Heme oxygenase (HO) catalyzes the oxidation of heme to generate carbon monoxide (CO) and bilirubin. CO increases cellular levels of cGMP, which regulates vascular tone and smooth muscle development. Bilirubin is a potent antioxidant. Hypoxia increases expression of the inducible HO isoform (HO-1) but not the constitutive isoform (HO-2). To determine whether HO-1 affects cellular adaptation to chronic hypoxia in vivo, we generated HO-1 null (HO-1–/–) mice and subjected them to hypoxia (10% oxygen) for five to seven weeks. Hypoxia caused similar increases in right ventricular systolic pressure in wild-type and HO-1–/– mice. Although ventricular weight increased in wild-type mice, the increase was greater in HO-1–/– mice. Similarly, the right ventricles were more dilated in HO-1–/– mice. After seven weeks of hypoxia, only HO-1–/– mice developed right ventricular infarcts with organized mural thrombi. No left ventricular infarcts were observed. Lipid peroxidation and oxidative damage occurred in right ventricular cardiomyocytes in HO-1–/–, but not wild-type, mice. We also detected apoptotic cardiomyocytes surrounding areas of infarcted myocardium by terminal deoxynucleotide transferase–mediated dUTP nick end-labeling (TUNEL) assays. Our data suggest that in the absence of HO-1, cardiomyocytes have a maladaptive response to hypoxia and subsequent pulmonary hypertension.
Shaw-Fang Yet, Mark A. Perrella, Matthew D. Layne, Chung-Ming Hsieh, Koji Maemura, Lester Kobzik, Philippe Wiesel, Helen Christou, Stella Kourembanas, Mu-En Lee
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M Rabinovitch |
Pediatric Cardiovascular Medicine Moller/Pediatric Cardiovascular Medicine | 2012 |
Concomitant Induction of Heme Oxygenase-1 Attenuates the Cytotoxicity of Arsenic Species from Lumbricus Extract in Human Liver HepG2 Cells
H Qi, B Chen, XC Le, J Rong |
Chemistry & Biodiversity | 2012 |
Protecting the heart through delivering DNA encoding for heme oxygenase-1 into skeletal muscle
D Bilbija, J Gravning, F Haugen, H Attramadal, G Valen |
Life Sciences | 2012 |
Heme oxygenase-1 and chronic hypoxia
JA Neubauer, J Sunderram |
Respiratory Physiology & Neurobiology | 2012 |
Long-term reparative effects of mesenchymal stem cell therapy following neonatal hyperoxia-induced lung injury
RP Sutsko, KC Young, A Ribeiro, E Torres, M Rodriguez, D Hehre, C Devia, I McNiece, C Suguihara |
Pediatric Research | 2012 |
Modulation of ion channels and transporters by carbon monoxide: causes for concern?
C Peers |
Frontiers in physiology | 2012 |
A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects
J Gomez-Arroyo, SJ Saleem, S Mizuno, AA Syed, HJ Bogaard, A Abbate, L Taraseviciene-Stewart, Y Sung, D Kraskauskas, D Farkas, DH Conrad, MR Nicolls, NF Voelkel |
American journal of physiology. Lung cellular and molecular physiology | 2012 |
Crossroads between Innate and Adaptive Immunity III
B Pulendran, PD Katsikis, SP Schoenberger |
2011 | |
Crossroads between Innate and Adaptive Immunity III
B Pulendran, PD Katsikis, SP Schoenberger |
2011 | |
Crossroads between Innate and Adaptive Immunity III
B Pulendran, PD Katsikis, SP Schoenberger |
2011 | |
Crossroads between Innate and Adaptive Immunity III
B Pulendran, PD Katsikis, SP Schoenberger |
2011 | |
Crossroads between Innate and Adaptive Immunity III
B Pulendran, PD Katsikis, SP Schoenberger |
2011 | |
Comprehensive Physiology
NF Voelkel, R Natarajan, JI Drake, HJ Bogaard |
Comprehensive Physiology | 2011 |
Mesenchymal Stromal Cells Expressing Heme Oxygenase-1 Reverse Pulmonary Hypertension
OD Liang, SA Mitsialis, MS Chang, E Vergadi, C Lee, M Aslam, A Fernandez-Gonzalez, X Liu, R Baveja, S Kourembanas |
Stem Cells | 2011 |
Heme Oxygenase in the Regulation of Vascular Biology: From Molecular Mechanisms to Therapeutic Opportunities
YM Kim, HO Pae, JE Park, YC Lee, JM Woo, NH Kim, YK Choi, BS Lee, SR Kim, HT Chung |
Antioxidants & Redox Signaling | 2011 |
Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases
Y Naito, T Takagi, K Uchiyama, T Yoshikawa |
Journal of Clinical Biochemistry and Nutrition | 2011 |
Bradykinin and the Heart: Left, Right, or Both?
