Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
Ravi K. Amaravadi, … , Andrei Thomas-Tikhonenko, Craig B. Thompson
Ravi K. Amaravadi, … , Andrei Thomas-Tikhonenko, Craig B. Thompson
Published February 1, 2007
Citation Information: J Clin Invest. 2007;117(2):326-336. https://doi.org/10.1172/JCI28833.
View: Text | PDF
Research Article Oncology Article has an altmetric score of 19

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

  • Text
  • PDF
Abstract

Autophagy is a lysosome-dependent degradative pathway frequently activated in tumor cells treated with chemotherapy or radiation. Whether autophagy observed in treated cancer cells represents a mechanism that allows tumor cells to survive therapy or a mechanism for initiating a nonapoptotic form of programmed cell death remains controversial. To address this issue, the role of autophagy in a Myc-induced model of lymphoma generated from cells derived from p53ERTAM/p53ERTAM mice (with ER denoting estrogen receptor) was examined. Such tumors are resistant to apoptosis due to a lack of nuclear p53. Systemic administration of tamoxifen led to p53 activation and tumor regression followed by tumor recurrence. Activation of p53 was associated with the rapid appearance of apoptotic cells and the induction of autophagy in surviving cells. Inhibition of autophagy with either chloroquine or ATG5 short hairpin RNA (shRNA) enhanced the ability of either p53 activation or alkylating drug therapy to induce tumor cell death. These studies provide evidence that autophagy serves as a survival pathway in tumor cells treated with apoptosis activators and a rationale for the use of autophagy inhibitors such as chloroquine in combination with therapies designed to induce apoptosis in human cancers.

Authors

Ravi K. Amaravadi, Duonan Yu, Julian J. Lum, Thi Bui, Maria A. Christophorou, Gerard I. Evan, Andrei Thomas-Tikhonenko, Craig B. Thompson

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 7 13 16 23 28 19 28 30 38 41 36 58 62 47 48 33 31 18 9 585
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2013 (62)

