Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
Simon A. Jones, … , Jürgen Scheller, Stefan Rose-John
Simon A. Jones, … , Jürgen Scheller, Stefan Rose-John
Published September 1, 2011
Citation Information: J Clin Invest. 2011;121(9):3375-3383. https://doi.org/10.1172/JCI57158.
View: Text | PDF
Science in Medicine Article has an altmetric score of 23

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

  • Text
  • PDF
Abstract

The successful treatment of certain autoimmune conditions with the humanized anti–IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory regulator. Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer.

Authors

Simon A. Jones, Jürgen Scheller, Stefan Rose-John

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 Total
Citations: 8 10 10 29 33 27 21 21 35 24 28 25 29 19 1 1 321
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2020 (27)

Title and authors Publication Year
Immunopathobiology and therapeutic targets related to cytokines in liver diseases
Y He, S Hwang, YA Ahmed, D Feng, N Li, M Ribeiro, F Lafdil, T Kisseleva, G Szabo, B Gao
Cellular and Molecular Immunology 2020
Treatments for COVID-19: emerging drugs against the coronavirus
Francesco Potì, Cristina Pozzoli, Maristella Adami, Enzo Poli, Lucio G Costa
Acta bio-medica : Atenei Parmensis 2020
Serum Levels of Interleukin-8 and Soluble Interleukin-6 Receptor in Patients with Stage-I Multiple Myeloma: A Case-Control Study
M Kohsari, MH Khadem-Ansari, Y Rasmi, H Sayyadi
Asian Pacific Journal of Cancer Prevention 2020
Overview of the STAT‑3 signaling pathway in cancer and the development of specific inhibitors (Review)
Y Gu, I Mohammad, Z Liu
Oncology Letters 2020
Targeting Signal 3 Extracellularly and Intracellularly in Graft-Versus-Host Disease
S Kim, P Reddy
Frontiers in immunology 2020
Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
M Amaya-Montoya, A Pérez-Londoño, V Guatibonza-García, A Vargas-Villanueva, CO Mendivil
Advances in Therapy 2020
Ocular cytomegalovirus latency exacerbates the development of choroidal neovascularization
J Xu, X Liu, X Zhang, B Marshall, Z Dong, Y Liu, DG EspinosaHeidmann, M Zhang
The Journal of Pathology 2020
IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR T cells
Z Jiang, R Liao, J Lv, S Li, D Zheng, L Qin, D Wu, S Chen, Y Long, Q Wu, S Wang, S Lin, X Huang, Z Tang, P Shi, H Zhou, Q Liu, R Zhao, Y Li, Y Jie, W Wei, P Lai, X Du, S Cui, R Weinkove, P Liu, D Pei, Y Yao, P Li
Leukemia 2020
Advances in targeted therapy for malignant lymphoma
L Wang, W Qin, YJ Huo, X Li, Q Shi, JE Rasko, A Janin, WL Zhao
Signal Transduction and Targeted Therapy 2020
In vitro and in vivo pharmacokinetic characterization of LMT-28 as a novel small molecular interleukin-6 inhibitor
SH Ahn, TH Heo, HS Jun, Y Choi
Asian-Australasian Journal of Animal Sciences 2020
Effective treatment of severe COVID-19 patients with tocilizumab
X Xu, M Han, T Li, W Sun, D Wang, B Fu, Y Zhou, X Zheng, Y Yang, X Li, X Zhang, A Pan, H Wei
Proceedings of the National Academy of Sciences 2020
Neuroimmunomodulatory and Neuroprotective Effects of the Flavonoid Apigenin in in vitro Models of Neuroinflammation Associated With Alzheimer’s Disease
NS Dourado, C dos Santos Souza, MM de Almeida, AB da Silva, BL dos Santos, VD Silva, AM Assis, JS da Silva, DO Souza, M de Fatima Dias Costa, AM Butt, SL Costa
Frontiers in aging neuroscience 2020
SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the ‘culprit lesion’ of ARDS onset? What is there besides Tocilizumab? SGP130Fc
G Magro
2020
HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling
Y Higuchi, J Yasunaga, Y Mitagami, H Tsukamoto, K Nakashima, K Ohshima, M Matsuoka
Proceedings of the National Academy of Sciences 2020
COVID-19 Drug Treatment in China
L Fan, S Jiang, X Yang, Z Wang, C Yang
Current Pharmacology Reports 2020
Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries
TS Ghosh, S Rampelli, IB Jeffery, A Santoro, M Neto, M Capri, E Giampieri, A Jennings, M Candela, S Turroni, EG Zoetendal, GD Hermes, C Elodie, N Meunier, CM Brugere, E Pujos-Guillot, AM Berendsen, LC Groot, EJ Feskins, J Kaluza, B Pietruszka, MJ Bielak, B Comte, M Maijo-Ferre, C Nicoletti, WM Vos, S Fairweather-Tait, A Cassidy, P Brigidi, C Franceschi, PW O'Toole
Gut 2020
Emerging roles for the IL-6 family of cytokines in pancreatic cancer
G van Duijneveldt, MD Griffin, TL Putoczki
Clinical Science 2020
Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors
E Alfinito, M Beccaria, M Ciccarese
Biosensors 2020
The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis
R Davies, J Williams, K Sime, HS Jin, C Thompson, L Jordan, D Lang, JP Halcox, E Ellins, GW Jones, SA Jones, S Rose-John, A Williams, E Choy
Rheumatology 2020
Multiphase Assembly of Small Molecule Microcrystalline Peptide Hydrogel Allows Immunomodulatory Combination Therapy for Long‐Term Heart Transplant Survival
P Majumder, Y Zhang, M Iglesias, L Fan, JA Kelley, C Andrews, N Patel, JR Stagno, BC Oh, GJ Furtmüller, CC Lai, YX Wang, G Brandacher, G Raimondi, JP Schneider
Small (Weinheim an Der Bergstrasse, Germany) 2020

Diagnosis, Screening and Treatment of Patients with Palmoplantar Pustulosis (PPP): A Review of Current Practices and Recommendations


E Freitas, MA Rodrigues, T Torres
Clinical, cosmetic and investigational dermatology 2020
Association between cytokine profiles and lung injury in COVID-19 pneumonia
LD Chen, ZY Zhang, XJ Wei, YQ Cai, WZ Yao, MH Wang, QF Huang, XB Zhang
Respiratory Research 2020
Inhibiting IL-6 in COVID-19: we are not sure
PM Honore, LB Gutierrez, L Kugener, S Redant, R Attou, A Gallerani, DD Bels
Critical Care 2020
Interactions among Interleukin-6, C-Reactive Protein and Interleukin-6 (-174) G/C Polymorphism in the Pathogenesis of Crohn’s Disease and Ulcerative Colitis
B Takač
ACTA CLIN CROAT 2020
Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study
S Fantone, G Tossetta, R Montironi, M Senzacqua, D Marzioni, R Mazzucchelli
European Journal of Histochemistry : EJH 2020
Super-enhancers modulate interleukin-6 expression and function in cancers.
Bao Y, Wu Y, Tao B, Sun R, Lin T, Zheng Y, Zhu X, Shen H, Chen W, Fan Y
Translational cancer research 2020
Thermoresponsive, hollow, degradable core-shell nanoparticles for intraarticular delivery of anti-inflammatory peptide
Deloney M, Smart K, Christiansen BA, Panitch A
Journal of Controlled Release 2020

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Blogged by 1
Posted by 1 X users
Referenced in 40 patents
Referenced in 1 Wikipedia pages
481 readers on Mendeley
1 readers on CiteULike
See more details