T Lahm |
Journal of Surgical Research | 2011 |
A Central Role of Heme Oxygenase-1 in Cardiovascular Protection
ML Wu, YC Ho, SF Yet |
Antioxidants & Redox Signaling | 2011 |
Sickle Hemoglobin Confers Tolerance to Plasmodium Infection
A Ferreira, I Marguti, I Bechmann, V Jeney, Â Chora, NR Palha, S Rebelo, A Henri, Y Beuzard, MP Soares |
Cell | 2011 |
Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer
T Simon, I Anegon, P Blancou |
Immunotherapy | 2011 |
Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat
D Shukla, S Saxena, J Purushothaman, K Shrivastava, M Singh, S Shukla, VK Malhotra, S Mustoori, A Bansal |
European Journal of Pharmacology | 2011 |
Heme Oxygenase-1 Does Not Mediate the Effects of Extracellular Acidosis on Vascular Smooth Muscle Cell Proliferation, Migration, and Susceptibility to Apoptosis
L Brenninkmeijer, C Kuehl, AM Geldart, E Arons, H Christou |
Journal of Vascular Research | 2011 |
Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide
ML Zenclussen, PA Casalis, T El-Mousleh, S Rebelo, S Langwisch, N Linzke, HD Volk, S Fest, MP Soares, AC Zenclussen |
The Journal of Pathology | 2011 |
Different Patterns of Adaptation of the Right Ventricle to Pressure Overload: A Comparison between Pulmonary Hypertension and Pulmonary Stenosis
R Jurcut, S Giusca, R Ticulescu, E Popa, MS Amzulescu, I Ghiorghiu, IM Coman, BA Popescu, JU Voigt, C Ginghina |
Journal of the American Society of Echocardiography | 2011 |
Heme Oxygenase-1 Inhibition Prevents Intimal Hyperplasia Enhancing Nitric Oxide-Dependent Apoptosis of Vascular Smooth Muscle Cells
MG Cerrito, A Scagliarini, A Froio, A Liloia, M Busnelli, R Giovannoni, LE Otterbein, L Mainetti, M Villa, FH Bach, BE Leone, GM Biasi, M Lavitrano |
Biological & Pharmaceutical Bulletin | 2011 |
Carbon monoxide: A vital signalling molecule and potent toxin in the myocardium
C Peers, DS Steele |
Journal of Molecular and Cellular Cardiology | 2011 |
Preconditioning effect of cobalt chloride supplementation on hypoxia induced oxidative stress in male albino rats
P Thomas, A Bansal, M Singh, D Shukla, S Saxena |
Biomedicine & Preventive Nutrition | 2011 |
Exacerbation of Oxidative Stress-Induced Cell Death and Differentiation in Induced Pluripotent Stem Cells Lacking Heme Oxygenase-1
CY Lin, CY Peng, TT Huang, ML Wu, YL Lai, DH Peng, PF Chen, HF Chen, BL Yen, KK Wu, SF Yet |
Stem Cells and Development | 2011 |
An Interesting Tetrad of Asplenia, Inflammation, Hemolysis, and Nephritis
N Radhakrishnan, SP Yadav, A Sachdeva, T Wada, A Yachie |
Pediatric Hematology-Oncology | 2011 |
Heme oxygenase-1 in inflammation and cardiovascular disease
ML Wu, YC Ho, CY Lin, SF Yet |
American Journal of Cardiovascular Disease | 2011 |
Early Macrophage Recruitment and Alternative Activation Are Critical for the Later Development of Hypoxia-Induced Pulmonary Hypertension
E Vergadi, MS Chang, C Lee, OD Liang, X Liu, A Fernandez-Gonzalez, SA Mitsialis, S Kourembanas |
Circulation | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2010 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2010 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2010 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2010 |
Altered expression of the natriuretic peptide system in genetically modified heme oxygenase-1 mice treated with high dietary salt
DW Armstrong, MY Tse, LG Melo, SC Pang |
Molecular and Cellular Biochemistry | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Suppression and Regulation of Immune Responses
MC Cuturi, I Anegon |
Suppression and Regulation of Immune Responses | 2010 |
Sex Hormones and Vascular Protection in Pulmonary Arterial Hypertension
HA Christou, RA Khalil |
Journal of Cardiovascular Pharmacology | 2010 |
Heme Oxygenase-1 Deficiency Leads to Alteration of Soluble Guanylate Cyclase Redox Regulation
AW Jones, W Durante, RJ Korthuis |
The Journal of pharmacology and experimental therapeutics | 2010 |
A Central Role for Free Heme in the Pathogenesis of Severe Sepsis
R Larsen, R Gozzelino, V Jeney, L Tokaji, FA Bozza, AM Japiassu, D Bonaparte, MM Cavalcante, A Chora, A Ferreira, I Marguti, S Cardoso, N Sepulveda, A Smith, MP Soares |
Science Translational Medicine | 2010 |
Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBPalpha to increase expression
CC Hung, X Liu, MY Kwon, YH Kang, SW Chung, MA Perrella |
American journal of physiology. Lung cellular and molecular physiology | 2010 |
Mechanisms of Cell Protection by Heme Oxygenase-1
R Gozzelino, V Jeney, MP Soares |
Annual Review of Pharmacology and Toxicology | 2010 |
Regulation of Vulnerable Plaque Development by the Heme Oxygenase/Carbon Monoxide System
K Larsen, C Cheng, HJ Duckers |
Trends in Cardiovascular Medicine | 2010 |
Redox Control in Mammalian Embryo Development
C Ufer, CC Wang, A Borchert, D Heydeck, H Kuhn |
Antioxidants & Redox Signaling | 2010 |
Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1
H Qi, SO Siu, Y Chen, Y Han, IK Chu, Y Tong, AS Lau, J Rong |
Chemico-Biological Interactions | 2010 |
Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1—evidence for direct and indirect antioxidant actions of bilirubin
T Jansen, M Hortmann, M Oelze, B Opitz, S Steven, R Schell, M Knorr, S Karbach, S Schuhmacher, P Wenzel, T Münzel, A Daiber |
Journal of Molecular and Cellular Cardiology | 2010 |
Targeting Heme Oxygenase-1 in Vascular Disease
W Durante |
Current drug targets | 2010 |
Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBPα to increase expression
CC Hung, X Liu, MY Kwon, YH Kang, SW Chung, MA Perrella |
American journal of physiology. Lung cellular and molecular physiology | 2010 |
Textbook of Pulmonary Vascular Disease
, JG Garcia, JB West, CA Hales, S Rich, SL Archer |
2010 | |
Neprilysin Null Mice Develop Exaggerated Pulmonary Vascular Remodeling in Response to Chronic Hypoxia
EC Dempsey, MJ Wick, V Karoor, EJ Barr, DW Tallman, CA Wehling, SJ Walchak, S Laudi, M Le, M Oka, S Majka, CD Cool, KA Fagan, DJ Klemm, LB Hersh, NP Gerard, C Gerard, YE Miller |
The American Journal of Pathology | 2009 |
Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia
SH Vitali, SA Mitsialis, OD Liang, X Liu, A Fernandez-Gonzalez, H Christou, X Wu, FX McGowan, S Kourembanas |
PloS one | 2009 |
The Right Ventricle Under Pressure
HJ Bogaard, K Abe, AV Noordegraaf, NF Voelkel |
Chest | 2009 |
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers |
2009 | |
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers |
2009 | |
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers |
2009 | |
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers |
2009 | |
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers |
2009 | |
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers |
2009 | |
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers |
2009 | |
Heme oxygenase-1: from biology to therapeutic potential
MP Soares, FH Bach |
