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Citations to this article

Th9 cells promote antitumor immune responses in vivo
Yong Lu, … , Jianfei Qian, Qing Yi
Yong Lu, … , Jianfei Qian, Qing Yi
Published October 15, 2012
Citation Information: J Clin Invest. 2012;122(11):4160-4171. https://doi.org/10.1172/JCI65459.
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Research Article Article has an altmetric score of 17

Th9 cells promote antitumor immune responses in vivo

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Abstract

Th9 cells are a subset of CD4+ Th cells that produce the pleiotropic cytokine IL-9. IL-9/Th9 can function as both positive and negative regulators of immune response, but the role of IL-9/Th9 in tumor immunity is unknown. We examined the role of IL-9/Th9 in a model of pulmonary melanoma in mice. Lack of IL-9 enhanced tumor growth, while tumor-specific Th9 cell treatment promoted stronger antitumor responses in both prophylactic and therapeutic models. Th9 cells also elicited strong host antitumor CD8+ CTL responses by promoting Ccl20/Ccr6-dependent recruitment of DCs to the tumor tissues. Subsequent tumor antigen delivery to the draining LN resulted in CD8+ T cell priming. In agreement with this model, Ccr6 deficiency abrogated the Th9 cell–mediated antitumor response. Our data suggest a distinct role for tumor-specific Th9 cells in provoking CD8+ CTL-mediated antitumor immunity and indicate that Th9 cell–based cancer immunotherapy may be a promising therapeutic approach.

Authors

Yong Lu, Sungyoul Hong, Haiyan Li, Jungsun Park, Bangxing Hong, Lijuan Wang, Yuhuan Zheng, Zhiqiang Liu, Jingda Xu, Jin He, Jing Yang, Jianfei Qian, Qing Yi

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2009 Total
Citations: 3 14 16 15 17 21 17 20 14 12 13 15 9 1 1 188
Citation information
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Citations to this article in year 2022 (15)

Title and authors Publication Year
Pulmonary interstitial macrophages are required to mediate the pro-tumorigenic effects of IL-9
Yongyao Fu, Jocelyn Wang, Baohua Zhou, Hongyu Gao, Huaxin Zhou, Amanda Fisher, David Omstead, Sabrina Khan, Lei Han, Abigail Pajulas, Jean-Christophe Renauld, Sophie Paczesny, Yunlong Liu, Lei Yang, Robert Tighe, Paula Licona-Limón, Richard Flavell, Shogo Takatsuka, Daisuke Kitamura, Jie Sun, Basar Bilgicer, Catherine Sears, Kai Yang, Mark Kaplan
Nature Communications 2022
Epigenetic Regulation: A Link between Inflammation and Carcinogenesis
B Vezzani, M Carinci, M Previati, S Giacovazzi, M Sala, R Gafà, G Lanza, M Wieckowski, P Pinton, C Giorgi
Cancers 2022
Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy
M Khelil, Y Godet, S Abdeljaoued, C Borg, O Adotévi, R Loyon
Cancers 2022
The Roles of IRF-8 in Regulating IL-9-Mediated Immunologic Mechanisms in the Development of DLBCL: A State-of-the-Art Literature Review
M Cai, N Chen
Frontiers in Oncology 2022
Intravenous Oncolytic Vaccinia Virus Therapy Results in a Differential Immune Response between Cancer Patients
E West, K Scott, E Tidswell, K Bendjama, N Stojkowitz, M Lusky, M Kurzawa, R Prasad, G Toogood, C Ralph, D Anthoney, A Melcher, F Collinson, A Samson
Cancers 2022
Potentiating adoptive cell therapy using synthetic IL-9 receptors
A Kalbasi, M Siurala, L Su, M Tariveranmoshabad, L Picton, P Ravikumar, P Li, J Lin, H Escuin-Ordinas, T Da, S Kremer, A Sun, S Castelli, S Agarwal, J Scholler, D Song, P Rommel, E Radaelli, R Young, W Leonard, A Ribas, C June, K Garcia
Nature 2022
IL-9 Producing Tumor-Infiltrating Lymphocytes and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer
Heim L, Yang Z, Tausche P, Hohenberger K, Chiriac MT, Koelle J, Geppert CI, Kachler K, Miksch S, Graser A, Friedrich J, Kharwadkar R, Rieker RJ, Trufa DI, Sirbu H, Neurath MF, Kaplan MH, Finotto S
Frontiers in immunology 2022
First Characterization of Chicken Interleukin-9
He S, Chen L, Hao X, Yang Y, Shang S
Frontiers in immunology 2022
IRF8: Mechanism of Action and Health Implications.
Moorman HR, Reategui Y, Poschel DB, Liu K
Cells 2022
Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation
Park SA, Lim YJ, Ku WL, Zhang D, Cui K, Tang LY, Chia C, Zanvit P, Chen Z, Jin W, Wang D, Xu J, Liu O, Wang F, Cain A, Guo N, Nakatsukasa H, Wu C, Zhang YE, Zhao K, Chen W
Nature Communications 2022
Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion
Kaminskiy Y, Kuznetsova V, Kudriaeva A, Zmievskaya E, Bulatov E
Frontiers in immunology 2022
IL-1β promotes IL-9-producing Th cell differentiation in IL-2-limiting conditions through the inhibition of BCL6
Canaria DA, Clare MG, Yan B, Campbell CB, Ismaio ZA, Anderson NL, Park S, Dent AL, Kazemian M, Olson MR
Frontiers in immunology 2022
Enhancement of T cell infiltration via tumor-targeted Th9 cell delivery improves the efficacy of antitumor immunotherapy of solid tumors
Chen T, Xue Y, Wang S, Lu J, Zhou H, Zhang W, Zhou Z, Li B, Li Y, Wang Z, Li C, Eloy Y, Sun H, Shen Y, Diarra MD, Ge C, Chai X, Mou H, Lin P, Yu X, Ye Z
Bioactive Materials 2022
PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells.
Gerlach K, Popp V, Wirtz S, Al-Saifi R, Gonzalez Acera M, Atreya R, Dregelies T, Vieth M, Fichtner-Feigl S, McKenzie ANJ, Rosenbauer F, Weigmann B, Neurath MF
Journal of Crohn's & colitis 2022
Distinct T helper cell-mediated antitumor immunity: T helper 2 cells in focus
Silva RC, Lopes MF, Travassos LH
2022

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