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Citations to this article

Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice
Shaw-Fang Yet, … , Stella Kourembanas, Mu-En Lee
Shaw-Fang Yet, … , Stella Kourembanas, Mu-En Lee
Published April 15, 1999
Citation Information: J Clin Invest. 1999;103(8):R23-R29. https://doi.org/10.1172/JCI6163.
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Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice

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Abstract

Heme oxygenase (HO) catalyzes the oxidation of heme to generate carbon monoxide (CO) and bilirubin. CO increases cellular levels of cGMP, which regulates vascular tone and smooth muscle development. Bilirubin is a potent antioxidant. Hypoxia increases expression of the inducible HO isoform (HO-1) but not the constitutive isoform (HO-2). To determine whether HO-1 affects cellular adaptation to chronic hypoxia in vivo, we generated HO-1 null (HO-1–/–) mice and subjected them to hypoxia (10% oxygen) for five to seven weeks. Hypoxia caused similar increases in right ventricular systolic pressure in wild-type and HO-1–/– mice. Although ventricular weight increased in wild-type mice, the increase was greater in HO-1–/– mice. Similarly, the right ventricles were more dilated in HO-1–/– mice. After seven weeks of hypoxia, only HO-1–/– mice developed right ventricular infarcts with organized mural thrombi. No left ventricular infarcts were observed. Lipid peroxidation and oxidative damage occurred in right ventricular cardiomyocytes in HO-1–/–, but not wild-type, mice. We also detected apoptotic cardiomyocytes surrounding areas of infarcted myocardium by terminal deoxynucleotide transferase–mediated dUTP nick end-labeling (TUNEL) assays. Our data suggest that in the absence of HO-1, cardiomyocytes have a maladaptive response to hypoxia and subsequent pulmonary hypertension.

Authors

Shaw-Fang Yet, Mark A. Perrella, Matthew D. Layne, Chung-Ming Hsieh, Koji Maemura, Lester Kobzik, Philippe Wiesel, Helen Christou, Stella Kourembanas, Mu-En Lee

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 Total
Citations: 6 4 2 9 9 7 7 7 16 12 16 11 16 24 30 28 24 16 19 18 12 18 17 19 16 2 365
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2009 (28)

Title and authors Publication Year
Neprilysin Null Mice Develop Exaggerated Pulmonary Vascular Remodeling in Response to Chronic Hypoxia
EC Dempsey, MJ Wick, V Karoor, EJ Barr, DW Tallman, CA Wehling, SJ Walchak, S Laudi, M Le, M Oka, S Majka, CD Cool, KA Fagan, DJ Klemm, LB Hersh, NP Gerard, C Gerard, YE Miller
The American Journal of Pathology 2009
Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia
SH Vitali, SA Mitsialis, OD Liang, X Liu, A Fernandez-Gonzalez, H Christou, X Wu, FX McGowan, S Kourembanas
PloS one 2009
The Right Ventricle Under Pressure
HJ Bogaard, K Abe, AV Noordegraaf, NF Voelkel
Chest 2009
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers
2009
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers
2009
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers
2009
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers
2009
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers
2009
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers
2009
Arterial Chemoreceptors
C Gonzalez, CA Nurse, C Peers
2009
Heme oxygenase-1: from biology to therapeutic potential
MP Soares, FH Bach
Trends in Molecular Medicine 2009
Induction of heme oxygenase-1 in factor VIII-deficient mice reduces the immune response to therapeutic factor VIII
JD Dimitrov, S Dasgupta, AM Navarrete, S Delignat, Y Repesse, Y Meslier, C Planchais, M Teyssandier, R Motterlini, J Bayry, SV Kaveri, S Lacroix-Desmazes
Blood 2009
Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells
H Matsushima, H Tanaka, N Mizumoto, A Takashima
Blood 2009
Heme oxygenase-1 affords protection against noncerebral forms of severe malaria
E Seixas, R Gozzelino, A Chora, A Ferreira, G Silva, R Larsen, S Rebelo, C Penido, NR Smith, A Coutinho, MP Soares
Proceedings of the National Academy of Sciences 2009
Role of haem oxygenase-1 in microbial host defence
SW Chung, SR Hall, MA Perrella
Cellular Microbiology 2009
Carbon Monoxide Rescues Heme Oxygenase-1-Deficient Mice from Arterial Thrombosis in Allogeneic Aortic Transplantation
B Chen, L Guo, C Fan, S Bolisetty, R Joseph, MM Wright, A Agarwal, JF George
The American Journal of Pathology 2009
Targeting Heme Oxygenase
SJ Peterson, WH Frishman
Cardiology in Review 2009
Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy
SW Ryter, AM Choi
American journal of respiratory cell and molecular biology 2009
Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats
HH Hsu, WJ Ko, JY Hsu, JS Chen, YC Lee, IR Lai, CF Chen
Respiratory Research 2009
Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: implications for multiple sclerosis
A Bishop, KG Hobbs, A Eguchi, S Jeffrey, L Smallwood, C Pennie, J Anderson, AG Estévez
Journal of Neurochemistry 2009
Mitigation of peroxynitrite-mediated nitric oxide (NO) toxicity as a mechanism of induced adaptive NO resistance in the CNS
A Bishop, R Gooch, A Eguchi, S Jeffrey, L Smallwood, J Anderson, AG Estevez
Journal of Neurochemistry 2009
Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor
M Nomoto, M Miyata, S Yin, Y Kurata, M Shimada, K Yoshinari, FJ Gonzalez, K Suzuki, S Shibasaki, T Kurosawa, Y Yamazoe
Biological & Pharmaceutical Bulletin 2009
NS398 protects cells from sodium nitroprusside-mediated cytotoxicity through enhancing HO-1 induction independent of COX-2 inhibition
IT Nizamutdinova, JH Lee, HG Seo, KC Chang, HJ Kim
Archives of Pharmacal Research 2009
Bile Acid-Induced Elevated Oxidative Stress in the Absence of Farnesoid X Receptor
M Nomoto, M Miyata, S Yin, Y Kurata, M Shimada, K Yoshinari, FJ Gonzalez, K Suzuki, S Shibasaki, T Kurosawa, Y Yamazoe
Biological & Pharmaceutical Bulletin 2009
A role for regulatory T cells in renal acute kidney injury
RM Monteiro, NO Camara, MM Rodrigues, F Tzelepis, MJ Damião, MA Cenedeze, VP Teixeira, MA Reis, A Pacheco-Silva
Transplant Immunology 2009
Protective Effects of a Heme Oxygenase-1-Secreting Lactococcus lactis on Mucosal Injury Induced by Hemorrhagic Shock in Rats
Q Pang, Y Ji, LG Bermúdez-Humarán, Q Zhou, G Hu, Y Zeng
Journal of Surgical Research 2009
Heme oxygenase-1-dependent central cardiorespiratory adaptations to chronic hypoxia in mice
J Sunderram, J Semmlow, S Thakker-Varia, M Bhaumik, O Hoang-Le, JA Neubauer
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2009
Gene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by Upregulating Heme Oxygenase-1 Via a Nuclear Factor-κB-Dependent Pathway
Q Li, Y Guo, Q Ou, C Cui, WJ Wu, W Tan, X Zhu, LB Lanceta, SK Sanganalmath, B Dawn, K Shinmura, GD Rokosh, S Wang, R Bolli
Circulation 2009

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