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Citations to this article

Th9 cells promote antitumor immune responses in vivo
Yong Lu, … , Jianfei Qian, Qing Yi
Yong Lu, … , Jianfei Qian, Qing Yi
Published October 15, 2012
Citation Information: J Clin Invest. 2012;122(11):4160-4171. https://doi.org/10.1172/JCI65459.
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Research Article Article has an altmetric score of 17

Th9 cells promote antitumor immune responses in vivo

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Abstract

Th9 cells are a subset of CD4+ Th cells that produce the pleiotropic cytokine IL-9. IL-9/Th9 can function as both positive and negative regulators of immune response, but the role of IL-9/Th9 in tumor immunity is unknown. We examined the role of IL-9/Th9 in a model of pulmonary melanoma in mice. Lack of IL-9 enhanced tumor growth, while tumor-specific Th9 cell treatment promoted stronger antitumor responses in both prophylactic and therapeutic models. Th9 cells also elicited strong host antitumor CD8+ CTL responses by promoting Ccl20/Ccr6-dependent recruitment of DCs to the tumor tissues. Subsequent tumor antigen delivery to the draining LN resulted in CD8+ T cell priming. In agreement with this model, Ccr6 deficiency abrogated the Th9 cell–mediated antitumor response. Our data suggest a distinct role for tumor-specific Th9 cells in provoking CD8+ CTL-mediated antitumor immunity and indicate that Th9 cell–based cancer immunotherapy may be a promising therapeutic approach.

Authors

Yong Lu, Sungyoul Hong, Haiyan Li, Jungsun Park, Bangxing Hong, Lijuan Wang, Yuhuan Zheng, Zhiqiang Liu, Jingda Xu, Jin He, Jing Yang, Jianfei Qian, Qing Yi

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2009 Total
Citations: 3 14 16 15 17 21 17 20 14 12 13 15 9 1 1 188
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2014 (15)

Title and authors Publication Year
USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity
B Hong, H Li, Y Lu, M Zhang, Y Zheng, J Qian, Q Yi
Molecular Cancer 2014
The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment
J Zhou, Y Xiang, T Yoshimura, K Chen, W Gong, J Huang, Y Zhou, X Yao, X Bian, JM Wang
BioMed Research International 2014
Reducing CD73 Expression by IL1 -Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors
S Chatterjee, K Thyagarajan, P Kesarwani, JH Song, M Soloshchenko, J Fu, SR Bailey, C Vasu, AS Kraft, CM Paulos, XZ Yu, S Mehrotra
Cancer research 2014
Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers
Y Lu, B Hong, H Li, Y Zheng, M Zhang, S Wang, J Qian, Q Yi
Proceedings of the National Academy of Sciences 2014
Anticancer Tc9 cells
Y Lu, Q Wang, Q Yi
OncoImmunology 2014
CIMT 2014: Next waves in cancer immunotherapy - Report on the 12th annual meeting of the Association for Cancer Immunotherapy: May 6–8 2014, Mainz, Germany
M Diken, S Boegel, C Grunwitz, LM Kranz, K Reuter, N de Roemer, F Vascotto, M Vormehr, S Kreiter
Human Vaccines & Immunotherapeutics 2014
The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells
F Végran, H Berger, R Boidot, G Mignot, M Bruchard, M Dosset, F Chalmin, C Rébé, V Dérangère, B Ryffel, M Kato, A Prévost-Blondel, F Ghiringhelli, L Apetoh
Nature Immunology 2014
TGFβ in T cell biology and tumor immunity: Angel or devil?
E Tu, PZ Chia, W Chen
Cytokine & Growth Factor Reviews 2014
USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses
Q Zou, J Jin, H Hu, HS Li, S Romano, Y Xiao, M Nakaya, X Zhou, X Cheng, P Yang, G Lozano, C Zhu, SS Watowich, SE Ullrich, SC Sun
Nature Immunology 2014
Human TH9 Cells Are Skin-Tropic and Have Autocrine and Paracrine Proinflammatory Capacity
C Schlapbach, A Gehad, C Yang, R Watanabe, E Guenova, JE Teague, L Campbell, N Yawalkar, TS Kupper, RA Clark
Science Translational Medicine 2014
Murine Th9 cells promote the survival of myeloid dendritic cells in cancer immunotherapy
J Park, H Li, M Zhang, Y Lu, B Hong, Y Zheng, J He, J Yang, J Qian, Q Yi
Cancer Immunology, Immunotherapy 2014
Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression
W Liao, R Spolski, P Li, N Du, EE West, M Ren, S Mitra, WJ Leonard
Proceedings of the National Academy of Sciences 2014
Serum levels of interleukin-9 correlate with negative prognostic factors in extranodal NK/T-cell lymphoma
J Zhang, W Wang, QR Geng, L Wang, XQ Chen, CC Liu, Y Lv
PloS one 2014
Neutralization of interleukin-9 ameliorates symptoms of experimental autoimmune myasthenia gravis in rats by decreasing effector T cells and altering humoral responses
X Yao, Q Kong, X Xie, J Wang, N Li, Y Liu, B Sun, Y Li, G Wang, W Li, S Qu, H Zhao, D Wang, X Liu, Y Zhang, L Mu, H Li
Immunology 2014
Inhibition of Adaptive Immunity by IL9 Can Be Disrupted to Achieve Rapid T-cell Sensitization and Rejection of Progressive Tumor Challenges
DB Hoelzinger, AL Dominguez, PA Cohen, SJ Gendler
Cancer research 2014

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