The successful treatment of certain autoimmune conditions with the humanized anti–IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory regulator. Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer.
Simon A. Jones, Jürgen Scheller, Stefan Rose-John
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Transcriptional network systems in cartilage development and disease
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Histochemistry and Cell Biology | 2018 |
The Effect of Inhalant Organic Dust on Bone Health
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Current Allergy and Asthma Reports | 2018 |
Multifaceted Roles of Interleukin-6 in Adipocyte–Breast Cancer Cell Interaction
J Gyamfi, M Eom, JS Koo, J Choi |
Translational oncology | 2018 |
The role of interleukin‑6‑STAT3 signalling in glioblastoma (Review)
A West, V Tsui, S Stylli, H Nguyen, A Morokoff, A Kaye, R Luwor |
Oncology Letters | 2018 |
Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells
M Valle, J Dworshak, A Sharma, A Ibrahim, M Al-Shabrawey, S Sharma |
Experimental Eye Research | 2018 |
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
Q Wang, Z He, M Huang, T Liu, Y Wang, H Xu, H Duan, P Ma, L Zhang, SS Zamvil, J Hidalgo, Z Zhang, DM ORourke, N Dahmane, S Brem, Y Mou, Y Gong, Y Fan |
Nature Communications | 2018 |
Cytokines, breast cancer stem cells (BCSCs) and chemoresistance
W Chen, Y Qin, S Liu |
Clinical and Translational Medicine | 2018 |
Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice
J Hu, X Feng, M Valdearcos, D Lutrin, Y Uchida, SK Koliwad, M Maze |
British Journal of Anaesthesia | 2018 |
Effects of human umbilical cord-derived mesenchymal stem cells on hematologic malignancies
Q Li, Y Pang, T Liu, Y Tang, J Xie, B Zhang, H Chen |
Oncology Letters | 2018 |
Oral Vaccination with a DNA Vaccine Encoding Capsid Protein of Duck Tembusu Virus Induces Protection Immunity
J Huang, H Shen, R Jia, M Wang, S Chen, D Zhu, M Liu, X Zhao, Q Yang, Y Wu, Y Liu, L Zhang, Z Yin, B Jing, A Cheng |
Viruses | 2018 |
DNA methylation rather than single nucleotide polymorphisms regulates the production of an aberrant splice variant of IL6R in mastitic cows
Y Zhang, X Wang, Q Jiang, H Hao, Z Ju, C Yang, Y Sun, C Wang, J Zhong, J Huang, H Zhu |
Cell Stress and Chaperones | 2018 |
IL-27: a double agent in the IL-6 family: IL-27 and IL-6 in inflammatory arthritis
GW Jones, DG Hill, A Cardus, SA Jones |
Clinical & Experimental Immunology | 2018 |
ATM inhibition prevents interleukin-6 from contributing to the proliferation of glioblastoma cells after ionizing radiation
YC Lim, H Quek, C Offenhäuser, S Fazry, A Boyd, M Lavin, T Roberts, B Day |
Journal of Neuro-Oncology | 2018 |
ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling
S Schmidt, N Schumacher, J Schwarz, S Tangermann, L Kenner, M Schlederer, M Sibilia, M Linder, A Altendorf-Hofmann, T Knösel, ES Gruber, G Oberhuber, J Bolik, A Rehman, A Sinha, J Lokau, P Arnold, AS Cabron, F Zunke, C Becker-Pauly, A Preaudet, P Nguyen, J Huynh, S Afshar-Sterle, AL Chand, J Westermann, PJ Dempsey, C Garbers, D Schmidt-Arras, P Rosenstiel, T Putoczki, M Ernst, S Rose-John |
Journal of Experimental Medicine | 2018 |
Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble interleukin-6 (IL6) receptor
Y Zhou, Z Xia, Z Cheng, G Xu, X Yang, S Liu, Y Zhu |
The Journal of biological chemistry | 2018 |