Title and authors Publication Year
Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells
S Zhu, L Cao, Y Yu, L Yang, M Yang, K Liu, J Huang, R Kang, KM Livesey, D Tang
Autophagy 2013
Autophagy: a targetable linchpin of cancer cell metabolism
RD Leone, RK Amaravadi
Trends in Endocrinology & Metabolism 2013
Autophagy and genomic integrity
AT Vessoni, EC Filippi-Chiela, CF Menck, G Lenz
Cell Death and Differentiation 2013
Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms
D Kumar, S Shankar, RK Srivastava
Molecular Cancer 2013
Autophagy in blood cancers: biological role and therapeutic implications
A Nencioni, M Cea, F Montecucco, VD Longo, F Patrone, AM Carella, TL Holyoake, GV Helgason
Haematologica 2013
Autophagy and cancer
SZ Lu, DD Harrison-Findik
World journal of biological chemistry 2013
Advances in Cancer Research
SK Bhutia, S Mukhopadhyay, N Sinha, DN Das, PK Panda, SK Patra, TK Maiti, M Mandal, P Dent, XY Wang, SK Das, D Sarkar, PB Fisher
Advances in cancer research 2013
Autophagy: a potential therapeutic target in lung diseases
K Nakahira, AM Choi
American journal of physiology. Lung cellular and molecular physiology 2013
Interaction between Her2 and Beclin-1 proteins underlies a new mechanism of reciprocal regulation
J Han, W Hou, C Lu, LA Goldstein, DB Stolz, SC Watkins, H Rabinowich
The Journal of biological chemistry 2013
Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy
JM Park, S Huang, TT Wu, NR Foster, FA Sinicrope
Cancer biology & therapy 2013
Therapeutic Targeting of Autophagy in Disease: Biology and Pharmacology
Y Cheng, X Ren, WN Hait, JM Yang
2013
Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy
Y Takahashi, T Hori, TK Cooper, J Liao, N Desai, JM Serfass, MM Young, S Park, Y Izu, HG Wang
Blood 2013
Why should autophagic flux be assessed?
X Zhang, S Chen, K Huang, W Le
Acta Pharmacologica Sinica 2013
Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer
RL Zinn, EE Gardner, I Dobromilskaya, S Murphy, L Marchionni, CL Hann, CM Rudin
Molecular Cancer 2013
Mouse embryonic stem cells undergo charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment
ED Tichy, ZA Stephan, A Osterburg, G Noel, PJ Stambrook
Stem Cell Research 2013
Autophagy modulation as a target for anticancer drug discovery
X Li, H Xu, Y Liu, N An, S Zhao, J Bao
Acta Pharmacologica Sinica 2013
Interplay between autophagy and apoptosis in pancreatic tumors in response to gemcitabine
DL Papademetrio, V Cavaliere, T Simunovich, S Costantino, MD Campos, T Lombardo, CM Kaiser, É Álvarez
Targeted Oncology 2013
Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons
S Almeida, E Gascon, H Tran, HJ Chou, TF Gendron, S DeGroot, AR Tapper, C Sellier, N Charlet-Berguerand, A Karydas, WW Seeley, AL Boxer, L Petrucelli, BL Miller, FB Gao
Acta Neuropathologica 2013
Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer
L Bracci, G Schiavoni, A Sistigu, F Belardelli
Cell Death and Differentiation 2013
Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments
H Inoue, K Tani
Cell Death and Differentiation 2013
Myc inhibition impairs autophagosome formation
PP Toh, S Luo, FM Menzies, T Rasko, EE Wanker, DC Rubinsztein
Human Molecular Genetics 2013
Punicalagin induces apoptotic and autophagic cell death in human U87MG glioma cells
S Wang, M Huang, J Li, F Lai, H Lee, Y Hsu
Acta Pharmacologica Sinica 2013
Autophagy and human diseases
P Jiang, N Mizushima
Cell Research 2013
Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells
X Zhang, W Li, C Wang, X Leng, S Lian, J Feng, J Li, H Wang
Molecular and Cellular Biochemistry 2013
Salinomycin activates AMP-activated protein kinase-dependent autophagy in cultured osteoblastoma cells: a negative regulator against cell apoptosis
L Zhu, Y Zhen, Y Zhang, Z Guo, J Dai, X Wang
PloS one 2013
Impairment of Atg5-Dependent Autophagic Flux Promotes Paraquat- and MPP+-Induced Apoptosis But Not Rotenone or 6-Hydroxydopamine Toxicity
A Garcia-Garcia, A Anandhan, M Burns, H Chen, Y Zhou, R Franco
Toxicological Sciences 2013
Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours
E Seront, R Boidot, C Bouzin, O Karroum, BF Jordan, B Gallez, JP Machiels, O Feron
British Journal of Cancer 2013
Cancer drug resistance: an evolving paradigm
C Holohan, SV Schaeybroeck, DB Longley, PG Johnston
Nature Reviews Cancer 2013
Mitophagy in hematopoietic stem cells: The case for exploration
A Joshi, M Kundu
Autophagy 2013
Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy
YH Jang, KY Choi, DS Min
Cell Death and Differentiation 2013
The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death
S Qiao, S Tao, MR de la Vega, SL Park, AA Vonderfecht, SL Jacobs, DD Zhang, GT Wondrak
Autophagy 2013
How do I kill thee? Let me count the ways: p53 regulates PARP-1 dependent necrosis
R Elkholi, JE Chipuk
BioEssays : news and reviews in molecular, cellular and developmental biology 2013
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment
X Sui, R Chen, Z Wang, Z Huang, N Kong, M Zhang, W Han, F Lou, J Yang, Q Zhang, X Wang, C He, H Pan
Cell Death and Disease 2013
Calcium-permeable ion channels in control of autophagy and cancer
A Kondratskyi, M Yassine, K Kondratska, R Skryma, C Slomianny, N Prevarskaya
