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Citations to this article

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
Simon A. Jones, … , Jürgen Scheller, Stefan Rose-John
Simon A. Jones, … , Jürgen Scheller, Stefan Rose-John
Published September 1, 2011
Citation Information: J Clin Invest. 2011;121(9):3375-3383. https://doi.org/10.1172/JCI57158.
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Science in Medicine Article has an altmetric score of 23

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

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Abstract

The successful treatment of certain autoimmune conditions with the humanized anti–IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory regulator. Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer.

Authors

Simon A. Jones, Jürgen Scheller, Stefan Rose-John

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 Total
Citations: 7 10 10 29 33 27 21 21 35 24 28 25 29 19 1 1 320
Citation information
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Frontiers in immunology 2018
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Clinical & Experimental Immunology 2018
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Journal of Neuro-Oncology 2018
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S Schmidt, N Schumacher, J Schwarz, S Tangermann, L Kenner, M Schlederer, M Sibilia, M Linder, A Altendorf-Hofmann, T Knösel, ES Gruber, G Oberhuber, J Bolik, A Rehman, A Sinha, J Lokau, P Arnold, AS Cabron, F Zunke, C Becker-Pauly, A Preaudet, P Nguyen, J Huynh, S Afshar-Sterle, AL Chand, J Westermann, PJ Dempsey, C Garbers, D Schmidt-Arras, P Rosenstiel, T Putoczki, M Ernst, S Rose-John
Journal of Experimental Medicine 2018
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The Journal of biological chemistry 2018

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