Hanief Sofi, Shilpak Chatterjee, Shikhar Mehrotra, Andrew S Kraft, Xue-Zhong Yu |
Journal of Clinical Investigation | 2018 |
|
Th1/Th17-polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters
Ricardo da Silva Antunes, Mariana Babor, Chelsea Carpenter, Natalie Khalil, Mario Cortese, Alexander J Mentzer, Grégory Seumois, Christopher D. Petro, Lisa A. Purcell, Pandurangan Vijayanand, Shane Crotty, Bali Pulendran, Bjorn Peters, Alessandro Sette |
Journal of Clinical Investigation | 2018 |
|
Synovial IL-9 facilitates neutrophil survival, function and differentiation of Th17 cells in rheumatoid arthritis
K Chowdhury, U Kumar, S Das, J Chaudhuri, P Kumar, M Kanjilal, P Ghosh, G Sircar, RK Basyal, U Kanga, S Bandyopadhaya, DK Mitra |
Arthritis Research & Therapy | 2018 |
|
CD96 expression determines the inflammatory potential of IL-9–producing Th9 cells
K Stanko, C Iwert, C Appelt, K Vogt, J Schumann, FJ Strunk, S Ahrlich, S Schlickeiser, C Romagnani, K Jürchott, C Meisel, G Willimsky, AA Kühl, B Sawitzki |
Proceedings of the National Academy of Sciences | 2018 |
|
Cholesterol negatively regulates IL-9–producing CD8 + T cell differentiation and antitumor activity
X Ma, E Bi, C Huang, Y Lu, G Xue, X Guo, A Wang, M Yang, J Qian, C Dong, Q Yi |
Journal of Experimental Medicine | 2018 |
|
CD38-NAD + Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
S Chatterjee, A Daenthanasanmak, P Chakraborty, MW Wyatt, P Dhar, SP Selvam, J Fu, J Zhang, H Nguyen, I Kang, K Toth, M Al-Homrani, M Husain, G Beeson, L Ball, K Helke, S Husain, E Garrett-Mayer, G Hardiman, M Mehrotra, MI Nishimura, CC Beeson, MG Bupp, J Wu, B Ogretmen, CM Paulos, J Rathmell, XZ Yu, S Mehrotra |
Cell Metabolism | 2018 |
|
The multifaceted role of autophagy in cancer and the microenvironment: FOLKERTS et al
H Folkerts, S Hilgendorf, E Vellenga, E Bremer, VR Wiersma |
Medicinal Research Reviews | 2018 |
|
Transcriptional Control of Th9 Cells: Role of Foxo1 in Interleukin-9 Induction
S Malik, A Awasthi |
Frontiers in immunology | 2018 |
|
Th9 Cells Represent a Unique Subset of CD4 + T Cells Endowed with the Ability to Eradicate Advanced Tumors
Y Lu, Q Wang, G Xue, E Bi, X Ma, A Wang, J Qian, C Dong, Q Yi |
Cancer Cell | 2018 |
|
Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions
E Jacquin, L Apetoh |
Frontiers in immunology | 2018 |
|
TGF-β in T Cell Biology: Implications for Cancer Immunotherapy
A Dahmani, JS Delisle |
Cancers | 2018 |
|
Role of Cytokine Combinations on CD4+ T Cell Differentiation, Partial Polarization, and Plasticity: Continuous Network Modeling Approach
ME Martinez-Sanchez, L Huerta, ER Alvarez-Buylla, CV Luján |
Frontiers in physiology | 2018 |
|
[Expression of interleukin-9 in colon cancer tissues and its clinical significance]
Jin Wang, Xiaoqiang Dong, Xinguo Zhu, Hua Zhao, Deli Mao, Xin Zhao |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | 2018 |
|
Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation
X Xiao, Y Fan, J Li, X Zhang, X Lou, Y Dou, X Shi, P Lan, Y Xiao, L Minze, XC Li |
Journal of Experimental Medicine | 2018 |
|
Interleukin-33 Contributes to the Induction of Th9 Cells and Antitumor Efficacy by Dectin-1-Activated Dendritic Cells
