Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
Ravi K. Amaravadi, … , Andrei Thomas-Tikhonenko, Craig B. Thompson
Ravi K. Amaravadi, … , Andrei Thomas-Tikhonenko, Craig B. Thompson
Published February 1, 2007
Citation Information: J Clin Invest. 2007;117(2):326-336. https://doi.org/10.1172/JCI28833.
View: Text | PDF | Corrigendum
Research Article Oncology Article has an altmetric score of 19

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

  • Text
  • PDF
Abstract

Autophagy is a lysosome-dependent degradative pathway frequently activated in tumor cells treated with chemotherapy or radiation. Whether autophagy observed in treated cancer cells represents a mechanism that allows tumor cells to survive therapy or a mechanism for initiating a nonapoptotic form of programmed cell death remains controversial. To address this issue, the role of autophagy in a Myc-induced model of lymphoma generated from cells derived from p53ERTAM/p53ERTAM mice (with ER denoting estrogen receptor) was examined. Such tumors are resistant to apoptosis due to a lack of nuclear p53. Systemic administration of tamoxifen led to p53 activation and tumor regression followed by tumor recurrence. Activation of p53 was associated with the rapid appearance of apoptotic cells and the induction of autophagy in surviving cells. Inhibition of autophagy with either chloroquine or ATG5 short hairpin RNA (shRNA) enhanced the ability of either p53 activation or alkylating drug therapy to induce tumor cell death. These studies provide evidence that autophagy serves as a survival pathway in tumor cells treated with apoptosis activators and a rationale for the use of autophagy inhibitors such as chloroquine in combination with therapies designed to induce apoptosis in human cancers.

Authors

Ravi K. Amaravadi, Duonan Yu, Julian J. Lum, Thi Bui, Maria A. Christophorou, Gerard I. Evan, Andrei Thomas-Tikhonenko, Craig B. Thompson

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 7 13 16 23 28 19 28 30 38 41 36 58 62 47 48 33 31 18 9 585
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2018 (30)

