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Tamara Tchkonia, … , Judith Campisi, James L. Kirkland
Published March 1, 2013
Citation Information: J Clin Invest. 2013;123(3):966-972. https://doi.org/10.1172/JCI64098.
Citation Information: J Clin Invest. 2013;123(3):966-972. https://doi.org/10.1172/JCI64098.
Abstract
Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations. New findings suggest that aging is a modifiable risk factor, and it may be feasible to delay age-related diseases as a group by modulating fundamental aging mechanisms. One such mechanism is cellular senescence, which can cause chronic inflammation through the senescence-associated secretory phenotype (SASP). We review the mechanisms that induce senescence and the SASP, their associations with chronic disease and frailty, therapeutic opportunities based on targeting senescent cells and the SASP, and potential paths to developing clinical interventions.
Authors
Tamara Tchkonia, Yi Zhu, Jan van Deursen, Judith Campisi, James L. Kirkland
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Citations to this article (910)
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Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
Liu Y, Ye J, Fan Z, Wu X, Zhang Y, Yang R, Jiang B, Wang Y, Wu M, Zhou J, Meng J, Ge Z, Zhou G, Zhu Y, Xiao Y, Zheng M, Zhang S |
Advanced Science | 2024 |
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Inhibiting Glutaminase Exerts Opposite Effects on Ovariectomy-Induced and Age-Related Reductions in Murine Bone Mass
Guo Q, Zhao H, Dong Z, Cheng H, Zhu M, Fang Z |
Aging and Disease | 2024 |
|
Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes
Pangrazzi L, Meryk A |
Biology | 2024 |
|
Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics
Al\u2010Naggar IM, Antony M, Baker D, Wang L, Godoy LD, Kuo C, Fraser MO, Smith PP, Xu M, Kuchel GA |
Aging Cell | 2024 |
|
Multiparity increases the risk of diabetes by impairing the proliferative capacity of β cells
Joon Moon, Joonyub Lee, Hyun Jung Kim, Hyeongseok Kim, Hye-Na Cha, Jungsun Park, Hyeonkyu Lee, Kyun Hoo Kim, So-young Park, Hak Jang, Hail Kim |
Experimental & molecular medicine | 2023 |
|
Aging increases visceral adipose tissue inflammation to promote monocyte chemotaxis and enhance atherosclerosis
Jianrui Song, Diana Farris, Paola Ariza, Smriti Moorjani, Muriel Blin, Daniel Tyrrell, Min Zhang, Mita Varghese, Kanakadurga Singer, Morgan Salmon, Daniel R. Goldstein |
Aging Cell | 2023 |
|
Male sex hormones, aging, and inflammation
Ketchem JM, Bowman EJ, Isales CM |
Biogerontology | 2023 |
|
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling
Yun J, Hansen S, Morris O, Madden DT, Libeu CP, Kumar AJ, Wehrfritz C, Nile AH, Zhang Y, Zhou L, Liang Y, Modrusan Z, Chen MB, Overall CC, Garfield D, Campisi J, Schilling B, Hannoush RN, Jasper H |
Nature Communications | 2023 |
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Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton
Doolittle ML, Saul D, Kaur J, Rowsey JL, Vos SJ, Pavelko KD, Farr JN, Monroe DG, Khosla S |
2023 | |
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Inhibition of Klf10 Attenuates Oxidative Stress-Induced Senescence of Chondrocytes via Modulating Mitophagy
Shang J, Lin N, Peng R, Jiang N, Wu B, Xing B, Lin S, Xu X, Lu H |
Molecules (Basel, Switzerland) | 2023 |
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Aging, Physical Exercise, Telomeres, and Sarcopenia: A Narrative Review
Hernández-Álvarez D, Rosado-Pérez J, Gavia-García G, Arista-Ugalde TL, Aguiñiga-Sánchez I, Santiago-Osorio E, Mendoza-Núñez VM |
Biomedicines | 2023 |
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Oxidative stress and epigenetics in ocular vascular aging: an updated review.
Zhao B, Zhu L, Ye M, Lou X, Mou Q, Hu Y, Zhang H, Zhao Y |
Molecular Medicine | 2023 |
|
Cholesterol drives inflammatory senescence.
Kuehnemann C, Wiley CD |
Nature metabolism | 2023 |
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Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant
Shilleh AH, Russ HA |
Cells | 2023 |
|
Influence of the Mediterranean Diet on Healthy Aging
Andreo-López MC, Contreras-Bolívar V, Muñoz-Torres M, García-Fontana B, García-Fontana C |
International journal of molecular sciences | 2023 |
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Molecular Basis beyond Interrelated Bone Resorption/Regeneration in Periodontal Diseases: A Concise Review
Sadek KM, El Moshy S, Radwan IA, Rady D, Abbass MM, El-Rashidy AA, Dörfer CE, Fawzy El-Sayed KM |
International journal of molecular sciences | 2023 |
|
DNA Repair Deficiency Regulates Immunity Response in Cancers: Molecular Mechanism and Approaches for Combining Immunotherapy.
Xu Y, Nowsheen S, Deng M |
Cancers | 2023 |
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Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability.
Nambiar A, Kellogg D 3rd, Justice J, Goros M, Gelfond J, Pascual R, Hashmi S, Masternak M, Prata L, LeBrasseur N, Limper A, Kritchevsky S, Musi N, Tchkonia T, Kirkland J |
EBioMedicine | 2023 |
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Fibroblast heterogeneity: Keystone of tissue homeostasis and pathology in inflammation and ageing
Gauthier V, Kyriazi M, Nefla M, Pucino V, Raza K, Buckley CD, Alsaleh G |
Frontiers in immunology | 2023 |
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The specific phagocytosis regulators could predict recurrence and therapeutic effect in thyroid cancer: A study based on bioinformatics analysis.
Hou C, Wu M, Zhang H, Yang Z |
Medicine | 2023 |
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Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue
Ikegami K, Yamashita M, Suzuki M, Nakamura T, Hashimoto K, Kitagaki J, Yanagita M, Kitamura M, Murakami S |
Aging | 2023 |
|
Aging Hallmarks and the Role of Oxidative Stress
Maldonado E, Morales-Pison S, Urbina F, Solari A |
Antioxidants | 2023 |
|
Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to Delay Age-Related Pathologies
Khalil R, Diab-Assaf M, Lemaitre JM |
Cells | 2023 |
|
Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice.
Benvie AM, Lee D, Steiner BM, Xue S, Jiang Y, Berry DC |
Nature Communications | 2023 |
|
Telomere dysfunction promotes cholangiocyte senescence and biliary fibrosis in Primary Sclerosing Cholangitis
Nidhi Jalan-Sakrikar, Abid Anwar, Usman Yaqoob, Can Gan, Anthony Lagnado, Alexander Q. Wixom, Diana Jurk, Robert Huebert |
JCI Insight | 2023 |
|
Thermogenic adipose tissue in energy regulation and metabolic health
Xue S, Lee D, Berry DC |
Frontiers in Endocrinology | 2023 |
|
Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema.
Park JJ, Oh K, Lee GW, Bang G, Park JH, Kim HB, Kim JY, Shin EY, Kim EG |
Experimental & molecular medicine | 2023 |
|
DNA Damage-Mediated Neurotoxicity in Parkinson's Disease.
Wang ZX, Li YL, Pu JL, Zhang BR |
International journal of molecular sciences | 2023 |
|
Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly
Li Z, Tian M, Wang G, Cui X, Ma J, Liu S, Shen B, Liu F, Wu K, Xiao X, Zhu C |
Frontiers in Cellular and Infection Microbiology | 2023 |
|
Biomarkers of aging.
Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo OJ, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y, Wang Y, Wu R, Xia K, Xiao FH, Xu L, Xu Y, Yan H, Yang L, Yang R, Yang Y, Ying Y, Zhang L, Zhang W, Zhang W, Zhang X, Zhang Z, Zhou M, Zhou R, Zhu Q, Zhu Z, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen HZ, Chen J, Ci W, Ding BS, Ding Q, Gao F, Han JJ, Huang K, Ju Z, Kong QP, Li J, Li J, Li X, Liu B, Liu F, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren J, Ren R, Song M, Songyang Z, Sun YE, Sun Y, Tian M, Wang S, Wang S, Wang X, Wang X, Wang YJ, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xie Z, Xu D, Ye J, Yue R, Zhang C, Zhang H, Zhang L, Zhang W, Zhang Y, Zhang YW, Zhang Z, Zhao T, Zhao Y, Zhu D, Zou W, Pei G, Liu GH |
Science China Life Sciences | 2023 |
|
Effect of age and gender on serum growth differentiation factor 15 and its relationship to bone density and bone turnover
Mattia L, Gossiel F, Walsh JS, Eastell R |
Bone Reports | 2023 |
|
Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies.
Cherry C, Andorko JI, Krishnan K, Mejías JC, Nguyen HH, Stivers KB, Gray-Gaillard EF, Ruta A, Han J, Hamada N, Hamada M, Sturmlechner I, Trewartha S, Michel JH, Davenport Huyer L, Wolf MT, Tam AJ, Peña AN, Keerthivasan S, Le Saux CJ, Fertig EJ, Baker DJ, Housseau F, van Deursen JM, Pardoll DM, Elisseeff JH |
GeroScience | 2023 |
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Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic.
Al-Mansour F, Alraddadi A, He B, Saleh A, Poblocka M, Alzahrani W, Cowley S, Macip S |
Aging | 2023 |
|
Myocardial Inflammation as a Manifestation of Genetic Cardiomyopathies: From Bedside to the Bench
Peretto G, Sommariva E, Di Resta C, Rabino M, Villatore A, Lazzeroni D, Sala S, Pompilio G, Cooper LT |
Biomolecules | 2023 |
|
Computational Analysis Reveals Distinctive Interaction of miRNAs with Target Genes in the Pathogenesis of Chronic Kidney Disease
Salim HM, Dandare A, Khalil F, Liaquat A, Khan MJ, Naeem A |
Genes & development | 2023 |
|
Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy
Hussong SA, Banh AQ, Van Skike CE, Dorigatti AO, Hernandez SF, Hart MJ, Ferran B, Makhlouf H, Gaczynska M, Osmulski PA, McAllen SA, Dineley KT, Ungvari Z, Perez VI, Kayed R, Galvan V |
Nature Communications | 2023 |
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Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats
Salas-Venegas V, Santín-Márquez R, Ramírez-Carreto RJ, Rodríguez-Cortés YM, Cano-Martínez A, Luna-López A, Chavarría A, Konigsberg M, López-Díazguerrero NE |
Frontiers in aging neuroscience | 2023 |
|
TFEB‐dependent lysosome biogenesis is required for senescence
Curnock R, Yalci K, Palmfeldt J, Jäättelä M, Liu B, Carroll B |
The EMBO Journal | 2023 |
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Senescent Cells: A Therapeutic Target in Cardiovascular Diseases.
Suda M, Paul KH, Minamino T, Miller JD, Lerman A, Ellison-Hughes GM, Tchkonia T, Kirkland JL |
Cells | 2023 |
|
Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells
Ramadhiani R, Ikeda K, Miyagawa K, Ryanto GR, Tamada N, Suzuki Y, Kirita Y, Matoba S, Hirata KI, Emoto N |
iScience | 2023 |
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Skin Ageing: A Progressive, Multi-Factorial Condition Demanding an Integrated, Multilayer-Targeted Remedy
Liang Y, Su W, Wang F |
Clinical, cosmetic and investigational dermatology | 2023 |
|
A chronic wound model to investigate skin cellular senescence
Wyles SP, Dashti P, Pirtskhalava T, Tekin B, Inman C, Gomez LS, Lagnado AB, Prata L, Jurk D, Passos JF, Tchkonia T, Kirkland JL |
Aging | 2023 |
|
SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption.
Aobulikasimu A, Liu T, Piao J, Sato S, Ochi H, Okawa A, Tsuji K, Asou Y |
Scientific Reports | 2023 |
|
Cuproptosis-a potential target for the treatment of osteoporosis
Li D, Gao Z, Li Q, Liu X, Liu H |
Frontiers in Endocrinology | 2023 |
|
Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice
Ueno D, Ikeda K, Yamazaki E, Katayama A, Urata R, Matoba S |
Scientific Reports | 2023 |
|
Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson–Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies
Hartinger R, Lederer EM, Schena E, Lattanzi G, Djabali K |
Cells | 2023 |
|
Therapeutic Perspectives for Inflammation and Senescence in Osteoarthritis Using Mesenchymal Stem Cells, Mesenchymal Stem Cell-Derived Extracellular Vesicles and Senolytic Agents
Rizzo MG, Best TM, Huard J, Philippon M, Hornicek F, Duan Z, Griswold AJ, Kaplan LD, Hare JM, Kouroupis D |
Cells | 2023 |
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Advances in PET imaging of cancer.
Schwenck J, Sonanini D, Cotton JM, Rammensee HG, la Fougère C, Zender L, Pichler BJ |
Nature reviews. Cancer | 2023 |
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RANKL+ senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics
Zhou Y, Nishiura A, Morikuni H, Deng W, Tsujibayashi T, Momota Y, Azetsu Y, Takami M, Honda Y, Matsumoto N |
International Journal of Oral Science | 2023 |
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Maladaptive Immune Activation in Age-Related Decline of Muscle Function.
Montano M, Correa-de-Araujo R |
The journals of gerontology. Series A, Biological sciences and medical sciences | 2023 |
|
Mapping cellular senescence networks in human diabetic foot ulcers.
Yu GT, Monie DD, Khosla S, Tchkonia T, Kirkland JL, Wyles SP |
GeroScience | 2023 |
|
Ageing in the brain: mechanisms and rejuvenating strategies
Gaspar-Silva F, Trigo D, Magalhaes J |
Cellular and Molecular Life Sciences | 2023 |
|
The Role of Oxidative Stress and Cellular Senescence in the Pathogenesis of Metabolic Associated Fatty Liver Disease and Related Hepatocellular Carcinoma
Anastasopoulos NA, Charchanti AV, Barbouti A, Mastoridou EM, Goussia AC, Karampa AD, Christodoulou D, Glantzounis GK |
Antioxidants | 2023 |
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Senopathies—Diseases Associated with Cellular Senescence
Lushchak O, Schosserer M, Grillari J |
Biomolecules | 2023 |
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Identification and validation of aging-related gene signatures and their immune landscape in diabetic nephropathy
Liang Y, Liang Z, Huang J, Jia M, Liu D, Zhang P, Fang Z, Hu X, Li H |
Frontiers in Medicine | 2023 |
|
Senescent CD8(+) T cells acquire NK cell-like innate functions to promote antitumor immunity.
Kakuda T, Suzuki J, Matsuoka Y, Kikugawa T, Saika T, Yamashita M |
Cancer Science | 2023 |
|
Skeletal Senescence with Aging and Type 2 Diabetes.
Farr JN |
2023 | |
|
Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters.
Delval L, Hantute-Ghesquier A, Sencio V, Flaman JM, Robil C, Angulo FS, Lipskaia L, Çobanoğlu O, Lacoste AS, Machelart A, Danneels A, Corbin M, Deruyter L, Heumel S, Idziorek T, Séron K, Sauve F, Bongiovanni A, Prévot V, Wolowczuk I, Belouzard S, Saliou JM, Gosset P, Bernard D, Rouillé Y, Adnot S, Duterque-Coquillaud M, Trottein F |
2023 | |
|
The epigenetic reader, BRD2, mediates cholangiocyte senescence via interaction with ETS1
Kang JH, Splinter PL, Trussoni CE, Pirius NE, Gores GJ, LaRusso NF, O'Hara SP |
Gastroenterology | 2023 |
|
Clinical Potential of Mesenchymal Stem Cell-Derived Exosomes in Bone Regeneration
Torrecillas-Baena B, Pulido-Escribano V, Dorado G, Gálvez-Moreno MÁ, Camacho-Cardenosa M, Casado-Díaz A |
Journal of Clinical Medicine | 2023 |
|
Age-related self-DNA accumulation may accelerate arthritis in rats and in human rheumatoid arthritis.
Luo WD, Wang YP, Lv J, Liu Y, Qu YQ, Xu XF, Yang LJ, Lin ZC, Wang LN, Chen RH, Yang JJ, Zeng YL, Zhang RL, Huang BX, Yun XY, Wang XY, Song LL, Wu JH, Wang XX, Chen X, Zhang W, Wang HM, Qu LQ, Liu MH, Liu L, Law BYK, Wong VKW |
Nature Communications | 2023 |
|
The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms.
Ungvari Z, Fazekas-Pongor V, Csiszar A, Kunutsor SK |
GeroScience | 2023 |
|
Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton.
Doolittle ML, Saul D, Kaur J, Rowsey JL, Vos SJ, Pavelko KD, Farr JN, Monroe DG, Khosla S |
Nature Communications | 2023 |
|
Dasatinib and quercetin increase testosterone and sperm concentration in mice
Garcia DN, Hense JD, Zanini BM, Isola JV, Pradiee J, Prosczek JB, Alvarado-Rincón JA, Mondadori RG, Mason JB, Brieño\u2011Enríquez MA, Barros CC, Stout MB, Masternak MM, Schneider A |
2023 | |
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A single nuclei atlas of aging human abdominal subcutaneous white adipose tissue
Sparks L, Whytock K, Divoux A, Sun Y, Pino M, Yu G, Smith S, Walsh M |
Research square | 2023 |
|
Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice
Wang J, Lu Y, Carr C, Dhandapani KM, Brann DW |
Frontiers in neuroscience | 2023 |
|
LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network.
Dong Q, Qiu H, Piao C, Li Z, Cui X |
Journal of experimental & clinical cancer research : CR | 2023 |
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Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss
Pimenta-Lopes C, Sánchez-de-Diego C, Deber A, Egea-Cortés A, Valer JA, Alcalá A, Méndez-Lucas A, Esteve-Codina A, Rosa JL, Ventura F |
Molecular Therapy | 2023 |
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In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers.
Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell GG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, Lebrasseur NK, Farr JN, Robbins PD, Khosla S |
Aging | 2023 |
|
DNA Damage Response-Associated Cell Cycle Re-Entry and Neuronal Senescence in Brain Aging and Alzheimer's Disease.
Wong GC, Chow KH |
Journal of Alzheimer's disease : JAD | 2023 |
|
The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse.
Fernandez-Fuente G, Overmyer KA, Lawton AJ, Kasza I, Shapiro SL, Gallego-Muñoz P, Coon JJ, Denu JM, Alexander CM, Puglielli L |
Communications biology | 2023 |
|
Application of mesenchymal stem cells for anti-senescence and clinical challenges.
Wang Y, Gao T, Wang B |
Stem Cell Research & Therapy | 2023 |
|
Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult
Chen BH, Lu XQ, Liang XH, Wang P |
Scientific Reports | 2023 |
|
Identifying Aging-Related Biomarkers and Immune Infiltration Features in Diabetic Nephropathy Using Integrative Bioinformatics Approaches and Machine-Learning Strategies
Liu T, Zhuang XX, Gao JR |
Biomedicines | 2023 |
|
Reversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes
Rubin de Celis MF, Bonner-Weir S |
Frontiers in Endocrinology | 2023 |
|
Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics
Adejuyigbe B, Kallini J, Chiou D, Kallini JR |
International journal of molecular sciences | 2023 |
|
Core fucosylation regulates alveolar epithelial cells senescence through activating of transforming growth factor-β pathway in pulmonary fibrosis
Jiang Y, Wang Z, Hu J, Wang W, Zhang N, Gao L |
Aging | 2023 |
|
Discovery of Salidroside as a Novel Non-Coding RNA Modulator to Delay Cellular Senescence and Promote BK-Dependent Apoptosis in Cerebrovascular Smooth Muscle Cells of Simulated Microgravity Rats
Ge Y, Zhang B, Song J, Cao Q, Bu Y, Li P, Bai Y, Yang C, Xie M |
International journal of molecular sciences | 2023 |
|
Cellular senescence-related genes: predicting prognosis in hepatocellular carcinoma
Yuan W, Xu Y, Wu Z, Huang Y, Meng L, Dai S, Ying S, Chen Z, Xu A |
BMC Cancer | 2023 |
|
TEAD4 antagonizes cellular senescence by remodeling chromatin accessibility at enhancer regions
Zhang D, Zhu Y, Ju Y, Zhang H, Zou X, She S, Zhu D, Guan Y |
Cellular and Molecular Life Sciences | 2023 |
|
The Association of Multiple Sensory Impairment and Telomere Length: The Health ABC Study
Vohra V, Cheng MZ, Xue QL, Simonsick EM, Lane AP, Agrawal Y, Rowan NR |
The Laryngoscope | 2023 |
|
Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes.
Bramwell LR, Harries LW |
GeroScience | 2023 |
|
Aging and oral squamous cell carcinoma development: the role of cellular senescence
Niklander SE, Aránguiz P, Faunes F, Martínez-Flores R |
2023 | |
|
Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis
Liu S, Cheng S, Chen B, Xiao P, Zhan J, Liu J, Chen Z, Liu J, Zhang T, Lei Y, Huang W |
Journal of nanobiotechnology | 2023 |
|
Cellular senescence triggers intracellular acidification and lysosomal pH alkalinized via ATP6AP2 attenuation in breast cancer cells
Li W, Kawaguchi K, Tanaka S, He C, Maeshima Y, Suzuki E, Toi M |
Communications biology | 2023 |
|
An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence.
Riviere-Cazaux C, Carlstrom LP, Neth BJ, Olson IE, Rajani K, Rahman M, Ikram S, Mansour MA, Mukherjee B, Warrington AE, Short SC, von Zglinicki T, Brown DA, Burma S, Tchkonia T, Schafer MJ, Baker DJ, Kizilbash SH, Kirkland JL, Burns TC |
npj Precision Oncology | 2023 |
|
Cellular senescence in brain aging and cognitive decline
Shafqat A, Khan S, Omer MH, Niaz M, Albalkhi I, AlKattan K, Yaqinuddin A, Tchkonia T, Kirkland JL, Hashmi SK |
Frontiers in aging neuroscience | 2023 |
|
Autophagy and Senescence: The Molecular Mechanisms and Implications in Liver Diseases
Li Q, Lin Y, Liang G, Xiao N, Zhang H, Yang X, Yang J, Liu A |
International journal of molecular sciences | 2023 |
|
The role of cellular senescence in skin aging and age-related skin pathologies
Chin T, Lee XE, Ng PY, Lee Y, Dreesen O |
Frontiers in physiology | 2023 |
|
The effect of metformin on senescence of T lymphocytes.