J Chen, Y Zhao, Y Jiang, S Gao, Y Wang, D Wang, A Wang, H Yi, R Gu, Q Yi, S Wang |
Frontiers in immunology | 2018 |
|
Ectopically Expressed Membrane-bound Form of IL-9 Exerts Immune-stimulatory Effect on CT26 Colon Carcinoma Cells
VA Thi, SM Park, H Lee, YS Kim |
Immune Network | 2018 |
|
Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells
TT Spear, Y Wang, TW Smith, PE Simms, E Garrett-Mayer, LM Hellman, BM Baker, MI Nishimura |
Molecular Therapy | 2018 |
|
Less cholesterol means better tumor killing for cytotoxic T9 cells
B Griesenauer, S Paczesny |
Journal of Experimental Medicine | 2018 |
|
TGF-β enhances the cytotoxic activity of Vδ2 T cells
C Peters, A Meyer, L Kouakanou, J Feder, T Schricker, M Lettau, O Janssen, D Wesch, D Kabelitz |
OncoImmunology | 2018 |
|
The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity
C Afferni, C Buccione, S Andreone, MR Galdiero, G Varricchi, G Marone, F Mattei, G Schiavoni |
Frontiers in immunology | 2018 |
|
Specifically differentiated T cell subset promotes tumor immunity over fatal immunity
A Ramadan, B Griesenauer, D Adom, R Kapur, H Hanenberg, C Liu, MH Kaplan, S Paczesny |
Journal of Experimental Medicine | 2017 |
|
Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
TR Vargas, Z Cai, Y Shen, M Dosset, I Benoit-Lizon, T Martin, A Roussey, RA Flavell, F Ghiringhelli, L Apetoh |
Nature Communications | 2017 |
|
IL-9 and Th9 cells in health and diseases—From tolerance to immunopathology
J Li, S Chen, X Xiao, Y Zhao, W Ding, XC Li |
Cytokine & Growth Factor Reviews | 2017 |
|
The Common Cytokine Receptor γ Chain Family of Cytokines
JX Lin, WJ Leonard |
Cold Spring Harbor perspectives in biology | 2017 |
|
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
LC Carrascosa, M Klein, Y Kitagawa, C Lückel, F Marini, A König, A Guralnik, H Raifer, S Hagner-Benes, D Rädler, A Böck, C Kang, M Lohoff, H Garn, B Schaub, F Berberich-Siebelt, S Sakaguchi, T Bopp, M Huber |
Nature Communications | 2017 |
|
Decreased frequency of circulating Th9 cells in patients with chronic hepatitis B infection
M Cui, Y Lv, J Lu, W Zhang, Y Duan, Y Huang, L Yang, M Li, W Liu, D Liu, H Yan |
Journal of Clinical Laboratory Analysis | 2017 |
|
Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities
J Masuda, E Takayama, W Strober, A Satoh, Y Morimoto, Y Honjo, T Ichinohe, SI Tokuno, T Ishizuka, T Nakata, A Mizutani, N Umemura, A Kitani, IJ Fuss, T Shigehiro, H Kawaki, M Mizuno-Kamiya, N Kondoh, M Seno |
Oncology reports | 2017 |
|
STAT3 Activation Impairs the Stability of Th9 Cells
BJ Ulrich, FF Verdan, AN McKenzie, MH Kaplan, MR Olson |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
|
LYG1 exerts anti-tumor function through promoting the activation, proliferation and function of CD4 + T cells
H Liu, Y Zhang, Z Liu, P Wang, X Mo, W Fu, W Liu, Y Cheng, W Han |
OncoImmunology | 2017 |
|
Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production
MR Olson, BJ Ulrich, SA Hummel, I Khan, B Meuris, Y Cherukuri, AL Dent, SC Janga, MH Kaplan |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
|
Induction of specific T helper-9 cells to inhibit glioma cell growth
H Zheng, B Yang, D Xu, W Wang, J Tan, L Sun, Q Li, L Sun, X Xia |
