Venous thrombosis is a leading cause of morbidity and mortality in industrialized countries, especially in the elderly. Many risk factors have been identified for venous thrombosis that alter blood flow, activate the endothelium, and increase blood coagulation. However, the precise mechanisms that trigger clotting in large veins have not been fully elucidated. The most common site for initiation of the thrombus appears to be the valve pocket sinus, due to its tendency to become hypoxic. Activation of endothelial cells by hypoxia or possibly inflammatory stimuli would lead to surface expression of adhesion receptors that facilitate the binding of circulating leukocytes and microvesicles. Subsequent activation of the leukocytes induces expression of the potent procoagulant protein tissue factor that triggers thrombosis. Understanding the mechanisms of venous thrombosis may lead to the development of new treatments.
Nigel Mackman
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The Role of Stroke as a Trigger for Incident Venous Thromboembolism: Results from a Population-based Case-Crossover Study
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Design and Utility of a Point-of-Care Microfluidic Platform to Assess Hematocrit and Blood Coagulation
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Cellular and Molecular Bioengineering | 2018 |
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Localization of Short-Chain Polyphosphate Enhances its Ability to Clot Flowing Blood Plasma
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Recent Progress in Research on the Pathogenesis of Pulmonary Thromboembolism: An Old Story with New Perspectives
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European Journal of Epidemiology | 2017 |
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The saponin D39 blocks dissociation of non-muscular myosin heavy chain IIA from TNF receptor 2, suppressing tissue factor expression and venous thrombosis: D39 inhibits thrombosis via NMMHC IIA
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Impact of Classical Risk Factors for Arterial or Venous Thrombosis in Patients With Antiphospholipid Syndrome
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Protective and Detrimental Effects of Neuroectodermal Cell-derived Tissue Factor in Mouse Models of Stroke
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JCI Insight | 2016 |
Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice
K Stark, V Philippi, S Stockhausen, J Busse, A Antonelli, M Miller, I Schubert, P Hoseinpour, S Chandraratne, ML Bruhl, F Gartner, M Lorenz, A Agresti, R Coletti, DJ Antoine, R Heermann, K Jung, S Reese, I Laitinen, M Schwaiger, A Walch, M Sperandio, PP Nawroth, C Reinhardt, S Jackel, ME Bianchi, S Massberg |
Blood | 2016 |
New findings on venous thrombogenesis:
JR Byrnes, AS Wolberg |
Hämostaseologie | 2016 |
Mouse models of deep vein thrombosis
T Schönfelder, S Jäckel, P Wenzel |
Gefässchirurgie | 2016 |
Dynamics of Blood Flow and Thrombus Formation in a Multi-Bypass Microfluidic Ladder Network
J Zilberman-Rudenko, JL Sylman, HH Lakshmanan, OJ McCarty, J Maddala |
Cellular and Molecular Bioengineering | 2016 |
Simulated thrombin responses in venous valves
EV Dydek, EL Chaikof |
Journal of Vascular Surgery: Venous and Lymphatic Disorders | 2016 |
A computational model based on fibrin accumulation for the prediction of stasis thrombosis following flow-diverting treatment in cerebral aneurysms
C Ou, W Huang, MM Yuen |
Medical & Biological Engineering & Computing | 2016 |
Dabigatran antagonizes growth, cell-cycle progression, migration, and endothelial tube formation induced by thrombin in breast and glioblastoma cell lines
F Vianello, L Sambado, A Goss, F Fabris, P Prandoni |
Cancer Medicine | 2016 |
Exploring potential anticoagulant drug formulations using thrombin generation test
E Zavyalova, A Kopylov |
Biochemistry and Biophysics Reports | 2016 |
A Mathematical Model of Venous Thrombosis Initiation
P Elizondo, AL Fogelson |
Biophysical Journal | 2016 |
Coagulation Abnormalities in Heart Failure: Pathophysiology and Therapeutic Implications
JH Kim, P Shah, US Tantry, PA Gurbel |
Current Heart Failure Reports | 2016 |
Endothelial cell control of thrombosis
JW Yau, H Teoh, S Verma |
BMC Cardiovascular Disorders | 2015 |
Assessment of Venous Thrombosis in Animal ModelsSignificance
SP Grover, CE Evans, AS Patel, B Modarai, P Saha, A Smith |
Arteriosclerosis, thrombosis, and vascular biology | 2015 |
Fluid Mechanics of Blood Clot Formation
AL Fogelson, KB Neeves |
Annual Review of Fluid Mechanics | 2015 |
Do pregnant women have a higher risk for venous thromboembolism following air travel?