Yang J, Liu HC, Zhang JQ, Zou JY, Zhang X, Chen WM, Gu Y, Hong H |
Immunity & ageing : I & A | 2023 |
|
Interleukin-11 and its eminent role in tissue fibrosis: a possible therapeutic target.
O'Reilly S |
Clinical & Experimental Immunology | 2023 |
|
Understanding cellular senescence: pathways involved, therapeutics and longevity aiding
Kumar A, Thirumurugan K |
Cell cycle (Georgetown, Tex.) | 2023 |
|
Molecular Mechanisms and the Interplay of Important Chronic Obstructive Pulmonary Disease Biomarkers Reveals Novel Therapeutic Targets
Sharma G, Banerjee R, Srivastava S |
ACS Omega | 2023 |
|
Circulating monocytes expressing senescence-associated features are enriched in COVID-19 patients with severe disease.
Lin Y, Postma DF, Steeneken LS, Melo Dos Santos LS, Kirkland JL, Espindola-Netto JM, Tchkonia T, Borghesan M, Bouma HR, Demaria M |
Aging Cell | 2023 |
|
The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency
Xu Z, Takahashi N, Harada M, Kunitomi C, Kusamoto A, Koike H, Tanaka T, Sakaguchi N, Urata Y, Wada-Hiraike O, Hirota Y, Osuga Y |
International journal of molecular sciences | 2023 |
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Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice
Barnhoorn S, Meima ME, Peeters RP, Darras VM, Leeuwenburgh S, Hoeijmakers JH, Vermeij WP, Visser WE |
European Thyroid Journal | 2023 |
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Regulation of Satellite Cells Functions during Skeletal Muscle Regeneration: A Critical Step in Physiological and Pathological Conditions
Careccia G, Mangiavini L, Cirillo F |
International journal of molecular sciences | 2023 |
|
What Does Sarcopenia Have to Do with Nonalcoholic Fatty Liver Disease?
Ferenc K, Jarmakiewicz-Czaja S, Filip R |
Life Sciences | 2023 |
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Geroscience-Centric Perspective for Geriatric Psychiatry: integrating aging biology with geriatric mental health research
Diniz BS, Seitz-Holland J, Sehgal R, Kasamoto J, Higgins-Chen AT, Lenze E |
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2023 |
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Telomeres as hotspots for innate immunity and inflammation
Nassour J, Przetocka S, Karlseder J |
DNA repair | 2023 |
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Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma
Gleason CE, Dickson MA, Klein (Dooley) ME, Antonescu CR, Gularte-Mérida R, Benitez M, Delgado JI, Kataru RP, Tan MW, Bradic M, Adamson TE, Seier K, Richards AL, Palafox M, Chan E, D'Angelo SP, Gounder MM, Keohan ML, Kelly CM, Chi P, Movva S, Landa J, Crago AM, Donoghue MT, Qin LX, Serra V, Turkekul M, Barlas A, Firester DM, Manova-Todorova K, Mehrara BJ, Kovatcheva M, Tan NS, Singer S, Tap WD, Koff A |
Clinical cancer research | 2023 |
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Potential Clinical Implications of Senotherapies for Cardiovascular Disease
Suda M, Katsuumi G, Tchkonia T, Kirkland JL, Minamino T |
Circulation journal : official journal of the Japanese Circulation Society | 2023 |
|
Biomimetic Therapeutics for Bone Regeneration: A Perspective on Antiaging Strategies
Miszuk J, Sun H |
Macromolecular Bioscience | 2023 |
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Translating the Biology of Aging into New Therapeutics for Alzheimer’s Disease: Senolytics
Riessland M, Orr ME |
The journal of prevention of Alzheimer's disease | 2023 |
|
Major depression, physical health and molecular senescence markers abnormalities.
Seitz-Holland J, Mulsant BH, Reynolds CF 3rd, Blumberger DM, Karp JF, Butters MA, Mendes-Silva AP, Vieira EL, Tseng G, Lenze EJ, Diniz BS, Seitz-Holland J, Mulsant BH, Reynolds CF 3rd, Blumberger DM, Karp JF, Butters MA, Mendes-Silva AP, Vieira EL, Tseng G, Lenze EJ, Diniz BS |
Nature. Mental health | 2023 |
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Telomeres: Dysfunction, Maintenance, Aging and Cancer.
Liao P, Yan B, Wang C, Lei P |
Aging and disease | 2023 |
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Senescence in diffuse systemic sclerosis is elevated and may play a role in fibrosis
O\u2019Reilly S |
Clinical and Experimental Immunology | 2023 |
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JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice
Cristina Rivellini, Emanuela Porrello, Giorgia Dina, Simona Mrakic-Sposta, Alessandra Vezzoli, Marco Bacigaluppi, Giorgia Serena Gullotta, Linda Chaabane, Letizia Leocani, Silvia Marenna, Emanuela Colombo, Cinthia Farina, Jia Newcombe, Klaus-Armin Nave, Ruggero Pardi, Angelo Quattrini, Stefano Previtali |
Journal of Clinical Investigation | 2022 |
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Cellular Senescence and the Skeleton: Pathophysiology and Therapeutic Implications
Sundeep Khosla, Joshua Farr, David Monroe |
Journal of Clinical Investigation | 2022 |
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The Achilles heel of cancer survivors: fundamentals of accelerated cellular senescence
Shameel Shafqat, Evelyn Arana Chicas, Areez Shafqat, Shahrukh Hashmi |
Journal of Clinical Investigation | 2022 |
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Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
Yi Zhu, Larissa G. P. Langhi Prata, Erin O. Wissler Gerdes, Jair Machado Espindola Netto, Tamar Pirtskhalava, Nino Giorgadze, Utkarsh Tripathi, Christina L. Inman, Kurt O. Johnson, Ailing Xue, Allyson Palmer, Tingjun Chen, Kalli Schaefer, Jamie N. Justice, Anoop M. Nambiar, Nicolas Musi, Steve Kritchevsky, Jun Chen, Sundeep Khosla, Diana Jurk, Marissa Schafer, Tamara Tchkonia, James. Kirkland |
EBioMedicine | 2022 |
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Senescent preosteoclast secretome promotes metabolic syndrome-associated osteoarthritis through COX2-PGE2
Weiping Su, Guanqiao Liu, Bahram Mohajer, Jiekang Wang, Alena J Shen, Weixin Zhang, Xiaonan Liu, Bin Liu, Ali Guermazi, Peisong Gao, Xu Cao, Shadpour Demehri, Mei Wan |
eLife | 2022 |
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Telomere dysfunction in ageing and age-related diseases
F Rossiello, D Jurk, J Passos, F dAdda di Fagagna |
Nature Cell Biology | 2022 |
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Cellular Senescence in Sarcopenia: Possible Mechanisms and Therapeutic Potential
Y He, W Xie, H Li, H Jin, Y Zhang, Y Li |
Frontiers in Cell and Developmental Biology | 2022 |
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Telomerase deficiency reflects age-associated changes in CD4+ T cells
D Matthe, O Thoma, T Sperka, M Neurath, M Waldner |
Immunity & Ageing | 2022 |
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CRISPR/Cas: A New Tool in the Research of Telomeres and Telomerase as Well as a Novel Form of Cancer Therapy
M Porika, R Tippani, G Saretzki |
International journal of molecular sciences | 2022 |
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The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
Y Sun, X Wang, T Liu, X Zhu, X Pan |
Cell & Bioscience | 2022 |
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Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation
Y Yegorov, A Poznyak, E Bezsonov, A Zhuravlev, N Nikiforov, K Vishnyakova, A Orekhov |
Biomedicines | 2022 |
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Cytokine-Induced Senescence in the Tumor Microenvironment and Its Effects on Anti-Tumor Immune Responses
M Rentschler, H Braumüller, P Briquez, T Wieder |
Cancers | 2022 |
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Mitochondrial and metabolic dysfunction in ageing and age-related diseases
J Amorim, G Coppotelli, A Rolo, C Palmeira, J Ross, D Sinclair |
Nature Reviews Endocrinology | 2022 |
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The shades of grey in adipose tissue reprogramming
Y Qi, X Hui |
Bioscience Reports | 2022 |
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Phosphate Metabolism: From Physiology to Toxicity
M Razzaque |
2022 | |
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Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain
T Kiss, Á Nyúl-Tóth, J DelFavero, P Balasubramanian, S Tarantini, J Faakye, R Gulej, C Ahire, A Ungvari, A Yabluchanskiy, G Wiley, L Garman, Z Ungvari, A Csiszar |
GeroScience | 2022 |
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Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence
Q Li, Y Deng, L Liu, C Zhang, Y Cai, T Zhang, M Han, G Xu |
Frontiers in immunology | 2022 |
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Decoy receptor 2 mediates the apoptosis-resistant phenotype of senescent renal tubular cells and accelerates renal fibrosis in diabetic nephropathy
J Chen, K Chen, L Wang, J Luo, Q Zheng, Y He |
Cell Death and Disease | 2022 |
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Association between mitochondrial and nuclear DNA damages and cellular senescence in the patients with biliary atresia undergoing Kasai portoenterostomy and liver transplantation
Y Nakajima, Y Yamazaki, X Gao, M Hashimoto, M Nio, M Wada, F Fujishima, H Sasano |
Medical Molecular Morphology | 2022 |
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Sorafenib, rapamycin, and venetoclax attenuate doxorubicin-induced senescence and promote apoptosis in HCT116 cells
H Sobeai, M Alohaydib, A Alhoshani, K Alhazzani, M Almutairi, T Saleh, D Gewirtz, M Alotiabi |
Saudi Pharmaceutical Journal | 2022 |
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IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma
L Homann, M Rentschler, E Brenner, K Böhm, M Röcken, T Wieder |
Cells | 2022 |
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Age-Related Changes in the Fibroblastic Differon of the Dermis: Role in Skin Aging
Zorina A, Zorin V, Kudlay D, Kopnin P |
International journal of molecular sciences | 2022 |
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Loss of legumain induces premature senescence and mediates aging‐related renal fibrosis
Wang D, Kang L, Chen C, Guo J, Du L, Zhou D, Li G, Zhang Y, Mi X, Zhang M, Liu S, Tan X |
Aging Cell | 2022 |
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Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD
Sreekumar PG, Reddy ST, Hinton DR, Kannan R |
Experimental Eye Research | 2022 |
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Green tea-derived theabrownin induces cellular senescence and apoptosis of hepatocellular carcinoma through p53 signaling activation and bypassed JNK signaling suppression
Xu J, Xiao X, Yan B, Yuan Q, Dong X, Du Q, Zhang J, Shan L, Ding Z, Zhou L, Efferth T |
Cancer Cell International | 2022 |
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A comprehensive analysis of age-related metabolomics and transcriptomics reveals metabolic alterations in rat bone marrow mesenchymal stem cells
Yu X, Sun H, Gao X, Zhang C, Sun Y, Wang H, Zhang H, Shi Y, He X |
Aging | 2022 |
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Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging
Safwan-Zaiter H, Wagner N, Michiels JF, Wagner KD |
Cells | 2022 |
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Glucose Metabolism and Aging of Hematopoietic Stem and Progenitor Cells
Poisa-Beiro L, Landry JJ, Raffel S, Tanaka M, Zaugg J, Gavin AC, Ho AD |
International journal of molecular sciences | 2022 |
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Identification of gingerenone A as a novel senolytic compound
Moaddel R, Rossi M, Rodriguez S, Munk R, Khadeer M, Abdelmohsen K, Gorospe M, Ferrucci L |
PloS one | 2022 |
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Association Between Changes in Frailty Index and Clinical Outcomes: An Observational Cohort Study
Ji S, Baek JY, Jin T, Lee E, Jang IY, Jung HW |
Clinical Interventions in Aging | 2022 |
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Comprehensive Analysis of Phagocytosis-Related Regulators to Aid Prognostic Prediction and Immunotherapy in Patients with Low-Grade Glioma
Li J, Huang Q, Mo L |
Disease Markers | 2022 |
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Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling
Kiss T, Nyúl-Tóth Á, Gulej R, Tarantini S, Csipo T, Mukli P, Ungvari A, Balasubramanian P, Yabluchanskiy A, Benyo Z, Conley SM, Wren JD, Garman L, Huffman DM, Csiszar A, Ungvari Z |
GeroScience | 2022 |
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SIRT6 Widely Regulates Aging, Immunity, and Cancer
Li Y, Jin J, Wang Y |
Frontiers in Oncology | 2022 |
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Leveraging Spaceflight to Advance Cardiovascular Research on Earth.
Scott JM, Stoudemire J, Dolan L, Downs M |
Circulation research | 2022 |
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Repression of the Antioxidant Pyrroloquinoline Quinone in Skin Aging Induced by Bmi-1 Deficiency
Li J, Liu M, Liang S, Yu Y, Gu M |
BioMed Research International | 2022 |
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Advances in cGAS-STING Signaling Pathway and Diseases
Yang Y, Huang Y, Zeng Z |
Frontiers in Cell and Developmental Biology | 2022 |
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Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse
Kallenbach JG, Freeberg MA, Abplanalp D, Alenchery RG, Ajalik RE, Muscat S, Myers JA, Ashton JM, Loiselle A, Buckley MR, van Wijnen AJ, Awad HA |
Scientific Reports | 2022 |
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Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity
Chandra A, Lagnado AB, Farr JN, Doolittle M, Tchkonia T, Kirkland JL, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Ikeno Y, Passos JF, Monroe DG, Pignolo RJ, Khosla S |
Aging Cell | 2022 |
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G-quadruplexes Stabilization Upregulates CCN1 and Accelerates Aging in Cultured Cerebral Endothelial Cells
Noh B, Blasco-Conesa MP, Lai YJ, Ganesh BP, Urayama A, Moreno-Gonzalez I, Marrelli SP, McCullough LD, Moruno-Manchon JF |
2022 | |
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Cell senescence, rapamycin and hyperfunction theory of aging
Blagosklonny MV |
Cell cycle (Georgetown, Tex.) | 2022 |
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Cellular Stress and Senescence Induction during Trypanosoma cruzi Infection
Guimarães-Pinto K, Ferreira JR, da Costa AL, Morrot A, Freire-de-Lima L, Decote-Ricardo D, Freire-de-Lima CG, Filardy AA |
Tropical Medicine and Infectious Disease | 2022 |
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Obesity, Senescence, and Senolytics.
Chaib S, Tchkonia T, Kirkland JL |
Handbook of experimental pharmacology | 2022 |
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Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis.
Ramírez R, Ceprian N, Figuer A, Valera G, Bodega G, Alique M, Carracedo J |
Journal of Personalized Medicine | 2022 |
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Age-Related Hearing Loss: The Link between Inflammaging, Immunosenescence, and Gut Dysbiosis.
Kociszewska D, Vlajkovic S |
International journal of molecular sciences | 2022 |
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Revisiting Epithelial Carcinogenesis.
Méndez-López LF |
International journal of molecular sciences | 2022 |
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Cellular senescence and senolytics: the path to the clinic.
Chaib S, Tchkonia T, Kirkland JL |
Nature Medicine | 2022 |
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Pharmacological Approaches to Decelerate Aging: A Promising Path.
Hassani B, Goshtasbi G, Nooraddini S, Firouzabadi N |
Oxidative medicine and cellular longevity | 2022 |
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Update on Melasma-Part I: Pathogenesis.
Espósito ACC, Cassiano DP, da Silva CN, Lima PB, Dias JAF, Hassun K, Bagatin E, Miot LDB, Miot HA |
Dermatology and Therapy | 2022 |
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Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
Bochyńska A, Stenzel AT, Boroujeni RS, Kuo CC, Barsoum M, Liang W, Bussmann P, Costa IG, Lüscher-Firzlaff J, Lüscher B |
Nucleic Acids Research | 2022 |
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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S |
Nature Communications | 2022 |
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Immunosenescence, aging and successful aging
Wang Y, Dong C, Han Y, Gu Z, Sun C |
Frontiers in immunology | 2022 |
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Identification of Human Breast Adipose Tissue Progenitors Displaying Distinct Differentiation Potentials and Interactions with Cancer Cells
Peraldi P, Loubat A, Chignon-Sicard B, Dani C, Ladoux A |
Biomedicines | 2022 |
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Accelerated aging-related transcriptome alterations in neurovascular unit cells in the brain of Alzheimer’s disease
Zhao Y, Xie YZ, Liu YS |
Frontiers in aging neuroscience | 2022 |
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As expected, based on rapamycin-like p53-mediated gerosuppression, mTOR inhibition acts as a checkpoint in p53-mediated tumor suppression
Blagosklonny MV |
Oncoscience | 2022 |
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Identification of Four Biomarkers of Human Skin Aging by Comprehensive Single Cell Transcriptome, Transcriptome, and Proteomics
Mao R, Wang Y, Wang F, Zhou L, Yan S, Lu S, Shi W, Zhang Y |
Frontiers in Genetics | 2022 |
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Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models.
Kaeppler JR, Chen J, Buono M, Vermeer J, Kannan P, Cheng WC, Voukantsis D, Thompson JM, Hill MA, Allen D, Gomes A, Kersemans V, Kinchesh P, Smart S, Buffa F, Nerlov C, Muschel RJ, Markelc B |
EMBO reports | 2022 |
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Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells.
Rysanek D, Vasicova P, Kolla JN, Sedlak D, Andera L, Bartek J, Hodny Z |
Aging | 2022 |
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Cultured Human Foreskin as a Model System for Evaluating Ionizing Radiation-Induced Skin Injury.
Hippchen Y, Tewary G, Jung D, Schmal Z, Meessen S, Palm J, Rübe CE |
International journal of molecular sciences | 2022 |
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Nutritional Niches of Cancer Therapy-Induced Senescent Cells.
Llop-Hernández À, Verdura S, Cuyàs E, Menendez JA |
Nutrients | 2022 |
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Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance
Zhang X, Pearsall VM, Carver CM, Atkinson EJ, Clarkson BD, Grund EM, Baez-Faria M, Pavelko KD, Kachergus JM, White TA, Johnson RK, Malo CS, Gonzalez-Suarez AM, Ayasoufi K, Johnson KO, Tritz ZP, Fain CE, Khadka RH, Ogrodnik M, Jurk D, Zhu Y, Tchkonia T, Revzin A, Kirkland JL, Johnson AJ, Howe CL, Thompson EA, LeBrasseur NK, Schafer MJ |
Nature Communications | 2022 |
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Soluble guanylate cyclase activator BAY 54–6544 improves vasomotor function and survival in an accelerated ageing mouse model
Ataei Ataabadi E, Golshiri K, Jüttner AA, de Vries R, Van den Berg\u2010Garrelds I, Nagtzaam NM, Khan HN, Leijten FP, Brandt RM, Dik WA, van der Pluijm I, Danser AH, Sandner P, Roks AJ |
Aging Cell | 2022 |
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Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long-lived individuals.
Siino V, Ali A, Accardi G, Aiello A, Ligotti ME, Mosquim Junior S, Candore G, Caruso C, Levander F, Vasto S |
Aging Cell | 2022 |
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Transcriptomics and Proteomics Analyses Reveal JAK Signaling and Inflammatory Phenotypes during Cellular Senescence in Blind Mole Rats: The Reflections of Superior Biology.
Inci N, Akyildiz EO, Bulbul AA, Turanli ET, Akgun E, Baykal AT, Colak F, Bozaykut P |
Biology | 2022 |
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Autophagy at the intersection of aging, senescence, and cancer
Cassidy LD, Narita M |
Molecular Oncology | 2022 |
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Cellular senescence and the tumour microenvironment
Takasugi M, Yoshida Y, Ohtani N |
Molecular Oncology | 2022 |
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The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity
Ali D, Tencerova M, Figeac F, Kassem M, Jafari A |
Frontiers in Endocrinology | 2022 |
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Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age
Marino F, Scalise M, Salerno N, Salerno L, Molinaro C, Cappetta D, Torella M, Greco M, Foti D, Sasso FC, Mastroroberto P, De Angelis A, Ellison-Hughes GM, Sampaolesi M, Rota M, Rossi F, Urbanek K, Nadal-Ginard B, Torella D, Cianflone E |
Diabetes | 2022 |
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Cellular Senescence in Immunity against Infections
Marrella V, Facoetti A, Cassani B |
International journal of molecular sciences | 2022 |
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Characterization of age-related immune features after autologous NK cell infusion: Protocol for an open-label and randomized controlled trial
Tang X, Deng B, Zang A, He X, Zhou Y, Wang D, Li D, Dai X, Chen J, Zhang X, Liu Y, Xu Y, Chen J, Zheng W, Zhang L, Gao C, Yang H, Li B, Wang X |
Frontiers in immunology | 2022 |
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K63 Ubiquitination of P21 Can Facilitate Pellino-1 in the Context of Chronic Obstructive Pulmonary Disease and Lung Cellular Senescence
Ma JH, Zhang YT, Wang LP, Sun QY, Zhang H, Li JJ, Han NN, Zhu YY, Xie XY, Li X |
Cells | 2022 |
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Upregulation of PD-L1 in Senescence and Aging.
Onorati A, Havas AP, Lin B, Rajagopal J, Sen P, Adams PD, Dou Z |
Molecular and cellular biology | 2022 |
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Research priorities for measuring biologic age: summary and future directions from the Research Centers Collaborative Network Workshop.
Brinkley TE, Justice JN, Basu S, Bauer SR, Loh KP, Mukli P, Ng TKS, Turney IC, Ferrucci L, Cummings SR, Kritchevsky SB |
GeroScience | 2022 |
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Cellular Senescence and Periodontitis: Mechanisms and Therapeutics.
Chen S, Zhou D, Liu O, Chen H, Wang Y, Zhou Y |
Biology | 2022 |
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Anti-Inflammatory and Antioxidant Properties of Physalis alkekengi L. Extracts In Vitro and In Vivo: Potential Application for Skin Care.
He BW, Wang FF, Qu LP |
Evidence-based complementary and alternative medicine : eCAM | 2022 |
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Aging of Liver in Its Different Diseases
Radonjić T, Dukić M, Jovanović I, Zdravković M, Mandić O, Popadić V, Popović M, Nikolić N, Klašnja S, Divac A, Todorović Z, Branković M |
International journal of molecular sciences | 2022 |
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Osteocytes regulate senescence of bone and bone marrow.
Ding P, Gao C, Gao Y, Liu D, Li H, Xu J, Chen X, Huang Y, Zhang C, Zheng M, Gao J |
eLife | 2022 |
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Dedifferentiation and in vivo reprogramming of committed cells in wound repair (Review).
Guo Y, Wu W, Yang X, Fu X |
Molecular medicine reports | 2022 |
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PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53.
Rubin de Celis MF, Garcia-Martin R, Syed I, Lee J, Aguayo-Mazzucato C, Bonner-Weir S, Kahn BB |
Proceedings of the National Academy of Sciences | 2022 |
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Biological and clinical review of IORT-induced wound fluid in breast cancer patients
Jeibouei S, Shams F, Mohebichamkhorami F, Sanooghi D, Faal B, Akbari ME, Zali H |
Frontiers in Oncology | 2022 |
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Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases
Sanz-Ros J, Mas-Bargues C, Romero-García N, Huete-Acevedo J, Dromant M, Borrás C |
International journal of molecular sciences | 2022 |
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The cGAS/STING signaling pathway: a cross-talk of infection, senescence and tumors
Zeng PH, Yin WJ |
Cell cycle (Georgetown, Tex.) | 2022 |
|
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice
Henn RE, Elzinga SE, Glass E, Parent R, Guo K, Allouch AA, Mendelson FE, Hayes J, Webber-Davis I, Murphy GG, Hur J, Feldman EL |
Immunity & ageing : I & A | 2022 |
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Impacts of Telomeric Length, Chronic Hypoxia, Senescence, and Senescence-Associated Secretory Phenotype on the Development of Thoracic Aortic Aneurysm
Aschacher T, Geisler D, Lenz V, Aschacher O, Winkler B, Schaefer AK, Mitterbauer A, Wolf B, Enzmann FK, Messner B, Laufer G, Ehrlich MP, Grabenwöger M, Bergmann M |
International journal of molecular sciences | 2022 |
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Molecular Mechanisms of Vascular Health: Insights from Vascular Aging and Calcification
Sutton NR, Malhotra R, Hilaire C, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y |
Arteriosclerosis, thrombosis, and vascular biology | 2022 |
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Prefrontally modulated vagal neuroimmunomodulation is associated with telomere length
Ask TF, Sütterlin S |
Frontiers in neuroscience | 2022 |
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Selenoproteins and the senescence-associated epitranscriptome.
Lee MY, Ojeda-Britez S, Ehrbar D, Samwer A, Begley TJ, Melendez JA |
Experimental biology and medicine (Maywood, N.J.) | 2022 |
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Post-GWAS functional analysis identifies CUX1 as a regulator of p16(INK4a) and cellular senescence.
Jiang D, Sun W, Wu T, Zou M, Vasamsetti SB, Zhang X, Zhao Y, Phillippi JA, Sawalha AH, Tavakoli S, Dutta P, Florentin J, Chan SY, Tollison TS, Di Wu, Cui J, Huntress I, Peng X, Finkel T, Li G |
2022 | |
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Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population
Daryle DePianto, Jason A. Vander Heiden, Katrina B. Morshead, Kai-Hui Sun, Zora Modrusan, Grace Teng, Paul J. Wolters, Joseph Arron |
JCI Insight | 2021 |
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IGF-1 Receptor Signaling Regulates Type II Pneumocyte Senescence and Resulting Macrophage Polarization in Lung Fibrosis
EJ Chung, S Kwon, JL Reedy, AO White, JS Song, I Hwang, JY Chung, K Ylaya, SM Hewitt, DE Citrin |
International journal of radiation oncology, biology, physics | 2021 |
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IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice
SE Catheline, RD Bell, LS Oluoch, MN James, K Escalera-Rivera, RD Maynard, ME Chang, C Dean, E Botto, JP Ketz, BF Boyce, MJ Zuscik, JH Jonason |
Science signaling | 2021 |
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Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials
R Franzin, A Stasi, E Ranieri, GS Netti, V Cantaluppi, L Gesualdo, G Stallone, G Castellano |
Frontiers in pharmacology | 2021 |
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Modulation of fracture healing by the transient accumulation of senescent cells
D Saul, DG Monroe, JL Rowsey, RL Kosinsky, SJ Vos, ML Doolittle, JN Farr, S Khosla |
eLife | 2021 |
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Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis
S Li, S Jiang, Q Zhang, B Jin, D Lv, W Li, M Zhao, C Jiang, C Dai, Z Liu |
Frontiers in Cell and Developmental Biology | 2021 |
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Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis
Q Li, JC Cheng, Q Jiang, WY Lee |
Aging Cell | 2021 |
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Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis
S Honda, K Ikeda, R Urata, E Yamazaki, N Emoto, S Matoba |
Scientific Reports | 2021 |
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Gender Differences in Urothelial Bladder Cancer: Effects of Natural Killer Lymphocyte Immunity
CT Lutz, L Livas, SR Presnell, M Sexton, P Wang |
Journal of Clinical Medicine | 2021 |
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Dynamic Aging: Channeled Through Microenvironment
Q Tan, N Liang, X Zhang, J Li |
Frontiers in physiology | 2021 |
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Senescence and Type 2 Diabetic Cardiomyopathy: How Young Can You Die of Old Age?
SM Henson, D Aksentijevic |
Frontiers in pharmacology | 2021 |
|
Age and Sex: Impact on adipose tissue metabolism and inflammation
M Varghese, J Song, K Singer |
Mechanisms of Ageing and Development | 2021 |
|
Heterogeneity and Dynamics of Vasculature in the Endocrine System During Aging and Disease
S Stucker, JD Angelis, AP Kusumbe |
Frontiers in physiology | 2021 |
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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
PD Robbins, D Jurk, S Khosla, JL Kirkland, NK LeBrasseur, JD Miller, JF Passos, RJ Pignolo, T Tchkonia, LJ Niedernhofer |
Annual Review of Pharmacology and Toxicology | 2021 |
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Strategies for targeting senescent cells in human disease
NS Gasek, GA Kuchel, JL Kirkland, M Xu |
2021 | |
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Strategies for late phase preclinical and early clinical trials of senolytics
EO Gerdes, A Misra, JM Netto, T Tchkonia, JL Kirkland |
Mechanisms of Ageing and Development | 2021 |
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A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?
M Sillen, PJ Declerck |
International journal of molecular sciences | 2021 |
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Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease
T Fulop, S Tripathi, S Rodrigues, M Desroches, T Bunt, A Eiser, F Bernier, PB Beauregard, AE Barron, A Khalil, A Plotka, K Hirokawa, A Larbi, C Bocti, B Laurent, EH Frost, JM Witkowski |
Neuropsychiatric Disease and Treatment | 2021 |
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The role of connexin proteins and their channels in radiation-induced atherosclerosis
R Ramadan, S Baatout, A Aerts, L Leybaert |
Cellular and Molecular Life Sciences | 2021 |
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COVID-19 Treatment: Drug Safety Prior to Conception and During Pregnancy and Breastfeeding
MB Cavalcante, CT de Melo Bezerra Cavalcante, AC Braga, DA Andrade, MA Montenegro, PA Santos, PV Motoyama, MG Rocha, LA Dib, EA Júnior |
Geburtshilfe und Frauenheilkunde | 2021 |
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Cell senescence in neuropathology: A focus on neurodegeneration and tumours
G Carreno, R Guiho, JP MartinezBarbera |
Neuropathology and Applied Neurobiology | 2021 |
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Bcl-xL as a Modulator of Senescence and Aging
C Mas-Bargues, C Borrás, J Viña |
International journal of molecular sciences | 2021 |
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Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis
W Gong, C Luo, F Peng, J Xiao, Y Zeng, B Yin, X Chen, S Li, X He, Y Liu, H Cao, J Xu, H Long |
Clinical Science | 2021 |
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The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice
X Yan, N Imano, K Tamaki, M Sano, K Shinmura, I Manabe |
PloS one | 2021 |
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Biological Aspects of Inflamm-Aging in Childhood Cancer Survivors
F Rossi, AD Paola, E Pota, M Argenziano, DD Pinto, MM Marrapodi, CD Leva, MD Martino, C Tortora |
Cancers | 2021 |
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Towards an understanding of the mechanoreciprocity process in adipocytes and its perturbation with aging
MD Luca, M Mandala, G Rose |
Mechanisms of Ageing and Development | 2021 |
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LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis
Y Tian, J Lv, Z Su, T Wu, X Li, X Hu, J Zhang, L Wu |
Proceedings of the National Academy of Sciences | 2021 |
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Aging of the Retina: Molecular and Metabolic Turbulences and Potential Interventions
L Campello, N Singh, J Advani, AK Mondal, X Corso-Díaz, A Swaroop |
Annual Review of Vision Science | 2021 |
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Friends and foes: Extracellular vesicles in aging and rejuvenation
BV Lananna, S Imai |
FASEB bioAdvances | 2021 |
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Recent Updates on the Involvement of PI3K/AKT/mTOR Molecular Cascade in the Pathogenesis of Hyperproliferative Skin Disorders
L Mercurio, C Albanesi, S Madonna |
Frontiers in Medicine | 2021 |
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Potential role of senescent macrophages in radiation-induced pulmonary fibrosis
L Su, Y Dong, Y Wang, Y Wang, B Guan, Y Lu, J Wu, X Wang, D Li, A Meng, F Fan |
Cell Death and Disease | 2021 |
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Pharmacologic Interventions for Fracture Risk Reduction in the Oldest Old: What Is the Evidence?
JG Sfeir, RJ Pignolo |
JBMR Plus | 2021 |
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Role of Complement in Regulating Inflammation Processes in Renal and Prostate Cancers
GS Netti, R Franzin, A Stasi, F Spadaccino, AD Strologo, B Infante, L Gesualdo, G Castellano, E Ranieri, G Stallone |
Cells | 2021 |
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Senescent cells and the incidence of age‐related diseases
I Katzir, M Adler, O Karin, N MendelsohnCohen, A Mayo, U Alon |
Aging Cell | 2021 |
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A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma
H Luo, C Tao, X Long, K Huang, X Zhu |
Aging | 2021 |
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Frailty in CKD and Transplantation
EC Lorenz, CC Kennedy, AD Rule, NK LeBrasseur, JL Kirkland, LT Hickson |
Kidney International Reports | 2021 |
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Hepatic Senescence Accompanies the Development of NAFLD in Non-Aged Mice Independently of Obesity
II Moustakas, A Katsarou, AI Legaki, I Pyrina, K Ntostoglou, AM Papatheodoridi, B Gercken, IS Pateras, VG Gorgoulis, M Koutsilieris, T Chavakis, A Chatzigeorgiou |
International journal of molecular sciences | 2021 |
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The Jekyll and Hyde of Cellular Senescence in Cancer
D Demirci, B Dayanc, FA Mazi, S Senturk |
Cells | 2021 |
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Impact of aging on gene expression response to x-ray irradiation using mouse blood
CG Broustas, AJ Duval, SA Amundson |
Scientific Reports | 2021 |
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Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src
X Xiao, M Xu, H Yu, L Wang, X Li, J Rak, S Wang, RC Zhao |
Signal Transduction and Targeted Therapy | 2021 |
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The role of senolytics in osteoporosis and other skeletal pathologies
ML Doolittle, DG Monroe, JN Farr, S Khosla |
Mechanisms of Ageing and Development | 2021 |
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SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
U Tripathi, R Nchioua, LG Prata, Y Zhu, EO Gerdes, N Giorgadze, T Pirtskhalava, E Parker, A Xue, JM Espindola-Netto, S Stenger, PD Robbins, LJ Niedernhofer, SL Dickinson, DB Allison, F Kirchhoff, KM Sparrer, T Tchkonia, JL Kirkland |
Aging | 2021 |
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Development of infrastructure for a systemic multidisciplinary approach to study aging in retired sled dogs
DI Fleyshman, JJ Wakshlag, HJ Huson, JP Loftus, NJ Olby, L Brodsky, AV Gudkov, EL Andrianova |
Aging | 2021 |
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Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway
S Zhang, W Liu, P Wang, B Hu, X Lv, S Chen, B Wang, Z Shao |
Molecular and Cellular Biochemistry | 2021 |
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Low magnitude vibration alleviates age-related bone loss by inhibiting cell senescence of osteogenic cells in naturally senescent rats
J Wen, M Bao, M Tang, X He, X Yao, L Li |
Aging | 2021 |
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Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study
Q Lyu, Y Wen, X Zhang, AB Addinsall, N Cacciani, L Larsson |
Skeletal Muscle | 2021 |
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Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin
C Xu, WB Shen, EA Reece, H Hasuwa, C Harman, S Kaushal, P Yang |
Science Advances | 2021 |
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Immune Reconstitution in the Aging Host: Opportunities for Mechanism-Based Therapy in Allogeneic Hematopoietic Cell Transplantation
RJ Lin, HK Elias, MR van den Brink |
Frontiers in immunology | 2021 |
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Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis
M Kirsch-Volders, M Fenech |
Mutation Research/Reviews in Mutation Research | 2021 |
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Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence
LB Gao, YH Wang, ZH Liu, Y Sun, P Cai, Q Jing |
Aging Cell | 2021 |
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Senescent Tissue-Resident Mesenchymal Stromal Cells Are an Internal Source of Inflammation in Human Osteoarthritic Cartilage
W Liu, AS Brodsky, M Feng, Y Liu, J Ding, CT Jayasuriya, Q Chen |
Frontiers in Cell and Developmental Biology | 2021 |
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Young at Gut—Turning Back the Clock with the Gut Microbiome
H Narasimhan, CC Ren, S Deshpande, KE Sylvia |
Microorganisms | 2021 |
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Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice
S Tarantini, P Balasubramanian, J Delfavero, T Csipo, A Yabluchanskiy, T Kiss, Á Nyúl-Tóth, P Mukli, P Toth, C Ahire, A Ungvari, Z Benyo, A Csiszar, Z Ungvari |
GeroScience | 2021 |
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Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard
S Rothmiller, N Jäger, N Meier, T Meyer, A Neu, D Steinritz, H Thiermann, M Scherer, C Rummel, A Mangerich, A Bürkle, A Schmidt |
Archives of Toxicology | 2021 |
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Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management
P Liu, Y Li, L Ma |
Frontiers in Nutrition | 2021 |
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Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions
U Tripathi, A Misra, T Tchkonia, JL Kirkland |
Mechanisms of Ageing and Development | 2021 |
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Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2 mouse
M Alsuraih, SP OHara, JE Woodrum, NE Pirius, NF LaRusso |
2021 | |
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Age-related immune alterations and cerebrovascular inflammation
CE Finger, I Moreno-Gonzalez, A Gutierrez, JF Moruno-Manchon, LD McCullough |
Molecular Psychiatry | 2021 |
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Immunology of Aging: the Birth of Inflammaging
T Fulop, A Larbi, G Pawelec, A Khalil, AA Cohen, K Hirokawa, JM Witkowski, C Franceschi |
Clinical Reviews in Allergy & Immunology | 2021 |
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Senolytics reduce coronavirus-related mortality in old mice
CD Camell, MJ Yousefzadeh, Y Zhu, LG Prata, MA Huggins, M Pierson, L Zhang, RD OKelly, T Pirtskhalava, P Xun, K Ejima, A Xue, U Tripathi, JM Espindola-Netto, N Giorgadze, EJ Atkinson, CL Inman, KO Johnson, SH Cholensky, TW Carlson, NK LeBrasseur, S Khosla, MG OSullivan, DB Allison, SC Jameson, A Meves, M Li, YS Prakash, SE Chiarella, SE Hamilton, T Tchkonia, LJ Niedernhofer, JL Kirkland, PD Robbins |
Science | 2021 |
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Evaluating causality of cellular senescence in non-alcoholic fatty liver disease
AS Meijnikman, H Herrema, TP Scheithauer, J Kroon, M Nieuwdorp, AK Groen |
2021 | |
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The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia
O Delbono, AC Rodrigues, HJ Bonilla, ML Messi |
Ageing Research Reviews | 2021 |
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Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging
A Dorronsoro, FE Santiago, D Grassi, T Zhang, RC Lai, SJ McGowan, L Angelini, M Lavasani, L Corbo, A Lu, RW Brooks, M GarciaContreras, DB Stolz, A Amelio, SV Boregowda, M Fallahi, A Reich, C Ricordi, DG Phinney, J Huard, SK Lim, LJ Niedernhofer, PD Robbins |
Aging Cell | 2021 |
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Tumorigenic Aspects of MSC Senescence—Implication in Cancer Development and Therapy
S Mojsilović, A Jauković, T Kukolj, H Obradović, IO Đorđević, A Petrović, D Bugarski |
Journal of Personalized Medicine | 2021 |
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Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8 + T cell immunosenescence signature linked to immunopathology
CH Fantecelle, LP Covre, RG de Moura, HL de Matos Guedes, CF Amorim, P Scott, D Mosser, A Falqueto, AN Akbar, DC Gomes |
Immunology | 2021 |
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Tumour burden and efficacy of immune-checkpoint inhibitors
F DallOlio, A Marabelle, C Caramella, C Garcia, M Aldea, N Chaput, C Robert, B Besse |
Nature Reviews Clinical Oncology | 2021 |
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Novel insights into the coupling of osteoclasts and resorption to bone formation
M Durdan, R Azaria, M Weivoda |
Seminars in Cell & Developmental Biology | 2021 |
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PTHG2 Reduces Bone Loss in Ovariectomized Mice by Directing Bone Marrow Mesenchymal Stem Cell Fate
J Chen, H Zhang, X Wu, F Wang, Y Wang, Q Gao, H Liu, Y Hu, J Su, Y Jing, B Mi |
Stem Cells International | 2021 |
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Interplay between Inflammaging, Frailty and Nutrition in Covid-19: Preventive and Adjuvant Treatment Perspectives
A de Lima, M Rogero, T Viel, H Garay-Malpartida, I Aprahamian, S Ribeiro |
The journal of nutrition, health & aging | 2021 |
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Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
BS de Alencar Silva, JS Uzeloto, FS Lira, T Pereira, MJ Coelho-E-Silva, A Caseiro |
International journal of environmental research and public health | 2021 |
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Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence
N Thorin-Trescases, P Labbé, P Mury, M Lambert, E Thorin |
International journal of molecular sciences | 2021 |
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PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair
Y Wang, Y Sui, A Lian, X Han, F Liu, K Zuo, M Liu, W Sun, Z Wang, Z Liu, F Zou, R Lu, M Jin, H Du, K Xu, X Liu, J Liu |
Frontiers in Cell and Developmental Biology | 2021 |
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Cellular Senescence in Adrenocortical Biology and Its Disorders
X Gao, F Li, B Liu, Y Wang, Y Wang, H Zhou |
Cells | 2021 |
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Senescent Cells in Cancer: Wanted or Unwanted Citizens
SE Niklander, DW Lambert, KD Hunter |
Cells | 2021 |
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Long-term cardiovascular complications following sepsis: is senescence the missing link?
H Merdji, V Schini-Kerth, F Meziani, F Toti |
Annals of Intensive Care | 2021 |
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Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease
SM Lynch, G Guo, DS Gibson, AJ Bjourson, TS Rai |
Cells | 2021 |
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Relationships Between Age, Soluble Triggering Receptor Expressed On Myeloid Cells-1 (Strem-1), And Mortality Among Critically Ill Adults: A Cohort Study
NA Sathe, PK Bhatraju, C Mikacenic, ED Morrell, FL Mabrey, WC Liles, MM Wurfel |
Shock | 2021 |
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No Time to Age: Uncoupling Aging from Chronological Time.
Larocca D, Lee J, West MD, Labat I, Sternberg H |
Genes & development | 2021 |
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Mechanisms of Hydroxyurea-Induced Cellular Senescence: An Oxidative Stress Connection?
Kapor S, Čokić V, Santibanez JF |
Oxidative medicine and cellular longevity | 2021 |
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Transcriptomic profiling and pathway analysis of cultured human lung microvascular endothelial cells following ionizing radiation exposure
Bouten RM, Dalgard CL, Soltis AR, Slaven JE, Day RM |
Scientific Reports | 2021 |
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nc886, a Non-Coding RNA, Is a New Biomarker and Epigenetic Mediator of Cellular Senescence in Fibroblasts
Kim Y, Ji H, Cho E, Park NH, Hwang K, Park W, Lee KS, Park D, Jung E |
International journal of molecular sciences | 2021 |
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Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling
Kwon JH, Kim M, Um S, Lee HJ, Bae YK, Choi SJ, Hwang HH, Oh W, Jin HJ |
Cells | 2021 |
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Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
Chang X, Gurung RL, Wang L, Jin A, Li Z, Wang R, Beckman KB, Adams-Haduch J, Meah WY, Sim KS, Lim WK, Davila S, Tan P, Teo JX, Yeo KK, M. Y, Liu S, Lim SC, Liu J, van Dam RM, Friedlander Y, Koh WP, Yuan JM, Khor CC, Heng CK, Dorajoo R |
2021 | |
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Targeting ATM to mitigate intervertebral disc degeneration
Pitcher LE, Wong AK, Robbins PD |
Aging | 2021 |
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Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds
Figuer A, Bodega G, Tato P, Valera G, Serroukh N, Ceprian N, de Sequera P, Morales E, Carracedo J, Ramírez R, Alique M |
International journal of environmental research and public health | 2021 |
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INHBA is a novel mediator regulating cellular senescence and immune evasion in colorectal cancer
Chen S, Gong Y, Shen Y, Liu Y, Fu Y, Dai Y, Rehman AU, Tang L, Liu H |
Journal of Cancer | 2021 |
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New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases
Ni YQ, Liu YS |
Aging and disease | 2021 |
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Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF
Anifandis G, Samara M, Simopoulou M, Messini CI, Chatzimeletiou K, Thodou E, Daponte A, Georgiou I |
Journal of Developmental Biology | 2021 |
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An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo
Wang B, Wang L, Gasek NS, Zhou Y, Kim T, Guo C, Jellison ER, Haynes L, Yadav S, Tchkonia T, Kuchel GA, Kirkland JL, Xu M |
2021 | |
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Strategies to Prevent Sarcopenia in the Aging Process: Role of Protein Intake and Exercise
Rogeri PS, Zanella R Jr, Martins GL, Garcia MD, Leite G, Lugaresi R, Gasparini SO, Sperandio GA, Ferreira LH, Souza-Junior TP, Lancha AH Jr |
Nutrients | 2021 |
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Prephase rituximab/prednisone therapy and aging-related, proinflammatory cytokine milieu in older, vulnerable patients with newly diagnosed diffuse large B-cell lymphoma
Lin RJ, Owens CN, Drill E, Iannotta A, Oliveros M, Schick DL, Noy A, Gerecitano JF, Drullinsky PR, Caron PC, Kumar A, Matasar MJ, Moskowitz C, Korc-Grodzicki B, Zelenetz AD, Salles GA, Hamlin PA |
Haematologica | 2021 |
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Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics
Zhu Y, Ge J, Huang C, Liu H, Jiang H |
Theranostics | 2021 |
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Cellular Mechanisms of FGF-Stimulated Tissue Repair
Prudovsky I |
Cells | 2021 |
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ΩqPCR measures telomere length from single-cells in base pair units
Xiong F, Frasch WD |
Nucleic Acids Research | 2021 |
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Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations
Kopf S, Kumar V, Kender Z, Han Z, Fleming T, Herzig S, Nawroth PP |
Frontiers in Endocrinology | 2021 |
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Marine n-3 Polyunsaturated Fatty Acids and Cellular Senescence Markers in Incident Kidney Transplant Recipients: The Omega-3 Fatty Acids in Renal Transplantation (ORENTRA) Randomized Clinical Trial
Chan J, Eide IA, Tannæs TM, Waldum-Grevbo B, Jenssen T, Svensson M |
2021 | |
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Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis.