Trends in Molecular Medicine | 2009 |
Induction of heme oxygenase-1 in factor VIII-deficient mice reduces the immune response to therapeutic factor VIII
JD Dimitrov, S Dasgupta, AM Navarrete, S Delignat, Y Repesse, Y Meslier, C Planchais, M Teyssandier, R Motterlini, J Bayry, SV Kaveri, S Lacroix-Desmazes |
Blood | 2009 |
Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells
H Matsushima, H Tanaka, N Mizumoto, A Takashima |
Blood | 2009 |
Heme oxygenase-1 affords protection against noncerebral forms of severe malaria
E Seixas, R Gozzelino, A Chora, A Ferreira, G Silva, R Larsen, S Rebelo, C Penido, NR Smith, A Coutinho, MP Soares |
Proceedings of the National Academy of Sciences | 2009 |
Role of haem oxygenase-1 in microbial host defence
SW Chung, SR Hall, MA Perrella |
Cellular Microbiology | 2009 |
Carbon Monoxide Rescues Heme Oxygenase-1-Deficient Mice from Arterial Thrombosis in Allogeneic Aortic Transplantation
B Chen, L Guo, C Fan, S Bolisetty, R Joseph, MM Wright, A Agarwal, JF George |
The American Journal of Pathology | 2009 |
Targeting Heme Oxygenase
SJ Peterson, WH Frishman |
Cardiology in Review | 2009 |
Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy
SW Ryter, AM Choi |
American journal of respiratory cell and molecular biology | 2009 |
Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats
HH Hsu, WJ Ko, JY Hsu, JS Chen, YC Lee, IR Lai, CF Chen |
Respiratory Research | 2009 |
Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: implications for multiple sclerosis
A Bishop, KG Hobbs, A Eguchi, S Jeffrey, L Smallwood, C Pennie, J Anderson, AG Estévez |
Journal of Neurochemistry | 2009 |
Mitigation of peroxynitrite-mediated nitric oxide (NO) toxicity as a mechanism of induced adaptive NO resistance in the CNS
A Bishop, R Gooch, A Eguchi, S Jeffrey, L Smallwood, J Anderson, AG Estevez |
Journal of Neurochemistry | 2009 |
Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor
M Nomoto, M Miyata, S Yin, Y Kurata, M Shimada, K Yoshinari, FJ Gonzalez, K Suzuki, S Shibasaki, T Kurosawa, Y Yamazoe |
Biological & Pharmaceutical Bulletin | 2009 |
NS398 protects cells from sodium nitroprusside-mediated cytotoxicity through enhancing HO-1 induction independent of COX-2 inhibition
IT Nizamutdinova, JH Lee, HG Seo, KC Chang, HJ Kim |
Archives of Pharmacal Research | 2009 |
Bile Acid-Induced Elevated Oxidative Stress in the Absence of Farnesoid X Receptor
M Nomoto, M Miyata, S Yin, Y Kurata, M Shimada, K Yoshinari, FJ Gonzalez, K Suzuki, S Shibasaki, T Kurosawa, Y Yamazoe |
Biological & Pharmaceutical Bulletin | 2009 |
A role for regulatory T cells in renal acute kidney injury
RM Monteiro, NO Camara, MM Rodrigues, F Tzelepis, MJ Damião, MA Cenedeze, VP Teixeira, MA Reis, A Pacheco-Silva |
Transplant Immunology | 2009 |
Protective Effects of a Heme Oxygenase-1-Secreting Lactococcus lactis on Mucosal Injury Induced by Hemorrhagic Shock in Rats
Q Pang, Y Ji, LG Bermúdez-Humarán, Q Zhou, G Hu, Y Zeng |
Journal of Surgical Research | 2009 |
Heme oxygenase-1-dependent central cardiorespiratory adaptations to chronic hypoxia in mice
J Sunderram, J Semmlow, S Thakker-Varia, M Bhaumik, O Hoang-Le, JA Neubauer |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2009 |
Gene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by Upregulating Heme Oxygenase-1 Via a Nuclear Factor-κB-Dependent Pathway
Q Li, Y Guo, Q Ou, C Cui, WJ Wu, W Tan, X Zhu, LB Lanceta, SK Sanganalmath, B Dawn, K Shinmura, GD Rokosh, S Wang, R Bolli |
Circulation | 2009 |
Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells
LE Fredenburgh, OD Liang, AA Macias, TR Polte, X Liu, DF Riascos, SW Chung, SL Schissel, DE Ingber, SA Mitsialis, S Kourembanas, MA Perrella |
Circulation | 2008 |
Pharmacological and Clinical Aspects of Heme Oxygenase
NG Abraham, A Kappas |
Pharmacological reviews | 2008 |
Pathogenic mechanisms of pulmonary arterial hypertension
SY Chan, J Loscalzo |
Journal of Molecular and Cellular Cardiology | 2008 |
Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress
DK Kaul, X Zhang, T Dasgupta, ME Fabry |
American journal of physiology. Heart and circulatory physiology | 2008 |
Hemoxygenase-1 in Cardiovascular Disease
NK Idriss, AD Blann, GY Lip |
Journal of the American College of Cardiology | 2008 |
Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2
DW Lin, IC Chang, A Tseng, ML Wu, CH Chen, CA Patenaude, MD Layne, SF Yet |
The Journal of biological chemistry | 2008 |
Bradykinin [corrected] B1 receptor antagonism is beneficial in renal ischemia-reperfusion injury
PH Wang, G Campanholle, MA Cenedeze, CQ Feitoza, GM Gonçalves, RG Landgraf, S Jancar, JB Pesquero, A Pacheco-Silva, NO Câmara |
PloS one | 2008 |
High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice
R Takamiya, CC Hung, SR Hall, K Fukunaga, T Nagaishi, T Maeno, C Owen, AA Macias, LE Fredenburgh, A Ishizaka, RS Blumberg, RM Baron, MA Perrella |
American journal of respiratory cell and molecular biology | 2008 |
Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection
MU Shiloh, P Manzanillo, JS Cox |
Cell Host & Microbe | 2008 |
Heme Oxygenase-1 and the Vascular Bed: From Molecular Mechanisms to Therapeutic Opportunities
A Loboda, A Jazwa, A Grochot-Przeczek, AJ Rutkowski, J Cisowski, A Agarwal, A Jozkowicz, J Dulak |
Antioxidants & Redox Signaling | 2008 |
Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin
AR Kinderlerer, IP Gregoire, SS Hamdulay, F Ali, R Steinberg, G Silva, N Ali, B Wang, DO Haskard, MP Soares, JC Mason |
Blood | 2008 |
Association betweenHMOX-1genotype and cardiac function during exercise
Z He, Y Hu, L Feng, Y Lu, D Bao, Y Xi, L Wen, A Lucia |
Applied Physiology, Nutrition, and Metabolism | 2008 |
Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1
HH Lin, YH Chen, PF Chang, YT Lee, SF Yet, LY Chau |
Journal of Molecular and Cellular Cardiology | 2008 |
Heme Oxygenase-1 Is an Anti-Inflammatory Host Factor that Promotes Murine Plasmodium Liver Infection
S Epiphanio, SA Mikolajczak, LA Gonçalves, A Pamplona, S Portugal, S Albuquerque, M Goldberg, S Rebelo, DG Anderson, A Akinc, HP Vornlocher, SH Kappe, MP Soares, MM Mota |
Cell Host & Microbe | 2008 |
Intragastric administration with recombinant Lactococcus lactis producing heme oxygenase-1 prevents lipopolysaccharide-induced endotoxemia in rats
Q Pang, Y Ji, Y Li, LG Bermúdez-Humarán, G Hu, Y Zeng |
FEMS Microbiology Letters | 2008 |
Ischemia-Induced Up-Regulation of Heme Oxygenase-1 Protects From Apoptotic Cell Death and Tissue Necrosis
Y Harder, M Amon, R Schramm, M Rücker, C Scheuer, B Pittet, D Erni, MD Menger |
Journal of Surgical Research | 2008 |
Carbon Monoxide Inhibits L-type Ca2+ Channels via Redox Modulation of Key Cysteine Residues by Mitochondrial Reactive Oxygen Species*
JL Scragg, ML Dallas, JA Wilkinson, G Varadi, C Peers |
The Journal of biological chemistry | 2008 |
Carbon monoxide poisoning, or carbon monoxide protection?
RL Owens, S Yim-Yeh, A Malhotra |
Chest | 2008 |
Brabykinin B1 Receptor Antagonism Is Beneficial in Renal Ischemia-Reperfusion Injury
PH Wang, G Campanholle, MA Cenedeze, CQ Feitoza, GM Gonçalves, RG Landgraf, S Jancar, JB Pesquero, A Pacheco-Silva, NO Câmara, P Bozza |
PloS one | 2008 |
Carbon Monoxide Inhibits L-type Ca 2+ Channels via Redox Modulation of Key Cysteine Residues by Mitochondrial Reactive Oxygen Species
JL Scragg, ML Dallas, JA Wilkinson, G Varadi, C Peers |
The Journal of biological chemistry | 2008 |
Transforming Growth Factor β Up-regulates Cysteine-rich Protein 2 in Vascular Smooth Muscle Cells via Activating Transcription Factor 2
DW Lin, IC Chang, A Tseng, ML Wu, CH Chen, CA Patenaude, MD Layne, SF Yet |
The Journal of biological chemistry | 2008 |
Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress
DK Kaul, X Zhang, T Dasgupta, ME Fabry |
American journal of physiology. Heart and circulatory physiology | 2008 |
Role of quercetin in modulating rat cardiomyocyte gene expression profile
C Angeloni, E Leoncini, M Malaguti, S Angelini, P Hrelia, S Hrelia |
American journal of physiology. Heart and circulatory physiology | 2008 |
Science and Practice of Pediatric Critical Care Medicine
DS Wheeler, HR Wong, TP Shanley |
2008 | |
Heme Oxygenase-1 and Carbon Monoxide Suppress Autoimmune Neuroinflammation
Ângelo A. Chora, Paulo Fontoura, Andreia Cunha, Teresa F. Pais, Sílvia Cardoso, Peggy P Ho, Lowen Y Lee, Raymond A. Sobel, Lawrence Steinman and Miguel P. Soares |
Journal of Clinical Investigation | 2007 |
Heme Oxygenase-1–derived Carbon Monoxide Enhances the Host Defense Response to Microbial Sepsis
Su Wol Chung, Xiaoli Liu, Alvaro A. Macias, Rebecca M. Baron, and Mark A. Perrella |
Journal of Clinical Investigation | 2007 |
CARBON MONOXIDE INHALATION RESCUES MICE FROM FULMINANT HEPATITIS THROUGH IMPROVING HEPATIC ENERGY METABOLISM
TY Tsui, A Obed, YT Siu, SF Yet, L Prantl, HJ Schlitt, ST Fan |
Shock | 2007 |
Mechanisms of Cell Death in Oxidative Stress
SW Ryter, HP Kim, A Hoetzel, JW Park, K Nakahira, X Wang, AM Choi |
Antioxidants & Redox Signaling | 2007 |
Heme Oxygenase-1 Inhibits the Expression of Adhesion Molecules Associated with Endothelial Cell Activation via Inhibition of NF-κB RelA Phosphorylation at Serine 276
MP Seldon, G Silva, N Pejanovic, R Larsen, IP Gregoire, J Filipe, J Anrather, MP Soares |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
Pathobiology of Pulmonary Hypertension
M Rabinovitch |
Annual Review of Pathology: Mechanisms of Disease | 2007 |
Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway
AS Pachori, A Smith, P McDonald, L Zhang, VJ Dzau, LG Melo |
Journal of Molecular and Cellular Cardiology | 2007 |
Astrocyte-specific heme oxygenase-1 hyperexpression attenuates heme-mediated oxidative injury
L Benvenisti-Zarom, RF Regan |
Neurobiology of Disease | 2007 |
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
A Pamplona, A Ferreira, J Balla, V Jeney, G Balla, S Epiphanio, Â Chora, CD Rodrigues, IP Gregoire, M Cunha-Rodrigues, S Portugal, MP Soares, MM Mota |
Nature Medicine | 2007 |
Beck and back: A paradigm change in coronary sinus interventions—pulsatile stretch on intact coronary venous endothelium
G Weigel, I Kajgana, H Bergmeister, G Riedl, HD Glogar, M Gyöngyösi, S Blasnig, G Heinze, W Mohl |
The Journal of Thoracic and Cardiovascular Surgery | 2007 |
Human heme oxygenase-1 deficiency: A lesson on serendipity in the discovery of the novel disease
S Koizumi |
Pediatrics International | 2007 |
Therapeutic Applications of Bilirubin and Biliverdin in Transplantation
R Öllinger, H Wang, K Yamashita, B Wegiel, M Thomas, R Margreiter, FH Bach |
Antioxidants & Redox Signaling | 2007 |
Post-Genomic Cardiology
J Marín-García, MJ Goldenthal, GW Moe |
Post-Genomic Cardiology | 2007 |
Protective Functions of Heme Oxygenase-1 and Carbon Monoxide in the Respiratory System
SW Ryter, HP Kim, K Nakahira, BS Zuckerbraun, D Morse, AM Choi |
Antioxidants & Redox Signaling | 2007 |
YS 51, 1-(β-naphtylmethyl)-6,7-dihydroxy-1,2,3,4,-tetrahydroisoquinoline, protects endothelial cells against hydrogen peroxide-induced injury via carbon monoxide derived from heme oxygenase-1
JM Heo, HJ Kim, YM Ha, MK Park, YJ Kang, YS Lee, HG Seo, JH Lee, HS Yun-Choi, KC Chang |
Biochemical Pharmacology | 2007 |
Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats
A L'Abbate, D Neglia, C Vecoli, M Novelli, V Ottaviano, S Baldi, R Barsacchi, A Paolicchi, P Masiello, GS Drummond, JA McClung, NG Abraham |
American journal of physiology. Heart and circulatory physiology | 2007 |
Carbon monoxide reverses established pulmonary hypertension
BS Zuckerbraun, BY Chin, B Wegiel, TR Billiar, E Czsimadia, J Rao, L Shimoda, E Ifedigbo, S Kanno, LE Otterbein |
Journal of Experimental Medicine | 2006 |
Heat shock response and acute lung injury
DS Wheeler, HR Wong |
Free radical biology & medicine | 2006 |
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts
K Nakahira, HP Kim, XH Geng, A Nakao, X Wang, N Murase, PF Drain, X Wang, M Sasidhar, EG Nabel, T Takahashi, NW Lukacs, SW Ryter, K Morita, AM Choi |
Journal of Experimental Medicine | 2006 |
Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function
X Liu, AS Pachori, CA Ward, JP Davis, M Gnecchi, D Kong, L Zhang, J Murduck, SF Yet, MA Perrella, RE Pratt, VJ Dzau, LG Melo |
The FASEB Journal | 2006 |
Role of carbon monxide in cardiovascular function
W Durante, FK Johnson, RA Johnson |
Journal of Cellular and Molecular Medicine | 2006 |
Protein kinase G-dependent heme oxygenase-1 induction by Agastache rugosa leaf extract protects RAW264.7 cells from hydrogen peroxide-induced injury
HM Oh, YJ Kang, YS Lee, MK Park, SH Kim, HJ Kim, HG Seo, JH Lee, KC Chang |
Journal of Ethnopharmacology | 2006 |
Carbon monoxide and bilirubin from heme oxygenase-1 suppresses reactive oxygen species generation and plasminogen activator inhibitor-1 induction
H Matsumoto, K Ishikawa, H Itabe, Y Maruyama |
Molecular and Cellular Biochemistry | 2006 |
The role of heme oxygenase-1 in pulmonary disease
LE Fredenburgh, MA Perrella, SA Mitsialis |
American journal of respiratory cell and molecular biology | 2006 |
Effect of heme oxygenase-1 on the vulnerability of astrocytes and neurons to hemoglobin
J Chen-Roetling, RF Regan |
Biochemical and Biophysical Research Communications | 2006 |
Carvedilol inhibits right ventricular hypertrophy induced by chronic hypobaric hypoxia
L Tual, OE Morel, F Favret, M Fouillit, C Guernier, A Buvry, L Germain, G Dhonneur, JF Bernaudin, JP Richalet |
Pflügers Archiv - European Journal of Physiology | 2006 |
Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats
SY Chen, G Hsiao, HR Hwang, PY Cheng, YM Lee |
Journal of Biomedical Science | 2006 |
Chronic Recurrent Myocardial Ischemic Injury Is Significantly Attenuated by Pre-Emptive Adeno-Associated Virus Heme Oxygenase-1 Gene Delivery
AS Pachori, LG Melo, L Zhang, SD Solomon, VJ Dzau |
Journal of the American College of Cardiology | 2006 |
Heme oxygenase-1 gene transfer inhibits angiotensin II-mediated rat cardiac myocyte apoptosis but not hypertrophy
RS Foo, RC Siow, MJ Brown, MR Bennett |
Journal of Cellular Physiology | 2006 |
Influence of bradykinin B1 and B2 receptors in the immune response triggered by renal ischemia–reperfusion injury
PH Wang, MA Cenedeze, JB Pesquero, A Pacheco-Silva, NO Câmara |
International Immunopharmacology | 2006 |
Encyclopedia of Respiratory Medicine
PD Wagner |
Encyclopedia of Respiratory Medicine | 2006 |
Role of carbon monoxide in cardiovascular function
William Durante, Fruzsina K Johnson, Robert A Johnson |
Journal of Cellular and Molecular Medicine | 2006 |
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
SW Ryter, J Alam, AM Choi |
Physiological reviews | 2006 |
Niacin-bound chromium enhances myocardial protection from ischemia-reperfusion injury
M Thirunavukkarasu, SV Penumathsa, B Juhasz, L Zhan, G Cordis, E Altaf, M Bagchi, D Bagchi, N Maulik |
American journal of physiology. Heart and circulatory physiology | 2006 |
Heme oxygenase‐1 is essential for and promotes tolerance to transplanted organs
K Yamashita, R Öllinger, J McDaid, H Sakahama, H Wang, S Tyagi, E Csizmadia, NR Smith, MP Soares, FH Bach |
The FASEB Journal | 2006 |
Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via HO-1 induction
Ikuo Nakamichi, Aida Habtezion, Bihui Zhong, Christopher H. Contag, Eugene C. Butcher and M. Bishr Omary |
Journal of Clinical Investigation | 2005 |
Transition from placental to air-breathing stimulates heme-oxygenase-1 expression without functional consequence for pulmonary vascular adaptation
S.J. Stanford, A.A. Hislop, E.G. Nabel, H. Sang, S.G. Haworth, J.A. Mitchell |
2005 | |
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
L Wu, R Wang |
Pharmacological reviews | 2005 |
Reciprocal regulation of airway rejection by the inducible gas-forming enzymes heme oxygenase and nitric oxide synthase
K Minamoto, H Harada, VN Lama, MA Fedarau, DJ Pinsky |
Journal of Experimental Medicine | 2005 |
Epidemiology, Risk Factors, and Genetics of High-Altitude–Related Pulmonary Disease
JP Maloney, U Broeckel |
Clinics in Chest Medicine | 2005 |
Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction
NO Camara, MP Soares |
Free radical biology & medicine | 2005 |
Study on changes of heme oxygenase-1 expression in patients with coronary heart disease
SM Chen, YG Li, DM Wang |
Clinical Cardiology | 2005 |
Increased heme oxygenase-1 expression in infarcted rat hearts following human bone marrow mesenchymal cell transplantation
S Zhang, S Lu, J Ge, J Guo, P Chen, T Li, P Zhang, Z Jia, K Ma, Y Liu, C Zhou, L Li |
Microvascular Research | 2005 |
Carbon monoxide protects cardiomyogenic cells against ischemic death through L-type Ca2+ channel inhibition
K Uemura, S Adachi-Akahane, K Shintani-Ishida, K Yoshida |
Biochemical and Biophysical Research Communications | 2005 |
Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to heme-mediated oxidative injury
J Chen-Roetling, L Benvenisti-Zarom, RF Regan |
Journal of Neuroscience Research | 2005 |
NeuroImmune Biology
R Solana, G Pawelec |
NeuroImmune Biology | 2005 |
Carbon Monoxide Signaling in Promoting Angiogenesis in Human Microvessel Endothelial Cells
GL Volti, D Sacerdoti, B Sangras, A Vanella, A Mezentsev, G Scapagnini, JR Falck, NG Abraham |
Antioxidants & Redox Signaling | 2005 |
Heme Oxygenase-1: From Bench to Bedside
D Morse, AM Choi |
American journal of respiratory and critical care medicine | 2005 |