Oncotarget | 2017 |
|
The γc family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response
R Spolski, D Gromer, WJ Leonard |
F1000Research | 2017 |
|
IRF8-dependent molecular complexes control the Th9 transcriptional program
E Humblin, M Thibaudin, F Chalmin, V Derangère, E Limagne, C Richard, RA Flavell, S Chevrier, S Ladoire, H Berger, R Boidot, L Apetoh, F Végran, F Ghiringhelli |
Nature Communications | 2017 |
|
Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of T H 9 cells programmed by IL-7
E Bi, X Ma, Y Lu, M Yang, Q Wang, G Xue, J Qian, S Wang, Q Yi |
Science signaling | 2017 |
|
Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells
Y Zhao, X Chu, J Chen, Y Wang, S Gao, Y Jiang, X Zhu, G Tan, W Zhao, H Yi, H Xu, X Ma, Y Lu, Q Yi, S Wang |
Nature Communications | 2016 |
|
MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2 α as an important regulator of T helper 9 and regulatory T-cell differentiation
Y Singh, OA Garden, F Lang, BS Cobb |
Immunology | 2016 |
|
Alkaline Cytosolic pH and High Sodium Hydrogen Exchanger 1 (NHE1) Activity in Th9 Cells
Y Singh, Y Zhou, X Shi, S Zhang, AT Umbach, MS Salker, KS Lang, F Lang |
The Journal of biological chemistry | 2016 |
|
Targeting B-cell malignancies through human B-cell receptor specific CD4 + T cells
J Weng, FE Baio, KE Moriarty, H Torikai, H Wang, Z Liu, SN Maiti, D Gwak, MS Popescu, SC Cha, LJ Cooper, SS Neelapu, LW Kwak |
OncoImmunology | 2016 |
|
TH9 cells in anti-tumor immunity
TR Vargas, E Humblin, F Végran, F Ghiringhelli, L Apetoh |
Seminars in Immunopathology | 2016 |
|
Dectin-1-activated dendritic cells: a potent Th9 cell inducer for tumor immunotherapy
J Chen, Y Zhao, X Chu, Y Lu, S Wang, Q Yi |
OncoImmunology | 2016 |
|
T cell cytokine signatures: Biomarkers in pediatric multiple sclerosis
CM Cala, CE Moseley, C Steele, SM Dowdy, GR Cutter, JM Ness, TM DeSilva |
Journal of Neuroimmunology | 2016 |
|
TH9 cells in skin disorders
RA Clark, C Schlapbach |
Seminars in Immunopathology | 2016 |
|
Human Vδ2 T cells are a major source of interleukin-9
C Peters, R Häsler, D Wesch, D Kabelitz |
Proceedings of the National Academy of Sciences | 2016 |
|
Peripheral blood Th9 cells are a possible pharmacodynamic biomarker of nivolumab treatment efficacy in metastatic melanoma patients
Y Nonomura, A Otsuka, C Nakashima, JA Seidel, A Kitoh, T Dainichi, S Nakajima, Y Sawada, S Matsushita, M Aoki, T Takenouchi, T Fujimura, N Hatta, S Koreeda, S Fukushima, T Honda, K Kabashima |
OncoImmunology | 2016 |
|
Discovery and initial characterization of Th9 cells: the early years
E Schmitt, T Bopp |
Seminars in Immunopathology | 2016 |
|
Information-dense analysis for information-dense understanding
NA Ivica, M Kaur, G Hu, J Chen |
Translational cancer research | 2016 |
|
ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease
J Zhang, AM Ramadan, B Griesenauer, W Li, MJ Turner, C Liu, R Kapur, H Hanenberg, BR Blazar, I Tawara, S Paczesny |
Science Translational Medicine | 2015 |
|
The development and in vivo function of T helper 9 cells
MH Kaplan, MM Hufford, MR Olson |
Nature Reviews Immunology | 2015 |
|
Sex chromosome loss and the pseudoautosomal region genes in hematological malignancies