Rübe CE, Bäumert C, Schuler N, Isermann A, Schmal Z, Glanemann M, Mann C, Scherthan H |
npj Aging and Mechanisms of Disease | 2021 |
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Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells.
Chen M, Xiao L, Dai G, Lu P, Zhang Y, Li Y, Ni M, Rui Y |
Frontiers in Cell and Developmental Biology | 2021 |
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Contrasting associations between nestling telomere length and pre and postnatal helpers' presence in a cooperatively breeding bird.
Quque M, Paquet M, Zahn S, Théron F, Faivre B, Sueur C, Criscuolo F, Doutrelant C, Covas R |
Oecologia | 2021 |
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N6-Methyladenosine Methylation of mRNA in Cell Senescence.
Zhang L, Xia J |
Cellular and Molecular Neurobiology | 2021 |
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Age-related cellular and microstructural changes in the rotator cuff enthesis.
Long Z, Nakagawa K, Wang Z, Amadio PC, Zhao C, Gingery A |
Journal of orthopaedic research : official publication of the Orthopaedic Research Society | 2021 |
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Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence.
Zoico E, Nori N, Darra E, Tebon M, Rizzatti V, Policastro G, De Caro A, Rossi AP, Fantin F, Zamboni M |
Scientific Reports | 2021 |
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hPMSCs-Derived Exosomal miRNA-21 Protects Against Aging-Related Oxidative Damage of CD4+ T Cells by Targeting the PTEN/PI3K-Nrf2 Axis.
Xiong Y, Xiong Y, Zhang H, Zhao Y, Han K, Zhang J, Zhao D, Yu Z, Geng Z, Wang L, Wang Y, Luan X |
Frontiers in immunology | 2021 |
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Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.
Dehkordi SK, Walker J, Sah E, Bennett E, Atrian F, Frost B, Woost B, Bennett RE, Orr TC, Zhou Y, Andhey PS, Colonna M, Sudmant PH, Xu P, Wang M, Zhang B, Zare H, Orr ME |
2021 | |
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Mediterranean diet and the hallmarks of ageing.
Shannon OM, Ashor AW, Scialo F, Saretzki G, Martin-Ruiz C, Lara J, Matu J, Griffiths A, Robinson N, Lillà L, Stevenson E, Stephan BCM, Minihane AM, Siervo M, Mathers JC |
European Journal of Clinical Nutrition | 2021 |
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Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation
Wyles SP, Tchkonia T, Kirkland JL |
Plastic and Reconstructive Surgery | 2021 |
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Healthspan Extension through Innovative Genetic Medicines
Garcia H, Brown D, Scholz M, Lewis JD |
Plastic and Reconstructive Surgery | 2021 |
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The potential of Senolytics in transplantation
T Matsunaga, J Iske, A Schroeter, H Azuma, H Zhou, SG Tullius |
Mechanisms of Ageing and Development | 2021 |
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Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux
Tai S, Sun J, Zhou Y, Zhu Z, He Y, Chen M, Yang H, Xiao Y, Tu T, Tang L, Li X, Zeng J, Zheng X, Zhou S |
Journal of Advanced Research | 2021 |
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Senolytic agents lessen the severity of abdominal aortic aneurysm in aged mice
Parvizi M, Franchi F, Arendt BK, Ebtehaj S, Rodriguez-Porcel M, Lanza IR |
Experimental gerontology | 2021 |
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Lymph node fibroblastic reticular cells deposit fibrosis-associated collagen following organ transplant
Xiaofei Li, Jing Zhao, Vivek Kasinath, Mayuko Uehara, Liwei Jiang, Naima Banouni, Martina M. McGrath, Takaharu Ichimura, Paolo Fiorina, Dario R. Lemos, Su Ryon Shin, Carl F. Ware, Jonathan S. Bromberg, Reza Abdi |
Journal of Clinical Investigation | 2020 |
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Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes
Brittany A. Eckhardt, Jennifer L. Rowsey, Brianne S. Thicke, Daniel G. Fraser, Katherine L. O’Grady, Olga P. Bondar, Jolaine M. Hines, Ravinder J. Singh, Andrew R. Thoreson, Kuntol Rakshit, Anthony B. Lagnado, João F. Passos, Adrian Vella, Aleksey V. Matveyenko, Sundeep Khosla, David G. Monroe, Joshua N. Farr |
JCI Insight | 2020 |
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Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
J Iske, M Seyda, T Heinbokel, R Maenosono, K Minami, Y Nian, M Quante, CS Falk, H Azuma, F Martin, JF Passos, CU Niemann, T Tchkonia, JL Kirkland, A Elkhal, SG Tullius |
Nature Communications | 2020 |
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Pro-Senescence and Anti-Senescence Mechanisms of Cardiovascular Aging: Cardiac MicroRNA Regulation of Longevity Drug-Induced Autophagy
L Pulakat, HH Chen |
Frontiers in pharmacology | 2020 |
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Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming
MY Lee, A Leonardi, TJ Begley, JA Melendez |
Redox Biology | 2020 |
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Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
R Thomas, W Wang, DM Su |
Immunity & Ageing | 2020 |
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Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
PR Coryell, BO Diekman, RF Loeser |
Nature Reviews Rheumatology | 2020 |
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Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
RP Maeyer, RC van de Merwe, R Louie, OV Bracken, OP Devine, DR Goldstein, M Uddin, AN Akbar, DW Gilroy |
Nature Immunology | 2020 |
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Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency
L Xiong, K Zhao, Y Cao, HH Guo, JX Pan, X Yang, X Ren, L Mei, WC Xiong, C Stewart |
PLoS Biology | 2020 |
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Current advances in regulation of bone homeostasis
AA AlBari, AA Mamun |
FASEB bioAdvances | 2020 |
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The role of cellular senescence in ageing and endocrine disease
S Khosla, JN Farr, T Tchkonia, JL Kirkland |
Nature Reviews Endocrinology | 2020 |
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Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice
MJ Yousefzadeh, J Zhao, C Bukata, EA Wade, SJ McGowan, LA Angelini, MP Bank, AU Gurkar, CA McGuckian, MF Calubag, JI Kato, CE Burd, PD Robbins, LJ Niedernhofer |
Aging Cell | 2020 |
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Senescent Cell Depletion Through Targeting BCL-Family Proteins and Mitochondria
Y Fan, J Cheng, H Zeng, L Shao |
Frontiers in physiology | 2020 |
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Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases
IS Pyo, S Yun, YE Yoon, JW Choi, SJ Lee |
Molecules (Basel, Switzerland) | 2020 |
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The emerging role of cellular senescence in renal diseases
B Zhou, Y Wan, R Chen, C Zhang, X Li, F Meng, S Glaser, N Wu, T Zhou, S Li, H Francis, G Alpini, P Zou |
Journal of Cellular and Molecular Medicine | 2020 |
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Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
S Song, EW Lam, T Tchkonia, JL Kirkland, Y Sun |
Trends in Biochemical Sciences | 2020 |
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Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
MJ Yousefzadeh, JE Wilkinson, B Hughes, N Gadela, WC Ladiges, N Vo, LJ Niedernhofer, DM Huffman, PD Robbins |
GeroScience | 2020 |
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Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast
YC Yu, TZ Hui, TH Kao, HF Liao, CY Yang, CC Hou, HT Hsieh, JY Chang, YT Tsai, M Pinskaya, KC Yang, YR Chen, A Morillon, MH Tsai, SP Lin |
Frontiers in Cell and Developmental Biology | 2020 |
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Discovery, development, and future application of senolytics: theories and predictions
EO Gerdes, Y Zhu, T Tchkonia, JL Kirkland |
The FEBS journal | 2020 |
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The Ercc 1 -/Δ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions
A Wong, T Kieu, PD Robbins |
Aging | 2020 |
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hPMSCs protects against d-galactose-induced oxidative damage of CD4+ T cells through activating Akt-mediated Nrf2 antioxidant signaling
Y Xiong, Y Wang, J Zhang, N Zhao, H Zhang, A Zhang, D Zhao, Z Yu, Y Yin, L Song, Y Xiong, X Luan |
Stem Cell Research & Therapy | 2020 |
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Considering Cause and Effect of Immune Cell Aging on Cardiac Repair after Myocardial Infarction
SW Tobin, FJ Alibhai, RD Weisel, RK Li |
Cells | 2020 |
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Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis
DJ Tyrrell, MG Blin, J Song, SC Wood, M Zhang, DA Beard, DR Goldstein |
Circulation research | 2020 |
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Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6
DJ Tyrrell, DR Goldstein |
Nature Reviews Cardiology | 2020 |
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Targeting Molecular Mechanism of Vascular Smooth Muscle Senescence Induced by Angiotensin II, A Potential Therapy via Senolytics and Senomorphics
K Okuno, S Cicalese, KJ Elliott, T Kawai, T Hashimoto, S Eguchi |
International journal of molecular sciences | 2020 |
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Nicotine in Senescence and Atherosclerosis
AM Centner, PG Bhide, G Salazar |
Cells | 2020 |
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Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
N Mabrouk, S Ghione, V Laurens, S Plenchette, A Bettaieb, C Paul |
Cancers | 2020 |
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ROCK inhibition modulates the senescence‐associated secretory phenotype (SASP) in oral keratinocytes
S Niklander, D Bandaru, DW Lambert, KD Hunter |
FEBS Open Bio | 2020 |
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Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
HN Wilkinson, MJ Hardman |
Frontiers in Cell and Developmental Biology | 2020 |
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Effect of rapamycin on aging and age-related diseases—past and future
R Selvarani, S Mohammed, A Richardson |
GeroScience | 2020 |
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Senotherapeutics for HIV and aging:
MA Szaniawski, AM Spivak |
Current Opinion in HIV and AIDS | 2020 |
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Periodontal Disease and Senescent Cells: New Players for an Old Oral Health Problem?
R Aquino-Martinez, S Khosla, JN Farr, DG Monroe |
International journal of molecular sciences | 2020 |
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Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases
MJ Kang |
Tuberculosis and Respiratory Diseases | 2020 |
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Potential Role of Cellular Senescence in Asthma
ZN Wang, RN Su, BY Yang, KX Yang, LF Yang, Y Yan, ZG Chen |
Frontiers in Cell and Developmental Biology | 2020 |
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Stem Cells of the Aging Brain
AM Nicaise, CM Willis, SJ Crocker, S Pluchino |
Frontiers in aging neuroscience | 2020 |
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NADPH Oxidase Inhibition in Fibrotic Pathologies
K Bernard, VJ Thannickal |
Antioxidants & Redox Signaling | 2020 |
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Senescence, the Janus of Lung Injury and Repair
SB Wallach-Dayan, M Rojas |
American journal of respiratory cell and molecular biology | 2020 |
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Innate Immune Signaling Contributes to Tubular Cell Senescence in the Glis2 Knockout Mouse Model of Nephronophthisis
H Jin, Y Zhang, D Liu, SS Wang, Q Ding, P Rastogi, M Purvis, A Wang, S Elhadi, C Ren, C Cao, Y Chai, P Igarashi, AM Jetten, D Lu, M Attanasio |
The American Journal of Pathology | 2020 |
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Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies
TG Heck, MS Ludwig, MN Frizzo, AA Rasia-Filho, |
Clinical Science | 2020 |
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Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis
M Varela-Eirín, P Carpintero-Fernández, A Sánchez-Temprano, A Varela-Vázquez, CL Paíno, A Casado-Díaz, AC Continente, V Mato, E Fonseca, M Kandouz, A Blanco, JR Caeiro, MD Mayán |
Aging | 2020 |
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Decreased autophagy and fuel switching occur in a senescent hepatic cell model system
BK Singh, M Tripathi, R Sandireddy, K Tikno, J Zhou, PM Yen |
Aging | 2020 |
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Cellular Senescence in Renal and Urinary Tract Disorders
Y Santin, P Lluel, P Rischmann, X Gamé, J Mialet-Perez, A Parini |
Cells | 2020 |
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FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling, and metastasis
Y Johmura, AS Harris, T Ohta, M Nakanishi |
Cancer Science | 2020 |
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Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
AJ Barinda, K Ikeda, DB Nugroho, DA Wardhana, N Sasaki, S Honda, R Urata, S Matoba, K Hirata, N Emoto |
Nature Communications | 2020 |
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Compromised DNA repair is responsible for diabetes‐associated fibrosis
V Kumar, R Agrawal, A Pandey, S Kopf, M Hoeffgen, S Kaymak, OR Bandapalli, V Gorbunova, A Seluanov, MA Mall, S Herzig, PP Nawroth |
The EMBO Journal | 2020 |
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Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration
Y Zhang, B Yang, J Wang, F Cheng, K Shi, L Ying, C Wang, K Xia, X Huang, Z Gong, C Yu, F Li, C Liang, Q Chen |
Oxidative medicine and cellular longevity | 2020 |
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Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV
A Dalzini, MR Petrara, G Ballin, M Zanchetta, C Giaquinto, AD Rossi |
Journal of Immunology Research | 2020 |
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Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2 / Mouse Model of Primary Sclerosing Cholangitis
K Kyritsi, H Francis, T Zhou, L Ceci, N Wu, Z Yang, F Meng, L Chen, L Baiocchi, D Kundu, L Kennedy, S Liangpunsakul, C Wu, S Glaser, G Alpini |
Gene expression | 2020 |
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Modulation of DNA Damage Response by Sphingolipid Signaling: An Interplay that Shapes Cell Fate
M Francis, AA Daher, P Azzam, M Mroueh, YH Zeidan |
International journal of molecular sciences | 2020 |
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Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage
R Ramadan, E Vromans, DC Anang, I Goetschalckx, D Hoorelbeke, E Decrock, S Baatout, L Leybaert, A Aerts |
Frontiers in pharmacology | 2020 |
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Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature
DJ Tyrrell, MG Blin, J Song, SC Wood, DR Goldstein |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2020 |
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Reducing Senescent Cell Burden in Aging and Disease
RJ Pignolo, JF Passos, S Khosla, T Tchkonia, JL Kirkland |
Trends in Molecular Medicine | 2020 |
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Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain
T Kiss, Á Nyúl-Tóth, P Balasubramanian, S Tarantini, C Ahire, J DelFavero, A Yabluchanskiy, T Csipo, E Farkas, G Wiley, L Garman, A Csiszar, Z Ungvari |
GeroScience | 2020 |
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Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin
A Sierra-Ramirez, JL López-Aceituno, LF Costa-Machado, A Plaza, M Barradas, PJ Fernandez-Marcos |
Aging | 2020 |
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Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
SD Stojanović, J Fiedler, J Bauersachs, T Thum, DG Sedding |
European Heart Journal | 2020 |
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The Dynamic Interplay Between Mast Cells, Aging/Cellular Senescence, and Liver Disease
D Kundu, L Kennedy, V Meadows, L Baiocchi, G Alpini, H Francis |
Gene expression | 2020 |
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The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications
N Basisty, A Kale, S Patel, J Campisi, B Schilling |
Expert Review of Proteomics | 2020 |
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Osteocyte Cellular Senescence
JN Farr, J Kaur, ML Doolittle, S Khosla |
Current Osteoporosis Reports | 2020 |
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Mechanisms of Vascular Aging, A Geroscience Perspective
Z Ungvari, S Tarantini, F Sorond, B Merkely, A Csiszar |
Journal of the American College of Cardiology | 2020 |
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A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells
H Li, W Zhang, K Zhao, D Zhao, S Zheng, Y Hu |
The Journal of biological chemistry | 2020 |
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Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells
YN Qu, L Zhang, T Wang, HY Zhang, ZJ Yang, FF Yuan, Y Wang, SW Li, XX Jiang, XH Xie |
Stem Cells International | 2020 |
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Involvement of Senescence and Mitochondrial Fission in Endothelial Cell Pro-Inflammatory Phenotype Induced by Angiotensin II
M Miyao, S Cicalese, T Kawai, HA Cooper, MJ Boyer, KJ Elliott, SJ Forrester, R Kuroda, V Rizzo, T Hashimoto, R Scalia, S Eguchi |
International journal of molecular sciences | 2020 |
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Sex differences in inflammation, redox biology, mitochondria and autoimmunity
DN Florio, J Sin, MJ Coronado, PS Atwal, DL Fairweather |
Redox Biology | 2020 |
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Cellular Senescence in Arterial Diseases
I Shimizu, T Minamino |
Journal of Lipid and Atherosclerosis | 2020 |
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Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice
A Yabluchanskiy, S Tarantini, P Balasubramanian, T Kiss, T Csipo, GA Fülöp, A Lipecz, C Ahire, J DelFavero, A Nyul-Toth, WE Sonntag, ML Schwartzman, J Campisi, A Csiszar, Z Ungvari |
GeroScience | 2020 |
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Shelterin Complex at Telomeres: Implications in Ageing SM Mir, SS Tehrani, G Goodarzi, , A Jahanbakhsh, N Khelghati, D Qujeq, M Maniati |
Clinical Interventions in Aging | 2020 |
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A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype
V Porterfield, SS Khan, EP Foff, MM Koseoglu, IK Blanco, S Jayaraman, E Lien, MJ McConnell, GS Bloom, JS Lazo, ER Sharlow |
Neurobiology of Aging | 2020 |
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The roles of osteocytes in alveolar bone destruction in periodontitis
X Huang, M Xie, Y Xie, F Mei, X Lu, X Li, L Chen |
Journal of Translational Medicine | 2020 |
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The conundrum of human immune system “senescence”
G Pawelec, A Bronikowski, SC Cunnane, L Ferrucci, C Franceschi, T Fülöp, P Gaudreau, VN Gladyshev, ES Gonos, V Gorbunova, BK Kennedy, A Larbi, JF Lemaître, GH Liu, AB Maier, JA Morais, OT Nóbrega, A Moskalev, MO Rikkert, A Seluanov, AM Senior, S Ukraintseva, Q Vanhaelen, J Witkowski, AA Cohen |
Mechanisms of Ageing and Development | 2020 |
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Senotherapeutic drugs for human intervertebral disc degeneration and low back pain
H Cherif, DG Bisson, M Mannarino, O Rabau, JA Ouellet, L Haglund |
eLife | 2020 |
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miR-34a: A Promising Target for Inflammaging and Age-Related Diseases
A Raucci, MC Vinci |
International journal of molecular sciences | 2020 |
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DNA Damage Response and Immune Defense
C Nastasi, L Mannarino, M DIncalci |
International journal of molecular sciences | 2020 |
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Cellular senescence: friend or foe to respiratory viral infections?
WJ Kelley, RL Zemans, DR Goldstein |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2020 |
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Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity
Y He, W Li, D Lv, X Zhang, X Zhang, YT Ortiz, V Budamagunta, J Campisi, G Zheng, D Zhou |
Aging Cell | 2020 |
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Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence
G Batshon, J Elayyan, O Qiq, E Reich, L Ben-Aderet, L Kandel, A Haze, J Steinmeyer, V Lefebvre, H Zhang, J Elisseeff, Y Henrotin, A Mobasheri, M Dvir-Ginzberg |
Annals of the rheumatic diseases | 2020 |
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Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells
A Qadir, S Liang, Z Wu, Z Chen, L Hu, A Qian |
International journal of molecular sciences | 2020 |
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Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche
X Peng, Y Wu, U Brouwer, T van Vliet, B Wang, M Demaria, L Barazzuol, RP Coppes |
Cell Death and Disease | 2020 |
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Middle-Aged Indians with Type 2 Diabetes Are at Higher Risk of Biological Ageing with Special Reference to Serum CDKN2A
J Banerjee, Y Dhas, N Mishra |
Journal of Diabetes Research | 2020 |
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Pathobiology of frailty in lung disease
B Koons, JR Greenland, JM Diamond, JP Singer |
Translational research : the journal of laboratory and clinical medicine | 2020 |
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Chronic Intermittent Hypoxia Triggers a Senescence-like Phenotype in Human White Preadipocytes
K Polonis, C Becari, CA Chahal, Y Zhang, AM Allen, TA Kellogg, VK Somers, P Singh |
Scientific Reports | 2020 |
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A proteomic atlas of senescence-associated secretomes for aging biomarker development
N Basisty, A Kale, OH Jeon, C Kuehnemann, T Payne, C Rao, A Holtz, S Shah, V Sharma, L Ferrucci, J Campisi, B Schilling, M Serrano |
PLoS Biology | 2020 |
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Strategies to Prevent or Remediate Cancer and Treatment-Related Aging
JL Guida, T Agurs-Collins, TA Ahles, J Campisi, W Dale, W Demark-Wahnefried, J Dietrich, R Fuldner, L Gallicchio, PA Green, A Hurria, MC Janelsins, C Jhappan, JL Kirkland, R Kohanski, V Longo, S Meydani, S Mohile, LJ Niedernhofer, C Nelson, F Perna, K Schadler, JM Scott, JA Schrack, RP Tracy, J van Deursen, KK Ness |
JNCI Journal of the National Cancer Institute | 2020 |
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Regulation of cGAS‐Mediated Immune Responses and Immunotherapy
AF Saeed, X Ruan, H Guan, J Su, S Ouyang |
Advanced Science | 2020 |
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Osteoporosis: Pathophysiology and therapeutic options
Ursula Föger-Samwald, Peter Dovjak, Ursula Azizi-Semrad, Katharina Kerschan-Schindl, Peter Pietschmann |
EXCLI J | 2020 |
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Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.