Divergent contractile and structural responses of the murine PKC-ε null pulmonary circulation to chronic hypoxia
CM Littler, CA Wehling, MJ Wick, KA Fagan, CD Cool, RO Messing, EC Dempsey |
American journal of physiology. Lung cellular and molecular physiology | 2005 |
Interaction between endothelial heme oxygenase-2 and endothelin-1 in altered aortic reactivity after hypoxia in rats
V Govindaraju, H Teoh, Q Hamid, P Cernacek, ME Ward |
American journal of physiology. Heart and circulatory physiology | 2005 |
Inhibition of heme oxygenase?1 impairs cardiac muscle sensitivity to beta?adrenergic stimulation
VF Segers, K Lemmens, J Hendrickx, SU Sys, GW Keulenaer |
Basic Research in Cardiology | 2005 |
Cell Signaling in Vascular Inflammation
J Bhattacharya |
2005 | |
Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension
H Zhou, H Liu, SL Porvasnik, N Terada, A Agarwal, Y Cheng, GA Visner |
Laboratory Investigation | 2005 |
Phosphorylation and hypoxia-induced heme oxygenase-1 gene expression in cardiomyocytes
G Wu, J Marín-García, TB Rogers, EG Lakatta, X Long |
Journal of Cardiac Failure | 2004 |
Effects of endogenous carbon monoxide on collagen synthesis in pulmonary artery in rats under hypoxia
L Gong, J Du, L Shi, Y Shi, C Tang |
Life Sciences | 2004 |
Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2
T Adachi, K Ishikawa, W Hida, H Matsumoto, T Masuda, F Date, K Ogawa, K Takeda, K Furuyama, Y Zhang, T Kitamuro, H Ogawa, Y Maruyama, S Shibahara |
Biochemical and Biophysical Research Communications | 2004 |
A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia
A Bishop, SF Yet, ME Lee, MA Perrella, B Demple |
Biochemical and Biophysical Research Communications | 2004 |
Induction of Heme Oxygenase-1 Expression Inhibits Platelet-Dependent Thrombosis
L Peng, L Mundada, JM Stomel, JJ Liu, J Sun, SF Yet, WP Fay |
Antioxidants & Redox Signaling | 2004 |
Introduction to Serial Review on Heme oxygenase in human disease
PA Dennery |
Free radical biology & medicine | 2004 |
Induction of heat shock protein 32 (Hsp32) in the rat cochlea following hyperthermia
DA Fairfield, AC Kanicki, MI Lomax, RA Altschuler |
Hearing Research | 2004 |
Development of Vascular Biology over the past 10 Years: Heme Oxygenase-1 in Cardiovascular Homeostasis
K Ohta, A Yachie |
Journal of Endovascular Therapy | 2004 |
Myocardial injury and its prevention in the perioperative setting
M Zaugg, MC Schaub, P Foëx |
British Journal of Anaesthesia | 2004 |
The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury
EM Sikorski, T Hock, N Hill-Kapturczak, A Agarwal |
American journal of physiology. Renal physiology | 2004 |
Cardioprotective and vasomotor effects of HO activity during acute and chronic hypoxia
CL Hartsfield, IF McMurtry, DD Ivy, KG Morris, S Vidmar, DM Rodman, KA Fagan |
American journal of physiology. Heart and circulatory physiology | 2004 |
Development of Vascular Biology Over the Past 10 Years: Heme Oxygenase-1 in Cardiovascular Homeostasis
K Ohta, A Yachie |
Journal of Endovascular Therapy | 2004 |
CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin
F Zhang |
American journal of physiology. Heart and circulatory physiology | 2003 |
Cytosolic phospholipase A2alpha in mouse platelets
DA Wong, N Uozumi, Y Kita, T Shimizu |
Advances in experimental medicine and biology | 2003 |
Heme oxygenase-1 in growth control and its clinical application to vascular disease
W Durante |
Journal of Cellular Physiology | 2003 |
HO-1 induction attenuates renal damage and oxidative stress induced by K2Cr2O7
D Barrera, PD Maldonado, ON Medina-Campos, R Hernández-Pando, ME Ibarra-Rubio, J Pedraza-Chaverrrí |
Free radical biology & medicine | 2003 |
Heme oxygenase-1 and carbon monoxide in pulmonary medicine
DJ Slebos, SW Ryter, AM Choi |
Respiratory Research | 2003 |
Heme and Iron Metabolism: Role in Cerebral Hemorrhage
KR Wagner, FR Sharp, TD Ardizzone, A Lu, JF Clark |
Journal of Cerebral Blood Flow & Metabolism | 2003 |
Heme oxygenase-1 expression levels are cell cycle dependent
C Colombrita, G Lombardo, G Scapagnini, NG Abraham |
Biochemical and Biophysical Research Communications | 2003 |
Human heme oxygenase: Cell cycle-dependent expression and DNA microarray identification of multiple gene responses after transduction of endothelial cells
NG Abraham, G Scapagnini, A Kappas |
Journal of Cellular Biochemistry | 2003 |
Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress
T Satoh, M Baba, D Nakatsuka, Y Ishikawa, H Aburatani, K Furuta, T Ishikawa, H Hatanaka, M Suzuki, Y Watanabe |
European Journal of Neuroscience | 2003 |
Heme oxygenase attenuated angiotensin II-mediated increase in cyclooxygenase activity and decreased isoprostane F2α in endothelial cells
NG Abraham |
Thrombosis Research | 2003 |
Oxygen Sensing: Responses and Adaption to Hypoxia
B Dinger, L He, J Chen, L Stensaas, S Fidone |
Oxygen Sensing: Responses and Adaption to Hypoxia | 2003 |
Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function
YH Chen, SF Yet, MA Perrella |
Experimental biology and medicine (Maywood, N.J.) | 2003 |
TIN???Mesoporphyrin for Inhibition of Heme Oxygenase During Long-Term Hyperdynamic Porcine Endotoxemia:
M Nalos, D Vassilev, A Pittner, P Asfar, UB Brckner, EM Schneider, M Georgieff, P Radermacher, G Froeba |
Shock | 2003 |
