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Citations to this article

Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation
John D. Lang Jr., … , Devin E. Eckhoff, Rakesh P. Patel
John D. Lang Jr., … , Devin E. Eckhoff, Rakesh P. Patel
Published September 4, 2007
Citation Information: J Clin Invest. 2007;117(9):2583-2591. https://doi.org/10.1172/JCI31892.
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Research Article Article has an altmetric score of 1

Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation

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Abstract

Ischemia/reperfusion (IR) injury in transplanted livers contributes to organ dysfunction and failure and is characterized in part by loss of NO bioavailability. Inhalation of NO is nontoxic and at high concentrations (80 ppm) inhibits IR injury in extrapulmonary tissues. In this prospective, blinded, placebo-controlled study, we evaluated the hypothesis that administration of inhaled NO (iNO; 80 ppm) to patients undergoing orthotopic liver transplantation inhibits hepatic IR injury, resulting in improved liver function. Patients were randomized to receive either placebo or iNO (n = 10 per group) during the operative period only. When results were adjusted for cold ischemia time and sex, iNO significantly decreased hospital length of stay, and evaluation of serum transaminases (alanine transaminase, aspartate aminotransferase) and coagulation times (prothrombin time, partial thromboplastin time) indicated that iNO improved the rate at which liver function was restored after transplantation. iNO did not significantly affect changes in inflammatory markers in liver tissue 1 hour after reperfusion but significantly lowered hepatocyte apoptosis. Evaluation of circulating NO metabolites indicated that the most likely candidate transducer of extrapulmonary effects of iNO was nitrite. In summary, this study supports the clinical use of iNO as an extrapulmonary therapeutic to improve organ function following transplantation.

Authors

John D. Lang Jr., Xinjun Teng, Phillip Chumley, Jack H. Crawford, T. Scott Isbell, Balu K. Chacko, Yuliang Liu, Nirag Jhala, D. Ralph Crowe, Alvin B. Smith, Richard C. Cross, Luc Frenette, Eric E. Kelley, Diana W. Wilhite, Cheryl R. Hall, Grier P. Page, Michael B. Fallon, J. Steven Bynon, Devin E. Eckhoff, Rakesh P. Patel

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 3 3 4 4 2 4 3 4 6 4 13 9 3 10 9 13 6 7 107
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2016 (4)

Title and authors Publication Year
Role of nitric oxide in liver transplantation: Should it be routinely used?
K Fukazawa, JD Lang
World journal of hepatology 2016
The Protective Effects of Trypsin Inhibitor on Hepatic Ischemia-Reperfusion Injury and Liver Graft Survival
L Guan, H Liu, P Fu, Z Li, P Li, L Xie, M Xin, Z Wang, W Li
Oxidative medicine and cellular longevity 2016
Beyond Preconditioning: Postconditioning as an Alternative Technique in the Prevention of Liver Ischemia-Reperfusion Injury
K Theodoraki, I Karmaniolou, A Tympa, MK Tasoulis, C Nastos, I Vassiliou, N Arkadopoulos, V Smyrniotis
Oxidative medicine and cellular longevity 2016
Protective effect of eNOS overexpression against ischemia/reperfusion injury in small-for-size liver transplantation
B Zhang, QH Liu, CJ Zhou, MZ Hu, HX Qian
Experimental and therapeutic medicine 2016

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