Al Suraih MS, Trussoni CE, Splinter PL, LaRusso NF, O'Hara SP |
Liver international : official journal of the International Association for the Study of the Liver | 2020 |
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Radiation-Induced Senescence Bystander Effect: The Role of Exosomes
Elbakrawy E, Kaur Bains S, Bright S, AL-Abedi R, Mayah A, Goodwin E, Kadhim M |
Biology | 2020 |
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IGF-1 induces cellular senescence in rat articular chondrocytes via Akt pathway activation
Zhao LD, Bie LY, Hu L, Zhu ZH, Meng XH, Cong LL, Zhang S, Ma N, Xiao JH |
Experimental and therapeutic medicine | 2020 |
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Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts
Guan Y, Zhang C, Lyu G, Huang X, Zhang X, Zhuang T, Jia L, Zhang L, Zhang C, Li C, Tao W |
Nucleic Acids Research | 2020 |
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Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
Wissler Gerdes EO, Zhu Y, Weigand BM, Tripathi U, Burns TC, Tchkonia T, Kirkland JL |
International review of neurobiology | 2020 |
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Mechanisms of aging, age-associated diseases, and lifespan determination
Matsuyama S |
Experimental Biology and Medicine | 2020 |
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Continuous Exposure to Low Doses of Ultrafine Black Carbon Reduces the Vitality of Immortalized Lung-Derived Cells and Activates Senescence
Salinas ME, Gutiérrez DA, Varela-Ramírez A, Garza KM |
Journal of Toxicology | 2020 |
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The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification
Zuccolo E, Badi I, Scavello F, Gambuzza I, Mancinelli L, Macrì F, Tedesco CC, Veglia F, Bonfigli AR, Olivieri F, Raucci A |
International journal of molecular sciences | 2020 |
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Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs
Liu H, Huang B, Xue S, U KP, Tsang LL, Zhang X, Li G, Jiang X |
Stem Cell Research & Therapy | 2020 |
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Ganoderma microsporum immunomodulatory protein, GMI, promotes C2C12 myoblast differentiation in vitro via upregulation of Tid1 and STAT3 acetylation
Teo WH, Lo JF, Fan YN, Huang CY, Huang TF |
PloS one | 2020 |
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Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion
Ansere VA, Ali-Mondal S, Sathiaseelan R, Garcia DN, Isola JV, Henseb JD, Saccon TD, Ocañas SR, Tooley KB, Stout MB, Schneider A, Freeman WM |
Mechanisms of Ageing and Development | 2020 |
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Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells
Li Y, Meng Y, Zhu X, Saadiq IM, Jordan KL, Eirin A, Lerman LO |
Cell communication and signaling : CCS | 2020 |
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Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway
Wang ST, Huang SW, Liu KT, Lee TY, Shieh JJ, Wu CY |
Cell Death Discovery | 2020 |
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Challenges in Tracking of Fluorochrome-Labelled Nanoparticles in Mice via Whole Body NIRF Imaging
Gaffron F, Tilch A, Grüttner C, Kowalski A, Kramer M, Teichgräber U, Hilger I |
Nanomaterials | 2020 |
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Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood
Kiss T, Tarantini S, Csipo T, Balasubramanian P, Nyúl-Tóth Á, Yabluchanskiy A, Wren JD, Garman L, Huffman DM, Csiszar A, Ungvari Z |
GeroScience | 2020 |
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COVID-19: A Personalized Cardiometabolic Approach for Reducing Complications and Costs. The Role of Aging beyond Topics
Saban-Ruiz J, Ly-Pen D |
The journal of nutrition, health & aging | 2020 |
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Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence
Isermann A, Mann C, Rübe CE |
International journal of molecular sciences | 2020 |
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TP53 Mutations and Outcomes in Breast Cancer: Reading beyond the Headlines.
Shahbandi A, Nguyen HD, Jackson JG |
Trends in Cancer | 2020 |
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Altered glucocorticoid metabolism represents a feature of macroph-aging.
Valbuena Perez JV, Linnenberger R, Dembek A, Bruscoli S, Riccardi C, Schulz MH, Meyer MR, Kiemer AK, Hoppstädter J |
Aging Cell | 2020 |
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Apocalyptic horsemen of geriatric oncology
Berger NA |
Translational cancer research | 2020 |
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Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors
Lee Y, Choi JJ, Ahn SI, Lee NH, Han WM, Mohiuddin M, Shin EJ, Wood L, Park KD, Kim Y, Jang YC |
Advanced Functional Materials | 2020 |
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Epithelial innate immunity mediates tubular cell senescence after kidney injury
Heng Jin, Yan Zhang, Qiong Ding, Shan Shan Wang, Prerna Rastogi, Dao-Fu Dai, Dongmei Lu, Dingxiao Liu, Madison Purvis, Chao Cao, Angela Wang, Chongyu Ren, Sarah Elhadi, Ming Chang Hu, Yanfen Chai, Diana Zepeda-Orozco, Judith Campisi, Massimo Attanasio |
JCI Insight | 2019 |
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Prelamin A mediates inflammation in dilated and HIV associated cardiomyopathies
Daniel Brayson, Andrea Frustaci, Romina Verardo, Cristina Chimenti, Matteo Antonio Russo, Robert Hayward, Sadia Ahmad, Gema Vizcay-Barrena, Andrea Protti, Peter S. Zammit, Cristobal G. dos Remedios, Elisabeth Ehler, Ajay M Shah, Catherine M. Shanahan |
JCI Insight | 2019 |
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Mixing old and young: Enhancing rejuvenation and accelerating aging
Ashley Lau, Brian Kennedy, James Kirkland, Stefan Tullius |
Journal of Clinical Investigation | 2019 |
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1,25‐Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axis
R Yang, J Chen, J Zhang, R Qin, R Wang, Y Qiu, Z Mao, D Goltzman, D Miao |
Aging Cell | 2019 |
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Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
R Summer, H Shaghaghi, DL Schriner, W Roque, D Sales, K Cuevas-Mora, V Desai, A Bhushan, MI Ramirez, F Romero |
American journal of physiology. Lung cellular and molecular physiology | 2019 |
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Gut microbiota in liver disease: too much is harmful, nothing at all is not helpful either
P Hartmann, H Chu, Y Duan, B Schnabl |
AJP Gastrointestinal and Liver Physiology | 2019 |
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Sarcopenia: Aging-Related Loss of Muscle Mass and Function
L Larsson, H Degens, M Li, L Salviati, Y il Lee, W Thompson, JL Kirkland, M Sandri |
Physiological reviews | 2019 |
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Cellular Senescence: Methods and Protocols
M Demaria |
2019 | |
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The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
W Ying, W Fu, YS Lee, JM Olefsky |
Nature Reviews Endocrinology | 2019 |
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Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology
W Gilbert, R Bragg, AM Elmansi, ME McGee-Lawrence, CM Isales, MW Hamrick, WD Hill, S Fulzele |
Cytokine | 2019 |
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Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions
M Erickson, W Banks |
International journal of molecular sciences | 2019 |
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Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans
JN Farr, JL Rowsey, BA Eckhardt, BS Thicke, DG Fraser, T Tchkonia, JL Kirkland, DG Monroe, S Khosla |
Journal of Bone and Mineral Research | 2019 |
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Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses
SN Crooke, IG Ovsyannikova, GA Poland, RB Kennedy |
Experimental Gerontology | 2019 |
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Circulating Pro-Vascular Progenitor Cell Depletion During Type 2 Diabetes
DC Terenzi, M Al-Omran, A Quan, H Teoh, S Verma, DA Hess |
JACC: Basic to Translational Science | 2019 |
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Cellular plasticity and metastasis in breast cancer: a pre- and post-malignant problem
JM Smigiel, SE Taylor, BL Bryson, I Tamagno, K Polak, MW Jackson |
Journal of Cancer Metastasis and Treatment | 2019 |
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Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?
E Cianflone, M Torella, C Chimenti, AD Angelis, AP Beltrami, K Urbanek, M Rota, D Torella |
Oxidative medicine and cellular longevity | 2019 |
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Cellular senescence in bone
JN Farr, S Khosla |
Bone | 2019 |
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Aged-senescent cells contribute to impaired heart regeneration
FC Lewis-McDougall, PJ Ruchaya, E Domenjo-Vila, TS Teoh, L Prata, BJ Cottle, JE Clark, PP Punjabi, W Awad, D Torella, T Tchkonia, JL Kirkland, GM Ellison-Hughes |
Aging Cell | 2019 |
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Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes
C Aguayo-Mazzucato, J Andle, TB Lee, A Midha, L Talemal, V Chipashvili, J Hollister-Lock, J van Deursen, G Weir, S Bonner-Weir |
Cell Metabolism | 2019 |
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Cellular senescence in the lung across the age spectrum
P Parikh, S Wicher, K Khandalavala, CM Pabelick, RD Britt, YS Prakash |
American journal of physiology. Lung cellular and molecular physiology | 2019 |
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Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools
SN Knoppert, FA Valentijn, TQ Nguyen, R Goldschmeding, LL Falke |
Frontiers in pharmacology | 2019 |
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Involvement of adiponectin in age-related increases in tear production in mice
Y Shikama, M Kurosawa, M Furukawa, N Ishimaru, K Matsushita |
Aging | 2019 |
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NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
D Kabacaoglu, DA Ruess, J Ai, H Algül |
Cancers | 2019 |
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Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity
GM Pagnotti, M Styner, G Uzer, VS Patel, LE Wright, KK Ness, TA Guise, J Rubin, CT Rubin |
Nature Reviews Endocrinology | 2019 |
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Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS
E Trias, PR Beilby, M Kovacs, S Ibarburu, V Varela, R Barreto-Núñez, SC Bradford, JS Beckman, L Barbeito |
Frontiers in aging neuroscience | 2019 |
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The Signaling of Cellular Senescence in Diabetic Nephropathy
Y Xiong, L Zhou |
Oxidative medicine and cellular longevity | 2019 |
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Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis
AG Elkahloun, JM Saavedra |
Molecular Neurobiology | 2019 |
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At the Crossroads Between Neurodegeneration and Cancer: A Review of Overlapping Biology and Its Implications
AL Houck, S Seddighi, JA Driver |
Current aging science | 2019 |
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PAI-1, A New Target for Controlling Lung-Cell Senescence and Fibrosis?
S Adnot, M Breau, A Houssaini |
American journal of respiratory cell and molecular biology | 2019 |
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Mechanisms underlying T cell ageing
JJ Goronzy, CM Weyand |
Nature Reviews Immunology | 2019 |
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Cellular Senescence in the Kidney
MH Docherty, ED OSullivan, JV Bonventre, DA Ferenbach |
Journal of the American Society of Nephrology : JASN | 2019 |
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Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality
U Kulkarni, RL Zemans, CA Smith, SC Wood, JC Deng, DR Goldstein |
Mucosal Immunology | 2019 |
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Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis
LP Covre, RF Martins, OP Devine, ES Chambers, M Vukmanovic-Stejic, JA Silva, R Dietze, RR Rodrigues, HL de Matos Guedes, A Falqueto, AN Akbar, DC Gomes |
Frontiers in immunology | 2019 |
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Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
M Ogrodnik, Y Zhu, LG Langhi, T Tchkonia, P Krüger, E Fielder, S Victorelli, RA Ruswhandi, N Giorgadze, T Pirtskhalava, O Podgorni, G Enikolopov, KO Johnson, M Xu, C Inman, M Schafer, M Weigl, Y Ikeno, TC Burns, JF Passos, T von Zglinicki, JL Kirkland, D Jurk |
Cell Metabolism | 2019 |
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Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease—A Novel Target for Treatment
S Hobson, S Arefin, K Kublickiene, P Shiels, P Stenvinkel |
Toxins | 2019 |
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ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells
Y Wu, X Li, J Yu, M Björkholm, D Xu |
Cell Death and Disease | 2019 |
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The angiotensin-(1-7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation
A Romero, ÁS Hipólito-Luengo, LA Villalobos, S Vallejo, I Valencia, P Michalska, N Pajuelo-Lozano, I Sánchez-Pérez, R León, JL Bartha, MJ Sanz, JD Erusalimsky, CF Sánchez-Ferrer, T Romacho, C Peiró |
Aging Cell | 2019 |
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Role of smooth muscle cell p53 in pulmonary arterial hypertension
T Wakasugi, I Shimizu, Y Yoshida, Y Hayashi, R Ikegami, M Suda, G Katsuumi, M Nakao, M Hoyano, T Kashimura, K Nakamura, H Ito, T Nojiri, T Soga, T Minamino, Y Taniyama |
PloS one | 2019 |
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Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity
Y Yoshida, I Shimizu, Y Hayashi, R Ikegami, M Suda, G Katsuumi, T Wakasugi, M Nakao, H Nakagami, R Morishita, T Minamino |
Scientific Reports | 2019 |
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Perceived stress, cytomegalovirus titers, and late-differentiated T and NK cells: Between-, within-person associations in a longitudinal study of older adults
RG Reed, SR Presnell, A Al-Attar, CT Lutz, SC Segerstrom |
Brain, Behavior, and Immunity | 2019 |
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Establishment of Novel Murine Model showing Vascular Inflammation-derived Cognitive Dysfunction
T Hashizume, BK Son, S Taniguchi, K Ito, Y Noda, T Endo, M Nanao-Hamai, S Ogawa, M Akishita |
Scientific Reports | 2019 |
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Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells
S Fulzele, B Mendhe, A Khayrullin, M Johnson, H Kaiser, Y Liu, CM Isales, MW Hamrick |
Aging | 2019 |
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COPD as a Disease of Immunosenescence
WK Cho, CG Lee, LK Kim |
Yonsei Medical Journal | 2019 |
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Flavonoids: Broad Spectrum Agents on Chronic Inflammation
H Lim, MY Heo, HP Kim |
Biomolecules and Therapeutics | 2019 |
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Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions
DL Palliyaguru, JM Moats, CD Germanio, M Bernier, R de Cabo |
Mechanisms of Ageing and Development | 2019 |
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Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity
D Hu, C Yin, S Luo, AJ Habenicht, SK Mohanta |
Frontiers in immunology | 2019 |
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A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence
D Wu, B Pepowski, S Takahashi, SJ Kron |
BMC Genomics | 2019 |
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Epigenetics recording varied environment and complex cell events represents the origin of cellular aging
X Guo, D Yang, X Zhang |
Journal of Zhejiang University SCIENCE B | 2019 |
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Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease
L Dai, AR Qureshi, A Witasp, B Lindholm, P Stenvinkel |
Computational and Structural Biotechnology Journal | 2019 |
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Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury
G Castellano, R Franzin, F Sallustio, A Stasi, B Banelli, M Romani, GD Palma, G Lucarelli, C Divella, M Battaglia, A Crovace, F Staffieri, G Grandaliano, G Stallone, P Ditonno, P Cravedi, V Cantaluppi, L Gesualdo |
Aging | 2019 |
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Biologic Mechanisms Linked to Prognosis in Ovarian Cancer that May Be Affected by Aging
HS Chon, M Sehovic, D Marchion, C Walko, Y Xiong, M Extermann |
Journal of Cancer | 2019 |
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Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice
S Kumar, S Suman, AJ Fornace, K Datta |
Aging | 2019 |
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Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue
SS Dipali, CR Ferreira, LT Zhou, MT Pritchard, FE Duncan |
Reproductive Biology and Endocrinology | 2019 |
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Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells
P Parikh, RD Britt, LJ Manlove, SA Wicher, A Roesler, J Ravix, J Teske, MA Thompson, GC Sieck, JL Kirkland, N LeBrasseur, DJ Tschumperlin, CM Pabelick, YS Prakash |
American journal of respiratory cell and molecular biology | 2019 |
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Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice
CT Cottage, N Peterson, J Kearley, A Berlin, X Xiong, A Huntley, W Zhao, C Brown, A Migneault, K Zerrouki, G Criner, R Kolbeck, J Connor, R Lemaire |
2019 | |
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Inflammation in multimorbidity and disability: An integrative review
E Friedman, C Shorey |
Health Psychology | 2019 |
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Cellular senescence: at the nexus between ageing and diabetes
AK Palmer, B Gustafson, JL Kirkland, U Smith |
Diabetologia | 2019 |
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Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin
SR Kim, K Jiang, M Ogrodnik, X Chen, XY Zhu, H Lohmeier, L Ahmed, H Tang, T Tchkonia, LT Hickson, JL Kirkland, LO Lerman |
Translational research : the journal of laboratory and clinical medicine | 2019 |
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Senescent HUVECs-secreted exosomes trigger endothelial barrier dysfunction in young endothelial cells
Pooi-Fong Wong, Kind-Leng Tong, Juliana Jamal, Eng-Soon Khor, Siew-Li Lai, Mohd Rais Mustafa |
EXCLI J | 2019 |
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Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion
H Niu, L Qian, B Sun, W Liu, F Wang, Q Wang, X Ji, Y Luo, EU Nesa, H Lou, H Yuan |
Acta pharmaceutica Sinica. B | 2019 |
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Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex
KA Nath, VD Garovic, JP Grande, AJ Croatt, AW Ackerman, G Farrugia, ZS Katusic, JD Belcher, GM Vercellotti |
American journal of physiology. Renal physiology | 2019 |
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Cardiac glycosides are broad-spectrum senolytics
A Guerrero, N Herranz, B Sun, V Wagner, S Gallage, R Guiho, K Wolter, J Pombo, EE Irvine, AJ Innes, J Birch, J Glegola, S Manshaei, D Heide, G Dharmalingam, J Harbig, A Olona, J Behmoaras, D Dauch, AG Uren, L Zender, S Vernia, JP Martínez-Barbera, M Heikenwalder, DJ Withers, J Gil |
2019 | |
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Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions
A Lipecz, L Miller, I Kovacs, C Czakó, T Csipo, J Baffi, A Csiszar, S Tarantini, Z Ungvari, A Yabluchanskiy, S Conley |
GeroScience | 2019 |
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Amelioration of age‐related brain function decline by Bruton's tyrosine kinase inhibition
AE EkpenyongAkiba, M Poblocka, M Althubiti, M Rada, D Jurk, S Germano, G KocsisFodor, Y Shi, JJ Canales, S Macip |
Aging Cell | 2019 |
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Targeting senescent cells: approaches, opportunities, challenges
C von Kobbe |
Aging | 2019 |
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Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation
P Zhang, Q Wang, L Nie, R Zhu, X Zhou, P Zhao, N Ji, X Liang, Y Ding, Q Yuan, Q Wang |
The Journal of biological chemistry | 2019 |
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The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis
ME Guicciardi, CE Trussoni, NF LaRusso, GJ Gores |
Hepatology | 2019 |
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Manufacturing of primed mesenchymal stromal cells for therapy
J Yin, J Zhu, J Ankrum |
Nature Biomedical Engineering | 2019 |
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Mechanisms of obesity-induced metabolic and vascular dysfunctions
Atawia RT, Bunch KL, Toque HA, Caldwell RB, Caldwell RW |
2019 | |
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Cellular senescence in cancer
Kim YH, Park TJ |
BMB Reports | 2019 |
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Meta‐inflammaging at the crossroad of geroscience
Chen G, Yung R |
2019 | |
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Stimulation of prostate cells by the senescence phenotype of epithelial and stromal cells: Implication for benign prostate hyperplasia
Jiang S, Song CS, Chatterjee B |
FASEB bioAdvances | 2019 |
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G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence
Santos-Otte P, Leysen H, van Gastel J, Hendrickx JO, Martin B, Maudsley S |
Computational and Structural Biotechnology Journal | 2019 |
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Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long‐lived and cancer‐resistant subterranean wild rodent, Spalax
Odeh A, Dronina M, Domankevich V, Shams I, Manov I |
Aging Cell | 2019 |
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Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition
Di Benedetto S, Müller L |
Nutrition and Immunity | 2019 |
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Raman fingerprints as promising markers of cellular senescence and aging
Liendl L, Grillari J, Schosserer M |
GeroScience | 2019 |
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AGS and NIA Bench-to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders.
