Citations to this article

Islet β cell failure in type 2 diabetes
Marc Prentki, Christopher J. Nolan
Marc Prentki, Christopher J. Nolan
Published July 3, 2006
Citation Information: J Clin Invest. 2006;116(7):1802-1812. https://doi.org/10.1172/JCI29103.
View: Text | PDF
Review Series Article has an altmetric score of 34

Islet β cell failure in type 2 diabetes

Abstract

The major focus of this Review is on the mechanisms of islet β cell failure in the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of β cell compensation for insulin resistance, consideration is also given to the mechanisms involved in the compensation process, including mechanisms for expansion of β cell mass and for enhanced β cell performance. The importance of genetic, intrauterine, and environmental factors in the determination of “susceptible” islets and overall risk for T2D is reviewed. The likely mechanisms of β cell failure are discussed within the two broad categories: those with initiation and those with progression roles.

Authors

Marc Prentki, Christopher J. Nolan

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
Citations: 10 25 35 40 55 51 50 40 50 59 48 59 44 49 40 33 30 26 7 2 753
Citation information

Citations to this article (753)

Title and authors Publication Year
DECORIN, a triceps-derived myokine, protects β-cells against chronic inflammation associated with diabetes
Allan Langlois, Julien Cherfan, Caroline Arous, Claude Peronet, Harzo Hamdard, Bader Zarrouki, Bernhard Wehrle-Haller, Michel Pinget, Siobhan Craige, Karim Bouzakri. 		Acta physiologica (Oxford, England) 2025
Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure
Yuqing Zhang, Shourui Hu, Shan Han, Congcong Liu, Xiaofan Liang, Yuxuan Li, Zongxuan Lin, Yiming Qin, Chunxuan Geng, Yue Liu, Changming Zhang, Zhao Wang, Xin Liu, Jinlong Ma, Zi-Jiang Chen, Han Zhao 		Cell discovery 2025
Overcoming β-Cell Dysfunction in Type 2 Diabetes Mellitus: CD36 Inhibition and Antioxidant System
Park IR, Chung YG, Won KC 		Diabetes & Metabolism Journal 2025
Computational Elucidation of Human β-Defensin-2 as a Dual Inhibitor of MMP-9 and PKC-βII for Diabetic Wound Management
Sanapalli V, Sigalapalli DK, Shaik AB, Bhandare RR, Sanapalli BK 		ACS Omega 2025
Correlation between circulating microRNAs and vascular biomarkers in type 2 diabetes based upon physical activity: a biochemical analytic study
Al-Rawaf HA, Gabr SA, Alghadir T, Alghadir F, Iqbal A, Alghadir AH 		BMC Endocrine Disorders 2025
Cardioprotective effect of genetic ablation of the G-protein-coupled receptor kinase GRK2 in adult pancreatic β-cells during high-fat diet
Snyder J, Jiang CS, Choi RH, Morgan T, Roman J, Underwood L, Lucchese AM, Montgomery S, Grisanti LA, Doliba N, Holland WL, Sato PY 		The Journal of Biological Chemistry 2025
Regulating islet stress responses through CD47 activation.
Kale A, Azar M, Cheng V, Robertson H, Coulter S, Mehta PM, Julovi SM, Patrick E, Ghimire K, Rogers NM 		Diabetologia 2025
ADAM9 Genetic Variants and Their Role in Modulating Enzyme Activity in Diabetes and Metabolic Traits
Drobiova H, Al-Mulla F, Al-Temaimi R 		Journal of Diabetes Research 2025
β-Cells: So Sensitive
Norris N, Kebede MA, Laybutt DR, Gunton JE 		Diabetes 2025
Evaluation of the Effects of Monosodium Glutamate Overconsumption on the Functions of the Liver, Kidney, and Heart of Male Rats: The Involvement of Dyslipidemia, Oxidative Stress, and Inflammatory Responses
Abdou HM, El-Gendy AH, Aly RG, Abouzied MM, Eltahir HM, Al thagfan SS, Eweda SM 		Journal of Xenobiotics 2025
Metformin enhances METTL14-Mediated m6A methylation to alleviate NIT-1 cells apoptosis induced by hydrogen peroxide.
Zhou SM, Yao XM, Cheng Y, Xing YJ, Sun Y, Hua Q, Wan SJ, Meng XJ 		Heliyon 2024
Etiology of Drug-Induced Edema: A Review of Dihydropyridine, Thiazolidinedione, and Other Medications Causing Edema
Sinnathamby ES, Urban BT, Clark RA, Roberts LT, De Witt AJ, Wenger DM, Mouhaffel A, Willett O, Ahmadzadeh S, Shekoohi S, Kaye AD, Varrassi G 		Cureus 2024
Animal models for type 1 and type 2 diabetes: advantages and limitations
Singh R, Gholipourmalekabadi M, Shafikhani SH 		Frontiers in Endocrinology 2024
Calorie Restriction Using High-Fat/Low-Carbohydrate Diet Suppresses Liver Fat Accumulation and Pancreatic Beta-Cell Dedifferentiation in Obese Diabetic Mice
Lei X, Ishida E, Yoshino S, Matsumoto S, Horiguchi K, Yamada E 		Nutrients 2024
Roles of β-Cell Hypoxia in the Progression of Type 2 Diabetes
Yamagata K, Tsuyama T, Sato Y 		International journal of molecular sciences 2024
Innovations in bio-engineering and cell-based approaches to address immunological challenges in islet transplantation.
Ho BX, Teo AKK, Ng NHJ 		Frontiers in immunology 2024
Revisiting pancreatic islet isolation in murine models: A practical and effective technical protocol.
Fernandes-da-Silva A, Miranda RA, Lisboa PC, Souza-Mello V 		Physiological Reports 2024
Exploration of the shared pathways and common biomarker in adamantinomatous craniopharyngioma and type 2 diabetes using integrated bioinformatics analysis
Han Y, Wang Y, Li S, Sato K, Yamagishi S 		PloS one 2024
Insulin resistance in the retina: possible implications for certain ocular diseases
Zheng Z, Yu X 		Frontiers in Endocrinology 2024
Chronic Epinephrine-Induced Endoplasmic Reticulum and Oxidative Stress Impairs Pancreatic β-Cells Function and Fate
Zhang R, Yao B, Li R, Limesand SW, Zhao Y, Chen X 		International journal of molecular sciences 2024
LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance
Kubrak O, Jørgensen AF, Koyama T, Lassen M, Nagy S, Hald J, Mazzoni G, Madsen D, Hansen JB, Larsen MR, Texada MJ, Hansen JL, Halberg KV, Rewitz K 		Nature Communications 2024
Medicinal utilization and nutritional properties of drumstick (Moringa oleifera)—A comprehensive review
Zarina, Wani AW, Rawat M, Kaur H, Das S, Kaur T, Akram N, Faisal Z, Jan SS, Oyshe NN, Khan MR, Shah YA 		Food Science & Nutrition 2024
Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk
Mummey HM, Elison W, Korgaonkar K, Elgamal RM, Kudtarkar P, Griffin E, Benaglio P, Miller M, Jha A, Fox JE, McCarthy MI, Preissl S, Gloyn AL, MacDonald PE, Gaulton KJ 		bioRxiv 2024
A Novel "Endocrine Hormone": The Diverse Role of Extracellular Vesicles in Multiorgan Insulin Resistance.
Xu F, Dou L, Yu D, Wu X, Liu L, Man Y, Huang X 		International journal of medical sciences 2024
Advances and counterpoints in type 2 diabetes. What is ready for translation into real-world practice, ahead of the guidelines.
Schwartz SS, Corkey BE, R Gavin J 3rd, DeFronzo RA, Herman ME 		BMC medicine 2024
Metabolic and Molecular Amplification of Insulin Secretion.
Ferdaoussi M 		Advances in anatomy, embryology, and cell biology 2024
Exosomal miRNAs and isomiRs: potential biomarkers for type 2 diabetes mellitus
Sou YL, Chilian WM, Ratnam W, Zain SM, Syed Abdul Kadir SZ, Pan Y, Pung YF 		Precision Clinical Medicine 2024
Biomarkers of insulin sensitivity/resistance
Kosmas CE, Sourlas A, Oikonomakis K, Zoumi EA, Papadimitriou A, Kostara CE 		The Journal of International Medical Research 2024
A multiorgan map of metabolic, signaling, and inflammatory pathways that coordinately control fasting glycemia in mice
Mehl F, Sánchez-Archidona AR, Meitil I, Gerl M, Cruciani-Guglielmacci C, Wigger L, Le Stunff H, Meneyrol K, Lallement J, Denom J, Klose C, Simons K, Pagni M, Magnan C, Ibberson M, Thorens B 		iScience 2024
One path, two solutions: Network-based analysis identifies targetable pathways for the treatment of comorbid type II diabetes and neuropsychiatric disorders
Onisiforou A, Zanos P 		Computational and Structural Biotechnology Journal 2024
Assessing the validity of METS-IR for predicting the future onset of diabetes: an analysis using time-dependent receiver operating characteristics
Qiu J, He S, Yu C, Yang R, Kuang M, Sheng G, Zou Y 		BMC Endocrine Disorders 2024
HM-Chromanone Alleviates Hyperglycemia by Activating AMPK and PI3K/AKT Pathways in Mice Fed a High-Fat Diet
Park JE, Yoo J, Han JS 		Nutrients 2024
The selective serotonin reuptake inhibitors, sertraline and paroxetine, improve islet beta‐cell mass and function in vitro
Toczyska K, Haq N, Lyu Z, Bewick G, Zhao M, Rosa H, Starikova J, Liu B, Persaud SJ 		Diabetes, Obesity & Metabolism 2024
Menaquinone-7 and its therapeutic potential in type 2 diabetes mellitus based on a Zucker diabetic fatty rat model
Mrosewski I, Mantel V, Urbank M, Schulze-Tanzil G, Werner C, Gögele C, Kokozidou M, Bertsch T 		Heliyon 2024
Biphasic glucose-stimulated insulin secretion over decades: a journey from measurements and modeling to mechanistic insights
Peng X, Wang K, Chen L 		Life Metabolism 2024
Hypoxia causes pancreatic β-cell dysfunction by activating a transcriptional repressor BHLHE40
Tomonori Tsuyama, Yoshifumi Sato, Tatsuya Yoshizawa, Takaaki Matsuoka, Kazuya Yamagata 		EMBO reports 2023
TRPM7 kinase is required for insulin production and compensatory islet responses during obesity
Noushafarin Khajavi, Andreas Beck, Klea Ricku, Philipp Beyerle, Katharina Jacob, Sabrina Syamsul, Anouar Belkacemi, Houssein Salah, Tanja Popp, Aaron Novikoff, Andreas Breit, Vladimir Chubanov, Timo Müller, Susanna Zierler, Thomas Gudermann 		JCI Insight 2023
Luteolin-7-O-rutinoside Protects RIN-5F Cells from High-Glucose-Induced Toxicity, Improves Glucose Homeostasis in L6 Myotubes, and Prevents Onset of Type 2 Diabetes.
Subash-Babu P, Abdulaziz AlSedairy S, Abdulaziz Binobead M, Alshatwi AA 		Metabolites 2023
Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target.
Muehlebach ME, Holstein SA 		Clinical and Translational Medicine 2023
No Time to Die—How Islets Meet Their Demise in Transplantation
Kale A, Rogers NM 		Cells 2023
β‐Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control
Liu J, Fu H, Kang F, Ning G, Ni Q, Wang W, Wang Q 		Journal of Diabetes 2023
Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets.
Lorza-Gil E, Kaiser G, Carlein C, Hoffmann MDA, König GM, Haug S, Prates Roma L, Rexen Ulven E, Ulven T, Kostenis E, Birkenfeld AL, Häring HU, Ullrich S, Gerst F 		Diabetologia 2023
A highly sensitive strategy for monitoring real-time proliferation of targeted cell types in vivo.
Sugawara H, Imai J, Yamamoto J, Izumi T, Kawana Y, Endo A, Kohata M, Seike J, Kubo H, Komamura H, Munakata Y, Asai Y, Hosaka S, Sawada S, Kodama S, Takahashi K, Kaneko K, Katagiri H 		Nature Communications 2023
Prevalence of Type 2 Diabetes, Impaired Fasting Glucose, and Diabetes Risk in an Adult and Older North-Eastern Portuguese Population
Magalhães PM, Teixeira JE, Bragada JP, Duarte CM, Bragada JA 		Healthcare 2023
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
Xu W, Qadir MM, Nasteska D, de Sa PM, Gorvin CM, Blandino-Rosano M, Evans CR, Ho T, Potapenko E, Veluthakal R, Ashford FB, Bitsi S, Fan J, Bhondeley M, Song K, Sure VN, Sakamuri SS, Schiffer L, Beatty W, Wyatt R, Frigo DE, Liu X, Katakam PV, Arlt W, Buck J, Levin LR, Hu T, Kolls J, Burant CF, Tomas A, Merrins MJ, Thurmond DC, Bernal-Mizrachi E, Hodson DJ, Mauvais-Jarvis F 		Cell Reports 2023
Erigeron annuus Extract Alleviates Insulin Resistance via Regulating the Expression of Mitochondrial Damage and Endoplasmic Reticulum Stress-Related Genes
Lee HK, Nam YH, Shin SW, Kim MC, An JI, Kim NW, Shim JH, Srinath S, Hong BN, Kwak JH, Kang TH 		Nutrients 2023
An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes
Soldovieri L, Di Giuseppe G, Ciccarelli G, Quero G, Cinti F, Brunetti M, Nista EC, Gasbarrini A, Alfieri S, Pontecorvi A, Giaccari A, Mezza T 		Molecular Metabolism 2023
Regeneration of Pancreatic Beta Cells by Modulation of Molecular Targets Using Plant-Derived Compounds: Pharmacological Mechanisms and Clinical Potential.
Kimani CN, Reuter H, Kotzé SH, Muller CJF 		Current issues in molecular biology 2023
RESTORING CONNEXIN-36 FUNCTION IN DIABETOGENIC ENVIRONMENTS PRECLUDES MOUSE AND HUMAN ISLET DYSFUNCTION
St. Clair JR, Westacott MJ, Miranda J, Farnsworth NL, Kravets V, Schleicher WE, Dwulet JM, Levitt CH, Heintz A, Ludin NW, Benninger RK 		The Journal of Physiology 2023
The Interplay of Adipokines and Pancreatic Beta Cells in Metabolic Regulation and Diabetes
Kim J, Oh CM, Kim H 		Biomedicines 2023
Leucine suppresses glucagon secretion from pancreatic islets by directly modulating α-cell cAMP.
Knuth ER, Foster HR, Jin E, Merrins MJ 		bioRxiv : the preprint server for biology 2023
Optimizing diabetic kidney disease animal models: Insights from a meta-analytic approach.
Li F, Ma Z, Cai Y, Zhou J, Liu R 		2023
Beta-cell compensation and gestational diabetes
Usman TO, Chhetri G, Yeh H, Dong HH 		The Journal of biological chemistry 2023
Endoplasmic Reticulum Stress and Its Impact on Adipogenesis: Molecular Mechanisms Implicated
Kim G, Lee J, Ha J, Kang I, Choe W 		Nutrients 2023
Benefits and risks of drug combination therapy for diabetes mellitus and its complications: a comprehensive review
Xie X, Wu C, Hao Y, Wang T, Yang Y, Cai P, Zhang Y, Huang J, Deng K, Yan D, Lin H 		Frontiers in Endocrinology 2023
Slc12a2 loss in insulin-secreting β-cells links development of overweight and metabolic dysregulation to impaired satiation control of feeding
Rathod YD, Abdelgawad R, Hübner CA, Di Fulvio M 		American journal of physiology. Endocrinology and metabolism 2023
Transcriptome Changes and Metabolic Outcomes After Bariatric Surgery in Adults With Obesity and Type 2 Diabetes
Rashid M, Al Qarni A, Al Mahri S, Mohammad S, Khan A, Abdullah ML, Lehe C, Al Amoudi R, Aldibasi O, Bouchama A 		Journal of the Endocrine Society 2023
Glucose-Lowering Effects of Imeglimin and Its Possible Beneficial Effects on Diabetic Complications
Yanai H, Adachi H, Hakoshima M, Katsuyama H 		Biology 2023
The Role of Gut Microbiota in High-Fat-Diet-Induced Diabetes: Lessons from Animal Models and Humans
Qi Y, Wang X 		Nutrients 2023
Knowledge domain and emerging trends in beta‐cell research: A bibliometric and knowledge‐map analysis
Luo Y, Wang T, Chen Z, Zhang G 		Frontiers in Endocrinology 2023
Editorial: Study of pancreatic islets based on human models to understand pathogenesis of diabetes
Imai Y, Soleimanpour SA, Tessem JS 		Frontiers in Endocrinology 2023
Metabolic Characteristics of Gestational Diabetes Mellitus and the Effects on Pregnancy Outcomes
Luo P, Fan Y, Xiong Y, Zhang C, Yang Z, Sun F, Mei B 		2023
Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus.
Kamiński M, Mierzyński R, Poniedziałek-Czajkowska E, Sadowska A, Sotowski M, Leszczyńska-Gorzelak B 		International journal of molecular sciences 2023
Cardiometabolic Risk Factors Associated With Type 2 Diabetes Mellitus: A Mechanistic Insight.
Chakraborty S, Verma A, Garg R, Singh J, Verma H 		Clinical Medicine Insights. Endocrinology and Diabetes 2023
Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function and insulin sensitivity in Africans without type 2 diabetes.
Meeks KAC, Bentley AR, Assimes TL, Franceschini N, Adeyemo AA, Rotimi CN, Doumatey AP 		Genome Medicine 2023
Editorial: Pharmacological and non-pharmacological therapy for obesity and diabetes - volume II.
Oliveira AG, Carvalho BM, Zweig Rocha G 		Frontiers in Endocrinology 2023
Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment.
Ivić V, Zjalić M, Blažetić S, Fenrich M, Labak I, Scitovski R, Szűcs KF, Ducza E, Tábi T, Bagamery F, Szökő É, Vuković R, Rončević A, Mandić D, Debeljak Ž, Berecki M, Balog M, Seres-Bokor A, Sztojkov-Ivanov A, Hajagos-Tóth J, Gajović S, Imširović A, Bakula M, Mahiiovych S, Gaspar R, Vari SG, Heffer M 		Frontiers in Endocrinology 2023
Recent insights of obesity-induced gut and adipose tissue dysbiosis in type 2 diabetes.
Patra D, Banerjee D, Ramprasad P, Roy S, Pal D, Dasgupta S 		Frontiers in Molecular Biosciences 2023
Growth differentiation factor‑15 in patients with gestational diabetes mellitus and its relationship with microalbuminuria.
Gong Y, Shi J, Li J, Liu L 		Experimental and therapeutic medicine 2023
Moderate-intensity endurance training improves late phase β-cell function in adults with type 2 diabetes.
Zhang H, Simpson LK, Carbone NP, Hirshman MF, Nigro P, Vamvini M, Goodyear LJ, Middelbeek RJW 		iScience 2023
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance
S Skovsø, E Panzhinskiy, J Kolic, H Cen, D Dionne, X Dai, R Sharma, L Elghazi, C Ellis, K Faulkner, S Marcil, P Overby, N Noursadeghi, D Hutchinson, X Hu, H Li, H Modi, J Wildi, J Botezelli, H Noh, S Suk, B Gablaski, A Bautista, R Kim, C Cras-Méneur, S Flibotte, S Sinha, D Luciani, C Nislow, E Rideout, E Cytrynbaum, J Kim, E Bernal-Mizrachi, L Alonso, P MacDonald, J Johnson 		Nature Communications 2022
XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice
K Lee, J Chan, C Liang, C Ip, Y Shi, H Herzog, W Hughes, M Bensellam, V Delghingaro-Augusto, M Koina, C Nolan, D Laybutt 		Diabetologia 2022
Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic β-Cell Dysfunction and Senescence in Type 2 Diabetes
J Lee, J Lee 		International journal of molecular sciences 2022
Increased glycolysis affects β-cell function and identity in aging and diabetes
N Murao, N Yokoi, H Takahashi, T Hayami, Y Minami, S Seino 		Molecular Metabolism 2022
β-cell-specific deletion of PFKFB3 restores cell fitness competition and physiological replication under diabetogenic stress
J Min, F Ma, B Seyran, M Pellegrini, O Greeff, S Moncada, S Tudzarova 		2022
Lipid Droplets’ Role in the Regulation of β-Cell Function and β-Cell Demise in Type 2 Diabetes
X Tong, S Liu, R Stein, Y Imai 		Endocrinology 2022
Mechanisms Underlying the Expansion and Functional Maturation of β-Cells in Newborns: Impact of the Nutritional Environment
C Jacovetti, R Regazzi 		International journal of molecular sciences 2022
Long-Term Diabetes Improvement After Duodenal Exclusion in Zucker Diabetic Fatty Rats Is Associated with Prevention of Strain-Specific Pancreatic Remodeling and Increased Beta Cell Proliferation
G Seifert, A Malyi, P Bronsert, S Plohmann, R Kesselring, S Fichtner-Feigl, G Marjanovic, J Fink, C Laessle 		Obesity Surgery 2022
Early Effects of Metabolic Syndrome on ATP-Sensitive Potassium Channels from Rat Pancreatic Beta Cells
I Cruz-Cruz, G Bernate-Obando, C Larqué, R Escalona, R Pinto-Almazán, M Velasco 		Metabolites 2022
ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?