S Weng, SA Stoner, DE Zhang |
Oncotarget | 2015 |
|
TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer
Y Li, Q Yu, Z Zhang, J Wang, S Li, J Zhang, G Liu |
Oncotarget | 2015 |
|
A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity
ME Martinez-Sanchez, L Mendoza, C Villarreal, ER Alvarez-Buylla, J Bassaganya-Riera |
PLoS computational biology | 2015 |
|
Physical attraction of Th9 cells is skin deep
Valerie Dardalhon, Mary Collins, Vijay K. Kuchroo |
Annals of translational medicine | 2015 |
|
Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells
IK Kim, BS Kim, CH Koh, JW Seok, JS Park, KS Shin, EA Bae, GE Lee, H Jeon, J Cho, Y Jung, D Han, BS Kwon, HY Lee, Y Chung, CY Kang |
Nature Medicine | 2015 |
|
The DNA-binding inhibitor Id3 regulates IL-9 production in CD4+ T cells
H Nakatsukasa, D Zhang, T Maruyama, H Chen, K Cui, M Ishikawa, L Deng, P Zanvit, E Tu, W Jin, B Abbatiello, N Goldberg, Q Chen, L Sun, K Zhao, WJ Chen |
Nature Immunology | 2015 |
|
GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation
X Xiao, X Shi, Y Fan, X Zhang, M Wu, P Lan, L Minze, YX Fu, RM Ghobrial, W Liu, XC Li |
Nature Communications | 2015 |
|
Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells
M Takami, K Fujimaki, MI Nishimura, M Iwashima |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
|
p-STAT6, PU.1, and NF-κB are involved in allergen-induced late-phase airway inflammation in asthma patients
D Hoppenot, K Malakauskas, S Lavinskiene, R Sakalauskas |
BMC Pulmonary Medicine | 2015 |
|
GITR drives T H 9-mediated antitumor immunity
IK Kim, Y Chung, CY Kang |
OncoImmunology | 2015 |
|
Association between low expression levels of interleukin-9 and colon cancer progression
Y Huang, Y Cao, S Zhang, F Gao |
Experimental and therapeutic medicine | 2015 |
|
USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity
B Hong, H Li, Y Lu, M Zhang, Y Zheng, J Qian, Q Yi |
Molecular Cancer | 2014 |
|
The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment
J Zhou, Y Xiang, T Yoshimura, K Chen, W Gong, J Huang, Y Zhou, X Yao, X Bian, JM Wang |
BioMed Research International | 2014 |
|
Reducing CD73 Expression by IL1 -Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors
S Chatterjee, K Thyagarajan, P Kesarwani, JH Song, M Soloshchenko, J Fu, SR Bailey, C Vasu, AS Kraft, CM Paulos, XZ Yu, S Mehrotra |
Cancer research | 2014 |
|
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers
Y Lu, B Hong, H Li, Y Zheng, M Zhang, S Wang, J Qian, Q Yi |
Proceedings of the National Academy of Sciences | 2014 |
|
Anticancer Tc9 cells
Y Lu, Q Wang, Q Yi |
OncoImmunology | 2014 |
|
CIMT 2014: Next waves in cancer immunotherapy - Report on the 12th annual meeting of the Association for Cancer Immunotherapy: May 6–8 2014, Mainz, Germany
M Diken, S Boegel, C Grunwitz, LM Kranz, K Reuter, N de Roemer, F Vascotto, M Vormehr, S Kreiter |
Human Vaccines & Immunotherapeutics | 2014 |
|
The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells
F Végran, H Berger, R Boidot, G Mignot, M Bruchard, M Dosset, F Chalmin, C Rébé, V Dérangère, B Ryffel, M Kato, A Prévost-Blondel, F Ghiringhelli, L Apetoh |
Nature Immunology | 2014 |
|
TGFβ in T cell biology and tumor immunity: Angel or devil?