Colón-Emeric C, Whitson HE, Berry SD, Fielding RA, Houston DK, Kiel DP, Rosen CJ, Seldeen KL, Volpi E, White JP, Troen BR |
Journal of the American Geriatrics Society | 2019 |
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Resolution of organ fibrosis
Joon-Il Jun, Lester F. Lau |
Journal of Clinical Investigation | 2018 |
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Therapeutic strategies targeting cellular senescence
Yossi Ovadya, Valery Krizhanovsky |
Journal of Clinical Investigation | 2018 |
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Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis
DW Waters, KE Blokland, PS Pathinayake, JK Burgess, SE Mutsaers, CM Prele, M Schuliga, CL Grainge, DA Knight |
American journal of physiology. Lung cellular and molecular physiology | 2018 |
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Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype
Y Peng, SL Shapiro, VC Banduseela, IA Dieterich, KJ Hewitt, EH Bresnick, G Kong, J Zhang, KL Schueler, MP Keller, AD Attie, TA Hacker, R Sullivan, E Kielar-Grevstad, SI Apelo, DW Lamming, RM Anderson, L Puglielli |
Aging Cell | 2018 |
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Immunosenescence in neurocritical care
S Inoue, M Saito, J Kotani |
Journal of Intensive Care | 2018 |
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Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health
R Furuuchi, I Shimizu, Y Yoshida, Y Hayashi, R Ikegami, M Suda, G Katsuumi, T Wakasugi, M Nakao, T Minamino, Y Taniyama |
PloS one | 2018 |
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β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4
Y Han, T Bedarida, Y Ding, BK Somba, Q Lu, Q Wang, P Song, MH Zou |
Molecular Cell | 2018 |
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The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging: THE HALLMARKS OF SKELETAL AGING
JN Farr, M Almeida |
Journal of Bone and Mineral Research | 2018 |
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Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity
W Trim, JE Turner, D Thompson |
Frontiers in immunology | 2018 |
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Source of Chronic Inflammation in Aging
F Sanada, Y Taniyama, J Muratsu, R Otsu, H Shimizu, H Rakugi, R Morishita |
Frontiers in Cardiovascular Medicine | 2018 |
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Adipose tissue inflammation in aging
T Mau, R Yung |
Experimental Gerontology | 2018 |
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Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy
M Malavolta, M Bracci, L Santarelli, A Sayeed, E Pierpaoli, R Giacconi, L Costarelli, F Piacenza, A Basso, M Cardelli, M Provinciali |
Mediators of Inflammation | 2018 |
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Fisetin is a senotherapeutic that extends health and lifespan
MJ Yousefzadeh, Y Zhu, SJ McGowan, L Angelini, H Fuhrmann-Stroissnigg, M Xu, YY Ling, KI Melos, T Pirtskhalava, CL Inman, C McGuckian, EA Wade, JI Kato, D Grassi, M Wentworth, CE Burd, EA Arriaga, WL Ladiges, T Tchkonia, JL Kirkland, PD Robbins, LJ Niedernhofer |
EBioMedicine | 2018 |
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Aging Hallmarks: The Benefits of Physical Exercise
A Rebelo-Marques, AD Lages, R Andrade, CF Ribeiro, A Mota-Pinto, F Carrilho, J Espregueira-Mendes |
Frontiers in Endocrinology | 2018 |
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The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence
TF Ask, RG Lugo, S Sütterlin |
Frontiers in neuroscience | 2018 |
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The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates
C Franceschi, P Garagnani, C Morsiani, M Conte, A Santoro, A Grignolio, D Monti, M Capri, S Salvioli |
Frontiers in Medicine | 2018 |
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NADPH Oxidases and Mitochondria in Vascular Senescence
G Salazar |
International journal of molecular sciences | 2018 |
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Hsp90 inhibitors as senolytic drugs to extend healthy aging
H Fuhrmann-Stroissnigg, LJ Niedernhofer, PD Robbins |
Cell cycle (Georgetown, Tex.) | 2018 |
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Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells
B Fu, J Yang, J Chen, L Lin, K Chen, W Zhang, J Zhang, Y He |
Frontiers of Medicine | 2018 |
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Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis
SW Guo |
Reproductive Medicine and Biology | 2018 |
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Proximity of Cytomegalovirus-Specific CD8+ T Cells to Replicative Senescence in Human Immunodeficiency Virus-Infected Individuals
JJ Heath, NJ Fudge, ME Gallant, MD Grant |
Frontiers in immunology | 2018 |
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Overcoming Barriers of Age to Enhance Efficacy of Cancer Immunotherapy: The Clout of the Extracellular Matrix
M Owyong, G Efe, M Owyong, AJ Abbasi, V Sitarama, V Plaks |
Frontiers in Cell and Developmental Biology | 2018 |
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Vascular Senescence in Cardiovascular and Metabolic Diseases
G Katsuumi, I Shimizu, Y Yoshida, T Minamino |
Frontiers in Cardiovascular Medicine | 2018 |
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The importance of the vascular endothelial barrier in the immune-inflammatory response induced by radiotherapy
O Guipaud, C Jaillet, K Clément-Colmou, A François, S Supiot, F Milliat |
British Journal of Radiology | 2018 |
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The impact of mitotic errors on cell proliferation and tumorigenesis
MS Levine, AJ Holland |
Genes & development | 2018 |
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Targeting aging for disease modification in osteoarthritis:
JA Collins, BO Diekman, RF Loeser |
Current Opinion in Rheumatology | 2018 |
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Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease
R Tanaka, H Sugiura, M Yamada, T Ichikawa, A Koarai, N Fujino, S Yanagisawa, K Onodera, T Numakura, K Sato, Y Kyogoku, H Sano, S Yamanaka, T Okazaki, T Tamada, M Miura, T Takahashi, M Ichinose |
International journal of chronic obstructive pulmonary disease | 2018 |
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GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging
JY Lee, KR Yu, BC Lee, I Kang, JJ Kim, EJ Jung, HS Kim, Y Seo, SW Choi, KS Kang |
Experimental & molecular medicine | 2018 |
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The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation
J Suzuki, T Yamada, K Inoue, S Nabe, M Kuwahara, N Takemori, A Takemori, S Matsuda, M Kanoh, Y Imai, M Yasukawa, M Yamashita |
Nature Communications | 2018 |
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PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
A Georgilis, S Klotz, CJ Hanley, N Herranz, B Weirich, B Morancho, AC Leote, L D'Artista, S Gallage, M Seehawer, T Carroll, G Dharmalingam, KB Wee, M Mellone, J Pombo, D Heide, E Guccione, J Arribas, NL Barbosa-Morais, M Heikenwalder, GJ Thomas, L Zender, J Gil |
Cancer Cell | 2018 |
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Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy
MA Freeberg, YM Farhat, A Easa, JG Kallenbach, DW Malcolm, MR Buckley, DS Benoit, HA Awad |
Scientific Reports | 2018 |
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The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
E Kwon, K Todorova, J Wang, R Horos, KK Lee, VA Neel, GL Negri, PH Sorensen, SW Lee, MW Hentze, A Mandinova |
Nature Communications | 2018 |
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Organ reserve, excess metabolic capacity, and aging
H Atamna, A Tenore, F Lui, JM Dhahbi |
Biogerontology | 2018 |
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Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol
S Zonis, JJ Breunig, A Mamelak, K Wawrowsky, C Bresee, N Ginzburg, V Chesnokova |
Journal of Neuroinflammation | 2018 |
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Endothelial Cell Aging: How miRNAs Contribute?
M Yamakuchi, T Hashiguchi |
Journal of Clinical Medicine | 2018 |
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Paracrine roles of cellular senescence in promoting tumourigenesis
JM Gonzalez-Meljem, JR Apps, HC Fraser, JP Martinez-Barbera |
British Journal of Cancer | 2018 |
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Senescent T-Cells Promote Bone Loss in Rheumatoid Arthritis
J Fessler, R Husic, V Schwetz, E Lerchbaum, F Aberer, P Fasching, A Ficjan, B Obermayer-Pietsch, C Duftner, W Graninger, MH Stradner, C Dejaco |
Frontiers in immunology | 2018 |
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Oncogene-induced senescence: a double edged sword in cancer
X Liu, J Ding, L Meng |
Acta Pharmacologica Sinica | 2018 |
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Identification of p38 MAPK as a novel therapeutic target for Friedreich’s ataxia
MG Cotticelli, S Xia, A Kaur, D Lin, Y Wang, E Ruff, JW Tobias, RB Wilson |
Scientific Reports | 2018 |
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Targeting Mitochondria to Counteract Age-Related Cellular Dysfunction
C Madreiter-Sokolowski, A Sokolowski, M Waldeck-Weiermair, R Malli, W Graier |
Genes & development | 2018 |
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Anthropometric and Dietary Factors as Predictors of DNA Damage in Obese Women
M Włodarczyk, B Jabłonowska-Lietz, W Olejarz, G Nowicka |
Nutrients | 2018 |
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Anti-Inflamm-Ageing and/or Anti-Age-Related Disease Emerging Treatments: A Historical Alchemy or Revolutionary Effective Procedures?
CR Balistreri |
Mediators of Inflammation | 2018 |
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Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
X Liu, Y Wang, X Zhang, Z Gao, S Zhang, P Shi, X Zhang, L Song, H Hendrickson, D Zhou, G Zheng |
Bioorganic & Medicinal Chemistry | 2018 |
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Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician
BA Bottiger, A Nicoara, LD Snyder, PE Wischmeyer, JN Schroder, CB Patel, MA Daneshmand, RN Sladen, K Ghadimi |
Journal of Cardiothoracic and Vascular Anesthesia | 2018 |
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IGF Binding Protein-5 Induces Cell Senescence
F Sanada, Y Taniyama, J Muratsu, R Otsu, H Shimizu, H Rakugi, R Morishita |
Frontiers in Endocrinology | 2018 |
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Hepatocyte expression and prognostic importance of senescence marker p21 in liver histopathology samples from dogs with chronic hepatitis
AJ Kortum, EA Cloup, TL Williams, F Constantino-Casas, PJ Watson |
Journal of Veterinary Internal Medicine | 2018 |
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Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis
S Khosla, JN Farr, JL Kirkland |
The Journal of clinical endocrinology and metabolism | 2018 |
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Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer
KK Ness, JL Kirkland, MM Gramatges, Z Wang, M Kundu, K McCastlain, X Li-Harms, J Zhang, T Tchkonia, SM Pluijm, GT Armstrong |
Journal of Clinical Oncology | 2018 |
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Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review
M Li, L You, J Xue, Y Lu |
Frontiers in pharmacology | 2018 |
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Translational geroscience: From invertebrate models to companion animal and human interventions
MB Lee, M Kaeberlein |
Translational Medicine of Aging | 2018 |
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The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence
SM Ong, E Hadadi, TM Dang, WH Yeap, CT Tan, TP Ng, A Larbi, SC Wong |
Cell Death and Disease | 2018 |
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Senolytics improve physical function and increase lifespan in old age
M Xu, T Pirtskhalava, JN Farr, BM Weigand, AK Palmer, MM Weivoda, CL Inman, MB Ogrodnik, CM Hachfeld, DG Fraser, JL Onken, KO Johnson, GC Verzosa, LG Langhi, M Weigl, N Giorgadze, NK LeBrasseur, JD Miller, D Jurk, RJ Singh, DB Allison, K Ejima, GB Hubbard, Y Ikeno, H Cubro, VD Garovic, X Hou, SJ Weroha, PD Robbins, LJ Niedernhofer, S Khosla, T Tchkonia, JL Kirkland |
Nature Medicine | 2018 |
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Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype
L Terlecki-Zaniewicz, I Lämmermann, J Latreille, MR Bobbili, V Pils, M Schosserer, R Weinmüllner, H Dellago, S Skalicky, D Pum, JC Almaraz, M Scheideler, F Morizot, M Hackl, F Gruber, J Grillari |
Aging | 2018 |
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Delivery of Sonic Hedgehog Gene Repressed Irradiation-induced Cellular Senescence in Salivary Glands by Promoting DNA Repair and Reducing Oxidative Stress
B Hai, Q Zhao, MA Deveau, F Liu |
Theranostics | 2018 |
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Postinfarction Hearts Are Protected by Premature Senescent Cardiomyocytes Via GATA4‐Dependent CCN1 Secretion
S Cui, L Xue, F Yang, S Dai, Z Han, K Liu, B Liu, Q Yuan, Z Cui, Y Zhang, F Xu, Y Chen |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2018 |
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G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes
H Leysen, J van Gastel, J Hendrickx, P Santos-Otte, B Martin, S Maudsley |
International journal of molecular sciences | 2018 |
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Senescent fibroblasts drive ageing pigmentation: A potential therapeutic target for senile lentigo
JE Yoon, Y Kim, S Kwon, M Kim, YH Kim, JH Kim, TJ Park, HY Kang |
Theranostics | 2018 |
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Increased oxidative stress and coenzyme Q10 deficiency in centenarians
Midori Nagase, Yorihiro Yamamoto, Nozomi Matsumoto, Yasumichi Arai, Nobuyoshi Hirose |
Journal of Clinical Biochemistry and Nutrition | 2018 |
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Mitochondria, Oxidative Stress and Innate Immunity
Y Chen, Z Zhou, W Min |
Frontiers in physiology | 2018 |
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Heat shock protein 27 promotes cell cycle progression by down-regulating E2F transcription factor 4 and retinoblastoma family protein p130
AM Park, I Tsunoda, O Yoshie |
The Journal of biological chemistry | 2018 |
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Accelerated Glomerular Cell Senescence in Experimental Lupus Nephritis
C Yang, J Xue, N An, , Z Wu, L Ye, Z Li, S Wang, Q Pan, D Liang, H Liu |
Medical science monitor : international medical journal of experimental and clinical research | 2018 |
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Urothelial Senescence in the Pathophysiology of Diabetic Bladder Dysfunction—A Novel Hypothesis
NS Klee, CG McCarthy, S Lewis, JL McKenzie, JE Vincent, RC Webb |
Frontiers in Surgery | 2018 |
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The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential
KA Nath, DR OBrien, AJ Croatt, JP Grande, AW Ackerman, MC Nath, S Yamada, A Terzic, T Tchkonia, JL Kirkland, ZS Katusic |
American journal of physiology. Renal physiology | 2018 |
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The Interaction of miR-378i-Skp2 Regulates Cell Senescence in Diabetic Nephropathy
YC Tsai, PL Kuo, MC Kuo, WW Hung, LY Wu, WA Chang, PH Wu, SC Lee, HC Chen, YL Hsu |
Journal of Clinical Medicine | 2018 |
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Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation
GA Fulop, T Kiss, S Tarantini, P Balasubramanian, A Yabluchanskiy, E Farkas, F Bari, Z Ungvari, A Csiszar |
GeroScience | 2018 |
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Role of senescence induction in cancer treatment
S Qin, BA Schulte, GY Wang |
World journal of clinical oncology | 2018 |
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Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms
E Chiappini, M Bianconi, A Dalzini, MR Petrara, L Galli, C Giaquinto, AD Rossi |
Aging | 2018 |
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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
YY Kim, JH Um, J Yun |
Journal of visualized experiments : JoVE | 2018 |
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Adipose Tissue Senescence and Inflammation in Aging is Reversed by the Young Milieu
AK Ghosh, M OBrien, T Mau, N Qi, R Yung |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2018 |
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Occurrence of senescence-escaping cells in doxorubicin-induced senescence is enhanced by PD0332991, a cyclin-dependent kinase 4/6 inhibitor, in colon cancer HCT116 cells
K Kitada, F Pu, M Toi |
Oncology Letters | 2018 |
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Senescent cell clearance by the immune system: Emerging therapeutic opportunities
LG Prata, IG Ovsyannikova, T Tchkonia, JL Kirkland |
Seminars in Immunology | 2018 |
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Immune Deficiencies at the Extremes of Age
Goronzy JJ, Gustafson CE, Weyand CM |
Clinical Immunology | 2018 |
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Senescent tumor cells lead the collective invasion in thyroid cancer
YH Kim, YW Choi, J Lee, EY Soh, JH Kim, TJ Park |
Nature Communications | 2017 |
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Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis
J Fessler, A Raicht, R Husic, A Ficjan, C Schwarz, C Duftner, W Schwinger, WB Graninger, MH Stradner, C Dejaco |
Frontiers in immunology | 2017 |
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Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice
CK Wong, CA Smith, K Sakamoto, N Kaminski, JL Koff, DR Goldstein |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
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Identification of HSP90 inhibitors as a novel class of senolytics
H Fuhrmann-Stroissnigg, YY Ling, J Zhao, SJ McGowan, Y Zhu, RW Brooks, D Grassi, SQ Gregg, JL Stripay, A Dorronsoro, L Corbo, P Tang, C Bukata, N Ring, M Giacca, X Li, T Tchkonia, JL Kirkland, LJ Niedernhofer, PD Robbins |
Nature Communications | 2017 |
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The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
JR Aunan, WC Cho, K Søreide |
Aging and disease | 2017 |
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Immunosenescence and hurdles in the clinical management of older HIV-patients
M Ripa, S Chiappetta, G Tambussi |
Virulence | 2017 |
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Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury
EA McCart, RL Thangapazham, ED Lombardini, SR Mog, RA Panganiban, KM Dickson, RA Mansur, V Nagy, SY Kim, R Selwyn, MR Landauer, TN Darling, RM Day |
Journal of Radiation Research | 2017 |
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Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy
G Garibotto, A Carta, D Picciotto, F Viazzi, D Verzola |
Journal of Nephrology | 2017 |
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Immune dysfunctionality of replicative senescent mesenchymal stromal cells is corrected by IFNγ priming
R Chinnadurai, D Rajan, S Ng, K McCullough, D Arafat, EK Waller, LJ Anderson, G Gibson, J Galipeau |
Blood Advances | 2017 |
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The Effect of Osteopontin on Microglia
H Yu, X Liu, Y Zhong |
BioMed Research International | 2017 |
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The third path of tubulointerstitial fibrosis: aberrant endothelial secretome
M Lipphardt, JW Song, K Matsumoto, S Dadafarin, H Dihazi, G Müller, MS Goligorsky |
Kidney International | 2017 |
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Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation
Z Xu, W Feng, Q Shen, N Yu, K Yu, S Wang, Z Chen, S Shioda, Y Guo |
Aging and disease | 2017 |
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Senotherapy: growing old and staying young?
R Schmitt |
Pflügers Archiv - European Journal of Physiology | 2017 |
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Cellular Senescence: A Translational Perspective
JL Kirkland, T Tchkonia |
EBioMedicine | 2017 |
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Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women
JN Justice, H Gregory, T Tchkonia, NK LeBrasseur, JL Kirkland, SB Kritchevsky, BJ Nicklas |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2017 |
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The Clinical Potential of Senolytic Drugs
JL Kirkland, T Tchkonia, Y Zhu, LJ Niedernhofer, PD Robbins |
Journal of the American Geriatrics Society | 2017 |
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Successful and Maladaptive T Cell Aging
JJ Goronzy, CM Weyand |
Immunity | 2017 |
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Immunological aspects of age-related diseases
K Isobe, N Nishio, T Hasegawa |
World journal of biological chemistry | 2017 |
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Cooperation between p21 and Akt is required for p53-dependent cellular senescence
YY Kim, HJ Jee, JH Um, YM Kim, SS Bae, J Yun |
Aging Cell | 2017 |
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Local Production of Activated Factor X in Atherosclerotic Plaque Induced Vascular Smooth Muscle Cell Senescence
F Sanada, J Muratsu, R Otsu, H Shimizu, N Koibuchi, K Uchida, Y Taniyama, S Yoshimura, H Rakugi, R Morishita |
Scientific Reports | 2017 |
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From rapalogs to anti-aging formula
MV Blagosklonny |
Oncotarget | 2017 |
|
The role of epigenetics in renal ageing
PG Shiels, D McGuinness, M Eriksson, JP Kooman, P Stenvinkel |
Nature Reviews Nephrology | 2017 |
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Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
N Kubben, T Misteli |
Nature Reviews Molecular Cell Biology | 2017 |
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Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism
RR Flores, CL Clauson, J Cho, BC Lee, SJ McGowan, DJ Baker, LJ Niedernhofer, PD Robbins |
Aging Cell | 2017 |
|
Senescence-Inflammatory Regulation of Reparative Cellular Reprogramming in Aging and Cancer
JA Menendez, T Alarcón |
Frontiers in Cell and Developmental Biology | 2017 |
|
Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans
MJ Yousefzadeh, MJ Schafer, NN Hooten, EJ Atkinson, MK Evans, DJ Baker, EK Quarles, PD Robbins, WC Ladiges, NK LeBrasseur, LJ Niedernhofer |
Aging Cell | 2017 |
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Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats
L Grigorian-Shamagian, W Liu, S Fereydooni, RC Middleton, J Valle, JH Cho, E Marbán |
European Heart Journal | 2017 |
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Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans
DC Berry, Y Jiang, RW Arpke, EL Close, A Uchida, D Reading, ED Berglund, M Kyba, JM Graff |
Cell Metabolism | 2017 |
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The potential of targeting Sin3B and its associated complexes for cancer therapy
DJ Cantor, G David |
Expert Opinion on Therapeutic Targets | 2017 |
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The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1
DN Meijles, S Sahoo, IA Ghouleh, JH Amaral, R Bienes-Martinez, HE Knupp, S Attaran, JC Sembrat, SM Nouraie, MM Rojas, EM Novelli, MT Gladwin, JS Isenberg, E Cifuentes-Pagano, PJ Pagano |
Science signaling | 2017 |
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Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction
M Takano, S Kawabata, S Shibata, A Yasuda, S Nori, O Tsuji, N Nagoshi, A Iwanami, H Ebise, K Horiuchi, H Okano, M Nakamura |
Stem Cell Reports | 2017 |
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Aging: Molecular Pathways and Implications on the Cardiovascular System
AJ de Almeida, TP Ribeiro, IA de Medeiros |
Oxidative medicine and cellular longevity | 2017 |
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p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo
R Kannappan, A Matsuda, J Ferreira-Martins, E Zhang, G Palano, A Czarna, MC Cabral-Da-Silva, A Bastos-Carvalho, F Sanada, N Ide, M Rota, MA Blasco, M Serrano, P Anversa, A Leri |
EBioMedicine | 2017 |
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Telomere-driven diseases and telomere-targeting therapies
P Martínez, MA Blasco |
The Journal of Cell Biology | 2017 |
|
Frailty and Circulating Markers of Inflammation in HIV+ and HIV− Men in the Multicenter AIDS Cohort Study:
JB Margolick, JH Bream, O Martínez-Maza, J Lopez, X Li, JP Phair, SL Koletar, LP Jacobson |
Journal of acquired immune deficiency syndromes (1999) | 2017 |
|
Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study
M Tolahunase, R Sagar, R Dada |
Oxidative medicine and cellular longevity | 2017 |
|
Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases
A Lewinska, M Wnuk |
Biogerontology | 2017 |
|
Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment
V Camacho, V McClearn, S Patel, RS Welner |
International Journal of Hematology | 2017 |
|
Pathophysiology of heart failure and frailty: a common inflammatory origin?