C Nichols, N York, M Remedi 		Diabetes 2022
Links between Insulin Resistance and Periodontal Bacteria: Insights on Molecular Players and Therapeutic Potential of Polyphenols
K Thouvenot, T Turpin, J Taïlé, K Clément, O Meilhac, M Gonthier 		Biomolecules 2022
Is type 2 diabetes mellitus another intercellular junction-related disorder?
Collares-Buzato CB, Carvalho CP 		Experimental Biology and Medicine 2022
Inhibition of CXXC5 function reverses obesity‐related metabolic diseases
Seo SH, Kim E, Lee S, Lee Y, Han DH, Go H, Seong JK, Choi K 		Clinical and Translational Medicine 2022
Effects of Red Rice Bran Extract on High-Fat Diet-Induced Obesity and Insulin Resistance in Mice
Munkong N, Thim-Uam A, Pengnet S, Hansakul P, Somparn N, Naowaboot J, Tocharus J, Tocharus C 		Preventive Nutrition and Food Science 2022
N-acetyl-L-cysteine treatment reduces beta-cell oxidative stress and pancreatic stellate cell activity in a high fat diet-induced diabetic mouse model.
Schuurman M, Wallace M, Sahi G, Barillaro M, Zhang S, Rahman M, Sawyez C, Borradaile N, Wang R 		Frontiers in Endocrinology 2022
Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance.
Cen HH, Hussein B, Botezelli JD, Wang S, Zhang JA, Noursadeghi N, Jessen N, Rodrigues B, Timmons JA, Johnson JD 		The FASEB Journal 2022
Targeting pancreatic β cells for diabetes treatment.
Jain C, Ansarullah, Bilekova S, Lickert H 		Nature metabolism 2022
Role of Reactive Oxygen Species in Glucose Metabolism Disorder in Diabetic Pancreatic β-Cells
Mukai E, Fujimoto S, Inagaki N 		Biomolecules 2022
Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetes
Hou X, Yang D, Yang G, Li M, Zhang J, Zhang J, Zhang Y, Liu Y 		Frontiers in Endocrinology 2022
Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia.
Al-Mass A, Poursharifi P, Peyot ML, Lussier R, Chenier I, Leung YH, Ghosh A, Oppong A, Possik E, Mugabo Y, Ahmad R, Sladek R, Murthy Madiraju SR, Al-Mulla F, Prentki M 		Molecular Metabolism 2022
Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin.
Heras-Molina A, Yeste N, Pesantez-Pacheco JL, Astiz S, Vazquez-Gomez M, Bettiga A, Trevisani F, Garcia-Contreras C, Luis-Lima S, Bassols A, Porrini E, Gonzalez-Bulnes A 		Biology 2022
Sulfated Fucogalactan From Laminaria Japonica Ameliorates β-Cell Failure by Attenuating Mitochondrial Dysfunction via SIRT1-PGC1-α Signaling Pathway Activation.
Wu N, Jin W, Zhao Y, Wang H, He S, Zhang W, Zhou J 		Frontiers in Endocrinology 2022
Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Mice With Diet-Induced Obesity
Winn NC, Cottam MA, Bhanot M, Caslin HL, Garcia JN, Arrojo e Drigo R, Hasty AH 		Diabetes 2022
β-cell dynamics in type 2 diabetes and in dietary and exercise interventions.
Lv C, Sun Y, Zhang ZY, Aboelela Z, Qiu X, Meng ZX 		Journal of Molecular Cell Biology 2022
Data assimilation on mechanistic models of glucose metabolism predicts glycemic states in adolescents following bariatric surgery
Richter LR, Albert BI, Zhang L, Ostropolets A, Zitsman JL, Fennoy I, Albers DJ, Hripcsak G 		Frontiers in physiology 2022
Glycerate from Intestinal Fructose Metabolism Induces Islet Cell Damage and Glucose Intolerance
Wu Y, Wong CW, Chiles EN, Mellinger AL, Bae H, Jung S, Peterson T, Wang J, Negrete M, Huang Q, Wang L, Jang C, Muddiman DC, Su X, Williamson I, Shen X 		Cell Metabolism 2022
Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement
Goode RA, Hum JM, Kalwat MA 		Endocrinology 2022
Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo.
Wu SY, Wu HT, Wang YC, Chang CJ, Shan YS, Wu SR, Chiu YC, Hsu CL, Juan HF, Lan KY, Chu CW, Lee YR, Lan SH, Liu HS 		Autophagy 2022
Risk Factors for Glycemic Control in Hospitalized Patients with Type 2 Diabetes Receiving Continuous Subcutaneous Insulin Infusion Therapy
Wang SH, Shao W, Jiang QH, Zheng XL, Shen QB, Lin XY, Zhang QQ, Zhang LL, Shi XL, Wang WG, Li XJ 		Diabetes Therapy 2022
AM-879, a PPARy non-agonist and Ser273 phosphorylation blocker, promotes insulin sensitivity without adverse effects in mice
Terra MF, García-Arévalo M, Avelino TM, Degaki KY, Malospirito CC, de Carvalho M, Torres FR, Saito Â, Figueira AC 		2022
Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic β-Cells
Nagao Y, Amo-Shiinoki K, Nakabayashi H, Hatanaka M, Kondo M, Matsunaga K, Emoto M, Okuya S, Tanizawa Y, Tanabe K 		International journal of molecular sciences 2022
Do Thrifty Genes Exist? Revisiting Uricase
Johnson RJ, Sánchez-Lozada LG, Nakagawa T, Rodriguez-Iturbe B, Tolan D, Gaucher EA, Andrews P, Lanaspa MA 		Obesity (Silver Spring, Md.) 2022
Histomorphometric and oxidative evaluation of the offspring's testis from type 2 diabetic female rats treated with metformin and pentoxifylline
de Oliveira JS, Silva AA, Dias FC, de Oliveira EL, de Oliveira Filho EF, Soares PC, Ferreira CM, da Silva Junior VA 		International Journal of Experimental Pathology 2022
Serum Caveolin-1 Level is Inversely Associated with Serum Vaspin, Visfatin, and HbA1c in Newly Diagnosed Men with Type-2 Diabetes
Ali HH, AL-Rawi K, Khalaf Y, Alaaraji S, Aldahham B, Awad M, Al-ani O, Al-ani F, Ali AT 		Reports of Biochemistry & Molecular Biology 2022
Deep Insight of the Pathophysiology of Gestational Diabetes Mellitus
Sharma AK, Singh S, Singh H, Mahajan D, Kolli P, Mandadapu G, Kumar B, Kumar D, Kumar S, Jena MK 		Cells 2022
Verification of the folkloric and anecdotal antidiabetic effects of Hypoxis hemerocallidea (Fisch., C.A. Mey. & Avé-Lall) and isolated, β-sitosterol using early-stage type II spontaneous diabetic mutant BKS-Leprdb mice
Mkolo NM, Olaokun OO, King PH, Janse van Rensburg I, Eloff JN, Naidoo V 		2022
Identification of Type 2 Diabetes Biomarkers From Mixed Single-Cell Sequencing Data With Feature Selection Methods
Li Z, Pan X, Cai YD 		Frontiers in Bioengineering and Biotechnology 2022
Is Type 2 Diabetes a Primary Mitochondrial Disorder?
Weksler-Zangen S 		Cells 2022
Diabetogenic and Obesogenic Effects of Cadmium in Db/Db Mice and Rats at a Clinically Relevant Level of Exposure
Nguyen J, Patel A, Gensburg A, Bokhari R, Lamar P, Edwards J 		Toxics 2022
Benefits of Vitamin D Supplementation on Pregnancy of Rats with Pregestational Diabetes and Their Offspring.
Klöppel E, Sinzato YK, Rodrigues T, Gallego FQ, Karki B, Volpato GT, Corrente JE, Roy S, Damasceno DC 		Reproductive sciences (Thousand Oaks, Calif.) 2022
Deciphering regulatory protein activity in human pancreatic islets via reverse engineering of single-cell sequencing data
Yumi Umai 		Journal of Clinical Investigation 2021
Normal and defective pathways in biogenesis and maintenance of the insulin storage pool
Ming Liu, Yumeng Huang, Xiaoxi Xu, Xin Li, Maroof Alam, Anoop Arunagiri, Leena Haataja, Li Ding, Shusen Wang, Pamela Itkin-Ansari, Randal J. Kaufman, Billy Tsai, Ling Qi, Peter Arvan 		Journal of Clinical Investigation 2021
Islet cell dedifferentiation is a pathologic mechanism of longstanding progression of type 2 diabetes
Kikuko Amo-Shiinoki, Katsuya Tanabe, Yoshinobu Hoshii, Hiroto Matsui, Risa Harano, Tatsuya Fukuda, Takato Takeuchi, Ryotaro Bouchi, Tokiyo Takagi, Masayuki Hatanaka, Komei Takeda, Shigeru Okuya, Wataru Nishimura, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, Takumi Akashi, Tetsuya Yamada, Yoshihiro Ogawa, Eiji Ikeda, Hiroaki Nagano, Yukio Tanizawa 		JCI Insight 2021
Perilipin2 down-regulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria
Akansha Mishra, Siming Liu, Joseph Promes, Mikako Harata, William I. Sivitz, Brian D. Fink, Gourav Bhardwaj, Brian T. O'Neill, Chen Kang, Rajan Sah, Stefan Strack, Samuel B Stephens, Timothy H. King, Laura Jackson, Andrew Greenberg, Frederick Anokye-Danso, Rexford Ahima, James A. Ankrum, Yumi Imai 		JCI Insight 2021
Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes
L Cottle, WJ Gan, I Gilroy, JS Samra, AJ Gill, T Loudovaris, HE Thomas, WJ Hawthorne, MA Kebede, P Thorn 		Diabetologia 2021
New Aspects of Diabetes Research and Therapeutic Development
LS Satin, SA Soleimanpour, EM Walker, L Isom 		Pharmacological reviews 2021
Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
S Khetan, S Kales, R Kursawe, A Jillette, JC Ulirsch, SK Reilly, D Ucar, R Tewhey, ML Stitzel 		Nature Communications 2021
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function
M Duquenne, C Folgueira, C Bourouh, M Millet, A Silva, J Clasadonte, M Imbernon, D Fernandois, I Martinez-Corral, S Kusumakshi, E Caron, S Rasika, E Deliglia, N Jouy, A Oishi, M Mazzone, E Trinquet, J Tavernier, YB Kim, S Ory, R Jockers, M Schwaninger, U Boehm, R Nogueiras, JS Annicotte, S Gasman, J Dam, V Prévot 		2021
Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes
S Dhounchak, SK Popp, DJ Brown, DR Laybutt, TJ Biden, SR Bornstein, CR Parish, CJ Simeonovic, HL Stunff 		PloS one 2021
β-Cell Death in Diabetes: Past Discoveries, Present Understanding, and Potential Future Advances
N Mukherjee, L Lin, CJ Contreras, AT Templin 		Metabolites 2021
Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice
GA Bronczek, GM Soares, JF de Barros, JF Vettorazzi, MA Kurauti, E Marconato-Júnior, L Zangerolamo, C Marmentini, AC Boschero, JM Costa-Júnior 		Scientific Reports 2021
Glucokinase is required for high‐starch diet‐induced β‐cell mass expansion in mice
K Tsuchida, A Nakamura, H Miyoshi, K Yang, Y Yamauchi, S Kawata, K Omori, K Takahashi, N Kitao, H Nomoto, H Kameda, KY Cho, Y Seino, Y Terauchi, T Atsumi 		Journal of Diabetes Investigation 2021
Hyperinsulinemic Compensation for Insulin Resistance Occurs Independent of Elevated Glycemia in Male Dogs
M Ader, RN Bergman 		Endocrinology 2021
The Impact of Helminth Infection on the Incidence of Metabolic Syndrome: A Systematic Review and Meta-Analysis
C Rennie, R Fernandez, S Donnelly, KC McGrath 		Frontiers in Endocrinology 2021
Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice
N Shah, MA Abdalla, H Deshmukh, T Sathyapalan 		Therapeutic Advances in Endocrinology and Metabolism 2021
Insulin resistance in diabetes: The promise of using induced pluripotent stem cell technology
AK Elsayed, S Vimalraj, M Nandakumar, EM Abdelalim 		World journal of stem cells 2021
Hypoglycemic Effect of Electroacupuncture at ST25 Through Neural Regulation of the Pancreatic Intrinsic Nervous System
T Xu, Z Yu, Y Liu, M Lu, M Gong, Q Li, Y Xia, B Xu 		Molecular Neurobiology 2021
S1P Signaling Pathways in Pathogenesis of Type 2 Diabetes
Q He, J Bo, R Shen, Y Li, Y Zhang, J Zhang, J Yang, Y Liu, E Chiefari 		Journal of Diabetes Research 2021
The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice
F Zhang, Y Yang, , Y Liu, Q Hu, B Huang, Y Liu, Y Pan, Y Zhang, D Liu, R Liang, G Li, Q Wei, L Li, L Jin 		Nature Communications 2021
miR-344-5p Modulates Cholesterol-Induced β-Cell Apoptosis and Dysfunction Through Regulating Caveolin-1 Expression
X Sun, G Ji, P Li, W Li, J Li, L Zhu 		Frontiers in Endocrinology 2021
Detour Ahead: Incretin Hormone Signaling Alters Its Intracellular Path as β-Cell Failure Progresses During Diabetes
MA Hussain, E Laimon-Thomson, SM Mustafa, A Deck, B Song 		Frontiers in Endocrinology 2021
High Density Lipoproteins and Diabetes
BJ Cochran, KL Ong, B Manandhar, KA Rye 		Cells 2021
JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation
K Wang, Y Cui, P Lin, Z Yao, Y Sun 		Frontiers in Endocrinology 2021
Plasma triacylglycerols are biomarkers of β-cell function in mice and humans
AR Sánchez-Archidona, C Cruciani-Guglielmacci, C Roujeau, L Wigger, J Lallement, J Denom, M Barovic, N Kassis, F Mehl, J Weitz, M Distler, C Klose, K Simons, M Ibberson, M Solimena, C Magnan, B Thorens 		Molecular Metabolism 2021
A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets
S Kaur, AH Mirza, AJ Overgaard, F Pociot, J Størling 		Frontiers in Genetics 2021
A Review of Current Trends with Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments and Future Perspectives
J Reed, S Bain, V Kanamarlapudi 		Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2021
Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression
J Sheng, L Wang, PM Tang, HL Wang, JC Li, BH Xu, VW Xue, RZ Tan, N Jin, TF Chan, XR Huang, RC Ma, HY Lan 		Theranostics 2021
Metabolic Functions of G Protein-Coupled Receptors and β-Arrestin-Mediated Signaling Pathways in the Pathophysiology of Type 2 Diabetes and Obesity
CO de Souza, X Sun, D Oh 		Frontiers in Endocrinology 2021
Testosterone Protects Pancreatic β-cells from Apoptosis and Stress-Induced Accelerated Senescence
SM Kang, HS Jung, MJ Kwon, SH Lee, JH Park 		The World Journal of Men's Health 2021
Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes
N Ismail, N Abdullah, NA Murad, R Jamal, SA Sulaiman 		Diagnostics 2021
Epigenetic Changes in Gestational Diabetes Mellitus
DF Dłuski, E Wolińska, M Skrzypczak 		International journal of molecular sciences 2021
Neutral sphingomyelinase‐2 and cardiometabolic diseases
S Sindhu, YH Leung, H Arefanian, SR Madiraju, F AlMulla, R Ahmad, M Prentki 		Obesity reviews : an official journal of the International Association for the Study of Obesity 2021
Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand
I Sandovici, CM Hammerle, S Virtue, Y Vivas-Garcia, A Izquierdo-Lahuerta, SE Ozanne, A Vidal-Puig, G Medina-Gómez, M Constância 		Scientific Reports 2021
Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes
M Alam, A Arunagiri, L Haataja, M Torres, D Larkin, J Kappler, N Jin, P Arvan 		Diabetes 2021
Botanical Interventions to Improve Glucose Control and Options for Diabetes Therapy.
Smoak P, Burke SJ, Collier JJ 		2021
Lipotoxicity and β-Cell Failure in Type 2 Diabetes: Oxidative Stress Linked to NADPH Oxidase and ER Stress
Vilas-Boas EA, Almeida DC, Roma LP, Ortis F, Carpinelli AR 		Cells 2021
Circulating exosome-like vesicles of humans with nondiabetic obesity impaired islet β-cell proliferation, which was associated with decreased Omentin-1 protein cargo
Ge Q, Xie X, Chen X, Huang R, Rui CX, Zhen Q, Hu R, Wu M, Xiao X, Li X 		Genes & Diseases 2021
Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion
Oberhauser L, Maechler P 		International journal of molecular sciences 2021
Cholecystokinin Attenuates β-Cell Apoptosis in both Mouse and Human Islets
Kim HT, de Souza AH, Umhoefer H, Han J, Anzia L, Sacotte SJ, Williams RA, Blumer JT, Bartosiak JT, Fontaine DA, Baan M, Kibbe CR, Davis DB 		Translational research : the journal of laboratory and clinical medicine 2021
Characteristics of the New Insulin-Resistant Zebrafish Model
YH Nam, I Rodriguez, SW Shin, JH Shim, NW Kim, MC Kim, SY Jeong, W Nuankaew, BN Hong, H Kim, TH Kang 		Pharmaceuticals (Basel, Switzerland) 2021
Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle
A Langlois, A Forterre, M Pinget, K Bouzakri 		Journal of Endocrinological Investigation 2021
Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus
K Ramírez-Alarcón, M Victoriano, L Mardones, M Villagran, A Al-Harrasi, A Al-Rawahi, N Cruz-Martins, J Sharifi-Rad, M Martorell 		Frontiers in Endocrinology 2021
Feline comorbidities: Pathophysiology and management of the obese diabetic cat
M Clark, M Hoenig 		Journal of Feline Medicine & Surgery 2021
Recent Advances in the Generation of β-Cells from Induced Pluripotent Stem Cells as a Potential Cure for Diabetes Mellitus.
Agrawal A, Narayan G, Gogoi R, Thummer RP 		Advances in experimental medicine and biology 2021
Inappropriately sweet: Environmental endocrine-disrupting chemicals and the diabetes pandemic
Schulz MC, Sargis RM 		Advances in pharmacology (San Diego, Calif.) 2021
NADPH Oxidase (NOX) Targeting in Diabetes: A Special Emphasis on Pancreatic β-Cell Dysfunction
Elumalai S, Karunakaran U, Moon JS, Won KC 		Cells 2021
Electroacupuncture at ST36 Improve the Gastric Motility by Affecting Neurotransmitters in the Enteric Nervous System in Type 2 Diabetic Rats
Han X, Chen X, Wang X, Gong M, Lu M, Yu Z, Xu B, Yuan J 		Evidence-based complementary and alternative medicine : eCAM 2021
Tafazzin Deficiency Reduces Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets From Male Mice
Cole LK, Agarwal P, Doucette CA, Fonseca M, Xiang B, Sparagna GC, Seshadri N, Vandel M, Dolinsky VW, Hatch GM 		Endocrinology 2021
Solanum anguivi Lam. Fruits: Their Potential Effects on Type 2 Diabetes Mellitus
Nakitto AM, Muyonga JH, Byaruhanga YB, Wagner AE 		Molecules (Basel, Switzerland) 2021
Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese
Wang W, Jiang H, Zhang Z, Duan W, Han T, Sun C 		Genes & Nutrition 2021
Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes
Mir-Coll J, Moede T, Paschen M, Neelakandhan A, Valladolid-Acebes I, Leibiger B, Biernath A, Ämmälä C, Leibiger IB, Yesildag B, Berggren PO 		International journal of molecular sciences 2021
5-Bromoprotocatechualdehyde Combats against Palmitate Toxicity by Inhibiting Parkin Degradation and Reducing ROS-Induced Mitochondrial Damage in Pancreatic β-Cells
Cha SH, Zhang C, Heo SJ, Jun HS 		Antioxidants 2021
Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects
García-Aguilar A, Palomino O, Benito M, Guillén C 		Antioxidants 2021
Correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus
Dhumad MM, Hamdan FB, Khudhair MS, Al-Matubsi HY 		Scientific Reports 2021
HLA-DRB1 genes and the expression dynamics of HLA CIITA determine the susceptibility to T2DM.
