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Citations to this article

Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice
Shaw-Fang Yet, … , Stella Kourembanas, Mu-En Lee
Shaw-Fang Yet, … , Stella Kourembanas, Mu-En Lee
Published April 15, 1999
Citation Information: J Clin Invest. 1999;103(8):R23-R29. https://doi.org/10.1172/JCI6163.
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Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice

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Abstract

Heme oxygenase (HO) catalyzes the oxidation of heme to generate carbon monoxide (CO) and bilirubin. CO increases cellular levels of cGMP, which regulates vascular tone and smooth muscle development. Bilirubin is a potent antioxidant. Hypoxia increases expression of the inducible HO isoform (HO-1) but not the constitutive isoform (HO-2). To determine whether HO-1 affects cellular adaptation to chronic hypoxia in vivo, we generated HO-1 null (HO-1–/–) mice and subjected them to hypoxia (10% oxygen) for five to seven weeks. Hypoxia caused similar increases in right ventricular systolic pressure in wild-type and HO-1–/– mice. Although ventricular weight increased in wild-type mice, the increase was greater in HO-1–/– mice. Similarly, the right ventricles were more dilated in HO-1–/– mice. After seven weeks of hypoxia, only HO-1–/– mice developed right ventricular infarcts with organized mural thrombi. No left ventricular infarcts were observed. Lipid peroxidation and oxidative damage occurred in right ventricular cardiomyocytes in HO-1–/–, but not wild-type, mice. We also detected apoptotic cardiomyocytes surrounding areas of infarcted myocardium by terminal deoxynucleotide transferase–mediated dUTP nick end-labeling (TUNEL) assays. Our data suggest that in the absence of HO-1, cardiomyocytes have a maladaptive response to hypoxia and subsequent pulmonary hypertension.

Authors

Shaw-Fang Yet, Mark A. Perrella, Matthew D. Layne, Chung-Ming Hsieh, Koji Maemura, Lester Kobzik, Philippe Wiesel, Helen Christou, Stella Kourembanas, Mu-En Lee

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 Total
Citations: 6 4 2 9 9 7 7 7 16 12 16 11 16 24 30 28 24 16 19 18 12 18 17 19 16 2 365
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2023 (4)

Title and authors Publication Year
Altered Expression of Heme Oxygenase 2 in Heme Oxygenase 1-deficient Mouse Embryos.
Rana M, Bajaj D, Choubey P, Jain S, Basu-Modak S
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2023
Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia
Li X, Lozovatsky L, Tommasini SM, Fretz J, Finberg KE
Blood Advances 2023
Unleashing the Potential of Nrf2: A Novel Therapeutic Target for Pulmonary Vascular Remodeling
Fang Q, Bai Y, Hu S, Ding J, Liu L, Dai M, Qiu J, Wu L, Rao X, Wang Y
Antioxidants 2023
Nanomedicine‐Based Therapeutics for Myocardial Ischemic/Reperfusion Injury
Li X, Ou W, Xie M, Yang J, Li Q, Li T
Advanced Healthcare Materials 2023

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