L Bellumkonda, D Tyrrell, SL Hummel, DR Goldstein |
Aging Cell | 2017 |
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A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse
SS Deepa, S Bhaskaran, S Espinoza, SV Brooks, A McArdle, MJ Jackson, HV Remmen, A Richardson |
GeroScience | 2017 |
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Old Maids: Aging and Its Impact on Microglia Function
E Koellhoffer, L McCullough, R Ritzel |
International journal of molecular sciences | 2017 |
|
Molecular and phenotypic biomarkers of aging
X Xia, W Chen, J McDermott, JD Han |
F1000Research | 2017 |
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FOXQ1 regulates senescence-associated inflammation via activation of SIRT1 expression
P Wang, C Lv, T Zhang, J Liu, J Yang, F Guan, T Hong |
Cell Death and Disease | 2017 |
|
Preterm prelabor rupture of the membranes: A disease of the fetal membranes
R Menon, LS Richardson |
Seminars in Perinatology | 2017 |
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Does the human immune system ever really become “senescent”?
G Pawelec |
F1000Research | 2017 |
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The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis
CA Valenzuela, R Quintanilla, R Moore-Carrasco, NE Brown |
Frontiers in Oncology | 2017 |
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Senescence gives insights into the morphogenetic evolution of anamniotes
É Villiard, JF Denis, FS Hashemi, S Igelmann, G Ferbeyre, S Roy |
Biology Open | 2017 |
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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
S Glück, B Guey, MF Gulen, K Wolter, TW Kang, NA Schmacke, A Bridgeman, J Rehwinkel, L Zender, A Ablasser |
Nature Cell Biology | 2017 |
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Targeting cellular senescence prevents age-related bone loss in mice
JN Farr, M Xu, MM Weivoda, DG Monroe, DG Fraser, JL Onken, BA Negley, JG Sfeir, MB Ogrodnik, CM Hachfeld, NK LeBrasseur, MT Drake, RJ Pignolo, T Pirtskhalava, T Tchkonia, MJ Oursler, JL Kirkland, S Khosla |
Nature Medicine | 2017 |
|
Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence
LS McRobb, MJ McKay, JR Gamble, M Grace, V Moutrie, ED Santos, VS Lee, Z Zhao, MP Molloy, MA Stoodley |
Aging | 2017 |
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SSeCKS/AKAP12 scaffolding functions suppress B16F10-induced peritoneal metastasis by attenuating CXCL9/10 secretion by resident fibroblasts
M Muramatsu, L Gao, J Peresie, B Balderman, S Akakura, IH Gelman |
Oncotarget | 2017 |
|
The chromatin accessibility signature of human immune aging stems from CD8 + T cells
D Ucar, EJ Márquez, CH Chung, R Marches, RJ Rossi, A Uyar, TC Wu, J George, ML Stitzel, AK Palucka, GA Kuchel, J Banchereau |
Journal of Experimental Medicine | 2017 |
|
Very-long-chain ω -3 fatty acid supplements and adipose tissue functions: a randomized controlled trial
KC Hames, M Morgan-Bathke, DA Harteneck, L Zhou, JD Port, IR Lanza, MD Jensen |
The American journal of clinical nutrition | 2017 |
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Effect of etoposide-induced alteration of the Mdm2-Rb signaling pathway on cellular senescence in A549 lung adenocarcinoma cells
W Dai, Y Jiang, K Chen, J Qiu, J Sun, W Zhang, X Zhou, N Huang, Y Li, W Li |
Oncology Letters | 2017 |
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Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis
S Chen, RC Fisher, S Signs, LA Molina, AK Shenoy, MC Lopez, HV Baker, JM Koomen, Y Chen, H Gittleman, J Barnholtz-Sloan, A Berg, HD Appelman, EH Huang |
Oncotarget | 2017 |
|
MortalityPredictors.org: a manually-curated database of published biomarkers of human all-cause mortality
MV Peto, CD la Guardia, K Winslow, A Ho, K Fortney, E Morgen |
Aging | 2017 |
|
Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts
M Tofiño-Vian, MI Guillén, MD Caz, MA Castejón, MJ Alcaraz |
Oxidative medicine and cellular longevity | 2017 |
|
Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury
Y Wan, K McDaniel, N Wu, S Ramos-Lorenzo, T Glaser, J Venter, H Francis, L Kennedy, K Sato, T Zhou, K Kyritsi, Q Huang, T Annable, C Wu, S Glaser, G Alpini, F Meng |
The American Journal of Pathology | 2017 |
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A null mutation in SERPINE1 protects against biological aging in humans
SS Khan, SJ Shah, E Klyachko, AS Baldridge, M Eren, AT Place, A Aviv, E Puterman, DM Lloyd-Jones, M Heiman, T Miyata, S Gupta, AD Shapiro, DE Vaughan |
Science Advances | 2017 |
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Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics
N Frey, S Venturelli, L Zender, M Bitzer |
Nature Reviews Gastroenterology & Hepatology | 2017 |
|
Senescence and tumor suppression
P Hinds, J Pietruska |
F1000Research | 2017 |
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TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion
R Kandhaya-Pillai, F Miro-Mur, J Alijotas-Reig, T Tchkonia, JL Kirkland, S Schwartz |
Aging | 2017 |
|
The Role of Inflammation in Age-Related Sarcopenia
S Dalle, L Rossmeislova, K Koppo |
Frontiers in physiology | 2017 |
|
Biology of premature ageing in survivors of cancer
MC Cupit-Link, JL Kirkland, KK Ness, GT Armstrong, T Tchkonia, NK LeBrasseur, SH Armenian, KJ Ruddy, SK Hashmi |
ESMO Open | 2017 |
|
Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells
S Rockfield, I Flores, M Nanjundan |
Oncotarget | 2017 |
|
Extracellular vesicles and aging
PD Robbins |
Stem Cell Investigation | 2017 |
|
While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts
OV Leontieva, MV Blagosklonny |
Oncotarget | 2017 |
|
HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation
EV Efimova, N Ricco, E Labay, HJ Mauceri, AC Flor, A Ramamurthy, HG Sutton, RR Weichselbaum, SJ Kron |
Molecular cancer therapeutics | 2017 |
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Human CD8 + EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK
LA Callender, EC Carroll, RW Beal, ES Chambers, S Nourshargh, AN Akbar, SM Henson |
Aging Cell | 2017 |
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An Old Problem: Aging and Skeletal-Muscle-Strain Injury
BA Baker |
J SPORT REHABIL | 2017 |
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Autophagy Is Pro-Senescence When Seen in Close-Up, but Anti-Senescence in Long-Shot
Kwon Y, Kim JW, Jeoung JA, Kim MS, Kang C |
Molecules and Cells | 2017 |
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Metabolic Alterations at the Crossroad of Aging and Oncogenesis
Raffaghello L, Longo V |
International review of cell and molecular biology | 2017 |
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3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing
Younis LT, Abu Hassan MI, Taiyeb Ali TB, Bustami TJ |
Asian Journal of Pharmaceutical Sciences | 2017 |
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[Cellular senescence and colorectal cancer].
Foersch S |
Der Pathologe | 2017 |
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RelA controls Kras-driven pancreatic carcinogenesis via CXCL1/KC/CXCR2 dependent oncogene-induced senescence
Marina Lesina, Sonja Wörmann, Jennifer Morton, Kalliope Diakopoulos, Olga Korneeva, Margit Wimmer, Henrik Einwächter, Jan Sperveslage, Ihsan Ekin Demir, Timo Kehl, Dieter Saur, Bence Sipos, Mathias Heikenwälder, Jörg M. Steiner, Timothy C Wang, Owen Sansom, Roland M. Schmid, Hana Algül |
Journal of Clinical Investigation | 2016 |
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Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
MJ Schafer, TA White, G Evans, JM Tonne, GC Verzosa, MB Stout, DL Mazula, AK Palmer, DJ Baker, MD Jensen, MS Torbenson, JD Miller, Y Ikeda, T Tchkonia, JM van Deursen, JL Kirkland, NK LeBrasseur |
Diabetes | 2016 |
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Age-associated vascular inflammation promotes monocytosis during atherogenesis
W Du, C Wong, Y Song, H Shen, D Mori, N Rotllan, N Price, AD Dobrian, H Meng, SH Kleinstein, C Fernandez-Hernando, DR Goldstein |
Aging Cell | 2016 |
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Extracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity?
F Prattichizzo, A Giuliani, VD Nigris, G Pujadas, A Ceka, LL Sala, S Genovese, R Testa, AD Procopio, F Olivieri, A Ceriello |
Diabetes Obesity and Metabolism | 2016 |
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Intracellular signalling pathways: targets to reverse immunosenescence: Signaling targets to reverse immunosenescence
T Fulop, JM Witkowski, AL Page, C Fortin, G Pawelec, A Larbi |
Clinical & Experimental Immunology | 2016 |
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Role of IGFBP7 in Diabetic Nephropathy: TGF-β1 Induces IGFBP7 via Smad2/4 in Human Renal Proximal Tubular Epithelial Cells
J Watanabe, Y Takiyama, J Honjyo, Y Makino, Y Fujita, M Tateno, M Haneda, SR Singh |
PloS one | 2016 |
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Mitochondria are required for pro‐ageing features of the senescent phenotype
C CorreiaMelo, FD Marques, R Anderson, G Hewitt, R Hewitt, J Cole, BM Carroll, S Miwa, J Birch, A Merz, MD Rushton, M Charles, D Jurk, SW Tait, R Czapiewski, L Greaves, G Nelson, M BohloolyY, S RodriguezCuenca, A VidalPuig, D Mann, G Saretzki, G Quarato, DR Green, PD Adams, T Zglinicki, VI Korolchuk, JF Passos |
The EMBO Journal | 2016 |
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Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis
Y Li, J Liang, T Yang, JM Mena, C Huan, T Xie, A Kurkciyan, N Liu, D Jiang, PW Noble |
Matrix Biology | 2016 |
|
Challenges and opportunities for stem cell therapy in patients with chronic kidney disease
LT Hickson, A Eirin, LO Lerman |
Kidney International | 2016 |
|
Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules
S Kumar, DB Lombard |
F1000Research | 2016 |
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Energetic interventions for healthspan and resiliency with aging
DM Huffman, MJ Schafer, NK LeBrasseur |
Experimental Gerontology | 2016 |
|
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty
MB Stout, JN Justice, BJ Nicklas, JL Kirkland |
Physiology (Bethesda, Md.) | 2016 |
|
Aging and adipose tissue: potential interventions for diabetes and regenerative medicine
AK Palmer, JL Kirkland |
Experimental Gerontology | 2016 |
|
Cellular senescence: Implications for metabolic disease
MJ Schafer, JD Miller, NK LeBrasseur |
Molecular and Cellular Endocrinology | 2016 |
|
DNA Damage: A Main Determinant of Vascular Aging
P Bautista-Niño, E Portilla-Fernandez, D Vaughan, A Danser, A Roks |
International journal of molecular sciences | 2016 |
|
SNEV P rp19/ PSO 4 deficiency increases PUVA-induced senescence in mouse skin
R Monteforte, GF Beilhack, R Grausenburger, B Mayerhofer, R Bittner, R Grillari-Voglauer, M Sibilia, H Dellago, E Tschachler, F Gruber, J Grillari |
Experimental Dermatology | 2016 |
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Cellular senescence impact on immune cell fate and function
R Vicente, AL Mausset-Bonnefont, C Jorgensen, P Louis-Plence, JM Brondello |
Aging Cell | 2016 |
|
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
BM Hall, V Balan, AS Gleiberman, E Strom, P Krasnov, LP Virtuoso, E Rydkina, S Vujcic, K Balan, I Gitlin, K Leonova, A Polinsky, OB Chernova, AV Gudkov |
Aging | 2016 |
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Identification of Senescent Cells in the Bone Microenvironment: SENESCENCE IN THE BONE MICROENVIRONMENT
JN Farr, DG Fraser, H Wang, K Jaehn, MB Ogrodnik, MM Weivoda, MT Drake, T Tchkonia, NK LeBrasseur, JL Kirkland, LF Bonewald, RJ Pignolo, DG Monroe, S Khosla |
Journal of Bone and Mineral Research | 2016 |
|
Molecular pathology endpoints useful for aging studies
LJ Niedernhofer, JL Kirkland, W Ladiges |
Ageing Research Reviews | 2016 |
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Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease
D Lu, A Rauhauser, B Li, C Ren, K McEnery, J Zhu, M Chaki, K Vadnagara, S Elhadi, AM Jetten, P Igarashi, M Attanasio |
Kidney International | 2016 |
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The pathological role of vascular aging in cardio-metabolic disorder
G Katsuumi, I Shimizu, Y Yoshida, T Minamino |
Inflammation and Regeneration | 2016 |
|
Macrophages in age-related chronic inflammatory diseases
Y Oishi, I Manabe |
npj Aging and Mechanisms of Disease | 2016 |
|
Molecular mechanisms of biological aging in intervertebral discs: INTERVERTEBRAL DISC AGING
NV Vo, RA Hartman, PR Patil, MV Risbud, D Kletsas, JC Iatridis, JA Hoyland, CL le Maitre, GA Sowa, JD Kang |
Journal of Orthopaedic Research | 2016 |
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DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression
M Borghesan, C Fusilli, F Rappa, C Panebianco, G Rizzo, JA Oben, G Mazzoccoli, C Faulkes, I Pata, A Agodi, F Rezaee, S Minogue, A Warren, A Peterson, JM Sedivy, J Douet, M Buschbeck, F Cappello, T Mazza, V Pazienza, M Vinciguerra |
Cancer research | 2016 |
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Activated Factor X Induces Endothelial Cell Senescence Through IGFBP-5
F Sanada, Y Taniyama, J Muratsu, R Otsu, M Iwabayashi, M Carracedo, H Rakugi, R Morishita |
Scientific Reports | 2016 |
|
miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence
H Cui, J Ge, N Xie, S Banerjee, Y Zhou, VB Antony, VJ Thannickal, G Liu |
American journal of respiratory cell and molecular biology | 2016 |
|
Strategies and Challenges in Clinical Trials Targeting Human Aging
JC Newman, S Milman, SK Hashmi, SN Austad, JL Kirkland, JB Halter, N Barzilai |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2016 |
|
Host Resistance and Immune Aging
T Bandaranayake, AC Shaw |
Clinics in Geriatric Medicine | 2016 |
|
Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinic
DE Berryman, B Henry, R Hjortebjerg, EO List, JJ Kopchick |
Expert Review of Endocrinology & Metabolism | 2016 |
|
Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice
S Ock, WS Lee, J Ahn, HM Kim, H Kang, HS Kim, D Jo, ED Abel, TJ Lee, J Kim |
Endocrinology | 2016 |
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“Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes
F Prattichizzo, VD Nigris, LL Sala, AD Procopio, F Olivieri, A Ceriello |
Oxidative medicine and cellular longevity | 2016 |
|
BZLF1 Attenuates Transmission of Inflammatory Paracrine Senescence in Epstein-Barr Virus-Infected Cells by Downregulating Tumor Necrosis Factor Alpha
X Long, Y Li, M Yang, L Huang, W Gong, E Kuang, JU Jung |
Journal of virology | 2016 |
|
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
Y Zhu, T Tchkonia, H Fuhrmann-Stroissnigg, HM Dai, YY Ling, MB Stout, T Pirtskhalava, N Giorgadze, KO Johnson, CB Giles, JD Wren, LJ Niedernhofer, PD Robbins, JL Kirkland |
Aging Cell | 2016 |
|
Mesenchymal stem cell-derived inflammatory fibroblasts mediate interstitial fibrosis in the aging heart
JA Trial, ML Entman, KA Cieslik |
Journal of Molecular and Cellular Cardiology | 2016 |
|
Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
MC Marazita, A Dugour, MD Marquioni-Ramella, JM Figueroa, AM Suburo |
Redox Biology | 2016 |
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Urinary biomarkers for the differentiation of prerenal and intrinsic pediatric acute kidney injury
JH Westhoff, A Fichtner, S Waldherr, N Pagonas, FS Seibert, N Babel, B Tönshoff, F Bauer, TH Westhoff |
Pediatric Nephrology | 2016 |
|
Primary Sclerosing Cholangitis
JR Ingelfinger, KN Lazaridis, NF LaRusso |
New England Journal of Medicine | 2016 |
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HIF-1α and rapamycin act as gerosuppressant in multiple myeloma cells upon genotoxic stress
C Coudre, J Alani, W Ritchie, V Marsaud, B Sola, J Cahu |
Cell cycle (Georgetown, Tex.) | 2016 |
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Depleting senescent cells to combat aging
H Geiger |
Nature Medicine | 2016 |
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The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription
W Tang, AI Robles, RP Beyer, LT Gray, GH Nguyen, J Oshima, N Maizels, CC Harris, RJ Monnat |
Human Molecular Genetics | 2016 |
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Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice
M Xu, EW Bradley, MM Weivoda, SM Hwang, T Pirtskhalava, T Decklever, GL Curran, M Ogrodnik, D Jurk, KO Johnson, V Lowe, T Tchkonia, JJ Westendorf, JL Kirkland |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2016 |
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Role of the Braf V637E mutation in hepatocarcinogenesis induced by treatment with diethylnitrosamine in neonatal B6C3F1 mice: BRAF V637E MUTATION IN DEN-INDUCED HEPATIC TUMORS
M Yamamoto, H Tanaka, B Xin, Y Nishikawa, K Yamazaki, K Shimizu, K Ogawa |
Molecular Carcinogenesis | 2016 |
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Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells
H Lan, Z Tang, H Jin, Y Sun |
Scientific Reports | 2016 |
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SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
Y Johmura, J Sun, K Kitagawa, K Nakanishi, T Kuno, A Naiki-Ito, Y Sawada, T Miyamoto, A Okabe, H Aburatani, SF Li, I Miyoshi, S Takahashi, M Kitagawa, M Nakanishi |
Nature Communications | 2016 |
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Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases
Y Wang, M Boerma, D Zhou |
Radiation Research | 2016 |
|
Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus
I Martínez, V García-Carpizo, T Guijarro, A García-Gomez, D Navarro, A Aranda, A Zambrano |
Virulence | 2016 |
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Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction
M Xu, T Tchkonia, JL Kirkland |
Pharmacological Research | 2016 |
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Stroke and Risks of Development and Progression of Kidney Diseases and End-Stage Renal Disease: A Nationwide Population-Based Cohort Study
CL Wu, CC Tsai, CT Kor, DC Tarng, IB Lian, TH Yang, PF Chiu, CC Chang, EA Burdmann |
PloS one | 2016 |
|
Role of Telomeres and Telomerase in Aging and Cancer
JW Shay |
Cancer Discovery | 2016 |
|
Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish
MC Carneiro, CM Henriques, J Nabais, T Ferreira, T Carvalho, MG Ferreira, L Harrington |
PLoS genetics | 2016 |
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Glycemic Status and Infection Risk in Nondiabetic Autologous Hematopoietic Cell Transplantation Recipients
MJ Hammer, GD Melkus, MT Knobf, C Casper, J Fletcher, CM Cleland |
Biological research for nursing | 2016 |
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Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans
SS Shen-Orr, D Furman, BA Kidd, F Hadad, P Lovelace, YW Huang, Y Rosenberg-Hasson, S Mackey, FA Grisar, Y Pickman, HT Maecker, Y Chien, CL Dekker, JC Wu, AJ Butte, MM Davis |
Cell Systems | 2016 |
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Multiple facets of p53 in senescence induction and maintenance
Y Johmura, M Nakanishi |
Cancer Science | 2016 |
|
Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study
S Andersen, E Richardsen, L Moi, T Donnem, Y Nordby, N Ness, ME Holman, RM Bremnes, LT Busund |
Scientific Reports | 2016 |
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Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1
AC Panda, I Grammatikakis, KM Kim, S De, JL Martindale, R Munk, X Yang, K Abdelmohsen, M Gorospe |
Nucleic Acids Research | 2016 |
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Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
Y Wang, J Chang, X Liu, X Zhang, S Zhang, X Zhang, D Zhou, G Zheng |
Aging | 2016 |
|
Senescence associated macrophages and “macroph-aging”: are they pieces of the same puzzle?