Heme oxygenase‐1 related carbon monoxide production and ventricular fibrillation in isolated ischemic/reperfused mouse myocardium
I Bak, L Szendrei, T Turoczi, G Papp, F Joo, DK Das, J Leiris, P Der, B Juhasz, E Varga, I Bacskay, J Balla, P Kovacs, A Tosaki |
The FASEB Journal | 2003 |
Absence of heme oxygenase‐1 exacerbates atherosclerotic lesion formation and vascular remodeling
SF Yet, MD Layne, X Liu, YH Chen, B Ith, NE Sibinga, MA Perrella |
The FASEB Journal | 2003 |
Renal function following hematological stem cell transplantation in childhood
L Patzer, K Kentouche, F Ringelmann, J Misselwitz |
Pediatric Nephrology | 2003 |
Beneficial Effects of Heme Oxygenase-1 Up-Regulation in the Development of Experimental Inflammation Induced by Zymosan
AM Vicente, MI Guillén, A Habib, MJ Alcaraz |
The Journal of pharmacology and experimental therapeutics | 2003 |
Effects of Antioxidants in Diabetes-Induced Oxidative Stress in the Glomeruli of Diabetic Rats
D Koya, K Hayashi, M Kitada, A Kashiwagi, R Kikkawa, M Haneda |
Journal of the American Society of Nephrology : JASN | 2003 |
Carbon monoxide promotes hypoxic pulmonary vascular remodeling
MS Carraway, AJ Ghio, HB Suliman, JD Carter, AR Whorton, CA Piantadosi |
American journal of physiology. Lung cellular and molecular physiology | 2002 |
Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension
TK Jeffery, NW Morrell |
Progress in Cardiovascular Diseases | 2002 |
Heme Oxygenase and the Kidney
N Hill-Kapturczak, SH Chang, A Agarwal |
DNA and Cell Biology | 2002 |
Heme Oxygenase-1: Molecular Mechanisms of Gene Expression in Oxygen-Related Stress
SW Ryter, AM Choi |
Antioxidants & Redox Signaling | 2002 |
Selectin-Mediated Interactions Regulate Cytokine Networks and Macrophage Heme Oxygenase-1 Induction in Cardiac Allograft Recipients
AJ Coito, GD Shaw, J Li, B Ke, J Ma, RW Busuttil, JW Kupiec-Weglinski |
Laboratory Investigation | 2002 |
Modulation of the Thioredoxin System During Inflammatory Responses and Its Effect on Heme Oxygenase-1 Expression
K Ejima, MD Layne, IM Carvajal, H Nanri, B Ith, SF Yet, MA Perrella |
Antioxidants & Redox Signaling | 2002 |
Heme Oxygenase-1 Reduces Murine Monocrotaline-Induced Pulmonary Inflammatory Responses and Resultant Right Ventricular Overload
J Goto, K Ishikawa, K Kawamura, Y Watanabe, H Matumoto, D Sugawara, Y Maruyama |
Antioxidants & Redox Signaling | 2002 |
Reduction of hypoxia-inducible heme oxygenase-1 in the myocardium after left ventricular mechanical support
F Grabellus, C Schmid, B Levkau, D Breukelmann, PF Halloran, C August, N Takeda, A Takeda, M Wilhelm, MC Deng, HA Baba |
The Journal of Pathology | 2002 |
An extracellular source of heme can induce a significant heme oxygenase mediated relaxation in the rat aorta
S Hosein, GS Marks, JF Brien, BE McLaughlin, K Nakatsu |
Canadian Journal of Physiology and Pharmacology | 2002 |
1,2,3,4,6-Penta-O-galloyl-beta-d-glucose protects rat neuronal cells (Neuro 2A) from hydrogen peroxide-mediated cell death via the induction of heme oxygenase-1
B Choi |
Neuroscience Letters | 2002 |
Hypoxia and Carbon Monoxide in the Vasculature
S Kourembanas |
Antioxidants & Redox Signaling | 2002 |
Heme oxygenase-1 pathway is involved in delayed protection induced by heat stress against cardiac ischemia–reperfusion injury
R Lu, J Peng, L Xiao, HW Deng, YJ Li |
International Journal of Cardiology | 2002 |
Expression of Heme Oxygenase-1 in Response to Myocardial Infarction in Rats
P Lakkisto, E Palojoki, T Bäcklund, A Saraste, I Tikkanen, LM Voipio-Pulkki, K Pulkki |
Journal of Molecular and Cellular Cardiology | 2002 |
Heme Oxygenase in Biology and Medicine
NG Abraham |
2002 | |
Oxygen/Nitrogen Radicals: Cell Injury and Disease
V Vallyathan, X Shi, V Castranova |
2002 | |
Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance
Stefan W Ryter, Leo E Otterbein, Danielle Morse, Augustine M K Choi |
Molecular and Cellular Biochemistry | 2002 |
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
Ryter SW, Otterbein LE, Morse D, Choi AM |
Molecular and Cellular Biochemistry | 2002 |
Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants
K Sato, J Balla, L Otterbein, RN Smith, S Brouard, Y Lin, E Csizmadia, J Sevigny, SC Robson, G Vercellotti, AM Choi, FH Bach, MP Soares |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
T Minamino, H Christou, CM Hsieh, Y Liu, V Dhawan, NG Abraham, MA Perrella, SA Mitsialis, S Kourembanas |
Proceedings of the National Academy of Sciences | 2001 |
Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice
SF Yet, R Tian, MD Layne, ZY Wang, K Maemura, M Solovyeva, B Ith, LG Melo, L Zhang, JS Ingwall, VJ Dzau, ME Lee, MA Perrella |
Circulation research | 2001 |
Heme protein-induced chronic renal inflammation: Suppressive effect of induced heme oxygenase-11
KA Nath, GM Vercellotti, JP Grande, H Miyoshi, CV Paya, JC Manivel, JJ Haggard, AJ Croatt, WD Payne, J Alam |
Kidney International | 2001 |
Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis
P Inguaggiato, L Gonzalez-Michaca, AJ Croatt, JJ Haggard, J Alam, KA Nath |
Kidney International | 2001 |
Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein
MD Layne, SF Yet, K Maemura, CM Hsieh, M Bernfield, MA Perrella, ME Lee |
Molecular and cellular biology | 2001 |
Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?
