Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation
John D. Lang Jr., … , Devin E. Eckhoff, Rakesh P. Patel
John D. Lang Jr., … , Devin E. Eckhoff, Rakesh P. Patel
Published September 4, 2007
Citation Information: J Clin Invest. 2007;117(9):2583-2591. https://doi.org/10.1172/JCI31892.
View: Text | PDF
Research Article Article has an altmetric score of 1

Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation

  • Text
  • PDF
Abstract

Ischemia/reperfusion (IR) injury in transplanted livers contributes to organ dysfunction and failure and is characterized in part by loss of NO bioavailability. Inhalation of NO is nontoxic and at high concentrations (80 ppm) inhibits IR injury in extrapulmonary tissues. In this prospective, blinded, placebo-controlled study, we evaluated the hypothesis that administration of inhaled NO (iNO; 80 ppm) to patients undergoing orthotopic liver transplantation inhibits hepatic IR injury, resulting in improved liver function. Patients were randomized to receive either placebo or iNO (n = 10 per group) during the operative period only. When results were adjusted for cold ischemia time and sex, iNO significantly decreased hospital length of stay, and evaluation of serum transaminases (alanine transaminase, aspartate aminotransferase) and coagulation times (prothrombin time, partial thromboplastin time) indicated that iNO improved the rate at which liver function was restored after transplantation. iNO did not significantly affect changes in inflammatory markers in liver tissue 1 hour after reperfusion but significantly lowered hepatocyte apoptosis. Evaluation of circulating NO metabolites indicated that the most likely candidate transducer of extrapulmonary effects of iNO was nitrite. In summary, this study supports the clinical use of iNO as an extrapulmonary therapeutic to improve organ function following transplantation.

Authors

John D. Lang Jr., Xinjun Teng, Phillip Chumley, Jack H. Crawford, T. Scott Isbell, Balu K. Chacko, Yuliang Liu, Nirag Jhala, D. Ralph Crowe, Alvin B. Smith, Richard C. Cross, Luc Frenette, Eric E. Kelley, Diana W. Wilhite, Cheryl R. Hall, Grier P. Page, Michael B. Fallon, J. Steven Bynon, Devin E. Eckhoff, Rakesh P. Patel

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 3 3 4 4 2 4 3 4 6 4 13 9 3 10 9 13 6 7 107
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2012 (10)

Title and authors Publication Year
Ischaemia-reperfusion injury in liver transplantation--from bench to bedside
Y Zhai, H Petrowsky, JC Hong, RW Busuttil, JW Kupiec-Weglinski
Nature reviews. Gastroenterology & hepatology 2012
Comparing beneficial effects of inhaled nitric oxide to l-arginine in necrotizing enterocolitis model in neonatal rats
F Çekmez, T Purtuloğlu, G Aydemir, S Aydinoz, K Fidancı, A Karaoğlu, O Babacan, FE Canpolat, M Çetinkaya, T Tunc, S Süleymanoglu
Pediatric Surgery International 2012
The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury
W Li, Z Meng, Y Liu, RP Patel, JD Lang
Journal of Transplantation 2012
Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant function
SS Kelpke, B Chen, KM Bradley, X Teng, P Chumley, A Brandon, B Yancey, B Moore, H Head, L Viera, JA Thompson, DK Crossman, MS Bray, DE Eckhoff, A Agarwal, RP Patel
Kidney International 2012
Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation?
A Siriussawakul, LI Chen, JD Lang
Journal of Transplantation 2012
Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury
NM Rogers, AW Thomson, JS Isenberg
Journal of the American Society of Nephrology : JASN 2012
Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity
R Stapley, BY Owusu, A Brandon, M Cusick, C Rodriguez, MB Marques, JD Kerby, SR Barnum, JA Weinberg, JR Lancaster, RP Patel
Biochemical Journal 2012
Review of Inhaled Nitric Oxide in the Pediatric Cardiac Surgery Setting
PA Checchia, RA Bronicki, B Goldstein
Pediatric Cardiology 2012
The Influence of Pharmacological Preconditioning with Sevoflurane on Incidence of Early Allograft Dysfunction in Liver Transplant Recipients
AF Minou, AM Dzyadzko, AE Shcherba, OO Rummo
Anesthesiology Research and Practice 2012
Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers
Q Liu, H Rehman, Y Krishnasamy, VK Ramshesh, TP Theruvath, KD Chavin, RG Schnellmann, JJ Lemasters, Z Zhong
Free radical biology & medicine 2012

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Highlighted by 1 platforms
76 readers on Mendeley
See more details