F Prattichizzo, M Bonafè, F Olivieri, C Franceschi |
Aging | 2016 |
|
Physiologic Frailty in Nonelderly Hematopoietic Cell Transplantation Patients: Results From the Bone Marrow Transplant Survivor Study
M Arora, CL Sun, KK Ness, JB Teh, J Wu, L Francisco, SH Armenian, A Schad, G Namdar, A Bosworth, L Kuo, DJ Weisdorf, SJ Forman, S Bhatia |
JAMA Oncology | 2016 |
|
Translating the Science of Aging into Therapeutic Interventions
JL Kirkland |
Cold Spring Harbor Perspectives in Medicine | 2016 |
|
The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span
F Sierra |
Cold Spring Harbor Perspectives in Medicine | 2016 |
|
Articulating the Case for the Longevity Dividend
SJ Olshansky |
Cold Spring Harbor Perspectives in Medicine | 2016 |
|
Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
Prattichizzo F, Giuliani A, Recchioni R, Bonafè M, Marcheselli F, De Carolis S, Campanati A, Giuliodori K, Rippo MR, Brugè F, Tiano L, Micucci C, Ceriello A, Offidani A, Procopio AD, Olivieri F |
Oncotarget | 2016 |
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Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis
O'Hagan-Wong K, Nadeau S, Carrier-Leclerc A, Apablaza F, Hamdy R, Shum-Tim D, Rodier F, Colmegna I |
Oncotarget | 2016 |
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Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis
MO Grootaert, PA da Martins, N Bitsch, I Pintelon, GR de Meyer, W Martinet, DM Schrijvers |
Autophagy | 2015 |
|
Primary Biliary Cirrhosis Is a Generalized Autoimmune Epithelitis
J Gao, L Qiao, B Wang |
International journal of molecular sciences | 2015 |
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Exercise Attenuates the Major Hallmarks of Aging
N Garatachea, H Pareja-Galeano, F Sanchis-Gomar, A Santos-Lozano, C Fiuza-Luces, M Morán, E Emanuele, MJ Joyner, A Lucia |
Rejuvenation Research | 2015 |
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Targeting senescent cells enhances adipogenesis and metabolic function in old age: Primary subcutaneous human fat progenitors were labelled with DiI and seeded into wells containing either control or radiation-induced senescent preadipocytes. ( a ) Photographs were taken 15 days after initiating differentiation. Representative images are shown. DiI-positive cells are red and DAPI staining is blue. ( b ) Number of differentiated DiI positive cells as a percentage of total DiI positive cells is expressed as mean ± s.e.m. *p<0.00001. Results were obtained using separate strains of fat progenitors harvested from 6 healthy human subjects during surgery to donate a kidney (N=6). Two-tailed Student's t tests were used to determine statistical significance
M Xu, AK Palmer, H Ding, MM Weivoda, T Pirtskhalava, TA White, A Sepe, KO Johnson, MB Stout, N Giorgadze, MD Jensen, NK LeBrasseur, T Tchkonia, JL Kirkland |
eLife | 2015 |
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Therapeutic targeting of replicative immortality
P Yaswen, KL MacKenzie, WN Keith, P Hentosh, F Rodier, J Zhu, GL Firestone, A Matheu, A Carnero, A Bilsland, T Sundin, K Honoki, H Fujii, AG Georgakilas, A Amedei, A Amin, B Helferich, CS Boosani, G Guha, MR Ciriolo, S Chen, SI Mohammed, AS Azmi, D Bhakta, D Halicka, E Niccolai, K Aquilano, SS Ashraf, S Nowsheen, X Yang |
Seminars in Cancer Biology | 2015 |
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Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
AK Palmer, T Tchkonia, NK LeBrasseur, EN Chini, M Xu, JL Kirkland |
Diabetes | 2015 |
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Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing
RR White, B Milholland, A Bruin, S Curran, RM Laberge, H Steeg, J Campisi, AY Maslov, J Vijg |
Nature Communications | 2015 |
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Mutant lamin A links prophase to a p53 independent senescence program
O Moiseeva, F Lessard, M Acevedo-Aquino, M Vernier, YS Tsantrizos, G Ferbeyre |
Cell cycle (Georgetown, Tex.) | 2015 |
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Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid
A Gutierrez-Fernandez, C Soria-Valles, FG Osorio, J Gutierrez-Abril, C Garabaya, A Aguirre, A Fueyo, MS Fernandez-Garcia, XS Puente, C Lopez-Otin |
The EMBO Journal | 2015 |
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Nestlé Nutrition Institute Workshop Series: 83rd Nestlé Nutrition Institute Workshop, Barcelona, March 2014
NK LeBrasseur, T Tchkonia, JL Kirkland |
Nestle Nutrition Institute workshop series | 2015 |
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Inflammaging decreases adaptive and innate immune responses in mice and humans
D Frasca, BB Blomberg |
Biogerontology | 2015 |
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Parainflammation, chronic inflammation, and age-related macular degeneration
M Chen, H Xu |
Journal of leukocyte biology | 2015 |
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Diabetes mellitus—advances and challenges in human β-cell proliferation
P Wang, NM Fiaschi-Taesch, RC Vasavada, DK Scott, A García-Ocaña, AF Stewart |
Nature Reviews Endocrinology | 2015 |
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Immune aging, dysmetabolism, and inflammation in neurological diseases
M Deleidi, M Jäggle, G Rubino |
Frontiers in neuroscience | 2015 |
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Naive T Cell Maintenance and Function in Human Aging
JJ Goronzy, F Fang, MM Cavanagh, Q Qi, CM Weyand |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models
Y Liu, OE Hawkins, AE Vilgelm, JS Pawlikowski, JA Ecsedy, JA Sosman, MC Kelley, A Richmond |
Clinical cancer research | 2015 |
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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Y Zhu, T Tchkonia, T Pirtskhalava, AC Gower, H Ding, N Giorgadze, AK Palmer, Y Ikeno, GB Hubbard, M Lenburg, SP O'Hara, NF LaRusso, JD Miller, CM Roos, GC Verzosa, NK LeBrasseur, JD Wren, JN Farr, S Khosla, MB Stout, SJ McGowan, H Fuhrmann-Stroissnigg, AU Gurkar, J Zhao, D Colangelo, A Dorronsoro, YY Ling, AS Barghouthy, DC Navarro, T Sano, PD Robbins, LJ Niedernhofer, JL Kirkland |
Aging Cell | 2015 |
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Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians
Y Arai, CM Martin-Ruiz, M Takayama, Y Abe, T Takebayashi, S Koyasu, M Suematsu, N Hirose, T Zglinicki |
EBioMedicine | 2015 |
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Sustained Interleukin-1 β Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids
P Escoll, I Ranz, N Muñoz-Antón, A van-den-Rym, M Alvarez-Mon, C Martínez-Alonso, E Sanz, A de-la-Hera |
Mediators of Inflammation | 2015 |
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DDR-mediated crosstalk between DNA-damaged cells and their microenvironment
N Malaquin, A Carrier-Leclerc, M Dessureault, F Rodier |
Frontiers in Genetics | 2015 |
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The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation
C Beaupere, M Garcia, J Larghero, B Fève, J Capeau, C Lagathu |
Aging Cell | 2015 |
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Emerging targets in osteoarthritis therapy
MB Goldring, F Berenbaum |
Current Opinion in Pharmacology | 2015 |
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Programmed cell death in aging
J Tower |
Ageing Research Reviews | 2015 |
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Prostate stromal cell telomere shortening is associated with risk of prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial: Short Stromal Cell Telomeres
CM Heaphy, G Gaonkar, SB Peskoe, CE Joshu, AM de Marzo, MS Lucia, PJ Goodman, SM Lippman, IM Thompson, EA Platz, AK Meeker |
The Prostate | 2015 |
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Interventions to Slow Aging in Humans: Are We Ready?
VD Longo, A Antebi, A Bartke, N Barzilai, HM Brown-Borg, C Caruso, TJ Curiel, R Cabo, C Franceschi, D Gems, DK Ingram, TE Johnson, BK Kennedy, C Kenyon, S Klein, JJ Kopchick, G Lepperdinger, F Madeo, MG Mirisola, JR Mitchell, G Passarino, KL Rudolph, JM Sedivy, GS Shadel, DA Sinclair, SR Spindler, Y Suh, J Vijg, M Vinciguerra, L Fontana |
Aging Cell | 2015 |
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The cell secretome, a mediator of cell-to-cell communication
J Zullo, K Matsumoto, S Xavier, B Ratliff, MS Goligorsky |
Prostaglandins & Other Lipid Mediators | 2015 |
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DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function
Q Yu, YV Katlinskaya, CJ Carbone, B Zhao, KV Katlinski, H Zheng, M Guha, N Li, Q Chen, T Yang, CJ Lengner, RA Greenberg, FB Johnson, SY Fuchs |
Cell Reports | 2015 |
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Aging and malignant hemopathies
D Bron, L Ades, T Fulop, V Goede |
Haematologica | 2015 |
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Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes
F Prattichizzo, A Giuliani, A Ceka, MR Rippo, AR Bonfigli, R Testa, AD Procopio, F Olivieri |
Clinical Epigenetics | 2015 |
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High OCT4 and Low p16INK4A Expressions Determine In Vitro Lifespan of Mesenchymal Stem Cells
CA Piccinato, AL Sertie, N Torres, M Ferretti, E Antonioli |
Stem Cells International | 2015 |
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Stromal Fibroblast in Age-Related Cancer: Role in Tumorigenesis and Potential as Novel Therapeutic Target
A Elkhattouti, M Hassan, CR Gomez |
Frontiers in Oncology | 2015 |
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Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis in mice: HEPATOLOGY, Vol. XX, No. X, 2015
JH Tabibian, SP O'Hara, CE Trussoni, PS Tietz, PL Splinter, T Mounajjed, LR Hagey, NF LaRusso |
Hepatology | 2015 |
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Combined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue
H Atamna, W Atamna, G Al-Eyd, G Shanower, JM Dhahbi |
Redox Biology | 2015 |
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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
C Kang, Q Xu, TD Martin, MZ Li, M Demaria, L Aron, T Lu, BA Yankner, J Campisi, SJ Elledge |
Science | 2015 |
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Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold
MS Goligorsky |
Kidney Research and Clinical Practice | 2015 |
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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
N Herranz, S Gallage, M Mellone, T Wuestefeld, S Klotz, CJ Hanley, S Raguz, JC Acosta, AJ Innes, A Banito, A Georgilis, A Montoya, K Wolter, G Dharmalingam, P Faull, T Carroll, JP Martínez-Barbera, P Cutillas, F Reisinger, M Heikenwalder, RA Miller, D Withers, L Zender, GJ Thomas, J Gil |
Nature Cell Biology | 2015 |
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Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society
J Nikolich-Žugich, DP Goldman, PR Cohen, D Cortese, L Fontana, BK Kennedy, MJ Mohler, SJ Olshansky, T Perls, D Perry, A Richardson, C Ritchie, AM Wertheimer, RG Faragher, MJ Fain |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2015 |
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Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence
R Matsumoto, H Fukuoka, G Iguchi, Y Odake, K Yoshida, H Bando, K Suda, H Nishizawa, M Takahashi, S Yamada, W Ogawa, Y Takahashi, G Saretzki |
PloS one | 2015 |
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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
J Chang, Y Wang, L Shao, RM Laberge, M Demaria, J Campisi, K Janakiraman, NE Sharpless, S Ding, W Feng, Y Luo, X Wang, N Aykin-Burns, K Krager, U Ponnappan, M Hauer-Jensen, A Meng, D Zhou |
Nature Medicine | 2015 |
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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
M Xu, T Tchkonia, H Ding, M Ogrodnik, ER Lubbers, T Pirtskhalava, TA White, KO Johnson, MB Stout, V Mezera, N Giorgadze, MD Jensen, NK LeBrasseur, JL Kirkland |
Proceedings of the National Academy of Sciences | 2015 |
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Systems medicine of inflammaging
GC Castellani, G Menichetti, P Garagnani, MG Bacalini, C Pirazzini, C Franceschi, S Collino, C Sala, D Remondini, E Giampieri, E Mosca, M Bersanelli, S Vitali, IF Valle, P Liò, L Milanesi |
Briefings in Bioinformatics | 2015 |
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Cell aging and kidney repair
N Susnik, A Melk, R Schmitt |
Cell cycle (Georgetown, Tex.) | 2015 |
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Cell Therapy Strategies to Combat Immunosenescence
EC Stahl, BN Brown |
Organogenesis | 2015 |
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Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program
M Ferrand, O Kirsh, A Griveau, D Vindrieux, N Martin, PA Defossez, D Bernard |
Aging | 2015 |
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Chitosan Treatment Delays the Induction of Senescence in Human Foreskin Fibroblast Strains
CW Tsai, YT Kao, IN Chiang, JH Wang, TH Young, G Saretzki |
PloS one | 2015 |
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The Economic Promise of Delayed Aging
D Goldman |
Cold Spring Harbor Perspectives in Medicine | 2015 |
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The intrinsic stiffness of human trabecular meshwork cells increases with senescence.
Morgan JT, Raghunathan VK, Chang YR, Murphy CJ, Russell P |
Oncotarget | 2015 |
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The p53/miR-17/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells
Liu W, Qi M, Konermann A, Zhang L, Jin F, Jin Y |
Aging | 2015 |
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DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging.
Olivieri F, Albertini MC, Orciani M, Ceka A, Cricca M, Procopio AD, Bonafè M |
Oncotarget | 2015 |
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Senescence associated Sin3B promotes inflammation and pancreatic cancer progression
Maite Rielland, David Cantor, Richard Graveline, Cristina Hajdu, Lisa Mara, Beatriz De Diego Diaz, George Miller, Gregory David |
Journal of Clinical Investigation | 2014 |
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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
D Jurk, C Wilson, JF Passos, F Oakley, C Correia-Melo, L Greaves, G Saretzki, C Fox, C Lawless, R Anderson, G Hewitt, SL Pender, N Fullard, G Nelson, J Mann, B de Sluis, DA Mann, T Zglinicki |
Nature Communications | 2014 |
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Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
G Canaud, JV Bonventre |
Nephrology Dialysis Transplantation | 2014 |
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Macroautophagy and the Oncogene-Induced Senescence
D Grasso, MI Vaccaro |
Frontiers in Endocrinology | 2014 |
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The role of senescent cells in ageing
JM van Deursen |
Nature | 2014 |
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Defining the toxicology of aging
JA Sorrentino, HK Sanoff, NE Sharpless |
Trends in Molecular Medicine | 2014 |
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Age-Related Impairment of Pancreatic Beta-Cell Function: Pathophysiological and Cellular Mechanisms
VD Tata |
Frontiers in Endocrinology | 2014 |
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Clinical strategies and animal models for developing senolytic agents
JL Kirkland, T Tchkonia |
Experimental Gerontology | 2014 |
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Role of Cellular Senescence and NOX4-Mediated Oxidative Stress in Systemic Sclerosis Pathogenesis
S Piera-Velazquez, SA Jimenez |
Current Rheumatology Reports | 2014 |
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Advances in Immunology
A Marcus, BG Gowen, TW Thompson, A Iannello, M Ardolino, W Deng, L Wang, N Shifrin, DH Raulet |
Advances in immunology | 2014 |
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Koschei the immortal and anti-aging drugs
MV Blagosklonny |
Cell Death and Disease | 2014 |
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The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis
M Kuwahara, J Suzuki, S Tofukuji, T Yamada, M Kanoh, A Matsumoto, S Maruyama, K Kometani, T Kurosaki, O Ohara, T Nakayama, M Yamashita |
Nature Communications | 2014 |
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Senescence and apoptosis: dueling or complementary cell fates?
BG Childs, DJ Baker, JL Kirkland, J Campisi, JM van Deursen |
EMBO reports | 2014 |
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Adult Stem Cells and Diseases of Aging
L Boyette, R Tuan |
Journal of Clinical Medicine | 2014 |
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Oncogene-induced senescence as a new mechanism of disease: the paradigm of erdheim-chester disease
G Cavalli, R Biavasco, B Borgiani, L Dagna |
Frontiers in immunology | 2014 |
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Trial Watch: Radioimmunotherapy for oncological indications
N Bloy, J Pol, G Manic, I Vitale, A Eggermont, J Galon, E Tartour, L Zitvogel, G Kroemer, L Galluzzi |
OncoImmunology | 2014 |
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Effect of aging on microRNAs and regulation of pathogen recognition receptors
F Olivieri, AD Procopio, RR Montgomery |
Current Opinion in Immunology | 2014 |
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Better immunity in later life: a position paper
R Faragher, D Frasca, E Remarque, G Pawelec |
AGE | 2014 |
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Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model: Senescence Abrogates hMSCs Therapeutic Potential
JC Sepúlveda, M Tomé, ME Fernández, M Delgado, J Campisi, A Bernad, MA González |
Stem Cells | 2014 |
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Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program
OV Leontieva, ZN Demidenko, MV Blagosklonny |
Proceedings of the National Academy of Sciences | 2014 |
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Metabolic Consequences of HIV: Pathogenic Insights
AL Willig, ET Overton |
Current HIV/AIDS Reports | 2014 |
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Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies
JH Tabibian, SP O’Hara, KD Lindor |
Scandinavian Journal of Gastroenterology | 2014 |
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Cellular senescence and aging: the role of B-MYB
SN Mowla, EW Lam, PS Jat |
Aging Cell | 2014 |
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Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain
S Dassati, A Waldner, R Schweigreiter |
Neurobiology of Aging | 2014 |
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Proteomic Revelations
JM Davidson |
Journal of Investigative Dermatology | 2014 |
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Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions
PD Pezze, G Nelson, EG Otten, VI Korolchuk, TB Kirkwood, T Zglinicki, DP Shanley |
PLoS computational biology | 2014 |
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Shorter Ends, Faster End? Leukocyte Telomere Length and Mortality Among Older Taiwanese
DA Glei, N Goldman, M Weinstein, RA Risques |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2014 |
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Top 10 cardiovascular therapies and interventions for the next decade
V Fuster |
Nature Reviews Cardiology | 2014 |
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Are there roles for brain cell senescence in aging and neurodegenerative disorders?
FC Tan, ER Hutchison, E Eitan, MP Mattson |
Biogerontology | 2014 |
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Geroconversion: irreversible step to cellular senescence
MV Blagosklonny |
Cell cycle (Georgetown, Tex.) | 2014 |
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Frailty in childhood cancer survivors: Frailty in Childhood Cancer Survivors
KK Ness, GT Armstrong, M Kundu, CL Wilson, T Tchkonia, JL Kirkland |
Cancer | 2014 |
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Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis
M Sadagurski, T Landeryou, M Blandino-Rosano, G Cady, L Elghazi, D Meister, L See, A Bartke, E Bernal-Mizrachi, RA Miller |
American journal of physiology. Endocrinology and metabolism | 2014 |
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Innovating Aging: Promises and Pitfalls on the Road to Life Extension
J Vijg, AD de Grey |
Gerontology | 2014 |
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Targets of Immune Regeneration in Rheumatoid Arthritis
PJ Hohensinner, JJ Goronzy, CM Weyand |
Mayo Clinic Proceedings | 2014 |
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Senescent stroma promotes prostate cancer progression: The role of miR-210
ML Taddei, L Cavallini, G Comito, E Giannoni, M Folini, A Marini, P Gandellini, A Morandi, G Pintus, MR Raspollini, N Zaffaroni, P Chiarugi |
Molecular Oncology | 2014 |
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Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion
Leontieva OV, Blagosklonny MV |
Oncotarget | 2014 |
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Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells
Tsuchihashi NA, Hayashi K, Dan K, Goto F, Nomura Y, Fujioka M, Kanzaki S, Komune S, Ogawa K |
Oncotarget | 2014 |
|
Coming of age: molecular drivers of aging and therapeutic opportunities
Christopher Newgard, Norman Sharpless |
Journal of Clinical Investigation | 2013 |
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p53 isoforms regulate aging- and tumor-associated T lymphocyte replicative senescence
Abdul Mondal, Izumi Horikawa, Sharon Pine, Kaori Fujita, Katherine Morgan, Elsa Vera, Sharlyn Mazur, Ettore Appella, Borivoj Vojtesek, Maria Blasco, David Lane, Curtis Craig Harris |
Journal of Clinical Investigation | 2013 |
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Telomeres and age-related disease: how telomere biology informs clinical paradigms
Mary Armanios |
Journal of Clinical Investigation | 2013 |
|
Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
Z Yang, H Fujii, SV Mohan, JJ Goronzy, CM Weyand |
Journal of Experimental Medicine | 2013 |
|
TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists
MV Blagosklonny |
Cell Death and Disease | 2013 |
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Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53
G Despars, CL Carbonneau, P Bardeau, DL Coutu, CM Beauséjour |
PloS one | 2013 |
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The Molecular Balancing Act of p16INK4a in Cancer and Aging
KM LaPak, CE Burd |
Molecular cancer research : MCR | 2013 |
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Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling
J Piao, K Tsuji, H Ochi, M Iwata, D Koga, A Okawa, S Morita, S Takeda, Y Asou |
Scientific Reports | 2013 |
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Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis
A Macià, M Vaquero, M Gou-Fàbregas, E Castelblanco, JM Valdivielso, C Anerillas, D Mauricio, X Matias-Guiu, J Ribera, M Encinas |
Cell Death and Differentiation | 2013 |
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Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
SN Mowla, ND Perkins, PS Jat |
OncoTargets and therapy | 2013 |
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Age-Associated Defects in EphA2 Signaling Impair the Migration of Human Cardiac Progenitor Cells
P Goichberg, R Kannappan, M Cimini, Y Bai, F Sanada, A Sorrentino, S Signore, J Kajstura, M Rota, P Anversa, A Leri |
Circulation | 2013 |
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Cell and gene therapy for severe heart failure patients: The time and place for Pim-1 kinase
S Siddiqi, MA Sussman |
Expert Review of Cardiovascular Therapy | 2013 |
|
Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects
CN Sprung, A Ivashkevich, HB Forrester, CE Redon, A Georgakilas, OA Martin |
Cancer Letters | 2013 |
|
Immunosuppressants in cancer prevention and therapy
MV Blagosklonny |
OncoImmunology | 2013 |
|
Rapamycin induces pluripotent genes associated with avoidance of replicative senescence
TV Pospelova, TV Bykova, SG Zubova, NV Katolikova, NM Yartzeva, VA Pospelov |
Cell cycle (Georgetown, Tex.) | 2013 |
|
Do telomeres adapt to physiological stress? Exploring the effect of exercise on telomere length and telomere-related proteins
AT Ludlow, LW Ludlow, SM Roth |
BioMed Research International | 2013 |
|
A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells
Y Mistry, T Poolman, B Williams, KE Herbert |
Redox Biology | 2013 |
|
Death by transposition - the enemy within?
JM Sedivy, JA Kreiling, N Neretti, MD Cecco, SW Criscione, JW Hofmann, X Zhao, T Ito, AL Peterson |
BioEssays : news and reviews in molecular, cellular and developmental biology | 2013 |
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Mechanisms of radiation toxicity in transformed and non-transformed cells
RA Panganiban, AL Snow, RM Day |
International journal of molecular sciences | 2013 |
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NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
CR Balistreri, G Candore, G Accardi, G Colonna-Romano, D Lio |
Immunity & Ageing | 2013 |
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Loss of Arp2/3 induces an NF-κB–dependent, nonautonomous effect on chemotactic signaling
C Wu, EM Haynes, SB Asokan, JM Simon, NE Sharpless, AS Baldwin, IJ Davis, GL Johnson, JE Bear |
The Journal of Cell Biology | 2013 |
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Trial Watch
E Vacchelli, I Vitale, E Tartour, A Eggermont, C Sautès-Fridman, J Galon, L Zitvogel, G Kroemer, L Galluzzi |
OncoImmunology | 2013 |
|
Immune Surveillance of Unhealthy Cells by Natural Killer Cells
A Iannello, DH Raulet |
Cold Spring Harbor Symposia on Quantitative Biology | 2013 |
|
Are Short Telomeres Predictive of Advanced Cancer?
JW Shay |
Cancer Discovery | 2013 |
|
Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research
DP Goldman, D Cutler, JW Rowe, PC Michaud, J Sullivan, D Peneva, SJ Olshansky |
Health Affairs | 2013 |
|
eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies
Rajesh K, Papadakis AI, Kazimierczak U, Peidis P, Wang S, Ferbeyre G, Kaufman RJ, Koromilas AE |
Aging | 2013 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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