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Simon A. Jones, … , Jürgen Scheller, Stefan Rose-John
Published September 1, 2011
Citation Information: J Clin Invest. 2011;121(9):3375-3383. https://doi.org/10.1172/JCI57158.
Citation Information: J Clin Invest. 2011;121(9):3375-3383. https://doi.org/10.1172/JCI57158.
Abstract
The successful treatment of certain autoimmune conditions with the humanized anti–IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory regulator. Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer.
Authors
Simon A. Jones, Jürgen Scheller, Stefan Rose-John
Total citations by year
Citation information
Citations to this article in year 2012 (19)
| Title and authors | Publication | Year |
|---|---|---|
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Mucosal Immunology | 2012 |
|
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International journal of biological sciences | 2012 |
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Innate Immune Cells in Liver Inflammation
E Liaskou, DV Wilson, YH Oo |
Mediators of Inflammation | 2012 |
|
Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
S Vicent, LC Sayles, D Vaka, P Khatri, O Gevaert, R Chen, Y Zheng, AK Gillespie, N Clarke, Y Xu, J Shrager, CD Hoang, S Plevritis, AJ Butte, EA Sweet-Cordero |
Cancer research | 2012 |
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Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease?
C Finelli, G Tarantino |
World journal of gastroenterology : WJG | 2012 |
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HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice
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Blood | 2012 |
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Cardiovascular risk biomarkers in CKD: the inflammation link and the road less traveled
U Elewa, MD Sanchez-Niño, C Martin-Cleary, B Fernandez-Fernandez, J Egido, A Ortiz |
International Urology and Nephrology | 2012 |
|
Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer
C Johnson, Y Han, N Hughart, J McCarra, G Alpini, F Meng |
Translational gastrointestinal cancer | 2012 |
|
A designer hyper interleukin 11 (H11) is a biologically active cytokine
H Dams-Kozlowska, K Gryska, E Kwiatkowska-Borowczyk, D Izycki, S Rose-John, A Mackiewicz |
BMC Biotechnology | 2012 |
|
The Stress-Induced Cytokine Interleukin-6 Decreases the Inhibition/Excitation Ratio in the Rat Temporal Cortex via Trans-Signaling
F Garcia-Oscos, H Salgado, S Hall, F Thomas, GE Farmer, J Bermeo, LC Galindo, RD Ramirez, S D'Mello, S Rose-John, M Atzori |
Biological Psychiatry | 2012 |
|
JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia
A Bonetto, T Aydogdu, X Jin, Z Zhang, R Zhan, L Puzis, LG Koniaris, TA Zimmers |
American journal of physiology. Endocrinology and metabolism | 2012 |
|
Interleukin-6, a major cytokine in the central nervous system
M Erta, A Quintana, J Hidalgo |
International journal of biological sciences | 2012 |
|
d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers
E Magbanua, T Zivkovic, B Hansen, N Beschorner, C Meyer, I Lorenzen, J Grötzinger, J Hauber, AE Torda, G Mayer, S Rose-John, U Hahn |
RNA biology | 2012 |
|
Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3
KW Park, SE Nozell, EN Benveniste |
PloS one | 2012 |
|
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer
C Garbers, B Spudy, S Aparicio-Siegmund, GH Waetzig, J Sommer, C Hölscher, S Rose-John, J Grötzinger, I Lorenzen, J Scheller |
The Journal of biological chemistry | 2012 |
|
Interleukin-6--a key regulator of colorectal cancer development
MJ Waldner, S Foersch, MF Neurath |
International journal of biological sciences | 2012 |
|
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
S Rose-John |
International journal of biological sciences | 2012 |
|
Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress
M Girotti, JJ Donegan, DA Morilak |
Psychoneuroendocrinology | 2012 |
|
Role of inflammatory cytokines in peripheral nerve injury
Federica Fregnan, Federica Fregnan, Luisa Muratori, Luisa Muratori, Anabel Rodriguez Simões, Maria Giuseppina Giacobini-Robecchi, Stefania Raimondo |
Neural Regeneration Research | 2012 |
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