Chinniah R, Sevak V, Pandi S, Ravi PM, Vijayan M, Kannan A, Karuppiah B 		Immunogenetics 2021
Klf6 protects β-cells against insulin resistance-induced dedifferentiation
C Dumayne, D Tarussio, AR Sanchez-Archidona, A Picard, D Basco, XP Berney, M Ibberson, B Thorens 		Molecular Metabolism 2020
AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic β Cells
Z Peng, R Aggarwal, N Zeng, L He, EX Stiles, A Debebe, J Chen, CY Chen, BL Stiles 		Molecular and cellular biology 2020
Lemon Balm Extract ALS-L1023 Regulates Obesity and Improves Insulin Sensitivity via Activation of Hepatic PPARα in High-Fat Diet-Fed Obese C57BL/6J Mice
D Lee, Y Shin, JS Roh, J Ahn, S Jeoong, SS Shin, M Yoon 		International journal of molecular sciences 2020
The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
JS Moon, U Karunakaran, E Suma, SM Chung, KC Won 		Diabetes & Metabolism Journal 2020
Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress
SA White, LS Zhang, DJ Pasula, YH Yang, DS Luciani 		Scientific Reports 2020
Modeling different types of diabetes using human pluripotent stem cells
EM Abdelalim 		Cellular and Molecular Life Sciences 2020
Prospect of Sodium–Glucose Co-transporter 2 Inhibitors Combined With Insulin for the Treatment of Type 2 Diabetes
Y Yang, C Zhao, Y Ye, M Yu, X Qu 		Frontiers in Endocrinology 2020

Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
Z Wang, X Ni, L Zhang, L Sun, X Zhu, Q Zhou, Z Yang, H Yuan 		Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2020
Type 2 diabetes – unmet need, unresolved pathogenesis, mTORC1-centric paradigm
J Bar-Tana 		Reviews in Endocrine and Metabolic Disorders 2020
Loss of EGR-1 uncouples compensatory responses of pancreatic β cells
SY Leu, LH Kuo, WT Weng, IC Lien, CC Yang, TT Hsieh, YN Cheng, PH Chien, LC Ho, SH Chen, YS Shan, YW Chen, PC Chen, PJ Tsai, JM Sung, YS Tsai 		Theranostics 2020
Transcription factor GLIS3: Critical roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes
DW Scoville, HS Kang, AM Jetten 		Pharmacology & Therapeutics 2020
Developmental programming: Prenatal testosterone excess disrupts pancreatic islet developmental trajectory in female sheep
IJ Jackson, M Puttabytappa, M Anderson, M Muralidharan, A Veiga-Lopez, B Gregg, S Limesand, V Padmanabhan 		Molecular and Cellular Endocrinology 2020
Stress-Induced Translational Regulation Mediated by RNA Binding Proteins: Key Links to β-Cell Failure in Diabetes
AL Good, DA Stoffers 		Diabetes 2020
Dual effects of obesity on satellite cells and muscle regeneration
AE Geiger, MR Daughtry, CN Yen, LT Kirkpatrick, H Shi, DE Gerrard 		Physiological Reports 2020
Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells
A Gässler, C Quiclet, O Kluth, P Gottmann, K Schwerbel, A Helms, M Stadion, I Wilhelmi, W Jonas, M Ouni, F Mayer, J Spranger, A Schürmann, H Vogel 		Molecular Metabolism 2020
A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion
D Berdous, X Berney, AR Sanchez-Archidona, M Jan, C Roujeau, IC Lopez-Mejia, R Mynatt, B Thorens 		Molecular Metabolism 2020
Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications
T Filardi, G Catanzaro, S Mardente, A Zicari, C Santangelo, A Lenzi, S Morano, E Ferretti 		International journal of molecular sciences 2020
Epigenetics in β-cell adaptation and type 2 diabetes
H Kim, RN Kulkarni 		Current Opinion in Pharmacology 2020
Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling
JH Lee, JM Mellado-Gil, YJ Bahn, SM Pathy, YE Zhang, SG Rane 		Cell Death and Disease 2020
Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion
F Zhang, D Ma, W Zhao, D Wang, T Liu, Y Liu, Y Yang, Y Liu, J Mu, B Li, Y Zhang, Y Pan, C Guo, H Du, L Li, X Fu, Z Cao, L Jin 		Nature Communications 2020
Short-term inhibition of autophagy benefits pancreatic β-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding
KY Chu, N Mellet, LM Thai, PJ Meikle, TJ Biden 		Molecular Metabolism 2020
Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation
FF Zhang, YH Liu, DW Wang, TS Liu, Y Yang, JM Guo, Y Pan, YF Zhang, H Du, L Li, L Jin 		Diabetologia 2020
Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting β Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice
J Xue, Y Cheng, H Hao, J Gao, Y Yin, S Yu, J Zou, J Liu, Q Zhang, Y Mu 		Stem Cells International 2020
Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review.
Unuofin JO, Lebelo SL 		Oxidative medicine and cellular longevity 2020
ERp29 as a regulator of Insulin biosynthesis
J Viviano, M Brecker, C Ferrara-Cook, L Suaud, RC Rubenstein, IR Nabi 		PloS one 2020
The obesity paradox and diabetes
G Gravina, F Ferrari, G Nebbiai 		Eating and weight disorders : EWD 2020
White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice
CK Shih, CM Chen, V Varga, LC Shih, PR Chen, SF Lo, LF Shyur, SC Li 		Food & Nutrition Research 2020
Efficacy of mesenchymal stem cell therapy on glucose levels in type 2 diabetes mellitus: A systematic review and meta‐analysis
Ranjbaran H, Mohammadi Jobani B, Amirfakhrian E, Alizadeh\u2010Navaei R 		Journal of Diabetes Investigation 2020
Human Decidua Basalis mesenchymal stem/stromal cells reverse the damaging effects of high level of glucose on endothelial cells in vitro
Basmaeil YS, Bahattab E, Alshabibi MA, Abomaray FM, Abumaree M, Khatlani T 		Journal of Cellular and Molecular Medicine 2020
Phenotypic Sexual Dimorphism in Response to Dietary Fat Manipulation in C57BL/6J Mice
Casimiro I, Stull ND, Tersey SA, Mirmira RG 		Journal of Diabetes and its Complications 2020
Pancreatic Islets Accumulate Cadmium in a Rodent Model of Cadmium-Induced Hyperglycemia
Fitzgerald R, Olsen A, Nguyen J, Wong W, El Muayed M, Edwards J 		International journal of molecular sciences 2020
Duration of obesity exposure between ages 10 and 40 years and its relationship with cardiometabolic disease risk factors: A cohort study
Norris T, Cole TJ, Bann D, Hamer M, Hardy R, Li L, Ong KK, Ploubidis GB, Viner R, Johnson W 		PLoS Medicine 2020
Metabolic syndrome in type 2 diabetic patients: a review of current evidence
Regufe VM, Pinto CM, Perez PM 		Porto Biomedical Journal 2020
MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy
Zhao T, Ma J, Li L, Teng W, Tian Y, Ma Y, Wang W, Yan W, Jiao P 		International journal of molecular sciences 2020
Circ-Tulp4 promotes β-cell adaptation to lipotoxicity by regulating soat1 expression
Wu L, Xiong L, Li J, Peng Z, Zhang L, Shi P, Gong Y, Xiao H 		Journal of molecular endocrinology 2020
Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes
Ouni M, Saussenthaler S, Eichelmann F, Jähnert M, Stadion M, Wittenbecher C, Rönn T, Zellner L, Gottmann P, Ling C, Schulze MB, Schürmann A 		Diabetes 2020
Effects of dapagliflozin on cardiovascular outcomes in type 2 diabetes: Study protocol of a randomized controlled trial
Yin D, Hui Y, Yang C, Xu Y 		Medicine 2020
Flavonoids Identification and Pancreatic Beta-Cell Protective Effect of Lotus Seedpod
Lee MS, Chyau CC, Wang CP, Wang TH, Chen JH, Lin HH 		Antioxidants 2020
Loss of Caveolin-1 Is Associated with a Decrease in Beta Cell Death in Mice on a High Fat Diet
Lillo Urzúa P, Núñez Murillo O, Castro-Sepúlveda M, Torres-Quintana MA, Lladser Caldera Á, Quest AF, Espinoza Robles C, Llanos Vidal P, Wehinger S 		International journal of molecular sciences 2020
LDL, LDL receptors, and PCSK9 as modulators of the risk for type 2 diabetes: a focus on white adipose tissue
Faraj M 		Journal of Biomedical Research 2020
Adrenomedullin has a cytoprotective role against endoplasmic reticulum stress for pancreatic β‐cells in autocrine and paracrine manners
Suetomi R, Ohta Y, Akiyama M, Matsumura T, Taguchi A, Yamamoto K, Kamatani T, Tanizawa Y 		Journal of Diabetes Investigation 2020
Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation
Cheng YC, Li YH, Hsu CY, Lee IT 		Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2020
Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome
Zhang Z, Gallagher T, Scherer PE, Beutler B 		Proceedings of the National Academy of Sciences 2020
Genetic Association of SH2B1 Gene Polymorphisms in Jordanian Arab Patients with Type 2 Diabetes Mellitus
AL-Eitan LN, Aman H, Alkhatib R, Alghamdi MA 		Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2020
Administration of mulberry leaves maintains pancreatic β-cell mass in obese/type 2 diabetes mellitus mouse model
Suthamwong P, Minami M, Okada T, Shiwaku N, Uesugi M, Yokode M, Kamei K 		2020
Loss-of-function of the long non-coding RNA A830019P07Rik in mice does not affect insulin expression and secretion
Guay C, Abdulkarim B, Tan JY, Dubuis G, Rütti S, Ross Laybutt D, Widmann C, Regazzi R, Marques AC 		Scientific Reports 2020
A Novel Indoline Derivative Ameliorates Diabesity-Induced Chronic Kidney Disease by Reducing Metabolic Abnormalities
Permyakova A, Gammal A, Hinden L, Weitman M, Weinstock M, Tam J 		Frontiers in Endocrinology 2020
Heterogeneity in liver histopathology is associated with GSK-3β activity and mitochondrial dysfunction in end-stage diabetic rats on differential diets
Lee JH, Choi SB, Sung DJ, Jin M, Lee JH, Mun JY, Hwang TS, Han SD, Ro YT, Kim SY, You JS, Lim I, Noh YH 		BMB Reports 2020
VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake
Ning FC, Jensen N, Mi J, Lindström W, Balan M, Muhl L, Eriksson U, Nilsson I, Nyqvist D 		Scientific Reports 2020
Sleeve gastrectomy ameliorates alveolar structures and surfactant protein expression in lungs of obese and diabetic rats.
Ruze R, Li J, Xu Q, Zhong M, Xiong Y, Yan Z, Zhu J, Cheng Y, Ma Z, Hu S, Zhang G 		International Journal of Obesity 2020
Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention.
Yilmaz B, Terekeci H, Sandal S, Kelestimur F 		Reviews in endocrine & metabolic disorders 2020
β cell dysfunction during progression of metabolic syndrome to Type 2 Diabetes
Laura Hudish, Jane E.-B. Reusch, Lori Sussel 		Journal of Clinical Investigation 2019
Beta-cell tone is defined by proglucagon peptides through cyclic AMP signaling
Megan E Capozzi, Berit Svendsen, Sara E Encisco, Sophie L Lewandowski, MacKenzie Martin, Haopeng Lin, Justin L Jaffe, Reilly W Coch, Jonathan Haldeman, Patrick MacDonald, Matthew J. Merrins, David D'Alessio, Jonathan Campbell 		JCI Insight 2019
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis
EM Levasseur, K Yamada, AR Piñeros, W Wu, F Syed, KS Orr, E Anderson-Baucum, TL Mastracci, B Maier, AL Mosley, Y Liu, E Bernal-Mizrachi, LC Alonso, D Scott, A Garcia-Ocaña, SA Tersey, RG Mirmira 		Science signaling 2019
G-protein-coupled receptor 40 agonist GW9508 potentiates glucose-stimulated insulin secretion through activation of protein kinase Cα and ε in INS-1 cells
T Hashimoto, H Mogami, D Tsuriya, H Morita, S Sasaki, T Kumada, Y Suzuki, T Urano, Y Oki, T Suda, AG Obukhov 		PloS one 2019
Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice
V Patel, G Bidault, JE Chambers, S Carobbio, AJ Everden, C Garcés, LE Dalton, FM Gribble, A Vidal-Puig, SJ Marciniak 		Scientific Reports 2019
The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of β-cell mass
AF Close, N Dadheech, BS Villela, C Rouillard, J Buteau 		The Journal of biological chemistry 2019
Targeting innate immune mediators in type 1 and type 2 diabetes
MY Donath, CA Dinarello, T Mandrup-Poulsen 		Nature Reviews Immunology 2019
Discovery of N ‐(2‐(Benzylamino)‐2‐oxoethyl)benzamide analogs as a novel scaffold of pancreatic β‐cell protective agents against endoplasmic reticulum stress
V Eeda, O HerleaPana, HY Lim, W Wang 		Chemical Biology & Drug Design 2019
Pancreatic stellate cells in the islets as a novel target to preserve the pancreatic β‐cell mass and function
Y Yang, JW Kim, HS Park, EY Lee, KH Yoon 		Journal of Diabetes Investigation 2019
PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles
AW Fischer, K Albers, C Schlein, F Sass, LM Krott, H Schmale, PL Gordts, L Scheja, J Heeren 		Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2019
Early postnatal overnutrition accelerates aging-associated epigenetic drift in pancreatic islets
G Li, TD Petkova, E Laritsky, N Kessler, MS Baker, S Zhu, RA Waterland, M Skinner 		Environmental Epigenetics 2019
Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells
S Liu, X Li, J Yang, R Zhu, Z Fan, X Xu, W Feng, J Cui, J Sun, M Liu 		The FASEB Journal 2019
The role of membrane excitability in pancreatic β-cell glucotoxicity
ZA Shyr, Z Wang, NW York, CG Nichols, MS Remedi 		Scientific Reports 2019
Cellular Stress-Modulating Drugs Can Potentially Be Identified by in Silico Screening with Connectivity Map (CMap)
Y Gao, S Kim, YI Lee, J Lee 		International journal of molecular sciences 2019
Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic β cells
AL Good, MW Haemmerle, AU Oguh, NM Doliba, DA Stoffers 		Molecular Metabolism 2019
Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation
JH Moon, YG Kim, K Kim, S Osonoi, S Wang, DC Saunders, J Wang, K Yang, H Kim, J Lee, JS Jeong, RR Banerjee, SK Kim, Y Wu, H Mizukami, AC Powers, MS German, H Kim 		Diabetes 2019
Rho GTPases—Emerging Regulators of Glucose Homeostasis and Metabolic Health
Møller, Klip, Sylow 		Cells 2019
Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity
M Oshima, S Pechberty, L Bellini, SO Göpel, M Campana, C Rouch, J Dairou, C Cosentino, F Fantuzzi, S Toivonen, P Marchetti, C Magnan, M Cnop, HL Stunff, R Scharfmann 		Diabetologia 2019
Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes
A SalehMoin, AE Butler 		Current Diabetes Reports 2019
Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans
N Gómez-Banoy, JS Guseh, G Li, A Rubio-Navarro, T Chen, BA Poirier, G Putzel, C Rosselot, MA Pabón, JP Camporez, V Bhambhani, SJ Hwang, C Yao, RJ Perry, S Mukherjee, MG Larson, D Levy, LE Dow, GI Shulman, N Dephoure, A Garcia-Ocana, M Hao, BM Spiegelman, JE Ho, JC Lo 		Nature Medicine 2019
Targeting Islets: Metabolic Surgery Is More than a Bariatric Surgery
, J Zhang, Z Zhou 		Obesity Surgery 2019
The autonomic nervous system regulates pancreatic beta-cell proliferation in adult male rats
VS Moullé, C Tremblay, AL Castell, K Vivot, M Ethier, G Fergusson, T Alquier, J Ghislain, V Poitout 		American journal of physiology. Endocrinology and metabolism 2019
Lipid Droplet Accumulation in Human Pancreatic Islets is Dependent Upon Both Donor Age and Health
X Tong, C Dai, JT Walker, GG Nair, A Kennedy, RM Carr, M Hebrok, AC Powers, R Stein 		Diabetes 2019
Thiazolidinediones: the Forgotten Diabetes Medications
HE Lebovitz 		Current Diabetes Reports 2019
Administration of Tonsil-Derived Mesenchymal Stem Cells Improves Glucose Tolerance in High Fat Diet-Induced Diabetic Mice via Insulin-Like Growth Factor-Binding Protein 5-Mediated Endoplasmic Reticulum Stress Modulation
Y Lee, SH Shin, KA Cho, YH Kim, SY Woo, HS Kim, SC Jung, I Jo, HS Jun, WJ Park, JW Park, KH Ryu 		Cells 2019

Impact of Ginkgo biloba extract and magnetized water on the survival rate and functional capabilities of pancreatic β-cells in type 2 diabetic rat model
A Saleh, MM Anwar, AE Zayed, ME Eldeen, G Afifi, HM Alnashiri, AM Gomaa, M Abd-Elkareem, AS Abou-Elhamd, ES Shaheen, GA Mohamed, HF Hetta, AM Kotb 		Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019
Arsenite and its trivalent methylated metabolites inhibit glucose-stimulated calcium influx and insulin secretion in murine pancreatic islets
M Huang, C Douillet, M Stýblo 		Archives of Toxicology 2019
Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes
Y Imai, RS Cousins, S Liu, BM Phelps, JA Promes 		Annals of the New York Academy of Sciences 2019
Characterization of Novel Nonobese Type 2 Diabetes Rat Model with Enlarged Kidneys
A Domon, K Katayama, Y Tochigi, H Suzuki 		Journal of Diabetes Research 2019
Peptides come to the rescue of pancreatic β cells
MJ Spiering 		The Journal of biological chemistry 2019
Emerging role of testosterone in pancreatic β cell function and insulin secretion
W Xu, J Morford, F Mauvais-Jarvis 		Journal of Endocrinology 2019
Metabolic signatures suggest o-phosphocholine to UDP-N-acetylglucosamine ratio as a potential biomarker for high-glucose and/or palmitate exposure in pancreatic β-cells
S Yousf, DM Sardesai, AB Mathew, R Khandelwal, JD Acharya, S Sharma, J Chugh 		Metabolomics 2019
Anti-diabetic effect of loganin by inhibiting FOXO1 nuclear translocation via PI3K/Akt signaling pathway in INS-1 cell
Fang-Fang Mo, Hai-Xia Liu, Yi Zhang, Jing Hua, Dan-Dan Zhao, Tian An, Dong-Wei Zhang, Tian Tian, Si-Hua Gao 		Iranian Journal of Basic Medical Sciences 2019
Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants
C Lankatillake, T Huynh, DA Dias 		Plant Methods 2019
Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes
GC Weir 		Diabetes 2019
Antidiabetic Activity of Gold Nanoparticles Synthesized Using Wedelolactone in RIN-5F Cell Line
Ramachandran V, Arokia Vijaya Anand M, David E, Venkatachalam K, Vijayakumar S, Sankaran V, Balupillai A, Sangeetha CC, Gothandam KM, Kotakadi VS, Ghidan A, Al Antary T, Xu B 		Antioxidants 2019
Longitudinal examination of pancreatic β‐cell function in Japanese individuals
Fujikawa R, Ito C, Kira S, Misumi M 		Journal of Diabetes Investigation 2019
Curcumin protects islet cells from glucolipotoxicity by inhibiting oxidative stress and NADPH oxidase activity both in vitro and in vivo
Li J, Wu N, Chen X, Chen H, Yang X, Liu C 		Islets 2019
Serum Chromium Level is Increased in Jordanian Smokers, Decreased in Jordanians with Prediabetes and type 2 Diabetes, But not Altered in Jordanians with Hypertension, With Obesity, or With Family History of Diabetes
Banihani SA, Jaradat SA, Khader YS 		International journal of preventive medicine 2019
Catalpol in Diabetes and its Complications: A Review of Pharmacology, Pharmacokinetics, and Safety
Bai Y, Zhu R, Tian Y, Li R, Chen B, Zhang H, Xia B, Zhao D, Mo F, Zhang D, Gao S 		Molecules (Basel, Switzerland) 2019
Dietary antioxidant capacity and risk of type 2 diabetes mellitus, prediabetes and insulin resistance: the Rotterdam Study
van der Schaft N, Schoufour JD, Nano J, Kiefte-de Jong JC, Muka T, Sijbrands EJ, Ikram MA, Franco OH, Voortman T 		European Journal of Epidemiology 2019
Efficacy and safety of dapagliflozin as monotherapy in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials
Feng M, Lv H, Xu X, Wang J, Lyu W, Fu S 		Medicine 2019
The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis
Backe MB, Jin C, Andreone L, Sankar A, Agger K, Helin K, Madsen AN, Poulsen SS, Bysani M, Bacos K, Ling C, Perone MJ, Holst B, Mandrup-Poulsen T 		Journal of Diabetes Research 2019
Hedgehog Interacting Protein (Hhip) Regulates Insulin Secretion in Mice Fed High Fat Diets
Nchienzia H, Liao MC, Zhao XP, Chang SY, Lo CS, Chenier I, Ingelfinger JR, Chan JS, Zhang SL 		Scientific Reports 2019
Association of diabetes treatment with long‐term glycemic patterns in patients with type 2 diabetes mellitus: A prospective cohort study
Luo M, Tan CS, Lim WY, Chia KS, Tang WE, Tai ES, Venkataraman K 		Diabetes/Metabolism Research and Reviews 2019
Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling
Cheng ST, Li SY, Leung PS 		International journal of molecular sciences 2019
Heterogeneous Expression of Proinsulin Processing Enzymes in Beta Cells of Non-diabetic and Type 2 Diabetic Humans
Teitelman G 		Journal of Histochemistry & Cytochemistry 2019
Pancreatic AT1aR Deficiency Decreases Insulin Secretion in Obese C57BL/6 Mice
Shoemaker R, AlSiraj Y, Chen J, Cassis LA 		American Journal of Hypertension 2019
PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq
Tyler SR, Rotti PG, Sun X, Yi Y, Xie W, Winter MC, Flamme-Wiese MJ, Tucker BA, Mullins RF, Norris AW, Engelhardt JF 		Cell Reports 2019
A Novel Pentapeptide Inhibitor Reduces Amyloid Deposit Formation by Direct Interaction with hIAPP
Shi Y, Lv W, Jiao A, Zhang C, Zhang J 		International Journal of Endocrinology 2019
PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type2 diabetes patients
Pär Steneberg, Emma Lindahl, Ulf Dahl, Emmelie Lidh, Jurate Straseviciene, Fredrick Backlund, Elisabet Kjellkvist, Eva Berggren, Ingela Lundberg, Ingela Bergqvist, Madelene Ericsson, Björn Eriksson, Kajsa Linde, Jacob Westman, Thomas Edlund, Helena Edlund 		JCI Insight 2018
The role of beta cell heterogeneity in islet function and insulin release
D Nasteska, DJ Hodson 		Journal of Molecular Endocrinology 2018
Cation-Independent Mannose 6-Phosphate Receptor Deficiency Enhances β-Cell Susceptibility to Palmitate
AC Baldwin, A Naatz, RN Bohnsack, JT Bartosiak, BJ Oleson, PA Hansen, NM Dahms, JA Corbett 		Molecular and cellular biology 2018
Effect of the sodium–glucose cotransporter 2 inhibitor luseogliflozin on pancreatic beta cell mass in db/db mice of different ages
K Takahashi, A Nakamura, H Miyoshi, H Nomoto, N Kitao, K Omori, K Yamamoto, KY Cho, Y Terauchi, T Atsumi 		Scientific Reports 2018
Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity
S Yamamoto, K Kuramoto, N Wang, X Situ, M Priyadarshini, W Zhang, J Cordoba-Chacon, BT Layden, C He 		Cell Reports 2018
Blood-Based DNA Methylation Biomarkers for Type 2 Diabetes: Potential for Clinical Applications
T Willmer, R Johnson, J Louw, C Pheiffer 		Frontiers in Endocrinology 2018
Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity
AI Caria, C Nonaka, C Pereira, M Soares, S Macambira, B Souza 		International journal of molecular sciences 2018
Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
Y Xiao, C Wang, JY Chen, F Lu, J Wang, N Hou, X Hu, F Zeng, D Ma, X Sun, Y Ding, Y Zhang, W Zheng, Y Liu, H Shang, W Zhu, C Han, Y Zhang, K Ouyang, L Chen, J Chen, RP Xiao, CY Li, X Zhang 		Nature Communications 2018
SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells
J Nie, C Sun, Z Chang, N Musi, Y Shi 		Endocrinology 2018
Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets
R Veluthakal, OG Chepurny, CA Leech, F Schwede, GG Holz, DC Thurmond 		Diabetes 2018
Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell
T Kono, X Tong, S Taleb, RN Bone, H Iida, CC Lee, P Sohn, P Gilon, MW Roe, C Evans-Molina 		Diabetes 2018
SGLT2 knockout prevents hyperglycemia and is associated with reduced pancreatic β-cell death in genetically obese mice
MJ Jurczak, S Saini, S Ioja, DK Costa, N Udeh, X Zhao, JM Whaley, RG Kibbey 		Islets 2018
Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics
MG Hernández, AG Aguilar, J Burillo, RG Oca, MA Manca, A Novials, G Alcarraz-Vizan, C Guillén, M Benito 		Cell Death and Disease 2018
Thrombosis and Vascular Inflammation in Diabetes: Mechanisms and Potential Therapeutic Targets
N Pechlivani, RA Ajjan 		Frontiers in Cardiovascular Medicine 2018
Therapeutic Effects of Adipose Stem Cells from Diabetic Mice for the Treatment of Type 2 Diabetes
M Wang, L Song, C Strange, X Dong, H Wang 		Molecular Therapy 2018
Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat
LA Kury, M Smail, MA Qureshi, V Sydorenko, A Shmygol, M Oz, J Singh, FC Howarth 		Journal of Diabetes Research 2018
Reduced expression of stearoyl-CoA desaturase-1, but not free fatty acid receptor 2 or 4 in subcutaneous adipose tissue of patients with newly diagnosed type 2 diabetes mellitus
K Bódis, S Kahl, MC Simon, Z Zhou, H Sell, B Knebel, A Tura, K Strassburger, V Burkart, K Müssig, D Markgraf, H Al-Hasani, J Szendroedi, M Roden 		Nutrition and Diabetes 2018
Exploring the Dual Inhibitory Activity of Novel Anthranilic Acid Derivatives towards α-Glucosidase and Glycogen Phosphorylase Antidiabetic Targets: Design, In Vitro Enzyme Assay, and Docking Studies
S Ihmaid 		Molecules (Basel, Switzerland) 2018
Human chorionic villous mesenchymal stem/stromal cells protect endothelial cells from injury induced by high level of glucose
YS Basmaeil, AM Subayyil, T Khatlani, E Bahattab, M Al-Alwan, FM Abomaray, B Kalionis, MA Alshabibi, AS AlAskar, MH Abumaree 		Stem Cell Research & Therapy 2018
The Pathophysiology of Gestational Diabetes Mellitus
J Plows, J Stanley, P Baker, C Reynolds, M Vickers 		International journal of molecular sciences 2018
Multivalent activation of GLP-1 and Sulfonylurea receptors modulates β-cell Second Messenger Signaling and Insulin Secretion
NJ Hart, C Weber, KK Papas, SW Limesand, J Vagner, RM Lynch 		American journal of physiology. Cell physiology 2018
High Fat Diet induced Remission of Diabetes in a subset of KATP-GOF Insulin Secretory-Deficient mice
Yan Z, Shyr ZA, Fortunato M, Welscher A, Alisio M, Martino M, Finck BN, Conway H, Remedi MS 		Diabetes, obesity & metabolism 2018
Association of the Glycemic Fluctuation as well as Glycemic Control with the Pancreatic β-cell Function in Japanese Subjects with Type 2 Diabetes Mellitus
Takai M, Anno T, Kawasaki F, Kimura T, Hirukawa H, Mune T, Okimoto N, Kaku K, Kaneto H 		Internal Medicine 2018
A plasma circulating miRNAs profile predicts type 2 diabetes mellitus and prediabetes: from the CORDIOPREV study
Jiménez-Lucena R, Camargo A, Alcalá-Diaz JF, Romero-Baldonado C, Luque RM, van Ommen B, Delgado-Lista J, Ordovás JM, Pérez-Martínez P, Rangel-Zúñiga OA, López-Miranda J 		Experimental & molecular medicine 2018
Cardiovascular Autonomic Neuropathy Predicts Higher HbA1c Variability in Subjects with Type 2 Diabetes Mellitus
Yang Y, Lee EY, Cho JH, Park YM, Ko SH, Yoon KH, Kang MI, Cha BY, Lee SH 		Diabetes & Metabolism Journal 2018
A metabolome-wide characterization of the diabetic phenotype in ZDF rats and its reversal by pioglitazone
Jönsson TJ, Schäfer HL, Herling AW, Brönstrup M 		PloS one 2018
MicroRNA-182-5p contributes to the protective effects of thrombospondin 1 against lipotoxicity in INS-1 cells
Liu Y, Dong J, Ren B 		Experimental and therapeutic medicine 2018
Oral formulation of DPP-4 inhibitor plus Quercetin improves metabolic homeostasis in type 1 diabetic rats
Miranda PH, Lacerda KC, Araújo CM, Barichello JM, Lima WG, Costa DC 		Scientific Reports 2018
Use of the PET ligand florbetapir for in vivo imaging of pancreatic islet amyloid deposits in human islet amyloid polypeptide transgenic mice
Templin AT, Meier DT, Willard JR, Wolden-Hanson T, Conway K, Lin YG, Gillespie PJ, Bokvist KB, Attardo G, Kahn SE, Scheuner D, Hull RL 		Diabetologia 2018
High-Throughput Approaches onto Uncover (Epi)Genomic Architecture of Type 2 Diabetes
Dziewulska A, Dobosz AM, Dobrzyn A 		Genes & development 2018
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats
Kuga GK, Gaspar RC, Muñoz VR, Nakandakari SC, Breda L, Sandoval BM, Caetano FH, Leme JA, Pauli JR, Gomes RJ 		2018
MAFB mediates the therapeutic effect of sleeve gastrectomy for obese diabetes mellitus by activation of FXR expression
Xu J, Wang Y, Yin J, Yin M, Wang M, Liu J 		Brazilian Journal of Medical and Biological Research 2018
Dysfunction of Mesenchymal Stem Cells Isolated from Metabolic Syndrome and Type 2 Diabetic Patients as Result of Oxidative Stress and Autophagy may Limit Their Potential Therapeutic Use
Kornicka K, Houston J, Marycz K 		Stem Cell Reviews 2018
Pepsin Egg White Hydrolysate Improves Glucose Metabolism Complications Related to Metabolic Syndrome in Zucker Fatty Rats
Garcés-Rimón M, González C, Vera G, Uranga JA, López-Fandiño R, López-Miranda V, Miguel M 		Nutrients 2018
Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation
Miki A, Ricordi C, Sakuma Y, Yamamoto T, Misawa R, Mita A, Molano RD, Vaziri ND, Pileggi A, Ichii H 		PloS one 2018
Expression profiles of stress-related genes in islets from donors with progressively impaired glucose metabolism
Lundberg M, Stenwall A, Tegehall A, Korsgren O, Skog O 		Islets 2018
Suppressive Effects of Clerodendrum volubile P Beauv. [Labiatae] Methanolic Extract and Its Fractions on Type 2 Diabetes and Its Complications
Erukainure OL, Hafizur RM, Kabir N, Choudhary MI, Atolani O, Banerjee P, Preissner R, Chukwuma CI, Muhammad A, Amonsou EO, Islam MS 		Frontiers in pharmacology 2018
Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.
Bellini L, Campana M, Rouch C, Chacinska M, Bugliani M, Meneyrol K, Hainault I, Lenoir V, Denom J, Véret J, Kassis N, Thorens B, Ibberson M, Marchetti P, Blachnio-Zabielska A, Cruciani-Guglielmacci C, Prip-Buus C, Magnan C, Le Stunff H 		Diabetologia 2018
Insight into the interaction mechanism of human SGLT2 with its inhibitors: 3D-QSAR studies, homology modeling, and molecular docking and molecular dynamics simulations.
Dong L, Feng R, Bi J, Shen S, Lu H, Zhang J 		Journal of Molecular Modeling 2018
Sustained exenatide delivery via intracapsular microspheres for improved survival and function of microencapsulated porcine islets.
Lew B, Kim IY, Choi H, Kim KK 		Drug Delivery and Translational Research 2018
Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes
SY Kim, JH Lee, MJ Merrins, O Gavrilova, X Bisteau, P Kaldis, LS Satin, SG Rane 		The Journal of biological chemistry 2017
Nutrient regulation of pancreatic β-cell proliferation
VS Moullé, J Ghislain, V Poitout 		Biochimie 2017
Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells
Y Mugabo, S Zhao, J Lamontagne, A Al-Mass, ML Peyot, BE Corkey, E Joly, SR Madiraju, M Prentki 		The Journal of biological chemistry 2017
Menopausal Hormone Therapy and Type 2 Diabetes Prevention: Evidence, Mechanisms, and Clinical Implications
F Mauvais-Jarvis, JA Manson, JC Stevenson, VA Fonseca 		Endocrine reviews 2017
Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity
F Mauvais-Jarvis 		Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity 2017
Antioxidant properties of drugs used in Type 2 diabetes management: could they contribute to, confound or conceal effects of antioxidant therapy?
SW Choi, CK Ho 		Redox Report 2017
The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats
S Steven, M Oelze, A Hanf, S Kröller-Schön, F Kashani, S Roohani, P Welschof, M Kopp, U Gödtel-Armbrust, N Xia, H Li, E Schulz, KJ Lackner, L Wojnowski, SP Bottari, P Wenzel, E Mayoux, T Münzel, A Daiber 		Redox Biology 2017
The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury
FJ Kong, JH Wu, SY Sun, JQ Zhou 		Scientific Reports 2017
Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes
A Motterle, S Gattesco, ML Peyot, JL Esguerra, A Gomez-Ruiz, DR Laybutt, P Gilon, F Burdet, M Ibberson, L Eliasson, M Prentki, R Regazzi 		Molecular Metabolism 2017
Metabolic crosstalk between fatty pancreas and fatty liver: effects on local inflammation and insulin secretion
F Gerst, R Wagner, G Kaiser, M Panse, M Heni, J Machann, MN Bongers, T Sartorius, B Sipos, F Fend, C Thiel, S Nadalin, A Königsrainer, N Stefan, A Fritsche, HU Häring, S Ullrich, D Siegel-Axel 		Diabetologia 2017
Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats
H Ando, K Gotoh, K Fujiwara, M Anai, S Chiba, T Masaki, T Kakuma, H Shibata 		Scientific Reports 2017
Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism
J Yamamoto, J Imai, T Izumi, H Takahashi, Y Kawana, K Takahashi, S Kodama, K Kaneko, J Gao, K Uno, S Sawada, T Asano, VV Kalinichenko, EA Susaki, M Kanzaki, HR Ueda, Y Ishigaki, T Yamada, H Katagiri 		Nature Communications 2017
Saxagliptin Induces β-Cell Proliferation through Increasing Stromal Cell-Derived Factor-1α In Vivo and In Vitro
CJ Li, B Sun, QH Fang, M Ding, YZ Xing, LM Chen, DM Yu 		Frontiers in Endocrinology 2017
Diabetes Induces Abnormal Ovarian Function via Triggering Apoptosis of Granulosa Cells and Suppressing Ovarian Angiogenesis
Y Wu, Y Li, X Liao, Z Wang, R Li, S Zou, T Jiang, B Zheng, P Duan, J Xiao 		International journal of biological sciences 2017
Diabetes and Sepsis: Risk, Recurrence, and Ruination
LM Frydrych, F Fattahi, K He, PA Ward, MJ Delano 		Frontiers in Endocrinology 2017
Clinical relevance of epigenetics in the onset and management of type 2 diabetes mellitus
L Sommese, A Zullo, FP Mancini, R Fabbricini, A Soricelli, C Napoli 		Epigenetics : official journal of the DNA Methylation Society 2017
Clock Gene Dysregulation Induced by Chronic ER Stress Disrupts β-cell Function
Y Ohta, A Taguchi, T Matsumura, H Nakabayashi, M Akiyama, K Yamamoto, R Fujimoto, R Suetomi, A Yanai, K Shinoda, Y Tanizawa 		EBioMedicine 2017
How does obesity lead to insulin resistance?
CH Choi, P Cohen 		eLife 2017
Cerebral ischemic damage in diabetes: an inflammatory perspective
V Shukla, AK Shakya, MA Perez-Pinzon, KR Dave 		Journal of Neuroinflammation 2017
Sex- and Tissue-Specific Role of Estrogen Sulfotransferase in Energy Homeostasis and Insulin Sensitivity
WG Garbacz, M Jiang, M Xu, J Yamauchi, HH Dong, W Xie 		Endocrinology 2017
Interorgan Crosstalk Contributing to β -Cell Dysfunction
K Tanabe, K Amo-Shiinoki, M Hatanaka, Y Tanizawa 		Journal of Diabetes Research 2017
Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes
T Jourdan, G Szanda, R Cinar, G Godlewski, DJ Holovac, JK Park, S Nicoloro, Y Shen, J Liu, AZ Rosenberg, Z Liu, MP Czech, G Kunos 		Diabetes 2017
Decreasing CB 1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice
T Jourdan, SM Nicoloro, Z Zhou, Y Shen, J Liu, NJ Coffey, R Cinar, G Godlewski, B Gao, M Aouadi, MP Czech, G Kunos 		Molecular Metabolism 2017
Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function
H Dong, Y Zhang, J Wang, DS Kim, H Wu, B Sjögren, W Gao, L Luttrell, H Wang 		Cell Death and Disease 2017
Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet–Fed Mice
V Bergeron, J Ghislain, K Vivot, N Tamarina, LH Philipson, J Fielitz, V Poitout 		Diabetes 2017
mTORC1 inhibitors rapamycin and metformin affect cardiovascular markers differentially in ZDF rats
R Nistala, A Raja, L Pulakat 		Canadian Journal of Physiology and Pharmacology 2017
Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity
EA Alfar, D Kirova, J Konantz, S Birke, J Mansfeld, N Ninov 		Scientific Reports 2017
A 2A adenosine receptors control pancreatic dysfunction in high-fat-diet induced obesity
B Csóka, G Törő, J Vindeirinho, ZV Varga, B Koscsó, ZH Németh, E Kókai, L Antonioli, M Suleiman, P Marchetti, K Cseri, Á Deák, L Virág, P Pacher, P Bai, G Haskó 		The FASEB Journal 2017
Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice
E Nuñez-Durán, B Chanclón, S Sütt, J Real, HU Marschall, IW Asterholm, E Cansby, M Mahlapuu 		Journal of Endocrinology 2017
Reversal of endothelial dysfunction in aorta of streptozotocin-nicotinamide-induced type-2 diabetic rats by S-Allylcysteine
P Brahmanaidu, VV Uddandrao, V Sasikumar, RR Naik, S Pothani, MS Begum, MP Rajeshkumar, C Varatharaju, B Meriga, P Rameshreddy, A Kalaivani, G Saravanan 		Molecular and Cellular Biochemistry 2017
Exo-miR-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress
TA Kamalden, AM Macgregor-Das, SM Kannan, B Dunkerly-Eyring, N Khaliddin, Z Xu, AP Fusco, SA Yazib, RC Chow, EJ Duh, MK Halushka, C Steenbergen, S Das 		Antioxidants & Redox Signaling 2017
Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice
VA Matheus, LC Monteiro, RB Oliveira, DA Maschio, CB Collares-Buzato 		Experimental biology and medicine (Maywood, N.J.) 2017
Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects
AA Qarni, FE Joatar, N Das, M Awad, M Eltayeb, AG Al-Zubair, ME Ali, AA Masaud, AM Shire, K Gumaa, HA Giha 		Endocrinology and Metabolism 2017
Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca2+ Channels
T Suantawee, S Elazab, W Hsu, S Yao, H Cheng, S Adisakwattana 		Nutrients 2017
Fasting Insulin is Better Partitioned according to Family History of Type 2 Diabetes Mellitus than Post Glucose Load Insulin of Oral Glucose Tolerance Test in Young Adults
S Francis 		JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 2017
Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in healthy subjects
R Eldor, L Norton, M Fourcaudot, C Galindo, RA DeFronzo, M Abdul-Ghani, V Sánchez-Margalet 		PloS one 2017
Efficacy and safety of ipragliflozin in Japanese patients with type 2 diabetes receiving conventional therapy: clinical implication of the importance of exercise habits during treatment with ipragliflozin
Kato M, Sakai K, Saito K, Tsutsui K, Yamashita S, Kato N 		Diabetology International 2017
miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus
He Y, Bai J, Liu P, Dong J, Tang Y, Zhou J, Han P, Xing J, Chen Y, Yu X 		EXCLI journal 2017
Protective effect of metformin on toxicity of butyric acid and arsenic in isolated liver mitochondria and langerhans islets in male mice: an in vitro study
Ahangarpour A, Zeidooni L, Rezaei M, Alboghobeish S, Samimi A, Oroojan AA 		Iranian Journal of Basic Medical Sciences 2017
Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) β-cells using metformin-induced metabolic deceleration as a model
Lamontagne J, Al-Mass A, Nolan CJ, Corkey BE, Madiraju SR, Joly E, Prentki M 		The Journal of biological chemistry 2017
The Dual Role of Group V Secretory Phospholipase A2 in Pancreatic β-cells
Shridas P, Noffsinger VP, Trumbauer AC, Webb NR 		Endocrine 2017
Beneficial Effects of Small Molecule Oligopeptides Isolated from Panax ginseng Meyer on Pancreatic Beta-Cell Dysfunction and Death in Diabetic Rats
Xu M, Sun B, Li D, Mao R, Li H, Li Y, Wang J 		Nutrients 2017
Discovery of a benzamide derivative that protects pancreatic β-cells against endoplasmic reticulum stress
Duan H, Li Y, Arora D, Xu D, Lim HY, Wang W 		Journal of Medicinal Chemistry 2017
Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice
Ishida E, Kim-Muller JY, Accili D 		Diabetes 2017
Prolactin and oleic acid synergistically stimulate β-cell proliferation and growth in rat islets
Brelje TC, Bhagroo NV, Stout LE, Sorenson RL 		Islets 2017
Remote control of glucose homeostasis in vivo using photopharmacology
Mehta ZB, Johnston NR, Nguyen-Tu MS, Broichhagen J, Schultz P, Larner DP, Leclerc I, Trauner D, Rutter GA, Hodson DJ 		Scientific Reports 2017
Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats
Moullé VS, Vivot K, Tremblay C, Zarrouki B, Ghislain J, Poitout V 		Diabetologia 2017
Neo-Epitopes Generated on Hydroxyl Radical Modified GlycatedIgG Have Role in Immunopathology of Diabetes Type 2
Islam S, Mir AR, Raghav A, Khan F, Alam K, Ali A, Uddin M 		PloS one 2017
HSF1 acetylation decreases its transcriptional activity and enhances glucolipotoxicity-induced apoptosis in rat and human beta cells.
Purwana I, Liu JJ, Portha B, Buteau J 		Diabetologia 2017
BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression.
Alcarraz-Vizán G, Castaño C, Visa M, Montane J, Servitja JM, Novials A 		Cellular and molecular life sciences : CMLS 2017
Pancreatic beta-cell identity requires continual non-beta cell gene repression
Giselle Dominguez, Aaron S. Bender, Vincenzo Cirulli, Teresa Mastracci, Stephen Kelly, Aristostelis Tsirigos, Klaus Kaestner, Lori Sussel 		Journal of Clinical Investigation 2016
Interleukin-1 signaling contributes to acute islet compensation
Catherine Hajmrle, Nancy Smith, Aliya Spigelman, Xiao-Qing Dai, Laura Senior, Austin Bautista, Mourad Ferdaoussi, Patrick MacDonald 		JCI Insight 2016
Changes in beta cell function occur in prediabetes and early disease in the Lepr db mouse model of diabetes
OH Do, JE Gunton, HY Gaisano, P Thorn 		Diabetologia 2016
Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca 2+ Stores
A Marmugi, J Parnis, X Chen, LA Carmichael, J Hardy, N Mannan, P Marchetti, L Piemonti, D Bosco, P Johnson, JA Shapiro, C Cruciani-Guglielmacci, C Magnan, M Ibberson, B Thorens, HH Valdivia, GA Rutter, I Leclerc 		Diabetes 2016
The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity
L Vetterli, S Carobbio, F Frigerio, M Karaca, P Maechler 		The Journal of biological chemistry 2016
New obesity classification criteria as a tool for bariatric surgery indication
AD Lorenzo 		World journal of gastroenterology : WJG 2016
FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice
T Zhang, DH Kim, X Xiao, S Lee, Z Gong, R Muzumdar, V Calabuig-Navarro, J Yamauchi, H Harashima, R Wang, R Bottino, JC Alvarez-Perez, A Garcia-Ocaña, G Gittes, HH Dong 		Endocrinology 2016
The Genetic Program of Pancreatic β-Cell Replication In Vivo
A Klochendler, I Caspi, N Corem, M Moran, O Friedlich, S Elgavish, Y Nevo, A Helman, B Glaser, A Eden, S Itzkovitz, Y Dor 		Diabetes 2016
Mechanisms of β-cell functional adaptation to changes in workload
M Wortham, M Sander 		Diabetes Obesity and Metabolism 2016
The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus
P Leung 		Nutrients 2016
Identification of 1,2,3-triazole derivatives that protect pancreatic β cells against endoplasmic reticulum stress-mediated dysfunction and death through the inhibition of C/EBP-homologous protein expression
H Duan, D Arora, Y Li, H Setiadi, D Xu, HY Lim, W Wang 		Bioorganic & Medicinal Chemistry 2016
Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL
V Plaisance, S Brajkovic, M Tenenbaum, D Favre, H Ezanno, A Bonnefond, C Bonner, V Gmyr, J Kerr-Conte, BR Gauthier, C Widmann, G Waeber, F Pattou, P Froguel, A Abderrahmani, A Nadal 		PloS one 2016
Reduced insulin secretion function is associated with pancreatic islet redistribution of cell adhesion molecules (CAMs) in diabetic mice after prolonged high-fat diet
VT Falcão, DA Maschio, CC de Fontes, RB Oliveira, JC Santos-Silva, AC Almeida, EC Vanzela, MT Cartaxo, CP Carvalho, CB Collares-Buzato 		Histochemistry and Cell Biology 2016
Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling
L Yang, D Yao, H Yang, Y Wei, Y Peng, Y Ding, L Shu 		Molecular Endocrinology 2016
Pancreatic β Cell Mass Death
HI Marrif, SI Al-Sunousi 		Frontiers in pharmacology 2016
IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death
S Rütti, C Howald, C Arous, E Dermitzakis, PA Halban, K Bouzakri 		Molecular Metabolism 2016
Sources and implications of NADH/NAD+ redox imbalance in diabetes and its complications
LJ Yan, J Wu, Z Jin, H Zheng 		Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2016
G protein-coupled receptors as targets for anti-diabetic therapeutics
DY Oh, JM Olefsky 		Nature Reviews Drug Discovery 2016
Long Noncoding RNAs in Metabolic Syndrome Related Disorders
M Losko, J Kotlinowski, J Jura 		Mediators of Inflammation 2016
Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes
N Lawlor, J George, M Bolisetty, R Kursawe, L Sun, V Sivakamasundari, I Kycia, P Robson, ML Stitzel 		Genome research 2016
mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice
W li, H Zhang, A Nie, Q Ni, F Li, G Ning, X Li, Y Gu, Q Wang 		Endocrine 2016
LXR activation causes G1/S arrest through inhibiting SKP2 expression in MIN6 pancreatic beta cells
Y Li, C Jing, X Tang, Y Chen, X Han, Y Zhu 		Endocrine 2016
Pdcd2l Promotes Palmitate-Induced Pancreatic Beta-Cell Apoptosis as a FoxO1 Target Gene
Y Yin, W Yong, J Yu, X Zhang, H Lin, Y Zhu, X Han, B Wagner 		PloS one 2016
Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells
M Mirasierra, M Vallejo 		Diabetologia 2016
Pancreatic β-cell identity in diabetes
MS Remedi, C Emfinger 		Diabetes Obesity and Metabolism 2016
Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival
SR Villa, M Priyadarshini, MH Fuller, T Bhardwaj, MR Brodsky, AR Angueira, RE Mosser, BA Carboneau, SA Tersey, H Mancebo, A Gilchrist, RG Mirmira, M Gannon, BT Layden 		Scientific Reports 2016
Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism
BJ Cochran, L Hou, AP Manavalan, BM Moore, F Tabet, A Sultana, LC Torres, S Tang, S Shrestha, P Senanayake, M Patel, WJ Ryder, A Bongers, M Maraninchi, VC Wasinger, M Westerterp, AR Tall, PJ Barter, KA Rye 		Diabetes 2016
Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells
CT Vong, HH Tseng, YW Kwan, SM Lee, MP Hoi 		Frontiers in pharmacology 2016
Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon
R Cassel, S Ducreux, MR Alam, F Dingreville, C Berlé, K Burda-Jacob, MA Chauvin, K Chikh, L Païta, R Al-Mawla, CC da Silva, J Rieusset, C Thivolet, FV Coppenolle, AM Madec, A Abderrahmani 		PloS one 2016
A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells
V Cigliola, C Populaire, CL Pierri, S Deutsch, JA Haefliger, J Fadista, V Lyssenko, L Groop, R Rueedi, F Thorel, PL Herrera, P Meda, AH Kihara 		PloS one 2016
A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice
BJ Lamont, MF Waters, S Andrikopoulos 		Nutrition and Diabetes 2016
Increase of Calcium Sensing Receptor Expression Is Related to Compensatory Insulin Secretion during Aging in Mice
YS Oh, EH Seo, YS Lee, SC Cho, HS Jung, SC Park, HS Jun, M Claret 		PloS one 2016
Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes
P Shah, N Lueschen, A Ardestani, J Oberholzer, J Olerud, PO Carlsson, K Maedler, M Claret 		PloS one 2016
Glucagon secretion from pancreatic α-cells
L Briant, A Salehi, E Vergari, Q Zhang, P Rorsman 		Upsala Journal of Medical Sciences 2016
MitoNEET-Parkin Effects in Pancreatic α- and β-Cells, Cellular Survival, and Intrainsular Cross Talk
CM Kusminski, S Chen, R Ye, K Sun, QA Wang, SB Spurgin, PE Sanders, JT Brozinick, WJ Geldenhuys, W Li, RH Unger, PE Scherer 		Diabetes 2016
Chronic Glucose Exposure Systematically Shifts the Oscillatory Threshold of Mouse Islets: Experimental Evidence for an Early Intrinsic Mechanism of Compensation for Hyperglycemia
E Glynn, B Thompson, S Vadrevu, S Lu, RT Kennedy, J Ha, A Sherman, LS Satin 		Endocrinology 2016
Hexarelin Protects Rodent Pancreatic Β-Cells Function from Cytotoxic Effects of Streptozotocin Involving Mitochondrial Signalling Pathways In Vivo and In Vitro
Y Zhao, X Zhang, J Chen, C Lin, R Shao, C Yan, C Chen, IV Lebedeva 		PloS one 2016
Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression
É Pepin, A Al-Mass, C Attané, K Zhang, J Lamontagne, R Lussier, SR Madiraju, E Joly, NB Ruderman, R Sladek, M Prentki, ML Peyot, A Nadal 		PloS one 2016
Human islets contain four distinct subtypes of β cells
C Dorrell, J Schug, PS Canaday, HA Russ, BD Tarlow, MT Grompe, T Horton, M Hebrok, PR Streeter, KH Kaestner, M Grompe 		Nature Communications 2016
Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells
MA Kalwat, Z Huang, C Wichaidit, K McGlynn, S Earnest, C Savoia, EM Dioum, JW Schneider, MR Hutchison, MH Cobb 		ACS chemical biology 2016
Impaired fasting glucose is associated with increased regional cerebral amyloid
JK Morris, ED Vidoni, HM Wilkins, AE Archer, NC Burns, RT Karcher, RS Graves, RH Swerdlow, JP Thyfault, JM Burns 		Neurobiology of Aging 2016
Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress
H Duan, JW Lee, SW Moon, D Arora, Y Li, HY Lim, W Wang 		Journal of Medicinal Chemistry 2016
A stable isotope method for in vivo assessment of human insulin synthesis and secretion
S Jainandunsing, JN van Miert, T Rietveld, JL Wattimena, EJ Sijbrands, FW de Rooij 		Acta Diabetologica 2016
The effect of cholesteryl ester transfer protein on pancreatic beta cell dysfunction in mice
W Guo, Y Gong, Z Fu, J Fu, Y Sun, X Ju, Y Chang, W Wang, X Zhu, B Gao, X Liu, T Yang, H Zhou 		Nutrition & Metabolism 2016
Exendin-4 Promotes Survival of Mouse Pancreatic β -Cell Line in Lipotoxic Conditions, through the Extracellular Signal-Related Kinase 1/2 Pathway
J Gu, Q Wei, H Zheng, X Meng, J Zhang, D Wang 		Journal of Diabetes Research 2016
Liver triacylglycerol content and gestational diabetes: effects of moderate energy restriction
Hodson K, Dalla Man C, Smith FE, Barnes A, McParlin C, Cobelli C, Robson SC, Araújo-Soares V, Taylor R 		Diabetologia 2016
A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice
Attané C, Peyot ML, Lussier R, Poursharifi P, Zhao S, Zhang D, Morin J, Pineda M, Wang S, Dumortier O, Ruderman NB, Mitchell GA, Simons B, Madiraju SR, Joly E, Prentki M 		Diabetologia 2016
Real time imaging of intracellular hydrogen peroxide in pancreatic islets
Neal A, Rountree A, Kernan K, Van Yserloo B, Zhang H, Reed BJ, Osborne W, Wang W, Sweet IR 		Biochemical Journal 2016
Self-adjusting synthetic gene circuit for correcting insulin resistance
Ye H, Xie M, Xue S, Charpin-El Hamri G, Yin J, Zulewski H, Fussenegger M 		Nature Biomedical Engineering 2016
SIRT6 protects against palmitate-induced pancreatic β-cell dysfunction and apoptosis
Xiong X, Sun X, Wang Q, Qian X, Zhang Y, Pan X, Dong XC 		The Journal of endocrinology 2016
Oxidative Stress, DNA Damage and DNA Repair in Female Patients with Diabetes Mellitus Type 2.
Grindel A, Guggenberger B, Eichberger L, Pöppelmeyer C, Gschaider M, Tosevska A, Mare G, Briskey D, Brath H, Wagner KH 		PloS one 2016
Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes
Saleh Md Moin A, Dhawan S, Cory M, Butler PC, Rizza RA, Butler AE 		The Journal of clinical endocrinology and metabolism 2016
Pathway Analysis Incorporating Protein-Protein Interaction Networks Identified Candidate Pathways for the Seven Common Diseases
Lin PL, Yu YW, Chung RH 		PloS one 2016
Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
Dang F, Sun X, Ma X, Wu R, Zhang D, Chen Y, Xu Q, Wu Y, Liu Y 		Nature Communications 2016
Dopamine Receptor Signaling in MIN6 β-Cells Revealed by Fluorescence Fluctuation Spectroscopy
Caldwell B, Ustione A, Piston DW 		Biophysical Journal 2016
SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways
Zhou TT, Quan LL, Chen LP, Du T, Sun KX, Zhang JC, Yu L, Li Y, Wan P, Chen LL, Jiang BH, Hu LH, Chen J, Shen X 		Cell Death and Disease 2016
The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis
Yue S, Wu J, Zhang J, Liu L, Chen L 		Disease Markers 2016
Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells
Xiong X, Wang G, Tao R, Wu P, Kono T, Li K, Ding WX, Tong X, Tersey SA, Harris RA, Mirmira RG, Evans-Molina C, Dong XC 		Diabetologia 2016
Overall and central obesity with insulin sensitivity and secretion in a Han Chinese population: a Mendelian randomization analysis.
Wang T, Ma X, Tang T, Jin L, Peng D, Zhang R, Chen M, Yan J, Wang S, Yan D, He Z, Jiang F, Cheng X, Bao Y, Liu Z, Hu C, Jia W 		International Journal of Obesity 2016
Ryanodine receptor/calcium release channel regulates insulin release and glucose homeostasis
Gaetano santulli, Gennaro Pagano, Celestino Sardu, Wenjun xie, Steve Reiken, Salvatore D'Ascia, Michele Cannone, Nicola Marziliano, Bruno Trimarco, Theresa Guise, Alain Lacampagne, Andrew R. Marks 		Journal of Clinical Investigation 2015
DNA methylation directs functional maturation of pancreatic beta cells
Sangeeta Dhawan, Shuen-ing Tschen, Chun Zeng, Tingxia Guo, Matthias Hebrok, Aleksey Matveyenko, Anil Bhushan 		Journal of Clinical Investigation 2015
Thyroid dysfunction associated with follicular cell steatosis in obese male mice and humans
MH Lee, JU Lee, KH Joung, YK Kim, MJ Ryu, SE Lee, SJ Kim, HK Chung, MJ Choi, JY Chang, SH Lee, GR Kweon, HJ Kim, KS Kim, SM Kim, YS Jo, J Park, S Cheng, M Shong 		Endocrinology 2015
Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes
K Åvall, Y Ali, IB Leibiger, B Leibiger, T Moede, M Paschen, A Dicker, E Daré, M Köhler, E Ilegems, MH Abdulreda, M Graham, RM Crooke, VS Tay, E Refai, SK Nilsson, S Jacob, L Selander, PO Berggren, L Juntti-Berggren 		Proceedings of the National Academy of Sciences 2015
Pancreatic β-cell dysfunction in polycystic ovary syndrome: role of hyperglycemia-induced nuclear factor-κB activation and systemic inflammation
SK Malin, JP Kirwan, CL Sia, F González 		American journal of physiology. Endocrinology and metabolism 2015
Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity
NM Templeman, SM Clee, JD Johnson 		Diabetologia 2015
AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms
YL Dai, SL Huang, Y Leng 		International journal of biological sciences 2015
Prediabetes linked to excess glucagon in transgenic mice with pancreatic active AKT1
TM Albury-Warren, V Pandey, LP Spinel, MM Masternak, DA Altomare 		Journal of Endocrinology 2015
Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids
YS Oh 		Anatomy & cell biology 2015
Geniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway
DD Yao, L Yang, Y Wang, C Liu, YJ Wei, XB Jia, W Yin, L Shu 		Cell Death and Disease 2015
High-content screening identifies a role for Na + channels in insulin production
M Szabat, H Modi, R Ramracheya, V Girbinger, F Chan, JT Lee, M Piske, S Kamal, YH Yang, A Welling, P Rorsman, JD Johnson 		Royal Society Open Science 2015
Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes☆
J Sun, J Cui, Q He, Z Chen, P Arvan, M Liu 		Molecular Aspects of Medicine 2015
Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and Dysfunction
X Luo, R Li, LJ Yan 		Journal of Diabetes Research 2015
Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases
RM Mosa, Z Zhang, R Shao, C Deng, J Chen, C Chen 		Endocrine 2015
Hyperglycemia promotes p53-Mdm2 interaction but reduces p53 ubiquitination in RINm5F cells
BG Raúl, FL Antonio, BG Arturo, C Miguel, GM Rebeca, ÁR Alejandro, CR Alejandra, DF Margarita, OC Clara 		Molecular and Cellular Biochemistry 2015
Role of Pancreatic Transcription Factors in Maintenance of Mature β-Cell Function
H Kaneto, T Matsuoka 		International journal of molecular sciences 2015
Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity
Y Takagi, K Kinoshita, N Ozaki, Y Seino, Y Murata, Y Oshida, Y Hayashi, JA Chowen 		PloS one 2015
Increasing β-Cell Mass Requires Additional Stimulation for Adaptation to Secretory Demand
P Mondal, WJ Song, Y Li, KS Yang, MA Hussain 		Molecular Endocrinology 2015
Minireview: Autophagy in Pancreatic β-Cells and Its Implication in Diabetes
H Watada, Y Fujitani 		Molecular Endocrinology 2015
Plasma IL-1Ra: linking hyperapoB to risk factors for type 2 diabetes independent of obesity in humans
S Bissonnette, N Saint-Pierre, V Lamantia, Y Cyr, H Wassef, M Faraj 		Nutrition and Diabetes 2015
Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets
K Tugay, C Guay, AC Marques, F Allagnat, JM Locke, LW Harries, GA Rutter, R Regazzi 		Diabetologia 2015
miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development
M Latreille, K Herrmanns, N Renwick, T Tuschl, MT Malecki, MI McCarthy, KR Owen, T Rülicke, M Stoffel 		Journal of Molecular Medicine 2015
Combination therapy of sodium–glucose co-transporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors in type 2 diabetes: rationale and evidences
AK Singh, R Singh 		Expert Review of Clinical Pharmacology 2015
Beneficial Effects of Canagliflozin in Combination with Pioglitazone on Insulin Sensitivity in Rodent Models of Obese Type 2 Diabetes
Y Watanabe, K Nakayama, N Taniuchi, Y Horai, C Kuriyama, K Ueta, K Arakawa, T Senbonmatsu, M Shiotani, M Bader 		PloS one 2015
Diabetes mellitus related bone metabolism and periodontal disease
YY Wu, E Xiao, DT Graves 		International Journal of Oral Science 2015
Clinical characteristics and beta cell function in Chinese patients with newly diagnosed type 2 diabetes mellitus with different levels of serum triglyceride
S Zheng, H Zhou, T Han, Y Li, Y Zhang, W Liu, Y Hu 		BMC Endocrine Disorders 2015
High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice
T Shinjo, Y Nakatsu, M Iwashita, T Sano, H Sakoda, H Ishihara, A Kushiyama, M Fujishiro, F Nishimura, T Asano 		Diabetology & metabolic syndrome 2015
Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells
KA Erion, CA Berdan, NE Burritt, BE Corkey, JT Deeney 		The Journal of biological chemistry 2015
Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats
L Alán, T Olejár, M Cahová, J Zelenka, Z Berková, M Smětáková, F Saudek, R Matěj, P Ježek 		Journal of Diabetes Research 2015
Elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation during diet-induced insulin resistance in dogs
JL Broussard, CM Kolka, AV Castro, IA Bediako, RL Paszkiewicz, EW Szczepaniak, LS Szczepaniak, KL Knutson, SP Kim, RN Bergman 		Diabetologia 2015
Rapid development of cardiac dysfunction in a canine model of insulin resistance and moderate obesity
JL Broussard, MD Nelson, CM Kolka, IA Bediako, RL Paszkiewicz, L Smith, EW Szczepaniak, D Stefanovski, LS Szczepaniak, RN Bergman 		Diabetologia 2015
Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function
C Alarcon, BB Boland, Y Uchizono, PC Moore, B Peterson, S Rajan, OS Rhodes, AB Noske, L Haataja, P Arvan, BJ Marsh, J Austin, CJ Rhodes 		Diabetes 2015
Effects of the Combined Extracts of Grape Pomace and Omija Fruit on Hyperglycemia and Adiposity in Type 2 Diabetic Mice
SJ Cho, UJ Jung, HJ Kim, R Ryu, JY Ryoo, BS Moon, MS Choi 		Preventive Nutrition and Food Science 2015
Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells
J Janikiewicz, K Hanzelka, A Dziewulska, K Kozinski, P Dobrzyn, T Bernas, A Dobrzyn 		Journal of lipid research 2015
FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation
M Li, P Page-McCaw, W Chen 		Diabetes 2015
Efficacy of canagliflozin combined with antidiabetic drugs in treating type 2 diabetes mellitus: Meta‐analysis of randomized control trials
Meng Q, Shen Y, Liu D, Jiang F 		Journal of Diabetes Investigation 2015
Long noncoding RNAs in Diseases of Aging
Kim J, Kim KM, Noh JH, Yoon JH, Abdelmohsen K, Gorospe M 		Biochimica et Biophysica Acta 2015
Targeting insulin-degrading enzyme to treat type 2 diabetes
Tang WJ 		Trends in endocrinology and metabolism: TEM 2015
Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs
Bo J, Xie S, Guo Y, Zhang C, Guan Y, Li C, Lu J, Meng QH 		Journal of Diabetes Research 2015
Islet Stellate Cells Isolated from Fibrotic Islet of Goto-Kakizaki Rats Affect Biological Behavior of Beta-Cell
Li FF, Chen BJ, Li W, Li L, Zha M, Zhou S, Bachem MG, Sun ZL 		Journal of Diabetes Research 2015
The Initial Assessment of Daily Insulin Dose in Chinese Newly Diagnosed Type 2 Diabetes
Ma J, Zhou H, Xu H, Chen X, Teng X, Liu Q, Liu W 		Journal of Diabetes Research 2015
Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long Coenzyme Q Addition
González-Alonso A, Ramírez-Tortosa CL, Varela-López A, Roche E, Arribas MI, Ramírez-Tortosa MC, Giampieri F, Ochoa JJ, Quiles JL 		International journal of molecular sciences 2015
CNV Analysis Associates AKNAD1 with Type-2 Diabetes in Jordan Subpopulations
Dajani R, Li J, Wei Z, Glessner JT, Chang X, Cardinale CJ, Pellegrino R, Wang T, Hakooz N, Khader Y, Sheshani A, Zandaki D, Hakonarson H 		Scientific Reports 2015
Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic β-Cells via Regulation of Endoplasmic Reticulum Stress
Zhou Y, Sun P, Wang T, Chen K, Zhu W, Wang H 		PloS one 2015
CNC-bZIP Protein Nrf1-Dependent Regulation of Glucose-Stimulated Insulin Secretion
Zheng H, Fu J, Xue P, Zhao R, Dong J, Liu D, Yamamoto M, Tong Q, Teng W, Qu W, Zhang Q, Andersen ME, Pi J 		Antioxidants & Redox Signaling 2015
Effects of insulin therapy on weight gain and fat distribution in the HF/HS-STZ rat model of type 2 diabetes.
