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Yong Lu, … , Jianfei Qian, Qing Yi
Published October 15, 2012
Citation Information: J Clin Invest. 2012;122(11):4160-4171. https://doi.org/10.1172/JCI65459.
Citation Information: J Clin Invest. 2012;122(11):4160-4171. https://doi.org/10.1172/JCI65459.
Abstract
Th9 cells are a subset of CD4+ Th cells that produce the pleiotropic cytokine IL-9. IL-9/Th9 can function as both positive and negative regulators of immune response, but the role of IL-9/Th9 in tumor immunity is unknown. We examined the role of IL-9/Th9 in a model of pulmonary melanoma in mice. Lack of IL-9 enhanced tumor growth, while tumor-specific Th9 cell treatment promoted stronger antitumor responses in both prophylactic and therapeutic models. Th9 cells also elicited strong host antitumor CD8+ CTL responses by promoting Ccl20/Ccr6-dependent recruitment of DCs to the tumor tissues. Subsequent tumor antigen delivery to the draining LN resulted in CD8+ T cell priming. In agreement with this model, Ccr6 deficiency abrogated the Th9 cell–mediated antitumor response. Our data suggest a distinct role for tumor-specific Th9 cells in provoking CD8+ CTL-mediated antitumor immunity and indicate that Th9 cell–based cancer immunotherapy may be a promising therapeutic approach.
Authors
Yong Lu, Sungyoul Hong, Haiyan Li, Jungsun Park, Bangxing Hong, Lijuan Wang, Yuhuan Zheng, Zhiqiang Liu, Jingda Xu, Jin He, Jing Yang, Jianfei Qian, Qing Yi
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Citation information
Citations to this article (187)
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Proceedings of the National Academy of Sciences | 2018 |
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Cholesterol negatively regulates IL-9–producing CD8 + T cell differentiation and antitumor activity
X Ma, E Bi, C Huang, Y Lu, G Xue, X Guo, A Wang, M Yang, J Qian, C Dong, Q Yi |
Journal of Experimental Medicine | 2018 |
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CD38-NAD + Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
S Chatterjee, A Daenthanasanmak, P Chakraborty, MW Wyatt, P Dhar, SP Selvam, J Fu, J Zhang, H Nguyen, I Kang, K Toth, M Al-Homrani, M Husain, G Beeson, L Ball, K Helke, S Husain, E Garrett-Mayer, G Hardiman, M Mehrotra, MI Nishimura, CC Beeson, MG Bupp, J Wu, B Ogretmen, CM Paulos, J Rathmell, XZ Yu, S Mehrotra |
Cell Metabolism | 2018 |
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The multifaceted role of autophagy in cancer and the microenvironment: FOLKERTS et al
H Folkerts, S Hilgendorf, E Vellenga, E Bremer, VR Wiersma |
Medicinal Research Reviews | 2018 |
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Transcriptional Control of Th9 Cells: Role of Foxo1 in Interleukin-9 Induction
S Malik, A Awasthi |
Frontiers in immunology | 2018 |
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Th9 Cells Represent a Unique Subset of CD4 + T Cells Endowed with the Ability to Eradicate Advanced Tumors
Y Lu, Q Wang, G Xue, E Bi, X Ma, A Wang, J Qian, C Dong, Q Yi |
Cancer Cell | 2018 |
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Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions
E Jacquin, L Apetoh |
Frontiers in immunology | 2018 |
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TGF-β in T Cell Biology: Implications for Cancer Immunotherapy
A Dahmani, JS Delisle |
Cancers | 2018 |
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Role of Cytokine Combinations on CD4+ T Cell Differentiation, Partial Polarization, and Plasticity: Continuous Network Modeling Approach
ME Martinez-Sanchez, L Huerta, ER Alvarez-Buylla, CV Luján |
Frontiers in physiology | 2018 |
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[Expression of interleukin-9 in colon cancer tissues and its clinical significance]
Jin Wang, Xiaoqiang Dong, Xinguo Zhu, Hua Zhao, Deli Mao, Xin Zhao |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | 2018 |
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Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation
X Xiao, Y Fan, J Li, X Zhang, X Lou, Y Dou, X Shi, P Lan, Y Xiao, L Minze, XC Li |
