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Islet β cell failure in type 2 diabetes
Marc Prentki, Christopher J. Nolan
Marc Prentki, Christopher J. Nolan
Published July 3, 2006
Citation Information: J Clin Invest. 2006;116(7):1802-1812. https://doi.org/10.1172/JCI29103.
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Islet β cell failure in type 2 diabetes

Abstract

The major focus of this Review is on the mechanisms of islet β cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of β cell compensation for insulin resistance, consideration is also given to the mechanisms involved in the compensation process, including mechanisms for expansion of β cell mass and for enhanced β cell performance. The importance of genetic, intrauterine, and environmental factors in the determination of “susceptible” islets and overall risk for T2D is reviewed. The likely mechanisms of β cell failure are discussed within the two broad categories: those with initiation and those with progression roles.

Authors

Marc Prentki, Christopher J. Nolan

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