Skovsø S, Damgaard J, Fels JJ, Olsen GS, Wolf XA, Rolin B, Holst JJ 		International Journal of Obesity 2015
The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.
Natalicchio A, Tortosa F, Labarbuta R, Biondi G, Marrano N, Carchia E, Leonardini A, Cignarelli A, Bugliani M, Marchetti P, Fadini GP, Giorgio M, Avogaro A, Perrini S, Laviola L, Giorgino F 		Diabetologia 2015
Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans.
Begovatz P, Koliaki C, Weber K, Strassburger K, Nowotny B, Nowotny P, Müssig K, Bunke J, Pacini G, Szendrödi J, Roden M 		Diabetologia 2015
Pathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress
LJ Yan 		Journal of Diabetes Research 2014
Adipokines and insulin action: A sensitive issue
AJ Knights, AP Funnell, RC Pearson, M Crossley, KS Bell-Anderson 		Adipocyte 2014
Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors
B Gregg, L Elghazi, EU Alejandro, MR Smith, M Blandino-Rosano, D El-Gabri, C Cras-Méneur, E Bernal-Mizrachi 		Diabetologia 2014
Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function
MK Verma, MK Sadasivuni, AN Yateesh, K Neelima, S Mrudula, M Reddy, R Smitha, S Biswas, B Chandravanshi, PM Pallavi, AM Oommen, MR Jagannath, BB Somesh 		BMC cell biology 2014
Natural history of β-cell adaptation and failure in type 2 diabetes
EU Alejandro, B Gregg, M Blandino-Rosano, C Cras-Méneur, E Bernal-Mizrachi 		Molecular Aspects of Medicine 2014
Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes
J Montane, L Cadavez, A Novials 		Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2014
The Class I Histone Deacetylase Inhibitor MS-275 Prevents Pancreatic Beta Cell Death Induced by Palmitate
V Plaisance, L Rolland, V Gmyr, JS Annicotte, J Kerr-Conte, F Pattou, A Abderrahmani 		Journal of Diabetes Research 2014
Targeting inflammation in the treatment of type 2 diabetes: time to start
MY Donath 		Nature Reviews Drug Discovery 2014
Moderate Hypoxia Induces β-Cell Dysfunction with HIF-1–Independent Gene Expression Changes
Y Sato, M Inoue, T Yoshizawa, K Yamagata, T Minamino 		PloS one 2014
SH2B1 in β-Cells Promotes Insulin Expression and Glucose Metabolism in Mice
Z Chen, DL Morris, L Jiang, Y Liu, L Rui 		Molecular Endocrinology 2014
Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes
R Stienstra, Y Haim, Y Riahi, M Netea, A Rudich, G Leibowitz 		Diabetologia 2014
Long- But Not Short-Term Adult-Onset, Isolated GH Deficiency in Male Mice Leads to Deterioration of β-Cell Function, Which Cannot Be Accounted for by Changes in β-Cell Mass
J Cordoba-Chacon, MD Gahete, NK Pokala, D Geldermann, M Alba, R Salvatori, RM Luque, RD Kineman 		Endocrinology 2014
Adipsin Is an Adipokine that Improves β Cell Function in Diabetes
JC Lo, S Ljubicic, B Leibiger, M Kern, IB Leibiger, T Moede, ME Kelly, D Chatterjee Bhowmick, I Murano, P Cohen, AS Banks, MJ Khandekar, A Dietrich, JS Flier, S Cinti, M Blüher, NN Danial, PO Berggren, BM Spiegelman 		Cell 2014
Elevated Peripheral Frequencies of Th22 Cells: A Novel Potent Participant in Obesity and Type 2 Diabetes
R Zhao, D Tang, S Yi, W Li, C Wu, Y Lu, X Hou, J Song, P Lin, L Chen, L Sun, JM Lobaccaro 		PloS one 2014
Genetic deletion of Wdr13 improves the metabolic phenotype of Lepr db/db mice by modulating AP1 and PPARγ target genes
VP Singh, C Gurunathan, S Singh, B Singh, BJ Lakshmi, AP Mishra, S Kumar 		2014
Inhibition of Pancreatic  -Cell Ca2+/Calmodulin-dependent Protein Kinase II Reduces Glucose-stimulated Calcium Influx and Insulin Secretion, Impairing Glucose Tolerance
PK Dadi, NC Vierra, A Ustione, DW Piston, RJ Colbran, DA Jacobson 		The Journal of biological chemistry 2014
Islet-1 Is Essential for Pancreatic  -Cell Function
BN Ediger, A Du, J Liu, CS Hunter, ER Walp, J Schug, KH Kaestner, R Stein, DA Stoffers, CL May 		Diabetes 2014
Age-Related Impairment of Pancreatic Beta-Cell Function: Pathophysiological and Cellular Mechanisms
VD Tata 		Frontiers in Endocrinology 2014
Modeling type 2 diabetes in rats using high fat diet and streptozotocin
S Skovsø 		Journal of Diabetes Investigation 2014
12-Lipoxygenase Promotes Obesity-Induced Oxidative Stress in Pancreatic Islets
SA Tersey, B Maier, Y Nishiki, AV Maganti, JL Nadler, RG Mirmira 		Molecular and cellular biology 2014
High glucose aggravates the detrimental effects of pancreatic stellate cells on Beta-cell function
M Zha, W Xu, Q Zhai, F Li, B Chen, Z Sun 		International Journal of Endocrinology 2014
Isolation and characterization of islet stellate cells in rat
M Zha, F Li, W Xu, B Chen, Z Sun 		Islets 2014
Role of MicroRNAs in Islet Beta-Cell Compensation and Failure during Diabetes
V Plaisance, G Waeber, R Regazzi, A Abderrahmani 		Journal of Diabetes Research 2014
Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy
Z Wang, NW York, CG Nichols, MS Remedi 		Cell Metabolism 2014
Aberrant islet unfolded protein response in type 2 diabetes
F Engin, T Nguyen, A Yermalovich, GS Hotamisligil 		Scientific Reports 2014
Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics
RK Benninger, DW Piston 		Trends in Endocrinology & Metabolism 2014
Impaired compensatory beta-cell function and growth in response to high-fat diet in LDL receptor knockout mice
RB Oliveira, CP Carvalho, CC Polo, GG Dorighello, AC Boschero, HC Oliveira, CB Collares-Buzato 		International Journal of Experimental Pathology 2014
Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation
JI Sakamaki, A Fu, C Reeks, S Baird, C Depatie, MA Azzabi, N Bardeesy, AC Gingras, SP Yee, RA Screaton 		Nature Cell Biology 2014
Optical control of insulin release using a photoswitchable sulfonylurea
J Broichhagen, M Schönberger, SC Cork, JA Frank, P Marchetti, M Bugliani, AM Shapiro, S Trapp, GA Rutter, DJ Hodson, D Trauner 		Nature Communications 2014
Glutamine Stimulates Biosynthesis and Secretion of Insulin-like Growth Factor 2 (IGF2), an Autocrine Regulator of Beta Cell Mass and Function
H Modi, M Cornu, B Thorens 		The Journal of biological chemistry 2014
Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans
JL Esguerra, L Eliasson 		Frontiers in Genetics 2014
Insulin resistance and gray matter volume in neurodegenerative disease
JK Morris, ED Vidoni, RD Perea, R Rada, DK Johnson, K Lyons, R Pahwa, JM Burns, RA Honea 		Neuroscience 2014
JNK3 is required for the cytoprotective effect of exendin 4
H Ezanno, V Pawlowski, S Abdelli, R Boutry, V Gmyr, J Kerr-Conte, C Bonny, F Pattou, A Abderrahmani 		Journal of Diabetes Research 2014
Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans
DJ Hodson, AI Tarasov, SG Brias, RK Mitchell, NR Johnston, S Haghollahi, MC Cane, M Bugliani, P Marchetti, D Bosco, PR Johnson, SJ Hughes, GA Rutter 		Molecular Endocrinology 2014
Dapagliflozin for the treatment of type 2 diabetes: a review of the literature
P Narendran, M Saeed 		Drug design, development and therapy 2014
Renal sodium glucose cotransporter 2 inhibitors as a novel therapeutic approach to treatment of type 2 diabetes: Clinical data and mechanism of action
Y Fujita, N Inagaki 		Journal of Diabetes Investigation 2014
Low sensitivity of the metabolic syndrome to identify adolescents with impaired glucose tolerance: an analysis of NHANES 1999-2010
MD DeBoer, MJ Gurka 		Cardiovascular Diabetology 2014
Sweet Taste Receptors Regulate Basal Insulin Secretion and Contribute to Compensatory Insulin Hypersecretion During the Development of Diabetes in Male Mice
GA Kyriazis, KR Smith, B Tyrberg, T Hussain, RE Pratley 		Endocrinology 2014
Islet Autotransplantation and Total Pancreatectomy
Witkowski P, Savari O, Matthews JB 		Advances in Surgery 2014
Abdominal obesity and low physical activity are associated with insulin resistance in overweight adolescents: a cross-sectional study
Velásquez-Rodríguez CM, Velásquez-Villa M, Gómez-Ocampo L, Bermúdez-Cardona J 		BMC Pediatrics 2014
Identification of Small Molecules That Protect Pancreatic β Cells against Endoplasmic Reticulum Stress-Induced Cell Death
Tran K, Li Y, Duan H, Arora D, Lim HY, Wang W 		ACS chemical biology 2014
B7-H4 as a protective shield for pancreatic islet beta cells
Sun AC, Ou D, Luciani DS, Warnock GL 		World journal of diabetes 2014
A MATLAB tool for pathway enrichment using a topology-based pathway regulation score
Ibrahim M, Jassim S, Cawthorne MA, Langlands K 		BMC bioinformatics 2014
Final Height and Cardiometabolic Outcomes in Young Adults with Very Low Birth Weight (<1500 g)
Sato R, Maekawa M, Genma R, Shirai K, Ohki S, Morita H, Suda T, Watanabe H 		PloS one 2014
Profound Defects in β-Cell Function in Screen-Detected Type 2 Diabetes Are Not Improved with Glucose-Lowering Treatment in the Early Diabetes Prevention Program (EDIP)
Hannon TS, Kirkman, Patel YR, Considine RV, Mather KJ 		Diabetes/Metabolism Research and Reviews 2014
Comparative Analysis of the Mitochondrial Physiology of Pancreatic β Cells
Kim C, Patel P, Gouvin LM, Brown ML, Khalil A, Henchey EM, Heuck AP, Yadava N 		2014
Group X Secretory Phospholipase A2 Regulates Insulin Secretion through a Cyclooxygenase-2-dependent Mechanism
Shridas P, Zahoor L, Forrest KJ, Layne JD, Webb NR 		The Journal of biological chemistry 2014
Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway
Hatanaka M, Maier B, Sims EK, Templin AT, Kulkarni RN, Evans-Molina C, Mirmira RG 		Diabetes 2014
Characterisation of Potential Antidiabetic-Related Proteins from Pleurotus pulmonarius (Fr.) Quél. (Grey Oyster Mushroom) by MALDI-TOF/TOF Mass Spectrometry
Wahab NA, Abdullah N, Aminudin N 		BioMed Research International 2014
Effects of Exenatide in a Morbidly Obese Patient with Type 2 Diabetes
Kishimoto M, Noda M 		Diabetes Therapy 2014
Association of Dioxin and Other Persistent Organic Pollutants (POPs) with Diabetes: Epidemiological Evidence and New Mechanisms of Beta Cell Dysfunction
De Tata V 		International journal of molecular sciences 2014
Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis
Lin X, Guan H, Huang Z, Liu J, Li H, Wei G, Cao X, Li Y 		Journal of Diabetes Research 2014
Psoralea corylifolia L. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress
Seo E, Lee EK, Lee CS, Chun KH, Lee MY, Jun HS 		Oxidative medicine and cellular longevity 2014
The efficacy of dapagliflozin combined with hypoglycaemic drugs in treating type 2 diabetes mellitus: meta-analysis of randomised controlled trials
Sun YN, Zhou Y, Chen X, Che WS, Leung SW 		BMJ Open 2014
The Cytotoxic Role of Intermittent High Glucose on Apoptosis and Cell Viability in Pancreatic Beta Cells
Zhang Z, Li J, Yang L, Chen R, Yang R, Zhang H, Cai D, Chen H 		Journal of Diabetes Research 2014
Alterations of Pancreatic Islet Structure, Metabolism and Gene Expression in Diet-Induced Obese C57BL/6J Mice
Roat R, Rao V, Doliba NM, Matschinsky FM, Tobias JW, Garcia E, Ahima RS, Imai Y 		PloS one 2014
Analysis of Synaptic-Like Microvesicle Exocytosis of B-Cells Using a Live Imaging Technique
Bergeron A, Pucci L, Bezzi P, Regazzi R 		PloS one 2014
Morphological changes of post-isolation of caprine pancreatic islet.
Hani H, Allaudin ZN, Tengku Ibrahim TA, Mohd-Lila MA, Sarsaifi K, Camalxaman SN, Othman AM 		In vitro cellular & developmental biology. Animal 2014
Insulin resistance and beta cell function before and after sleeve gastrectomy in obese patients with impaired fasting glucose or type 2 diabetes.
Eickhoff H, Guimarães A, Louro TM, Seiça RM, Castro E Sousa F 		Surgical Endoscopy 2014
Chronic activation of a designer Gq-coupled receptor improves β-cell function
Shalini Jain, Inigo Ruiz de Azua, Huiyan Lu, Morris White, Jean-Marc Guettier, Jürgen Wess 		Journal of Clinical Investigation 2013
Incretin-regulated human beta cell connectivity: a target for lipotoxicity
David Hodson, Ryan Mitchell, Elisa Bellomo, Gao Sun, Laurent Vinet, Paolo Meda, Daliang Li, Wen-Hong Li, Marco Bugliani, Piero Marchetti, Domenico Bosco, Lorenzo Piemonti, Paul Johnson, Stephen Hughes, Guy Rutter 		Journal of Clinical Investigation 2013
Antidiabetic Actions of an Estrogen Receptor β Selective Agonist
P Alonso-Magdalena, AB Ropero, M García-Arévalo, S Soriano, I Quesada, SJ Muhammed, A Salehi, JA Gustafsson, Á Nadal 		Diabetes 2013
CCCTC-binding factor mediates effects of glucose on beta cell survival
S Tsui, W Dai, L Lu 		Cell Proliferation 2013
SH2B1 in  -Cells Regulates Glucose Metabolism by Promoting  -Cell Survival and Islet Expansion
Z Chen, DL Morris, L Jiang, Y Liu, L Rui 		Diabetes 2013
Grape seed proanthocyanidins ameliorate pancreatic beta-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress
Y Ding, Z Zhang, X Dai, Y Jiang, L Bao, Y Li, Y Li 		Nutrition & Metabolism 2013
Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity
BP Somesh, MK Verma, MK Sadasivuni, A Mammen-Oommen, S Biswas, PC Shilpa, AK Reddy, AN Yateesh, PM Pallavi, S Nethra, R Smitha, K Neelima, U Narayanan, MR Jagannath 		BMC cell biology 2013
Characterisation of age-dependent beta cell dynamics in the male db/db mice
LS Dalbøge, DL Almholt, TS Neerup, E Vassiliadis, N Vrang, L Pedersen, K Fosgerau, J Jelsing 		PloS one 2013
The Fractalkine/CX3CR1 System Regulates Beta Cell Function and Insulin Secretion
YS Lee, H Morinaga, JJ Kim, W Lagakos, S Taylor, M Keshwani, G Perkins, H Dong, AG Kayali, IR Sweet, J Olefsky 		Cell 2013
Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes
H Kaneto, TA Matsuoka 		World journal of diabetes 2013
Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate
EP Cai, X Wu, SA Schroer, AJ Elia, MC Nostro, E Zacksenhaus, M Woo 		Proceedings of the National Academy of Sciences 2013
Increased density of inhibitory noradrenergic parenchymal nerve fibers in hypertrophic islets of Langerhans of obese mice
I Giannulis, E Mondini, F Cinti, A Frontini, I Murano, R Barazzoni, G Barbatelli, D Accili, S Cinti 		Nutrition, Metabolism, and Cardiovascular Diseases 2013
A molecular rheostat at the interface of cancer and diabetes
MA Osman, FH Sarkar, E Rodriguez-Boulan 		Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2013
Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes
V Nesca, C Guay, C Jacovetti, V Menoud, ML Peyot, DR Laybutt, M Prentki, R Regazzi 		Diabetologia 2013
Osteocalcin Promotes  -Cell Proliferation During Development and Adulthood Through Gprc6a
J Wei, T Hanna, N Suda, G Karsenty, P Ducy 		Diabetes 2013
The GTPase Rab37 Participates in the Control of Insulin Exocytosis
S Ljubicic, P Bezzi, S Brajkovic, V Nesca, C Guay, N Ohbayashi, M Fukuda, A Abderrhamani, R Regazzi 		PloS one 2013
VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus
S Puri, H Akiyama, M Hebrok 		Genes & development 2013
Sweet and Sour  -Cells: ROS and Hif1  Induce Warburg-Like Lactate Production During Type 2 Diabetes
J Cantley, TJ Biden 		Diabetes 2013
Investigational anti-hyperglycemic agents: the future of type 2 diabetes therapy?
SK Majumdar, SE Inzucchi 		Endocrine 2013
SAD-A Potentiates Glucose-Stimulated Insulin Secretion as a Mediator of Glucagon-Like Peptide 1 Response in Pancreatic   Cells
J Nie, BN Lilley, YA Pan, O Faruque, X Liu, W Zhang, JR Sanes, X Han, Y Shi 		Molecular and cellular biology 2013
Genetic and epigenetic control of metabolic health
RW Schwenk, H Vogel, A Schürmann 		Molecular Metabolism 2013
Phenotypic characteristics of early Wolfram syndrome
BA Marshall, MA Permutt, AR Paciorkowski, J Hoekel, R Karzon, J Wasson, A Viehover, NH White, JS Shimony, L Manwaring, P Austin, TE Hullar, T Hershey, WT Group 		Orphanet Journal of Rare Diseases 2013
Pioglitazone acutely reduces energy metabolism and insulin secretion in rats
J Lamontagne, E Jalbert-Arsenault, E Pepin, ML Peyot, NB Ruderman, CJ Nolan, E Joly, SR Madiraju, V Poitout, M Prentki 		Diabetes 2013
Minireview: Intraislet Regulation of Insulin Secretion in Humans
GA Rutter, DJ Hodson 		Molecular Endocrinology 2013
β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice.