Journal of Experimental Medicine | 2018 |
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Interleukin-33 Contributes to the Induction of Th9 Cells and Antitumor Efficacy by Dectin-1-Activated Dendritic Cells
J Chen, Y Zhao, Y Jiang, S Gao, Y Wang, D Wang, A Wang, H Yi, R Gu, Q Yi, S Wang |
Frontiers in immunology | 2018 |
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Ectopically Expressed Membrane-bound Form of IL-9 Exerts Immune-stimulatory Effect on CT26 Colon Carcinoma Cells
VA Thi, SM Park, H Lee, YS Kim |
Immune Network | 2018 |
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Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells
TT Spear, Y Wang, TW Smith, PE Simms, E Garrett-Mayer, LM Hellman, BM Baker, MI Nishimura |
Molecular Therapy | 2018 |
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Less cholesterol means better tumor killing for cytotoxic T9 cells
B Griesenauer, S Paczesny |
Journal of Experimental Medicine | 2018 |
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TGF-β enhances the cytotoxic activity of Vδ2 T cells
C Peters, A Meyer, L Kouakanou, J Feder, T Schricker, M Lettau, O Janssen, D Wesch, D Kabelitz |
OncoImmunology | 2018 |
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The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity
C Afferni, C Buccione, S Andreone, MR Galdiero, G Varricchi, G Marone, F Mattei, G Schiavoni |
Frontiers in immunology | 2018 |
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Specifically differentiated T cell subset promotes tumor immunity over fatal immunity
A Ramadan, B Griesenauer, D Adom, R Kapur, H Hanenberg, C Liu, MH Kaplan, S Paczesny |
Journal of Experimental Medicine | 2017 |
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Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
TR Vargas, Z Cai, Y Shen, M Dosset, I Benoit-Lizon, T Martin, A Roussey, RA Flavell, F Ghiringhelli, L Apetoh |
Nature Communications | 2017 |
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IL-9 and Th9 cells in health and diseases—From tolerance to immunopathology
J Li, S Chen, X Xiao, Y Zhao, W Ding, XC Li |
Cytokine & Growth Factor Reviews | 2017 |
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The Common Cytokine Receptor γ Chain Family of Cytokines
JX Lin, WJ Leonard |
Cold Spring Harbor perspectives in biology | 2017 |
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Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
LC Carrascosa, M Klein, Y Kitagawa, C Lückel, F Marini, A König, A Guralnik, H Raifer, S Hagner-Benes, D Rädler, A Böck, C Kang, M Lohoff, H Garn, B Schaub, F Berberich-Siebelt, S Sakaguchi, T Bopp, M Huber |
Nature Communications | 2017 |
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Decreased frequency of circulating Th9 cells in patients with chronic hepatitis B infection
M Cui, Y Lv, J Lu, W Zhang, Y Duan, Y Huang, L Yang, M Li, W Liu, D Liu, H Yan |
Journal of Clinical Laboratory Analysis | 2017 |
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Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities
J Masuda, E Takayama, W Strober, A Satoh, Y Morimoto, Y Honjo, T Ichinohe, SI Tokuno, T Ishizuka, T Nakata, A Mizutani, N Umemura, A Kitani, IJ Fuss, T Shigehiro, H Kawaki, M Mizuno-Kamiya, N Kondoh, M Seno |
Oncology reports | 2017 |
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STAT3 Activation Impairs the Stability of Th9 Cells
BJ Ulrich, FF Verdan, AN McKenzie, MH Kaplan, MR Olson |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
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LYG1 exerts anti-tumor function through promoting the activation, proliferation and function of CD4 + T cells
H Liu, Y Zhang, Z Liu, P Wang, X Mo, W Fu, W Liu, Y Cheng, W Han |
OncoImmunology | 2017 |
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Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production
MR Olson, BJ Ulrich, SA Hummel, I Khan, B Meuris, Y Cherukuri, AL Dent, SC Janga, MH Kaplan |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
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Induction of specific T helper-9 cells to inhibit glioma cell growth