MJ Alemzadeh-Ansari, D Kazemisaleh, M Moshkani-Farahani, A Shafiee, M Izadi |
Advanced Biomedical Research | 2015 |
NMMHCIIA inhibition impedes tissue factor expression and venous thrombosis via Akt/GSK3β-NF-κB signalling pathways in the endothelium:
zhai, Y Tang, Y Zhang, F Li, Y Wang, Z Cao, J Yu, kou, B Yu |
Thrombosis and Haemostasis | 2015 |
Ultrasound Screening for Deep Venous Thrombosis Detection: A Prospective Evaluation of 200 Plastic Surgery Outpatients
E Swanson |
Plastic and Reconstructive Surgery Global Open | 2015 |
Tissue factor-dependent and -independent pathways of systemic coagulation activation in acute myeloid leukemia: a single-center cohort study
C Dicke, A Amirkhosravi, B Spath, M Jiménez-Alcázar, T Fuchs, M Davila, JL Francis, C Bokemeyer, F Langer |
Experimental Hematology and Oncology | 2015 |
Microparticles as Biomarkers of Blood Coagulation in Cancer
S Nomura, M Niki, T Tamaki, M Shimizu, T Nishizawa |
Biomarkers in Cancer | 2015 |
Swine Model of Thrombotic Caval Occlusion Created by Autologous Thrombus Injection with Assistance of Intra-caval Net Knitting
WY Shi, S Wu, LY Hu, CJ Liu, JP Gu |
Scientific Reports | 2015 |
Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study
AF Stein-Merlob, CW Kessinger, SS Erdem, H Zelada, SA Hilderbrand, CP Lin, GJ Tearney, MR Jaff, GL Reed, PK Henke, JR McCarthy, FA Jaffer |
Theranostics | 2015 |
Biological properties of extracellular vesicles and their physiological functions
Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Silva AC, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Linē A, Lipps G, Llorente A, Lötvall J, Manček-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O |
Journal of Extracellular Vesicles | 2015 |
Gain in translation: heme oxygenase-1 induced by activated protein C promotes thrombus resolution
H Deguchi, DJ Elias, JH Griffin |
Journal of Thrombosis and Haemostasis | 2014 |
Recently Identified Factors that Regulate Hemostasis and Thrombosis
JE Geddings, N Mackman |
Thrombosis and Haemostasis | 2014 |
Strengths and weaknesses of a new mouse model of thrombosis induced by inferior vena cava stenosis: communication from the SSC of the ISTH
J Geddings, MM Aleman, A Wolberg, ML Brühl, S Massberg, N Mackman |
Journal of Thrombosis and Haemostasis | 2014 |
Streptokinase production from Streptococcus dysgalactiae subsp. equisimilis SK-6 in the presence of surfactants, growth factors and trace elements
S Bhardwaj, J Angayarkanni |
3 Biotech | 2014 |
Mechanisms of thrombogenesis in polycythemia vera
MH Kroll, LC Michaelis, S Verstovsek |
Blood Reviews | 2014 |
Antithrombotics in heart failure
Miličić D, Samardžić J, Petričević M |
Croatian medical journal | 2014 |
Interplay between coagulation and vascular inflammation in sickle cell disease
E Sparkenbaugh, R Pawlinski |
British Journal of Haematology | 2013 |
Tumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patients
JE Geddings, N Mackman |
Blood | 2013 |
Venous thromboembolism in pediatric nephrotic syndrome
BA Kerlin, K Haworth, WE Smoyer |
Pediatric Nephrology | 2013 |
Antiplatelet therapy in prevention of cardio- and venous thromboembolic events
SR Steinhubl, JW Eikelboom, EM Hylek, HL Dauerman, SS Smyth, RC Becker |
Journal of Thrombosis and Thrombolysis | 2013 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |