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Citations to this article

Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation
John D. Lang Jr., … , Devin E. Eckhoff, Rakesh P. Patel
John D. Lang Jr., … , Devin E. Eckhoff, Rakesh P. Patel
Published September 4, 2007
Citation Information: J Clin Invest. 2007;117(9):2583-2591. https://doi.org/10.1172/JCI31892.
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Research Article Article has an altmetric score of 1

Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation

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Abstract

Ischemia/reperfusion (IR) injury in transplanted livers contributes to organ dysfunction and failure and is characterized in part by loss of NO bioavailability. Inhalation of NO is nontoxic and at high concentrations (80 ppm) inhibits IR injury in extrapulmonary tissues. In this prospective, blinded, placebo-controlled study, we evaluated the hypothesis that administration of inhaled NO (iNO; 80 ppm) to patients undergoing orthotopic liver transplantation inhibits hepatic IR injury, resulting in improved liver function. Patients were randomized to receive either placebo or iNO (n = 10 per group) during the operative period only. When results were adjusted for cold ischemia time and sex, iNO significantly decreased hospital length of stay, and evaluation of serum transaminases (alanine transaminase, aspartate aminotransferase) and coagulation times (prothrombin time, partial thromboplastin time) indicated that iNO improved the rate at which liver function was restored after transplantation. iNO did not significantly affect changes in inflammatory markers in liver tissue 1 hour after reperfusion but significantly lowered hepatocyte apoptosis. Evaluation of circulating NO metabolites indicated that the most likely candidate transducer of extrapulmonary effects of iNO was nitrite. In summary, this study supports the clinical use of iNO as an extrapulmonary therapeutic to improve organ function following transplantation.

Authors

John D. Lang Jr., Xinjun Teng, Phillip Chumley, Jack H. Crawford, T. Scott Isbell, Balu K. Chacko, Yuliang Liu, Nirag Jhala, D. Ralph Crowe, Alvin B. Smith, Richard C. Cross, Luc Frenette, Eric E. Kelley, Diana W. Wilhite, Cheryl R. Hall, Grier P. Page, Michael B. Fallon, J. Steven Bynon, Devin E. Eckhoff, Rakesh P. Patel

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 3 3 4 4 2 4 3 4 6 4 13 9 3 10 9 13 6 7 107
Citation information
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Citations to this article in year 2018 (4)

Title and authors Publication Year
Pharmacological preconditioning with inhaled nitric oxide (NO): Organ-specific differences in the lifetime of blood and tissue NO metabolites
Y Nagasaka, BO Fernandez, AU Steinbicker, E Spagnolli, R Malhotra, DB Bloch, KD Bloch, WM Zapol, M Feelisch
Nitric Oxide 2018
Hemodynamic effects of IV sodium nitrite in hospitalized comatose survivors of out of hospital cardiac arrest
C Dezfulian, M Olsufka, D Fly, S Scruggs, R Do, C Maynard, G Nichol, F Kim
Resuscitation 2018
Beneficial effects of inhaled nitric oxide with intravenous steroid in an ischemia–reperfusion model involving aortic clamping
W Gozdzik, S Zielinski, M Zielinska, K Ratajczak, P Skrzypczak, S Rodziewicz, A Kübler, K Löfström, P Dziegiel, M Olbromski, B Adamik, S Ryniak, P Harbut, J Albert, C Frostell
International journal of immunopathology and pharmacology 2018
Effects of inhaled nitric oxide on outcome after prolonged cardiac arrest in mild therapeutic hypothermia treated rats
A Brücken, C Bleilevens, P Berger, K Nolte, NT Gaisa, R Rossaint, G Marx, M Derwall, M Fries
Scientific Reports 2018

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