E Tu, PZ Chia, W Chen |
Cytokine & Growth Factor Reviews | 2014 |
|
USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses
Q Zou, J Jin, H Hu, HS Li, S Romano, Y Xiao, M Nakaya, X Zhou, X Cheng, P Yang, G Lozano, C Zhu, SS Watowich, SE Ullrich, SC Sun |
Nature Immunology | 2014 |
|
Human TH9 Cells Are Skin-Tropic and Have Autocrine and Paracrine Proinflammatory Capacity
C Schlapbach, A Gehad, C Yang, R Watanabe, E Guenova, JE Teague, L Campbell, N Yawalkar, TS Kupper, RA Clark |
Science Translational Medicine | 2014 |
|
Murine Th9 cells promote the survival of myeloid dendritic cells in cancer immunotherapy
J Park, H Li, M Zhang, Y Lu, B Hong, Y Zheng, J He, J Yang, J Qian, Q Yi |
Cancer Immunology, Immunotherapy | 2014 |
|
Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression
W Liao, R Spolski, P Li, N Du, EE West, M Ren, S Mitra, WJ Leonard |
Proceedings of the National Academy of Sciences | 2014 |
|
Serum levels of interleukin-9 correlate with negative prognostic factors in extranodal NK/T-cell lymphoma
J Zhang, W Wang, QR Geng, L Wang, XQ Chen, CC Liu, Y Lv |
PloS one | 2014 |
|
Neutralization of interleukin-9 ameliorates symptoms of experimental autoimmune myasthenia gravis in rats by decreasing effector T cells and altering humoral responses
X Yao, Q Kong, X Xie, J Wang, N Li, Y Liu, B Sun, Y Li, G Wang, W Li, S Qu, H Zhao, D Wang, X Liu, Y Zhang, L Mu, H Li |
Immunology | 2014 |
|
Inhibition of Adaptive Immunity by IL9 Can Be Disrupted to Achieve Rapid T-cell Sensitization and Rejection of Progressive Tumor Challenges
DB Hoelzinger, AL Dominguez, PA Cohen, SJ Gendler |
Cancer research | 2014 |
|
Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination
A Rostami, B Ciric |
Journal of the Neurological Sciences | 2013 |
|
Th9 cells: differentiation and disease
MH Kaplan |
Immunological Reviews | 2013 |
|
Utilizing TH9 cells as a novel therapeutic strategy for malignancies
Y Lu, Q Yi |
OncoImmunology | 2013 |
|
Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection
P Licona-Limón, J Henao-Mejia, AU Temann, N Gagliani, I Licona-Limón, H Ishigame, L Hao, DB Herbert, RA Flavell |
Immunity | 2013 |
|
IL-9 and Th9 cells: progress and challenges
P Zhao, X Xiao, RM Ghobrial, XC Li |
International Immunology | 2013 |
|
Rapamycin resistant murine th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity
CW Mangus, PR Massey, DH Fowler, S Amarnath |
PloS one | 2013 |
|
Circulating Th22 and Th9 levels in patients with acute coronary syndrome
Y Lin, B Wu, Z Lu, Y Huang, Y Shi, H Liu, L Liu, Q Zeng, X Wang, Q Ji |
Mediators of Inflammation | 2013 |
|
IL-4-, TGF-β-, and IL-1-dependent expansion of parasite antigen-specific Th9 cells is associated with clinical pathology in human lymphatic filariasis
R Anuradha, PJ George, LE Hanna, V Chandrasekaran, P Kumaran, TB Nutman, S Babu |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
|
AE37 peptide vaccination in prostate cancer: a 4-year immunological assessment updates on a phase I trial
Perez SA, Anastasopoulou EA, Tzonis P, Gouttefangeas C, Kalbacher H, Papamichail M, Baxevanis CN |
Cancer Immunology, Immunotherapy | 2013 |
|
Amazing IL-9: Revealing a new function for an “old” cytokine
Edgar Schmitt, Tobias Bopp |
Journal of Clinical Investigation | 2012 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)