Ravier MA, Leduc M, Richard J, Linck N, Varrault A, Pirot N, Roussel MM, Bockaert J, Dalle S, Bertrand G 		Diabetologia 2013
Diabetes and beta cell function: from mechanisms to evaluation and clinical implications
Cernea S, Dobreanu M 		Biochemia Medica 2013
Effects of insulin glargine versus metformin on glycemic variability, microvascular and beta-cell function in early type 2 diabetes
F Pistrosch, C Köhler, F Schaper, W Landgraf, T Forst, M Hanefeld 		Acta Diabetologica 2013
Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart Family Study
N Franceschini, K Haack, HH Göring, VS Voruganti, S Laston, L Almasy, ET Lee, LG Best, RR Fabsitz, KE North, JW MacCluer, JB Meigs, JS Pankow, SA Cole 		Diabetologia 2013
Maternal malnutrition and offspring sex determine juvenile obesity and metabolic disorders in a swine model of leptin resistance
A Barbero, S Astiz, CJ Lopez-Bote, ML Perez-Solana, M Ayuso, I Garcia-Real, A Gonzalez-Bulnes 		PloS one 2013
Epidermal Growth Factor Receptor Signaling Promotes Pancreatic  -Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1
B Zarrouki, I Benterki, G Fontes, ML Peyot, O Seda, M Prentki, V Poitout 		Diabetes 2013
Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced β-cell damage and pancreatic Glp-1 gene therapy
JM Tonne, T Sakuma, MC Deeds, M Munoz-Gomez, MA Barry, YC Kudva, Y Ikeda 		Disease models & mechanisms 2013
Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance.
Salinari S, Debard C, Bertuzzi A, Durand C, Zimmet P, Vidal H, Mingrone G 		PloS one 2013
The efficacy of dapagliflozin combined with hypoglycemic drugs in treating type 2 diabetes: protocol for meta-analysis of randomized controlled trials
Sun YN, Zhou Y, Chen X, Che WS, Leung SW 		Systematic Reviews 2013
ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes
Omikorede O, Qi C, Gorman T, Chapman P, Yu A, Smith DM, Herbert TP 		Nutrition & Diabetes 2013
The effect of duodenojejunal bypass for type 2 diabetes mellitus patients below body mass index 25 kg/m2: one year follow-up
Heo Y, Ahn JH, Shin SH, Lee YJ 		Journal of the Korean Surgical Society 2013
DC260126: A Small-Molecule Antagonist of GPR40 that Protects against Pancreatic β-Cells Dysfunction in db/db Mice
Sun P, Wang T, Zhou Y, Liu H, Jiang H, Zhu W, Wang H 		PloS one 2013
Duration of Abdominal Obesity Beginning in Young Adulthood and Incident Diabetes Through Middle Age: The CARDIA Study
Reis JP, Hankinson AL, Loria CM, Lewis CE, Powell-Wiley T, Wei GS, Liu K 		Diabetes care 2013
Systematic Proteomic Analysis Identifies β-Site Amyloid Precursor Protein Cleaving Enzyme 2 and 1 (BACE2 and BACE1) Substrates in Pancreatic β-Cells
Stützer I, Selevsek N, Esterházy D, Schmidt A, Aebersold R, Stoffel M 		The Journal of biological chemistry 2013
Islet autotransplantation to preserve beta cell mass in selected patients with chronic pancreatitis and diabetes mellitus undergoing total pancreatectomy
Bellin MD, Beilman GJ, Dunn T, Pruett T, Chinnakotla S, Ngo A, Radosevich DM, Freeman ML, Schwarzenberg SJ, Balamurugan AN, Hering BJ, Sutherland DE 		Pancreas 2013
Novel genes underlying beta cell survival in metabolic stress
Singh H, Farouk M, Bose BB, Singh P 		Bioinformation 2013
Stimulating β-Cell Regeneration by Combining a GPR119 Agonist with a DPP-IV Inhibitor
Ansarullah, Lu Y, Holstein M, DeRuyter B, Rabinovitch A, Guo Z 		PloS one 2013
Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients.
Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC 		Diabetologia 2013
14-3-3 proteins are essential signalling hubs for beta cell survival.
Lim GE, Piske M, Johnson JD 		Diabetologia 2013
Circulating microRNAs as novel biomarkers for diabetes mellitus.
Guay C, Regazzi R 		Nature reviews. Endocrinology 2013
MicroRNAs contribute to compensatory beta-cell expansion during pregnancy and obesity
Cécile Jacovetti, Amar Abderrahmani, Géraldine Parnaud, Jean-Christophe Jonas, Marie-Line Peyot, Marion Cornu, D. Ross Laybutt, Emmanuelle Meugnier, Sophie Rome, Bernard Thorens, Marc Prentki, Domenico Bosco, Romano Regazzi 		Journal of Clinical Investigation 2012
The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes
M Halperin-Sheinfeld, A Gertler, E Okun, B Sredni, HY Cohen 		Aging 2012
C-Peptide Prevents Hyperglycemia-Induced Endothelial Apoptosis Through Inhibition of Reactive Oxygen Species–Mediated Transglutaminase 2 Activation
MP Bhatt, YC Lim, JY Hwang, SH Na, YM Kim, KS Ha 		Diabetes 2012
APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice
KK Cheng, KS Lam, D Wu, Y Wang, G Sweeney, RL Hoo, J Zhang, A Xu 		Proceedings of the National Academy of Sciences 2012
The In Vivo  -to- -Cell Chat Room: Connexin Connections Matter
P Meda 		Diabetes 2012
Role of Transcription Factor Modifications in the Pathogenesis of Insulin Resistance
MY Kim, JS Bae, TH Kim, JM Park, YH Ahn 		Experimental Diabetes Research 2012
G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
M Ferdaoussi, V Bergeron, B Zarrouki, J Kolic, J Cantley, J Fielitz, EN Olson, M Prentki, T Biden, PE MacDonald, V Poitout 		Diabetologia 2012
Importance of oestrogen receptors to preserve functional β-cell mass in diabetes
JP Tiano, F Mauvais-Jarvis 		Nature Reviews Endocrinology 2012
Endoplasmic Reticulum Stress in the β-Cell Pathogenesis of Type 2 Diabetes
SH Back, SW Kang, J Han, HT Chung 		Experimental Diabetes Research 2012
Hepatitis C Virus Induced a Novel Apoptosis-Like Death of Pancreatic Beta Cells through a Caspase 3-Dependent Pathway
Q Wang, J Chen, Y Wang, X Han, X Chen 		PloS one 2012
Endoplasmic reticulum stress and type 2 diabetes
SH Back, RJ Kaufman 		Annual Review of Biochemistry 2012
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy
AH Schönthal 		Scientifica 2012
Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal insulin-secreting cells using chromatin immunoprecipitation coupled to DNA selection and ligation
HY Lin, Y Yin, JX Zhang, H Xuan, Y Zheng, SS Zhan, YX Zhu, X Han 		Diabetologia 2012
Involvement of Oxidative Stress in Suppression of Insulin Biosynthesis under Diabetic Conditions
H Kaneto, TA Matsuoka 		International journal of molecular sciences 2012
Nutrient Excess Stimulates  -Cell Neogenesis in Zebrafish
LA Maddison, W Chen 		Diabetes 2012
Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet
BK Cole, MA Morris, WJ Grzesik, KA Leone, JL Nadler 		Mediators of Inflammation 2012
Mitochondrial Dysfunction and β-Cell Failure in Type 2 Diabetes Mellitus
ZA Ma, Z Zhao, J Turk 		Experimental Diabetes Research 2012
Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines
ZX Meng, Y Yin, JH Lv, M Sha, Y Lin, L Gao, YX Zhu, YJ Sun, X Han 		Diabetologia 2012
Group VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents
S Bao, H Song, M Tan, M Wohltmann, JH Ladenson, J Turk 		Oxidative Medicine & Cellular Longevity 2012
Autofluorescence Imaging of Living Pancreatic Islets Reveals Fibroblast Growth Factor-21 (FGF21)-Induced Metabolism
MY Sun, E Yoo, BJ Green, SM Altamentova, DM Kilkenny, JV Rocheleau 		Biophysical Journal 2012
Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes
MD Bellin, FB Barton, A Heitman, R Alejandro, BJ Hering 		American Journal of Transplantation 2012
No Islets Left Behind: Islet Autotransplantation for Surgery-Induced Diabetes
MD Bellin, AN Balamurugan, TL Pruett, DE Sutherland 		Current Diabetes Reports 2012
Cholesterol‐enriched membrane rafts and insulin secretion
R Dirkx, M Solimena 		Journal of Diabetes Investigation 2012
Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in  -Cell Gene Expression and Progression to Diabetes
JY Chan, J Luzuriaga, M Bensellam, TJ Biden, DR Laybutt 		Diabetes 2012
The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote  -Cell Survival
WM McKimpson, J Weinberger, L Czerski, M Zheng, MT Crow, JE Pessin, SC Chua, RN Kitsis 		Diabetes 2012
The Nuclear Orphan Receptor Nur77 Is a Lipotoxicity Sensor Regulating Glucose-Induced Insulin Secretion in Pancreatic β-Cells
O Briand, A Helleboid-Chapman, M Ploton, N Hennuyer, R Carpentier, F Pattou, B Vandewalle, E Moerman, V Gmyr, J Kerr-Conte, J Eeckhoute, B Staels, P Lefebvre 		Molecular Endocrinology 2012
Do the Interactions between Glucocorticoids and Sex Hormones Regulate the Development of the Metabolic Syndrome?
M Alemany 		Frontiers in Endocrinology 2012
The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation
YJ Park, Z Ao, TJ Kieffer, H Chen, N Safikhan, DM Thompson, M Meloche, GL Warnock, L Marzban 		Diabetologia 2012
The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failure.
Ma ZA 		Current diabetes reviews 2012
The pancreatic beta cell surface proteome
I Stützer, D Esterházy, M Stoffel 		Diabetologia 2012
Diet-Induced Swine Model with Obesity/Leptin Resistance for the Study of Metabolic Syndrome and Type 2 Diabetes
L Torres-Rovira, S Astiz, A Caro, C Lopez-Bote, C Ovilo, P Pallares, ML Perez-Solana, R Sanchez-Sanchez, A Gonzalez-Bulnes 		The Scientific World JOURNAL 2012
Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase‐2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling
NG Kondegowda, A Mozar, C Chin, A Otero, A Garcia-Ocaña, RC Vasavada 		Diabetologia 2012
Dapagliflozin: an evidence-based review of its potential in the treatment of type-2 diabetes
EC Chao 		Core evidence 2012
Palmitate Activates Autophagy in INS-1E β-Cells and in Isolated Rat and Human Pancreatic Islets
L Martino, M Masini, M Novelli, P Beffy, M Bugliani, L Marselli, P Masiello, P Marchetti, VD Tata 		PloS one 2012
Adaptive changes of human islets to an obesogenic environment in the mouse
S Gargani, J Thévenet, JE Yuan, B Lefebvre, N Delalleau, V Gmyr, T Hubert, A Duhamel, F Pattou, J Kerr-Conte 		Diabetologia 2012
Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?
N Li, S Stojanovski, P Maechler 		Oxidative Medicine & Cellular Longevity 2012
Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model With Impaired Incretin Function and Reduced  -Cell Mass
S Renner, W Romisch-Margl, C Prehn, S Krebs, J Adamski, B Goke, H Blum, K Suhre, AA Roscher, E Wolf 		Diabetes 2012
Mitochondrial Dynamics and Morphology in Beta-Cells
Stiles L, Shirihai OS 		Best practice & research. Clinical endocrinology & metabolism 2012
Letter: Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1 (Diabetes Metab J 2012;36:275-9)
Cho JH 		Diabetes & Metabolism Journal 2012
Progression from High Insulin Resistance to Type 2 Diabetes Does Not Entail Additional Visceral Adipose Tissue Inflammation
Barbarroja N, Lopez-Pedrera C, Garrido-Sanchez L, Mayas MD, Oliva-Olivera W, Bernal-Lopez MR, El Bekay R, Tinahones FJ 		PloS one 2012
Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage
Yang B, Fu J, Zheng H, Xue P, Yarborough K, Woods CG, Hou Y, Zhang Q, Andersen ME, Pi J 		Toxicology and Applied Pharmacology 2012
DISCOVERY OF NOVEL GLUCOSE-REGULATED PROTEINS IN ISOLATED HUMAN PANCREATIC ISLETS USING LC-MS/MS-BASED PROTEOMICS
Schrimpe-Rutledge AC, Fontès G, Gritsenko MA, Norbeck AD, Anderson DJ, Waters KM, Adkins JN, Smith RD, Poitout V, Metz TO 		Journal of Proteome Research 2012
Antiaging Gene Klotho Enhances Glucose-Induced Insulin Secretion by Up-Regulating Plasma Membrane Levels of TRPV2 in MIN6 β-Cells
Lin Y, Sun Z 		Endocrinology 2012
Influence of gastrectomy for stomach cancer on type 2 diabetes mellitus for patients with a body mass index less than 30 kg/m2
Kang KC, Shin SH, Lee YJ, Heo YS 		Journal of the Korean Surgical Society 2012
In Vitro Proliferation of Adult Human Beta-Cells
Rutti S, Sauter NS, Bouzakri K, Prazak R, Halban PA, Donath MY 		PloS one 2012
Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1
Kebede M, Ferdaoussi M, Mancini A, Alquier T, Kulkarni RN, Walker MD, Poitout V 		Proceedings of the National Academy of Sciences 2012
Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets
Douillet C, Currier J, Saunders J, Bodnar WM, Matoušek T, Stýblo M 		Toxicology and Applied Pharmacology 2012
The roots of Atractylodes japonica Koidzumi promote adipogenic differentiation via activation of the insulin signaling pathway in 3T3-L1 cells
Han Y, Jung HW, Park YK 		BMC complementary and alternative medicine 2012
The telomere syndromes
Armanios M, Blackburn EH 		Nature reviews. Genetics 2012
Estrogen receptors reduce pancreatic islet lipid synthesis and prevent β-cell failure in rodent models of type 2 diabetes
Joseph Tiano, Viviane Delghingaro-Augusto, Cedric Le May, Suhuan Liu, Meenakshi Kaw, Saja Khuder, Martin Latour, Surabhi Bhatt, Kenneth S. Korach, Sonia Najjar, Marc Prentki, Franck Mauvais-Jarvis 		Journal of Clinical Investigation 2011
Digging deeper into obesity
Rexford S. Ahima 		Journal of Clinical Investigation 2011
Comprehensive Physiology
R Terjung 		Comprehensive Physiology 2011
The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes
J Xie, TP Herbert 		Cellular and Molecular Life Sciences 2011
Short telomeres compromise β-cell signaling and survival
N Guo, EM Parry, LS Li, F Kembou, N Lauder, MA Hussain, PO Berggren, M Armanios 		PloS one 2011
Type 2 diabetes as an inflammatory disease
MY Donath, SE Shoelson 		Nature Reviews Immunology 2011
Glucolipotoxicity in Pancreatic β-Cells
JW Kim, KH Yoon 		Diabetes & Metabolism Journal 2011
β-Cell failure in type 2 diabetes
G Leibowitz, N Kaiser, E Cerasi 		Journal of Diabetes Investigation 2011
β-cell mass in people with type 2 diabetes
JH Cho, JW Kim, JA Shin, J Shin, KH Yoon 		Journal of Diabetes Investigation 2011
Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion
T Nagare, H Sakaue, M Matsumoto, Y Cao, K Inagaki, M Sakai, Y Takashima, K Nakamura, T Mori, Y Okada, Y Matsuki, E Watanabe, K Ikeda, R Taguchi, N Kamimura, S Ohta, R Hiramatsu, M Kasuga 		The Journal of biological chemistry 2011
World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease: Part 3
ZT Bloomgarden 		Diabetes care 2011
Guards and Culprits in the Endoplasmic Reticulum: Glucolipotoxicity and β-Cell Failure in Type II Diabetes
U Karunakaran, HJ Kim, JY Kim, IK Lee 		Experimental Diabetes Research 2011
Endoplasmic reticulum stress and pancreatic beta cell death
SG Fonseca, J Gromada, F Urano 		Trends in endocrinology and metabolism: TEM 2011
Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function
PW Caton, J Kieswich, MM Yaqoob, MJ Holness, MC Sugden 		Diabetologia 2011
Gliclazide may have an antiapoptotic effect related to its antioxidant properties in human normal and cancer cells
A Sliwinska, A Rogalska, M Szwed, J Kasznicki, Z Jozwiak, J Drzewoski 		Molecular Biology Reports 2011
Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling
AT Templin, B Maier, Y Nishiki, SA Tersey, RG Mirmira 		Cell cycle (Georgetown, Tex.) 2011
Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo
Z Wang, E Oh, DW Clapp, J Chernoff, DC Thurmond 		The Journal of biological chemistry 2011
Nifedipine Protects INS-1 β-Cell from High Glucose-Induced ER Stress and Apoptosis
Y Wang, L Gao, Y Li, H Chen, Z Sun 		International journal of molecular sciences 2011
Snapin Mediates Incretin Action and Augments Glucose-Dependent Insulin Secretion
WJ Song, M Seshadri, U Ashraf, T Mdluli, P Mondal, M Keil, M Azevedo, LS Kirschner, CA Stratakis, MA Hussain 		Cell Metabolism 2011
Increased neuronal nitric oxide synthase dimerisation is involved in rat and human pancreatic beta cell hyperactivity in obesity
K Mezghenna, P Pomiès, A Chalançon, F Castex, J Leroy, N Niclauss, B Nadal, L Cambier, C Cazevieille, P Petit, R Gomis, T Berney, R Gross, AD Lajoix 		Diabetologia 2011
An Early Response Transcription Factor, Egr-1, Enhances Insulin Resistance in Type 2 Diabetes with Chronic Hyperinsulinism*
N Shen, X Yu, FY Pan, X Gao, B Xue, CJ Li 		The Journal of biological chemistry 2011
Sexually Dimorphic Diet-Induced Insulin Resistance in Obese Tissue Inhibitor of Metalloproteinase-2 (TIMP-2)-Deficient Mice
DM Jaworski, O Sideleva, HM Stradecki, GD Langlois, A Habibovic, B Satish, WG Tharp, J Lausier, K Larock, TL Jetton, M Peshavaria, RE Pratley 		Endocrinology 2011
Reduced Cytochrome c Is an Essential Regulator of Sustained Insulin Secretion by Pancreatic Islets*
SR Jung, IT Kuok, D Couron, N Rizzo, DH Margineantu, DM Hockenbery, F Kim, IR Sweet 		The Journal of biological chemistry 2011
Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance
MC Akerfeldt, DR Laybutt 		Diabetes 2011
Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome?
A Othman, MF Rütti, D Ernst, CH Saely, P Rein, H Drexel, C Porretta-Serapiglia, G Lauria, R Bianchi, A von Eckardstein, T Hornemann 		Diabetologia 2011
Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo
A Tahara, E Kurosaki, M Yokono, D Yamajuku, R Kihara, Y Hayashizaki, T Takasu, M Imamura, L Qun, H Tomiyama, Y Kobayashi, A Noda, M Sasamata, M Shibasaki 		Naunyn-Schmiedeberg's Archives of Pharmacology 2011
Glucagon-like Peptide–1 Analogues for Type 2 Diabetes Mellitus: Current and Emerging Agents
B Gallwitz 		Drugs 2011
Cholesterol induces pancreatic β cell apoptosis through oxidative stress pathway
Lu X, Liu J, Hou F, Liu Z, Cao X, Seo H, Gao B 		Cell Stress & Chaperones 2011
Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide.