C Hanselmann, C Mauch, S Werner |
Biochemical Journal | 2001 |
Enhancement of glomerular heme oxygenase-1 expression in diabetic rats
K Hayashi, M Haneda, D Koya, S Maeda, K Isshiki, R Kikkawa |
Diabetes Research and Clinical Practice | 2001 |
Carbon Monoxide and Cardiovascular Functions
R Johnson, F Johnson |
Carbon Monoxide and Cardiovascular Functions | 2001 |
Heme Oxygenase as an Intrinsic Defense System in Vascular Wall : Implication against Atherogenesis
K Ishikawa, Y Maruyama |
Journal of Atherosclerosis and Thrombosis | 2001 |
Hemin, inducer of heme-oxygenase 1, improves functional recovery from myocardial stunning in conscious dogs
TP Weber, A Meissner, P Boknik, MG Hartlage, T Möllhoff, HV Aken, N Rolf |
Journal of Cardiothoracic and Vascular Anesthesia | 2001 |
The other second messenger gas: Carbon monoxide signalling for myocardial protection?
S PEPE |
Heart, Lung and Circulation | 2001 |
Homogeneous segmental profile of carbon monoxide-mediated pulmonary vasodilation in rats
JS Naik, BR Walker |
American journal of physiology. Lung cellular and molecular physiology | 2001 |
Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis
T Fujita, K Toda, A Karimova, SF Yan, Y Naka, SF Yet, DJ Pinsky |
Nature Medicine | 2001 |
Heme oxygenase-1 protects against vascular constriction and proliferation
HJ Duckers, M Boehm, AL True, SF Yet, H San, JL Park, RC Webb, ME Lee, GJ Nabel, EG Nabel |
Nature Medicine | 2001 |
Heme Oxygenase-1 Inhibits Atherosclerotic Lesion Formation in LDL-Receptor Knockout Mice
K Ishikawa, D Sugawara, X Wang, K Suzuki, H Itabe, Y Maruyama, AJ Lusis |
Circulation research | 2001 |
Exacerbation of Chronic Renovascular Hypertension and Acute Renal Failure in Heme Oxygenase-1–Deficient Mice
P Wiesel, AP Patel, IM Carvajal, ZY Wang, A Pellacani, K Maemura, N DiFonzo, HG Rennke, MD Layne, SF Yet, ME Lee, MA Perrella |
Circulation research | 2001 |
Heme Oxygenase-1 Protects the Heart
AM Choi |
Circulation research | 2001 |
Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin
KF Wagner, DM Katschinski, J Hasegawa, D Schumacher, B Meller, U Gembruch, U Schramm, W Jelkmann, M Gassmann, J Fandrey |
Blood | 2001 |
The Indispensability of Heme Oxygenase-1 in Protecting against Acute Heme Protein-Induced Toxicity in Vivo
KA Nath, JJ Haggard, AJ Croatt, JP Grande, KD Poss, J Alam |
The American Journal of Pathology | 2000 |
Expression of heme oxygenase-1 by endothelial cells: a protective response to injury in transplantation
MP Soares, S Brouard, RN Smith, L Otterbein, AM Choi, FH Bach |
Expert Opinion on Therapeutic Targets | 2000 |
Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis
N Kaminski, JD Allard, JF Pittet, F Zuo, MJ Griffiths, D Morris, X Huang, D Sheppard, RA Heller |
Proceedings of the National Academy of Sciences | 2000 |
Signal Transduction Pathways in Hyperoxia-Induced Lung Cell Death
LL Mantell, PJ Lee |
Molecular Genetics and Metabolism | 2000 |
Induction of Heme Oxygenase-1 Can Act Protectively against Cardiac Ischemia/Reperfusion in Vivo
M Hangaishi, N Ishizaka, T Aizawa, Y Kurihara, J Taguchi, R Nagai, S Kimura, M Ohno |
Biochemical and Biophysical Research Communications | 2000 |
Oxidative degradation of bilirubin produces vasoactive compounds
KR Kranc, GJ Pyne, L Tao, TD Claridge, DA Harris, TA Cadoux-Hudson, JJ Turnbull, CJ Schofield, JF Clark |
European Journal of Biochemistry | 2000 |
Gene regulation of heme oxygenase-1 as a therapeutic target
S Immenschuh, G Ramadori |
Biochemical Pharmacology | 2000 |
Thioredoxin Facilitates the Induction of Heme Oxygenase-1 in Response to Inflammatory Mediators
P Wiesel, LC Foster, A Pellacani, MD Layne, CM Hsieh, GS Huggins, P Strauss, SF Yet, MA Perrella |
The Journal of biological chemistry | 2000 |
Heme oxygenase: colors of defense against cellular stress
LE Otterbein, AM Choi |
American journal of physiology. Lung cellular and molecular physiology | 2000 |
Hypoxia reduces atrial natriuretic peptide clearance receptor gene expression in ANP knockout mice
JZ Sun, SJ Chen, G Li, YF Chen |
American journal of physiology. Lung cellular and molecular physiology | 2000 |
Regulation of endothelial heme oxygenase activity during hypoxia is dependent on chelatable iron
SW Ryter, M Si, CC Lai, CY Su |
American journal of physiology. Heart and circulatory physiology | 2000 |
Inhaled carbon monoxide does not cause pulmonary vasodilation in the late-gestation fetal lamb
TR Grover, RL Rairigh, JP Zenge, SH Abman, JP Kinsella |
American journal of physiology. Lung cellular and molecular physiology | 2000 |
Heme oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin II
N Ishizaka, T Aizawa, I Mori, JI Taguchi, Y Yazaki, R Nagai, M Ohno |
American journal of physiology. Heart and circulatory physiology | 2000 |
Induction of Placental Heme Oxygenase-1 Is Protective Against TNFα-induced Cytotoxicity and Promotes Vessel Relaxation
A Ahmed, M Rahman, X Zhang, CH Acevedo, S Nijjar, I Rushton, B Bussolati, JS John |
Molecular Medicine | 2000 |
Carbon Monoxide in Vasoregulation: The Promise and the Challenge
F Coceani |
Circulation research | 2000 |
Endotoxin-Induced Mortality Is Related to Increased Oxidative Stress and End-Organ Dysfunction, Not Refractory Hypotension, in Heme Oxygenase-1–Deficient Mice
P Wiesel, AP Patel, N DiFonzo, PB Marria, CU Sim, A Pellacani, K Maemura, BW LeBlanc, K Marino, CM Doerschuk, SF Yet, ME Lee, MA Perrella |
Circulation | 2000 |
Heme oxygenase-1: a redoubtable response that limits reperfusion injury in the transplanted adipose liver
KA Nath |
Journal of Clinical Investigation | 1999 |
Recent advances in the vascular pathophysiology of heme oxygenase–carbon monoxide system
M Suematsu, N Makino, Y Ishimura |
Pathophysiology | 1999 |