Title and authors Publication Year
The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
PY Ke
International journal of molecular sciences 2018
Autophagy modulation: a prudent approach in cancer treatment?
E Bishop, TD Bradshaw
Cancer Chemotherapy and Pharmacology 2018
Exploiting Nanomaterial-Mediated Autophagy for Cancer Therapy
W Wei, ZT Rosenkrans, QY Luo, X Lan, W Cai
Small Methods 2018
Increased Macroautophagy in Interferon-Gamma-Producing T Cells from Patients with Newly Diagnosed Systemic Lupus Erythematosus
XY Luo, JL Yuan, J Liu, CN Luo, MH Yang, Q Wei, M Yang, Y Chen, Y Liu, GH Yuan
Chinese Medical Journal 2018
Targeting autophagy in cancer: Targeting Autophagy in Cancer
AV Onorati, M Dyczynski, R Ojha, RK Amaravadi
Cancer 2018
Chloroquine and nanoparticle drug delivery: A promising combination
J Pelt, S Busatto, M Ferrari, EA Thompson, K Mody, J Wolfram
Pharmacology & Therapeutics 2018
A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics
Y Wang, B Bonavida
Critical Reviews in Oncogenesis 2018
Autophagy sustains pancreatic cancer growth through both cell autonomous and non-autonomous mechanisms
A Yang, G Herter-Sprie, H Zhang, EY Lin, D Biancur, X Wang, J Deng, J Hai, S Yang, KK Wong, AC Kimmelman
Cancer Discovery 2018
SMAD4 gene mutation renders pancreatic cancer resistance to radiotherapy through promotion of autophagy
F Wang, X Xia, C Yang, J Shen, J Mai, HC Kim, D Kirui, Y Kang, JB Fleming, EJ Koay, S Mitra, M Ferrari, H Shen
Clinical cancer research 2018
Targeting the miR-665-3p-ATG4B-autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion
Z Li, G Wang, D Feng, G Zu, Y Li, X Shi, Y Zhao, H Jing, S Ning, W Le, J Yao, X Tian
Cell Death and Disease 2018
Functions of autophagy in the tumor microenvironment and cancer metastasis
EE Mowers, MN Sharifi, KF Macleod
The FEBS journal 2018
USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination
A Sharma, T Alswillah, K Singh, P Chatterjee, B Willard, M Venere, MK Summers, A Almasan
Autophagy 2018
Autophagy mediates glucose starvation-induced glioblastoma cell quiescence and chemoresistance through coordinating cell metabolism, cell cycle, and survival
L Wang, Z Shang, Y Zhou, X Hu, Y Chen, Y Fan, X Wei, L Wu, Q Liang, J Zhang, Z Gao
Cell Death and Disease 2018
Autophagy activation contributes to glutathione transferase Mu 1‑mediated chemoresistance in hepatocellular carcinoma
XT Fu, K Song, J Zhou, YH Shi, WR Liu, MX Tian, L Jin, GM Shi, Q Gao, ZB Ding, J Fan
Oncology Letters 2018
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
Z Cui, Y Zhang, K Xia, Q Yan, H Kong, J Zhang, X Zuo, J Shi, L Wang, Y Zhu, C Fan
Nature Communications 2018
The Role of NCOA4-Mediated Ferritinophagy in Health and Disease
N Santana-Codina, J Mancias
Pharmaceuticals (Basel, Switzerland) 2018
Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer
BK Kim, SW Nam, BS Min, HS Ban, S Paik, K Lee, JY Im, Y Lee, JT Park, SY Kim, M Kim, H Lee, M Won
British Journal of Cancer 2018
Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
YA Lee, LA Noon, KM Akat, MD Ybanez, TF Lee, ML Berres, N Fujiwara, N Goossens, HI Chou, FP Parvin-Nejad, B Khambu, EG Kramer, R Gordon, C Pfleger, D Germain, GR John, KN Campbell, Z Yue, XM Yin, AM Cuervo, MJ Czaja, MI Fiel, Y Hoshida, SL Friedman
Nature Communications 2018
Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells
R Jiménez-Guerrero, J Gasca, M Flores, B Pérez-Valderrama, C Tejera-Parrado, R Medina, M Tortolero, F Romero, M Japón, C Sáez
Cancers 2018
GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy
JH Im, KW Kang, SY Kim, YG Kim, YJ An, S Park, BH Jeong, SY Choi, JS Lee, KW Kang
Journal of Experimental & Clinical Cancer Research 2018
Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment
M Cordani, Á Somoza
Cellular and Molecular Life Sciences 2018
Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS
U Nazim, SY Park
International journal of molecular medicine 2018
Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in�vitro
L Yang, YS Cai, K Xu, JL Zhu, YB Li, XQ Wu, J Sun, SM Lu, P Xu
Molecular medicine reports 2018
Efficient Near Infrared Light Triggered Nitric Oxide Release Nanocomposites for Sensitizing Mild Photothermal Therapy.
Zhang X, Du J, Guo Z, Yu J, Gao Q, Yin W, Zhu S, Gu Z, Zhao Y
2018
Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma
Zhao YY, Tian Y, Liu L, Zhan JH, Hou X, Chen X, Zhou T, Huang Y, Zhang L
Drug design, development and therapy 2018
LINC00470 Coordinates the Epigenetic Regulation of ELFN2 to Distract GBM Cell Autophagy
Liu C, Fu H, Liu X, Lei Q, Zhang Y, She X, Liu Q, Liu Q, Sun Y, Li G, Wu M
Molecular Therapy 2018
Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition
Booth L, Roberts JL, Rais R, Cutler RE Jr, Diala I, Lalani AS, Poklepovic A, Dent P
Cancer biology & therapy 2018
Emerging Roles of p53 Family Members in Glucose Metabolism.
Itahana Y, Itahana K
International journal of molecular sciences 2018
Tubeimoside-1, a triterpenoid saponin, induces cytoprotective autophagy in human breast cancer cells in vitro via Akt-mediated pathway.
Jiang SL, Guan YD, Chen XS, Ge P, Wang XL, Lao YZ, Xiao SS, Zhang Y, Yang JM, Xu XJ, Cao DS, Cheng Y
Acta Pharmacologica Sinica 2018
[Role of cytoplasmic p53-mediated suppression of autophagy in heat stress-induced injury of cultured mouse aortic endothelial cells].
Zou Z, Gu Z, Li L, Zhao M, Su L
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2018

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 22 patents
Highlighted by 1 platforms
449 readers on Mendeley
1 readers on CiteULike
See more details