H Zheng, B Yang, D Xu, W Wang, J Tan, L Sun, Q Li, L Sun, X Xia |
Oncotarget | 2017 |
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The γc family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response
R Spolski, D Gromer, WJ Leonard |
F1000Research | 2017 |
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IRF8-dependent molecular complexes control the Th9 transcriptional program
E Humblin, M Thibaudin, F Chalmin, V Derangère, E Limagne, C Richard, RA Flavell, S Chevrier, S Ladoire, H Berger, R Boidot, L Apetoh, F Végran, F Ghiringhelli |
Nature Communications | 2017 |
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Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of T H 9 cells programmed by IL-7
E Bi, X Ma, Y Lu, M Yang, Q Wang, G Xue, J Qian, S Wang, Q Yi |
Science signaling | 2017 |
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Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells
Y Zhao, X Chu, J Chen, Y Wang, S Gao, Y Jiang, X Zhu, G Tan, W Zhao, H Yi, H Xu, X Ma, Y Lu, Q Yi, S Wang |
Nature Communications | 2016 |
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MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2 α as an important regulator of T helper 9 and regulatory T-cell differentiation
Y Singh, OA Garden, F Lang, BS Cobb |
Immunology | 2016 |
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Alkaline Cytosolic pH and High Sodium Hydrogen Exchanger 1 (NHE1) Activity in Th9 Cells
Y Singh, Y Zhou, X Shi, S Zhang, AT Umbach, MS Salker, KS Lang, F Lang |
The Journal of biological chemistry | 2016 |
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Targeting B-cell malignancies through human B-cell receptor specific CD4 + T cells
J Weng, FE Baio, KE Moriarty, H Torikai, H Wang, Z Liu, SN Maiti, D Gwak, MS Popescu, SC Cha, LJ Cooper, SS Neelapu, LW Kwak |
OncoImmunology | 2016 |
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TH9 cells in anti-tumor immunity
TR Vargas, E Humblin, F Végran, F Ghiringhelli, L Apetoh |
Seminars in Immunopathology | 2016 |
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Dectin-1-activated dendritic cells: a potent Th9 cell inducer for tumor immunotherapy
J Chen, Y Zhao, X Chu, Y Lu, S Wang, Q Yi |
OncoImmunology | 2016 |
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T cell cytokine signatures: Biomarkers in pediatric multiple sclerosis
CM Cala, CE Moseley, C Steele, SM Dowdy, GR Cutter, JM Ness, TM DeSilva |
Journal of Neuroimmunology | 2016 |
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TH9 cells in skin disorders
RA Clark, C Schlapbach |
Seminars in Immunopathology | 2016 |
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Human Vδ2 T cells are a major source of interleukin-9
C Peters, R Häsler, D Wesch, D Kabelitz |
Proceedings of the National Academy of Sciences | 2016 |
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Peripheral blood Th9 cells are a possible pharmacodynamic biomarker of nivolumab treatment efficacy in metastatic melanoma patients
Y Nonomura, A Otsuka, C Nakashima, JA Seidel, A Kitoh, T Dainichi, S Nakajima, Y Sawada, S Matsushita, M Aoki, T Takenouchi, T Fujimura, N Hatta, S Koreeda, S Fukushima, T Honda, K Kabashima |
OncoImmunology | 2016 |
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Discovery and initial characterization of Th9 cells: the early years
E Schmitt, T Bopp |
Seminars in Immunopathology | 2016 |
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Information-dense analysis for information-dense understanding
NA Ivica, M Kaur, G Hu, J Chen |
Translational cancer research | 2016 |
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ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease
J Zhang, AM Ramadan, B Griesenauer, W Li, MJ Turner, C Liu, R Kapur, H Hanenberg, BR Blazar, I Tawara, S Paczesny |
Science Translational Medicine | 2015 |
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The development and in vivo function of T helper 9 cells
MH Kaplan, MM Hufford, MR Olson |
Nature Reviews Immunology | 2015 |
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Sex chromosome loss and the pseudoautosomal region genes in hematological malignancies