Frontiers in physiology 2013
Piperlongumine induces autophagy by targeting p38 signaling
Y Wang, JW Wang, X Xiao, Y Shan, B Xue, G Jiang, Q He, J Chen, HG Xu, RX Zhao, KD Werle, R Cui, J Liang, YL Li, ZX Xu
Cell Death and Disease 2013
The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model
E Donohue, A Thomas, N Maurer, I Manisali, M Zeisser-Labouebe, N Zisman, HJ Anderson, SS Ng, M Webb, M Bally, M Roberge
Journal of Cancer 2013
Promoting colonization in metastatic HCC cells by modulation of autophagy
YF Peng, YH Shi, YH Shen, ZB Ding, AW Ke, J Zhou, SJ Qiu, J Fan
PloS one 2013
Autophagy plays a critical role in ChLym-1-induced cytotoxicity of non-hodgkin's lymphoma cells
J Fan, X Zeng, Y Li, S Wang, Z Wang, Y Sun, H Gao, G Zhang, M Feng, D Ju
PloS one 2013
Phase II randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases
LL Rojas-Puentes, M Gonzalez-Pinedo, A Crismatt, A Ortega-Gomez, C Gamboa-Vignolle, R Nuñez-Gomez, Y Dorantes-Gallareta, C Arce-Salinas, O Arrieta
Radiation Oncology 2013
Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster
P Nagy, A Varga, K Pircs, K Hegedűs, G Juhász
PLoS genetics 2013
Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide
D Biasoli, SA Kahn, TA Cornélio, M Furtado, L Campanati, H Chneiweiss, V Moura-Neto, HL Borges
Cell Death and Disease 2013
Autophagy Inhibition with Monensin Enhances Cell Cycle Arrest and Apoptosis Induced by mTOR or Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cells
HS Choi, EH Jeong, TG Lee, SY Kim, HR Kim, CH Kim
Tuberculosis and Respiratory Diseases 2013
Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinoma
J Wang, XL Pan, LJ Ding, DY Liu, DP Lei, T Jin
PloS one 2013
Pyrvinium targets autophagy addiction to promote cancer cell death
L Deng, Y Lei, R Liu, J Li, K Yuan, Y Li, Y Chen, Y Liu, Y Lu, CK 3rd, C Huang, Y Wei
Cell Death and Disease 2013
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma
X Xie, EP White, JM Mehnert
PloS one 2013
Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation
AJ Lakhter, RP Sahu, Y Sun, WK Kaufmann, EJ Androphy, JB Travers, SR Naidu
Journal of Investigative Dermatology 2013
A modified HSP70 inhibitor shows broad activity as an anticancer agent
GM Balaburski, JI Leu, N Beeharry, S Hayik, MD Andrake, G Zhang, M Herlyn, J Villanueva, RL Dunbrack, T Yen, DL George, ME Murphy
Molecular cancer research : MCR 2013
Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?
ML Bristol, SM Emery, P Maycotte, A Thorburn, S Chakradeo, DA Gewirtz
The Journal of pharmacology and experimental therapeutics 2013
Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism
PC Chen, EM Olson, Q Zhou, Y Kryukova, HM Sampson, DY Thomas, SL Shyng
The Journal of biological chemistry 2013
4-Hydroxytamoxifen induces autophagic death through K-Ras degradation
L Kohli, N Kaza, T Coric, SJ Byer, NM Brossier, BJ Klocke, MA Bjornsti, SL Carroll, KA Roth
Cancer research 2013
The HSP70 family and cancer
ME Murphy
Carcinogenesis 2013
Attacking breast cancer at the pre-invasion stage by targeting autophagy
V Espina, J Wysolmerski, K Edmiston, LA Liotta
Women's Health 2013
Crosstalk Between Apoptosis and Autophagy: Molecular Mechanisms and Therapeutic Strategies in Cancer
M Hassan, Y Haikel, D Selimovic, A El-Khattouti
Journal of cell death 2013
Chemoprevention of Prostate Cancer by D,L-Sulforaphane Is Augmented by Pharmacological Inhibition of Autophagy
AR Vyas, ER Hahm, JA Arlotti, S Watkins, DB Stolz, D Desai, S Amin, SV Singh
Cancer research 2013
Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPAR 2 degradation
C Zhang, Y He, M Okutsu, LC Ong, Y Jin, L Zheng, P Chow, S Yu, M Zhang, Z Yan
American journal of physiology. Endocrinology and metabolism 2013
Human T-Cell Leukemia Virus Type 1 Tax-Deregulated Autophagy Pathway and c-FLIP Expression Contribute to Resistance against Death Receptor-Mediated Apoptosis
W Wang, J Zhou, J Shi, Y Zhang, S Liu, Y Liu, D Zheng, SR Ross
Journal of virology 2013
On the origin of cancer metastasis.
Seyfried TN, Huysentruyt LC
Critical Reviews in Oncogenesis 2013
Dual role of dextran sulfate 5000 Da as anti-apoptotic and pro-autophagy agent.
Menvielle JP, Safini N, Tisminetzky SG, Skoko N
Molecular Biotechnology 2013
Autophagy fails to alter withaferin A-mediated lethality in human breast cancer cells.
Hahm ER, Singh SV
Current cancer drug targets 2013
Prognostic significance of Beclin-1 expression in laryngeal squamous cell carcinoma.
Huang L, Wang S, Li SS, Yang XM
Pathology oncology research : POR 2013
Telomelysin shows potent antitumor activity through apoptotic and non‐apoptotic cell death in soft tissue sarcoma cells
Li G, Kawashima H, Ogose A, Ariizumi T, Hotta T, Kuwano R, Urata Y, Fujiwara T, Endo N
Cancer Science 2013
ATG9A overexpression is associated with disease recurrence and poor survival in patients with oral squamous cell carcinoma.
Tang JY, Hsi E, Huang YC, Hsu NC, Chen YK, Chu PY, Chai CY
Virchows Archiv : an international journal of pathology 2013

← Previous 1 2 3 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 22 patents
Highlighted by 1 platforms
449 readers on Mendeley
1 readers on CiteULike
See more details