Venous thrombosis is a leading cause of morbidity and mortality in industrialized countries, especially in the elderly. Many risk factors have been identified for venous thrombosis that alter blood flow, activate the endothelium, and increase blood coagulation. However, the precise mechanisms that trigger clotting in large veins have not been fully elucidated. The most common site for initiation of the thrombus appears to be the valve pocket sinus, due to its tendency to become hypoxic. Activation of endothelial cells by hypoxia or possibly inflammatory stimuli would lead to surface expression of adhesion receptors that facilitate the binding of circulating leukocytes and microvesicles. Subsequent activation of the leukocytes induces expression of the potent procoagulant protein tissue factor that triggers thrombosis. Understanding the mechanisms of venous thrombosis may lead to the development of new treatments.
Nigel Mackman
Title and authors | Publication | Year |
---|---|---|
Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs
T Won, M Wood, D Hughes, M Talor, Z Ma, J Schneider, J Skinner, B Asady, E Goerlich, M Halushka, A Hays, D Kim, C Parikh, A Rosenberg, I Coppens, R Johns, N Gilotra, J Hooper, A Pekosz, D Čiháková |
EBioMedicine | 2022 |
Cancer-associated venous thromboembolism
A Khorana, N Mackman, A Falanga, I Pabinger, S Noble, W Ageno, F Moik, A Lee |
Nature Reviews Disease Primers | 2022 |
Emerging Role of Platelet-Endothelium Interactions in the Pathogenesis of Severe SARS-CoV-2 Infection-Associated Myocardial Injury
T Rossouw, R Anderson, P Manga, C Feldman |
Frontiers in immunology | 2022 |
Pathophysiology of deep vein thrombosis
S Navarrete, C Solar, R Tapia, J Pereira, E Fuentes, I Palomo |
Zeitschrift fü Die Gesamte Experimentelle Medizin | 2022 |
Endothelial Cell Phenotype, a Major Determinant of Venous Thrombo-Inflammation
M Pilard, E Ollivier, V Gourdou-Latyszenok, F Couturaud, C Lemarié |
Frontiers in Cardiovascular Medicine | 2022 |
Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis
S Grover, N Mackman |
Frontiers in Cardiovascular Medicine | 2022 |
Venous Thromboembolism in Sepsis: From Bench to Bedside
Galli E, Maggio E, Pomero F |
Biomedicines | 2022 |
The Role of Patient-Specific Morphological Features of the Left Atrial Appendage on the Thromboembolic Risk Under Atrial Fibrillation
Musotto G, Monteleone A, Vella D, Di Leonardo S, Viola A, Pitarresi G, Zuccarello B, Pantano A, Cook A, Bosi GM, Burriesci G |
Frontiers in Cardiovascular Medicine | 2022 |
Pathophysiological Aspects of Aging in Venous Thromboembolism: An Update
Akrivou D, Perlepe G, Kirgou P, Gourgoulianis KI, Malli F |
Medicina | 2022 |
The Vascular Endothelium and Coagulation: Homeostasis, Disease, and Treatment, with a Focus on the Von Willebrand Factor and Factors VIII and V
Pablo-Moreno JA, Serrano LJ, Revuelta L, Sánchez MJ, Liras A |
International journal of molecular sciences | 2022 |
The Pharmacological Effects of Silver Nanoparticles Functionalized with Eptifibatide on Platelets and Endothelial Cells
Hajtuch J, Iwicka E, Szczoczarz A, Flis D, Megiel E, Cieciórski P, Radomski MW, Santos-Martinez MJ, Inkielewicz-Stepniak I |
International Journal of Nanomedicine | 2022 |
A Review of the Prevalence of Thromboembolic Complications among Pregnant Women Infected with COVID-19
Mohd Ariff NS, Abdul Halim Zaki I, Mohd Noordin Z, Md Hussin NS, Goh KW, Ming LC, Zulkifly HH |
Journal of Clinical Medicine | 2022 |
The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis.
Kondreddy V, Keshava S, Das K, Magisetty J, Rao LVM, Pendurthi UR |
Blood | 2022 |
Impact of neutrophil extracellular traps on fluid properties, blood flow and complement activation
Burmeister A, Vidal-y-Sy S, Liu X, Mess C, Wang Y, Konwar S, Tschongov T, Häffner K, Huck V, Schneider SW, Gorzelanny C |
Frontiers in immunology | 2022 |
Promotion of a venous thromboembolism prevention protocol at a perioperative management center
Fujiwara H, Yamashita C, Kawaji T, Nakamura T, Kuriyama N, Hara Y, Komatsu S, Fukushima M, Suzuki S, Tsutsumi T, Nishida O |
Fujita medical journal | 2022 |
The mechanistic and structural role of von Willebrand factor in endotoxemia-enhanced deep vein thrombosis in mice.
Choi SJ, Dwyer CN, Rapkin L, Cormier M, Hindmarch CCT, Nesbitt K, Michels A, Hopman W, Swystun LL, Lillicrap D |
Journal of thrombosis and haemostasis : JTH | 2022 |