S Weng, SA Stoner, DE Zhang |
Oncotarget | 2015 |
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TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer
Y Li, Q Yu, Z Zhang, J Wang, S Li, J Zhang, G Liu |
Oncotarget | 2015 |
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A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity
ME Martinez-Sanchez, L Mendoza, C Villarreal, ER Alvarez-Buylla, J Bassaganya-Riera |
PLoS computational biology | 2015 |
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Physical attraction of Th9 cells is skin deep
Valerie Dardalhon, Mary Collins, Vijay K. Kuchroo |
Annals of translational medicine | 2015 |
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Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells
IK Kim, BS Kim, CH Koh, JW Seok, JS Park, KS Shin, EA Bae, GE Lee, H Jeon, J Cho, Y Jung, D Han, BS Kwon, HY Lee, Y Chung, CY Kang |
Nature Medicine | 2015 |
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The DNA-binding inhibitor Id3 regulates IL-9 production in CD4+ T cells
H Nakatsukasa, D Zhang, T Maruyama, H Chen, K Cui, M Ishikawa, L Deng, P Zanvit, E Tu, W Jin, B Abbatiello, N Goldberg, Q Chen, L Sun, K Zhao, WJ Chen |
Nature Immunology | 2015 |
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GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation
X Xiao, X Shi, Y Fan, X Zhang, M Wu, P Lan, L Minze, YX Fu, RM Ghobrial, W Liu, XC Li |
Nature Communications | 2015 |
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Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells
M Takami, K Fujimaki, MI Nishimura, M Iwashima |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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p-STAT6, PU.1, and NF-κB are involved in allergen-induced late-phase airway inflammation in asthma patients
D Hoppenot, K Malakauskas, S Lavinskiene, R Sakalauskas |
BMC Pulmonary Medicine | 2015 |
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GITR drives T H 9-mediated antitumor immunity
IK Kim, Y Chung, CY Kang |
OncoImmunology | 2015 |
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Association between low expression levels of interleukin-9 and colon cancer progression
Y Huang, Y Cao, S Zhang, F Gao |
Experimental and therapeutic medicine | 2015 |
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USP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity
B Hong, H Li, Y Lu, M Zhang, Y Zheng, J Qian, Q Yi |
Molecular Cancer | 2014 |
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The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment
J Zhou, Y Xiang, T Yoshimura, K Chen, W Gong, J Huang, Y Zhou, X Yao, X Bian, JM Wang |
BioMed Research International | 2014 |
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Reducing CD73 Expression by IL1 -Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors
S Chatterjee, K Thyagarajan, P Kesarwani, JH Song, M Soloshchenko, J Fu, SR Bailey, C Vasu, AS Kraft, CM Paulos, XZ Yu, S Mehrotra |
Cancer research | 2014 |
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Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers
Y Lu, B Hong, H Li, Y Zheng, M Zhang, S Wang, J Qian, Q Yi |
Proceedings of the National Academy of Sciences | 2014 |
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Anticancer Tc9 cells
Y Lu, Q Wang, Q Yi |
OncoImmunology | 2014 |
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CIMT 2014: Next waves in cancer immunotherapy - Report on the 12th annual meeting of the Association for Cancer Immunotherapy: May 6–8 2014, Mainz, Germany
M Diken, S Boegel, C Grunwitz, LM Kranz, K Reuter, N de Roemer, F Vascotto, M Vormehr, S Kreiter |
Human Vaccines & Immunotherapeutics | 2014 |
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The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells
F Végran, H Berger, R Boidot, G Mignot, M Bruchard, M Dosset, F Chalmin, C Rébé, V Dérangère, B Ryffel, M Kato, A Prévost-Blondel, F Ghiringhelli, L Apetoh |
Nature Immunology | 2014 |
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TGFβ in T cell biology and tumor immunity: Angel or devil?
