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Citations to this article

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tamara Tchkonia, … , Judith Campisi, James L. Kirkland
Tamara Tchkonia, … , Judith Campisi, James L. Kirkland
Published March 1, 2013
Citation Information: J Clin Invest. 2013;123(3):966-972. https://doi.org/10.1172/JCI64098.
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Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

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Abstract

Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations. New findings suggest that aging is a modifiable risk factor, and it may be feasible to delay age-related diseases as a group by modulating fundamental aging mechanisms. One such mechanism is cellular senescence, which can cause chronic inflammation through the senescence-associated secretory phenotype (SASP). We review the mechanisms that induce senescence and the SASP, their associations with chronic disease and frailty, therapeutic opportunities based on targeting senescent cells and the SASP, and potential paths to developing clinical interventions.

Authors

Tamara Tchkonia, Yi Zhu, Jan van Deursen, Judith Campisi, James L. Kirkland

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 Total
Citations: 52 104 103 88 110 105 77 72 74 64 49 37 26 1 962
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

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