Soty M, Visa M, Soriano S, Carmona Mdel C, Nadal Á, Novials A 		The Journal of biological chemistry 2011
Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass
Vivas Y, Martínez-García C, Izquierdo A, Garcia-Garcia F, Callejas S, Velasco I, Campbell M, Ros M, Dopazo A, Dopazo J, Vidal-Puig A, Medina-Gomez G 		BMC Medical Genomics 2011
AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells
Shaked M, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G 		PloS one 2011
Signaling Cross Talk between Growth Hormone (GH) and Insulin-Like Growth Factor-I (IGF-I) in Pancreatic Islet β-Cells
Ma F, Wei Z, Shi C, Gan Y, Lu J, Frank SJ, Balducci J, Huang Y 		Molecular Endocrinology 2011
Altered Islet Composition and Disproportionate Loss of Large Islets in Patients with Type 2 Diabetes
Kilimnik G, Zhao B, Jo J, Periwal V, Witkowski P, Misawa R, Hara M 		PloS one 2011
ID’ing a Novel Inhibitor of β-Cell Function, Id1
Billestrup N 		Diabetes 2011
Native low density lipoprotein induces pancreatic β cell apoptosis through generating excess reactive oxygen species
Lu X, Liu J, Cao X, Hou X, Wang X, Zhao C, Wang Y, Li Y, Seo H, Gao B 		Lipids in Health and Disease 2011
Functional, metabolic and morphological characteristics of a novel rat model of type 2 diabetes-associated erectile dysfunction
Albersen M, Lin G, Fandel TM, Zhang H, Qiu X, Lin CS, Lue TF 		Urology 2011
Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes
Ye R, Ni M, Wang M, Luo S, Zhu G, Chow RH, Lee AS 		The Journal of endocrinology 2011
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells
Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song WJ, Sereda S, Clerc P, Polster BM, Aja SM, Pletnikov MV, Kensler TW, Shirihai OS, Iijima M, Hussain MA, Sesaki H 		Molecular biology of the cell 2011
Decreased Expression and Induced Nucleocytoplasmic Translocation of Pancreatic and Duodenal Homeobox 1 in INS-1 Cells Exposed to High Glucose and Palmitate
Ryu GR, Yoo JM, Lee E, Ko SH, Ahn YB, Song KH 		Diabetes & Metabolism Journal 2011
Inulin Increases Short-Term Markers for Colonic Fermentation similarly in Healthy and Hyperinsulinemic Humans
Fernandes J, Vogt J, Wolever TM 		European Journal of Clinical Nutrition 2011
The Unique Hypusine Modification of eIF5A Promotes Islet beta Cell Inflammation and Dysfunction
Bernhard Maier, Takeshi Ogihara, Anthony Trace, Sarah A. Tersey, Reiesha D. Robbins, Swarup K. Chakrabarti, Craig S. Nunemaker, Natalie D. Stull, Catherine A. Taylor, John E. Thompson, Richard S. Dondero, Eli C. Lewis, Charles A. Dinarello, Jerry L. Nadler, Raghavendra G. Mirmira 		Journal of Clinical Investigation 2010
An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells
Jeffrey Sturek, David Castle, Anthony Trace, Laura Page, Anna Castle, Carmella Evans-Molina, John Parks, Raghavendra Mirmira, Catherine Hedrick 		Journal of Clinical Investigation 2010
Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic β-Cell Growth
CE Gleason, Y Ning, TP Cominski, R Gupta, KH Kaestner, JE Pintar, MJ Birnbaum 		Molecular Endocrinology 2010
Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis
H Kaneto, N Katakami, M Matsuhisa, T Matsuoka 		Mediators of Inflammation 2010
Differential Effects of Protein Kinase B/Akt Isoforms on Glucose Homeostasis and Islet Mass
F Buzzi, L Xu, RA Zuellig, SB Boller, GA Spinas, D Hynx, Z Chang, Z Yang, BA Hemmings, O Tschopp, M Niessen 		Molecular and cellular biology 2010
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis
SD Jordan, AC Könner, JC Brüning 		Cellular and Molecular Life Sciences 2010
Persistent correction of hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice by a non-conventional radical scavenger
M Novelli, B Bonamassa, M Masini, N Funel, D Canistro, VD Tata, M Martano, A Soleti, D Campani, M Paolini, P Masiello 		Naunyn-Schmiedeberg's Archives of Pharmacology 2010
Human beta cell proliferation by glucose—a complex scenario
M Tiedge 		Diabetologia 2010
Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets
M Mirasierra, A Fernández-Pérez, N Díaz-Prieto, M Vallejo 		Diabetologia 2010
Physiological Insights Gained from Gene Expression Analysis in Obesity and Diabetes
MP Keller, AD Attie 		Annual Review of Nutrition 2010
Protection of Pancreatic β-Cells by Group VIA Phospholipase A2-Mediated Repair of Mitochondrial Membrane Peroxidation
Z Zhao, X Zhang, C Zhao, J Choi, J Shi, K Song, J Turk, ZA Ma 		Endocrinology 2010
Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass
G Fontés, B Zarrouki, DK Hagman, MG Latour, M Semache, V Roskens, PC Moore, M Prentki, CJ Rhodes, TL Jetton, V Poitout 		Diabetologia 2010
Inhibition of Deoxyhypusine Synthase Enhances Islet β Cell Function and Survival in the Setting of Endoplasmic Reticulum Stress and Type 2 Diabetes*
RD Robbins, SA Tersey, T Ogihara, D Gupta, TB Farb, J Ficorilli, K Bokvist, B Maier, RG Mirmira 		The Journal of biological chemistry 2010
Cholesterol in β-cell Dysfunction: The Emerging Connection Between HDL Cholesterol and Type 2 Diabetes
LR Brunham, JK Kruit, MR Hayden, CB Verchere 		Current Diabetes Reports 2010
FoxM1 Is Up-Regulated by Obesity and Stimulates β-Cell Proliferation
DB Davis, JA Lavine, JI Suhonen, KA Krautkramer, ME Rabaglia, JM Sperger, LA Fernandez, BS Yandell, MP Keller, IM Wang, EE Schadt, AD Attie 		Molecular Endocrinology 2010
The role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus
D Gupta, T Kono, C Evans-Molina 		Diabetes, Obesity and Metabolism 2010
Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes
A Villasenor, ZV Wang, LB Rivera, O Ocal, IW Asterholm, PE Scherer, RA Brekken, O Cleaver, TM Wilkie 		Disease models & mechanisms 2010
Carriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic  -Cell Dysfunction
M Vergeer, LR Brunham, J Koetsveld, JK Kruit, CB Verchere, JJ Kastelein, MR Hayden, ES Stroes 		Diabetes care 2010
Transgenic pigs as models for translational biomedical research
B Aigner, S Renner, B Kessler, N Klymiuk, M Kurome, A Wünsch, E Wolf 		Journal of Molecular Medicine 2010
SGLT2 inhibition — a novel strategy for diabetes treatment
EC Chao, RR Henry 		Nature Reviews Drug Discovery 2010
The role of autophagy in β-cell lipotoxicity and type 2 diabetes
G Las, OS Shirihai 		Diabetes, Obesity and Metabolism 2010
Reversal of obesity and insulin resistance by a non-peptidic glucagon-like peptide-1 receptor agonist in diet-induced obese mice
M He, H Su, W Gao, SM Johansson, Q Liu, X Wu, J Liao, AA Young, T Bartfai, MW Wang 		PloS one 2010
Glucolipotoxicity of the pancreatic beta cell
V Poitout, J Amyot, M Semache, B Zarrouki, D Hagman, G Fontés 		Biochimica et Biophysica Acta 2010
Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets
DM Faleck, K Ali, R Roat, MJ Graham, RM Crooke, R Battisti, E Garcia, RS Ahima, Y Imai 		American journal of physiology. Endocrinology and metabolism 2010
New treatments in the management of type 2 diabetes: a critical appraisal of saxagliptin
B Gallwitz 		Diabetes, metabolic syndrome and obesity : targets and therapy 2010
Do insulinotropic glucose-lowering drugs do more harm than good? The hypersecretion hypothesis revisited.
Rustenbeck I, Baltrusch S, Tiedge M 		Diabetologia 2010
Benefit-risk assessment of exenatide in the therapy of type 2 diabetes mellitus.
Gallwitz B 		Drug Safety 2010
The Roles of ATF3, an Adaptive-Response Gene, in High-Fat-Diet-Induced Diabetes and Pancreatic β-Cell Dysfunction
Zmuda EJ, Qi L, Zhu MX, Mirmira RG, Montminy MR, Hai T 		Molecular Endocrinology 2010
Angiotensin I–Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice
Bindom SM, Hans CP, Xia H, Boulares AH, Lazartigues E 		Diabetes 2010
β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass
Peyot ML, Pepin E, Lamontagne J, Latour MG, Zarrouki B, Lussier R, Pineda M, Jetton TL, Madiraju SR, Joly E, Prentki M 		Diabetes 2010
Protection of Pancreatic β-Cells from Various Stress Conditions Is Mediated by DJ-1
Inberg A, Linial M 		The Journal of biological chemistry 2010
The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study
Miller ME, Bonds DE, Gerstein HC, Seaquist ER, Bergenstal RM, Calles-Escandon J, Childress RD, Craven TE, Cuddihy RM, Dailey G, Feinglos MN, Ismail-Beigi F, Largay JF, O\u2019Connor PJ, Paul T, Savage PJ, Schubart UK, Sood A, Genuth S 		2010
α-Synuclein binds the KATP channel at insulin-secretory granules and inhibits insulin secretion
Geng X, Lou H, Wang J, Li L, Swanson AL, Sun M, Beers-Stolz D, Watkins S, Perez RG, Drain P 		American journal of physiology. Endocrinology and metabolism 2010
Misfolded proinsulin affects bystander proinsulin in neonatal diabetes
I Hodish, M Liu, G Rajpal, D Larkin, RW Holz, A Adams, L Liu, P Arvan 		The Journal of biological chemistry 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd 		Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion
MM Sachdeva, DA Stoffers 		Molecular Endocrinology 2009
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
RA DeFronzo 		Diabetes 2009
Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic β-Cell at Submaximal Glucose Concentrations
J Lamontagne, E Pepin, ML Peyot, E Joly, NB Ruderman, V Poitout, SR Madiraju, CJ Nolan, M Prentki 		Endocrinology 2009
Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax
MD McKenzie, E Jamieson, ES Jansen, CL Scott, DC Huang, P Bouillet, J Allison, TW Kay, A Strasser, HE Thomas 		Diabetes 2009
Glucagon-Like Peptide-1 Protects  -Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop
M Cornu, JY Yang, E Jaccard, C Poussin, C Widmann, B Thorens 		Diabetes 2009
Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis
Z Zhao, C Zhao, XH Zhang, F Zheng, W Cai, H Vlassara, ZA Ma 		Endocrinology 2009
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress
MM Sachdeva, KC Claiborn, C Khoo, J Yang, DN Groff, RG Mirmira, DA Stoffers 		Proceedings of the National Academy of Sciences 2009
Regulation of MAP kinase-directed mitogenic and protein kinase B-mediated signaling by cannabinoid receptor type 1 in skeletal muscle cells
C Lipina, C Stretton, S Hastings, JS Hundal, K Mackie, AJ Irving, HS Hundal 		Diabetes 2009
Deletion of PKC  Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse  -Cells
J Cantley, JG Burchfield, GL Pearson, C Schmitz-Peiffer, M Leitges, TJ Biden 		Diabetes 2009
Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria
A Jauregui, DH Mintz, P Mundel, A Fornoni 		Current Opinion in Nephrology and Hypertension 2009
Peroxisome Proliferator-Activated Receptor γ Activation Restores Islet Function in Diabetic Mice through Reduction of Endoplasmic Reticulum Stress and Maintenance of Euchromatin Structure
C Evans-Molina, RD Robbins, T Kono, SA Tersey, GL Vestermark, CS Nunemaker, JC Garmey, TG Deering, SR Keller, B Maier, RG Mirmira 		Molecular and cellular biology 2009
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
B Ahrén 		Nature Reviews Drug Discovery 2009
Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells
SH Back, D Scheuner, J Han, B Song, M Ribick, J Wang, RD Gildersleeve, S Pennathur, RJ Kaufman 		Cell Metabolism 2009
Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass
V Delghingaro-Augusto, CJ Nolan, D Gupta, TL Jetton, MG Latour, M Peshavaria, SR Madiraju, É Joly, ML Peyot, M Prentki, J Leahy 		Diabetologia 2009
Peroxisome proliferator-activated receptor α (PPARα) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism
F Frigerio, T Brun, C Bartley, A Usardi, D Bosco, K Ravnskjær, S Mandrup, P Maechler 		Diabetologia 2009
Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells
ML Peyot, JP Gray, J Lamontagne, PJ Smith, GG Holz, SR Madiraju, M Prentki, E Heart 		PloS one 2009
Exploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific marker
M Karaca, J Castel, C Tourrel-Cuzin, M Brun, A Géant, M Dubois, S Catesson, M Rodriguez, S Luquet, P Cattan, B Lockhart, J Lang, A Ktorza, C Magnan, C Kargar 		PloS one 2009
Selective mtDNA mutation accumulation results in beta-cell apoptosis and diabetes development
KG Bensch, JL Mott, SW Chang, PA Hansen, MA Moxley, KT Chambers, W Graaf, HP Zassenhaus, JA Corbett 		American journal of physiology. Endocrinology and metabolism 2009
Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets
M Shaked, M Ketzinel-Gilad, Y Ariav, E Cerasi, N Kaiser, G Leibowitz 		Diabetologia 2009
Effect of Rosiglitazone and Ramipril on  -Cell Function in People With Impaired Glucose Tolerance or Impaired Fasting Glucose: The DREAM trial
AJ Hanley, B Zinman, P Sheridan, S Yusuf, HC Gerstein 		Diabetes care 2009
Minireview: Estrogenic Protection of β-Cell Failure in Metabolic Diseases
S Liu, F Mauvais-Jarvis 		Endocrinology 2009
Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets
Costes S, Vandewalle B, Tourrel-Cuzin C, Broca C, Linck N, Bertrand G, Kerr-Conte J, Portha B, Pattou F, Bockaert J, Dalle S 		Diabetes 2009
Effect of interactions between C peptide levels and insulin treatment on clinical outcomes among patients with type 2 diabetes mellitus
Ko GT, So WY, Tong PC, Chan WB, Yang X, Ma RC, Kong AP, Ozaki R, Yeung CY, Chow CC, Chan JC 		CMAJ : Canadian Medical Association Journal 2009
Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes
Deering TG, Ogihara T, Trace AP, Maier B, Mirmira RG 		Diabetes 2009
Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas
Wang S, Yan J, Anderson DA, Xu Y, Kanal MC, Cao Z, Wright CV, Gu G 		Developmental Biology 2009
Role of Vitamin D in Insulin Secretion and Insulin Sensitivity for Glucose Homeostasis
Alvarez JA, Ashraf A 		International Journal of Endocrinology 2009
Unusually rapid β-cell failure in a patient newly diagnosed with type 2 diabetes presenting acutely with unprovoked severe hyperglycaemic hyperosmolar state: a case report
Yeoh J, Huang JC, Cheng H, Muir KR 		Cases journal 2009
Development of Insulin Producing Cells From Primitive Biologic Precursors
Evans-Molina C, Vestermark GL, Mirmira RG 		Current Opinion in Organ Transplantation 2009
Genetic deletion of C/EBP homologous protein CHOP reduces oxidative stress, improves beta cell function, and prevents diabetes
Benbo Song, Donalyn Scheuner, David Ron, Subramaniam Pennathur, and Randal J. Kaufman 		Journal of Clinical Investigation 2008
Cholesterol in islet dysfunction and type 2 diabetes
Liam R. Brunham, Janine K. Kruit, C. Bruce Verchere and Michael R. Hayden 		Journal of Clinical Investigation 2008
Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age
MV Chakravarthy, Y Zhu, MB Wice, T Coleman, KL Pappan, CA Marshall, ML McDaniel, CF Semenkovich 		Diabetes 2008
β-cell failure as a complication of diabetes
KJ Chang-Chen, R Mullur, E Bernal-Mizrachi 		Reviews in Endocrine and Metabolic Disorders 2008
Mice with beta cell overexpression of glycogen synthase kinase-3β have reduced beta cell mass and proliferation
Z Liu, K Tanabe, E Bernal-Mizrachi, MA Permutt 		Diabetologia 2008
The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia
NS Sauter, FT Schulthess, R Galasso, LW Castellani, K Maedler 		Endocrinology 2008
Positional Cloning of “Lisch-like”, a Candidate Modifier of Susceptibility to Type 2 Diabetes in Mice
M Dokmanovic-Chouinard, WK Chung, JC Chevre, E Watson, J Yonan, B Wiegand, Y Bromberg, N Wakae, CV Wright, J Overton, S Ghosh, GM Sathe, CE Ammala, KK Brown, R Ito, C LeDuc, K Solomon, SG Fischer, RL Leibel, GS Barsh 		PLoS genetics 2008
Why are we shaped differently, and why does it matter?
S Santosa, MD Jensen 		American journal of physiology. Endocrinology and metabolism 2008
Noninvasive monitoring of changes in pancreatic beta-cell mass by bioluminescent imaging in MIP-luc transgenic mice
SY Park, GI Bell 		Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008
The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies
S Cauchi, KT Nead, H Choquet, F Horber, N Potoczna, B Balkau, M Marre, G Charpentier, P Froguel, D Meyre 		BMC Medical Genetics 2008
Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function
JA Lavine, PW Raess, DB Davis, ME Rabaglia, BK Presley, MP Keller, MC Beinfeld, AS Kopin, CB Newgard, AD Attie 		Molecular Endocrinology 2008
Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging
PF Antkowiak, SA Tersey, JD Carter, MH Vandsburger, JL Nadler, FH Epstein, RG Mirmira 		American journal of physiology. Endocrinology and metabolism 2008
 -Cell Mass and Type 1 Diabetes: Going, Going, Gone?
E Akirav, JA Kushner, KC Herold 		Diabetes 2008
Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest
ZX Meng, J Nie, JJ Ling, JX Sun, YX Zhu, L Gao, JH Lv, DY Zhu, YJ Sun, X Han 		Diabetologia 2008
Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin
K Aston-Mourney, J Proietto, G Morahan, S Andrikopoulos 		Diabetologia 2008
The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach
H Lu, Y Yang, EM Allister, N Wijesekara, MB Wheeler 		Molecular & cellular proteomics : MCP 2008
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells
J Zehetner, C Danzer, S Collins, K Eckhardt, PA Gerber, P Ballschmieter, J Galvanovskis, K Shimomura, FM Ashcroft, B Thorens, P Rorsman, W Krek 		Genes & development 2008
Sodium-Glucose Cotransport Inhibition With Dapagliflozin in Type 2 Diabetes
JF List, V Woo, E Morales, W Tang, FT Fiedorek 		2008
Selective Small-Molecule Agonists of G Protein-Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice
CP Tan, Y Feng, YP Zhou, GJ Eiermann, A Petrov, C Zhou, S Lin, G Salituro, P Meinke, R Mosley, TE Akiyama, M Einstein, S Kumar, JP Berger, SG Mills, NA Thornberry, L Yang, AD Howard 		Diabetes 2008
Analysis of gene expression in pancreatic islets from diet-induced obese mice
Imai Y, Patel HR, Doliba NM, Matschinsky FM, Tobias JW, Ahima RS 		Physiological genomics 2008
Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction
Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang JY, Widmann C, Abderrahmani A, Regazzi R 		Diabetes 2008
Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2
Jansson D, Ng AC, Fu A, Depatie C, Al Azzabi M, Screaton RA 		Proceedings of the National Academy of Sciences 2008
Palmitate-Induced β-Cell Dysfunction Is Associated with Excessive NO Production and Is Reversed by Thiazolidinedione-Mediated Inhibition of GPR40 Transduction Mechanisms
Meidute Abaraviciene S, Lundquist I, Galvanovskis J, Flodgren E, Olde B, Salehi A 		PloS one 2008
Pdx1 and BETA2/NeuroD1 Participate in a Transcriptional Complex That Mediates Short-range DNA Looping at the Insulin Gene
Babu DA, Chakrabarti SK, Garmey JC, Mirmira RG 		The Journal of biological chemistry 2008
Glucolipotoxicity of the pancreatic beta-cell: Myth or reality?
Poitout V 		Biochemical Society Transactions 2008
TCF7L2 expression in diabetic patients undergoing bariatric surgery.
Hindle AK, Brody F, Tevar R, Kluk B, Hill S, McCaffrey T, Fu S 		Surgical Endoscopy 2008
FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults
A Mukherjee, Y Sidis, A Mahan, MJ Raher, Y Xia, ED Rosen, KD Bloch, MK Thomas, AL Schneyer 		Proceedings of the National Academy of Sciences 2007
Glucolipotoxicity: fuel excess and beta-cell dysfunction
V Poitout, RP Robertson 		Endocrine reviews 2007
Identification of a WD40 Repeat-Containing Isoform of PHIP as a Novel Regulator of β-Cell Growth and Survival
A Podcheko, P Northcott, G Bikopoulos, A Lee, SR Bommareddi, JA Kushner, J Farhang-Fallah, M Rozakis-Adcock 		Molecular and cellular biology 2007
Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets
DK Hagman, MG Latour, SK Chakrabarti, G Fontes, J Amyot, C Tremblay, M Semache, JA Lausier, V Roskens, RG Mirmira, TL Jetton, V Poitout 		Diabetes 2007
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
P Marchetti, M Bugliani, R Lupi, L Marselli, M Masini, U Boggi, F Filipponi, GC Weir, DL Eizirik, M Cnop 		Diabetologia 2007
To boldly go--or to go too boldly? The accelerator hypothesis revisited.
Gale EA 		Diabetologia 2007
Long-term control of type 2 diabetes mellitus and the other major components of the metabolic syndrome after biliopancreatic diversion in patients with BMI < 35 kg/m2.
Scopinaro N, Papadia F, Marinari G, Camerini G, Adami G 		Obesity surgery 2007
Insulin resistance and pancreatic β cell failure
M Kasuga 		Journal of Clinical Investigation 2006
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates
G Solinas, W Naugler, F Galimi, MS Lee, M Karin 		Proceedings of the National Academy of Sciences 2006

Advertisement