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Citations to this article

New insights into the mechanisms of venous thrombosis
Nigel Mackman
Nigel Mackman
Published July 2, 2012
Citation Information: J Clin Invest. 2012;122(7):2331-2336. https://doi.org/10.1172/JCI60229.
View: Text | PDF | Corrigendum
Science in Medicine Article has an altmetric score of 5

New insights into the mechanisms of venous thrombosis

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Abstract

Venous thrombosis is a leading cause of morbidity and mortality in industrialized countries, especially in the elderly. Many risk factors have been identified for venous thrombosis that alter blood flow, activate the endothelium, and increase blood coagulation. However, the precise mechanisms that trigger clotting in large veins have not been fully elucidated. The most common site for initiation of the thrombus appears to be the valve pocket sinus, due to its tendency to become hypoxic. Activation of endothelial cells by hypoxia or possibly inflammatory stimuli would lead to surface expression of adhesion receptors that facilitate the binding of circulating leukocytes and microvesicles. Subsequent activation of the leukocytes induces expression of the potent procoagulant protein tissue factor that triggers thrombosis. Understanding the mechanisms of venous thrombosis may lead to the development of new treatments.

Authors

Nigel Mackman

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 Total
Citations: 9 22 12 16 12 10 14 11 19 11 11 6 4 1 158
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2018 (11)

Title and authors Publication Year
Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA
MR Dyer, Q Chen, S Haldeman, H Yazdani, R Hoffman, P Loughran, A Tsung, BS Zuckerbraun, RL Simmons, MD Neal
Scientific Reports 2018
Serpins: Methods and Protocols
A Lucas
2018
Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice
T Yago, Z Liu, J Ahamed, RP McEver
Blood 2018
Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis
T Schönfelder, M Brandt, S Kossmann, T Knopp, T Münzel, U Walter, SH Karbach, P Wenzel
Scientific Reports 2018
Design and Utility of a Point-of-Care Microfluidic Platform to Assess Hematocrit and Blood Coagulation
J Zilberman-Rudenko, RM White, DA Zilberman, HH Lakshmanan, RA Rigg, JJ Shatzel, J Maddala, OJ McCarty
Cellular and Molecular Bioengineering 2018
The sequence of the evil: A case report of Idiopathic Non- Cirrhotic Portal Hypertension associated with littoral cell angioma of the spleen, four years after successful treatment of a colon cancer
K Fotis, L Christina, P Ioannis, K Angelos, L Dionysios, K Evangelos
Journal of Clinical and Experimental Hepatology 2018
Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases
J Yeung, W Li, M Holinstat, LL Isom
Pharmacological reviews 2018
Platelets Drive Thrombus Propagation in a Hematocrit and Glycoprotein VI–Dependent Manner in an In Vitro Venous Thrombosis ModelHighlights
M Lehmann, RM Schoeman, PJ Krohl, AM Wallbank, JR Samaniuk, M Jandrot-Perrus, KB Neeves
Arteriosclerosis, thrombosis, and vascular biology 2018
Recurrent venous thrombosis in a patient with Ebstein’s anomaly
D Gashgarey, H Alzahrani, S Alfadl, S Alsobayeg
SAUDI MED J 2018
Evaluation of thrombosis-related biomarkers before and after therapy in patients with multiple myeloma
S Nomura, T Ito, H Yoshimura, M Hotta, T Nakanishi, S Fujita, A Nakaya, A Satake, K Ishii
Journal of blood medicine 2018
Detection of lower limb deep vein thrombosis: Comparison between radionuclide venography and venous ultrasonography
D Theerakulpisut, N Wongsurawat, C Somboonporn
World Journal of Nuclear Medicine 2018

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