E Tu, PZ Chia, W Chen |
Cytokine & Growth Factor Reviews | 2014 |
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USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses
Q Zou, J Jin, H Hu, HS Li, S Romano, Y Xiao, M Nakaya, X Zhou, X Cheng, P Yang, G Lozano, C Zhu, SS Watowich, SE Ullrich, SC Sun |
Nature Immunology | 2014 |
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Human TH9 Cells Are Skin-Tropic and Have Autocrine and Paracrine Proinflammatory Capacity
C Schlapbach, A Gehad, C Yang, R Watanabe, E Guenova, JE Teague, L Campbell, N Yawalkar, TS Kupper, RA Clark |
Science Translational Medicine | 2014 |
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Murine Th9 cells promote the survival of myeloid dendritic cells in cancer immunotherapy
J Park, H Li, M Zhang, Y Lu, B Hong, Y Zheng, J He, J Yang, J Qian, Q Yi |
Cancer Immunology, Immunotherapy | 2014 |
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Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression
W Liao, R Spolski, P Li, N Du, EE West, M Ren, S Mitra, WJ Leonard |
Proceedings of the National Academy of Sciences | 2014 |
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Serum levels of interleukin-9 correlate with negative prognostic factors in extranodal NK/T-cell lymphoma
J Zhang, W Wang, QR Geng, L Wang, XQ Chen, CC Liu, Y Lv |
PloS one | 2014 |
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Neutralization of interleukin-9 ameliorates symptoms of experimental autoimmune myasthenia gravis in rats by decreasing effector T cells and altering humoral responses
X Yao, Q Kong, X Xie, J Wang, N Li, Y Liu, B Sun, Y Li, G Wang, W Li, S Qu, H Zhao, D Wang, X Liu, Y Zhang, L Mu, H Li |
Immunology | 2014 |
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Inhibition of Adaptive Immunity by IL9 Can Be Disrupted to Achieve Rapid T-cell Sensitization and Rejection of Progressive Tumor Challenges
DB Hoelzinger, AL Dominguez, PA Cohen, SJ Gendler |
Cancer research | 2014 |
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Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination
A Rostami, B Ciric |
Journal of the Neurological Sciences | 2013 |
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Th9 cells: differentiation and disease
MH Kaplan |
Immunological Reviews | 2013 |
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Utilizing TH9 cells as a novel therapeutic strategy for malignancies
Y Lu, Q Yi |
OncoImmunology | 2013 |
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Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection
P Licona-Limón, J Henao-Mejia, AU Temann, N Gagliani, I Licona-Limón, H Ishigame, L Hao, DB Herbert, RA Flavell |
Immunity | 2013 |
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IL-9 and Th9 cells: progress and challenges
P Zhao, X Xiao, RM Ghobrial, XC Li |
International Immunology | 2013 |
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Rapamycin resistant murine th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity
CW Mangus, PR Massey, DH Fowler, S Amarnath |
PloS one | 2013 |
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Circulating Th22 and Th9 levels in patients with acute coronary syndrome
Y Lin, B Wu, Z Lu, Y Huang, Y Shi, H Liu, L Liu, Q Zeng, X Wang, Q Ji |
Mediators of Inflammation | 2013 |
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IL-4-, TGF-β-, and IL-1-dependent expansion of parasite antigen-specific Th9 cells is associated with clinical pathology in human lymphatic filariasis
R Anuradha, PJ George, LE Hanna, V Chandrasekaran, P Kumaran, TB Nutman, S Babu |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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AE37 peptide vaccination in prostate cancer: a 4-year immunological assessment updates on a phase I trial
Perez SA, Anastasopoulou EA, Tzonis P, Gouttefangeas C, Kalbacher H, Papamichail M, Baxevanis CN |
Cancer Immunology, Immunotherapy | 2013 |
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Amazing IL-9: Revealing a new function for an “old” cytokine
Edgar Schmitt, Tobias Bopp |
Journal of Clinical Investigation | 2012 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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