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Citations to this article

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
Ravi K. Amaravadi, … , Andrei Thomas-Tikhonenko, Craig B. Thompson
Ravi K. Amaravadi, … , Andrei Thomas-Tikhonenko, Craig B. Thompson
Published February 1, 2007
Citation Information: J Clin Invest. 2007;117(2):326-336. https://doi.org/10.1172/JCI28833.
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Research Article Oncology Article has an altmetric score of 19

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

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Abstract

Autophagy is a lysosome-dependent degradative pathway frequently activated in tumor cells treated with chemotherapy or radiation. Whether autophagy observed in treated cancer cells represents a mechanism that allows tumor cells to survive therapy or a mechanism for initiating a nonapoptotic form of programmed cell death remains controversial. To address this issue, the role of autophagy in a Myc-induced model of lymphoma generated from cells derived from p53ERTAM/p53ERTAM mice (with ER denoting estrogen receptor) was examined. Such tumors are resistant to apoptosis due to a lack of nuclear p53. Systemic administration of tamoxifen led to p53 activation and tumor regression followed by tumor recurrence. Activation of p53 was associated with the rapid appearance of apoptotic cells and the induction of autophagy in surviving cells. Inhibition of autophagy with either chloroquine or ATG5 short hairpin RNA (shRNA) enhanced the ability of either p53 activation or alkylating drug therapy to induce tumor cell death. These studies provide evidence that autophagy serves as a survival pathway in tumor cells treated with apoptosis activators and a rationale for the use of autophagy inhibitors such as chloroquine in combination with therapies designed to induce apoptosis in human cancers.

Authors

Ravi K. Amaravadi, Duonan Yu, Julian J. Lum, Thi Bui, Maria A. Christophorou, Gerard I. Evan, Andrei Thomas-Tikhonenko, Craig B. Thompson

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 7 13 16 23 28 19 28 30 38 41 36 58 62 47 48 33 31 18 9 585
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2009 (31)

Title and authors Publication Year
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Cristian Bellodi, Maria Rosa Lidonnici, Ashley Hamilton, G. Vignir Helgason,Angela Rachele Soliera, Mattia Ronchetti, Sara Galavotti, Kenneth W. Young, Tommaso Selmi, Richard A. Van Etten, Nick Donato, Ann Hunter, David Dinsdale, Elena Tirro’, Paolo Vigneri, Pierluigi Nicotera, Martin J. Dyer, Tessa Holyoake, Paolo Salomoni and Bruno Calabretta
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Journal of Clinical Investigation 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
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MT Rosenfeldt, KM Ryan
Expert Reviews in Molecular Medicine 2009
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E White, RS DiPaola
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CM Payne, C Crowley-Skillicorn, H Holubec, K Dvorak, C Bernstein, MP Moyer, H Garewal, H Bernstein
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AR Young, M Narita, M Ferreira, K Kirschner, M Sadaie, JF Darot, S Tavaré, S Arakawa, S Shimizu, FM Watt, M Narita
Genes & development 2009
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N Chen, V Karantza-Wadsworth
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2009
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WX Ding, HM Ni, W Gao, X Chen, JH Kang, DB Stolz, J Liu, XM Yin
Molecular cancer therapeutics 2009
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T Copetti, C Bertoli, E Dalla, F Demarchi, C Schneider
Molecular and cellular biology 2009
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D Tormo, A Checińska, D Alonso-Curbelo, E Pérez-Guijarro, E Cañón, E Riveiro-Falkenbach, TG Calvo, L Larribere, D Megías, F Mulero, MA Piris, R Dash, PM Barral, JL Rodríguez-Peralto, P Ortiz-Romero, T Tüting, PB Fisher, MS Soengas
Cancer Cell 2009
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M Shanmugam, SK McBrayer, J Qian, K Raikoff, MJ Avram, S Singhal, V Gandhi, PT Schumacker, NL Krett, ST Rosen
The Journal of biological chemistry 2009
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RH Kim, JM Coates, TL Bowles, GP McNerney, J Sutcliffe, JU Jung, R Gandour-Edwards, FY Chuang, RJ Bold, HJ Kung
Cancer research 2009
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K Zhu, K Dunner, DJ McConkey
Oncogene 2009
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A Vazquez-Martin, C Oliveras-Ferraros, JA Menendez
PloS one 2009
Cytochrome c/cardiolipin relations in mitochondria: a kiss of death
VE Kagan, HA Bayir, NA Belikova, O Kapralov, YY Tyurina, VA Tyurin, J Jiang, DA Stoyanovsky, P Wipf, PM Kochanek, JS Greenberger, B Pitt, AA Shvedova, G Borisenko
Free radical biology & medicine 2009
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A Fontanini, C Foti, H Potu, E Crivellato, R Maestro, P Bernardi, F Demarchi, C Brancolini
The Journal of biological chemistry 2009
Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression
Y Chen, Y Lu, C Lu, L Zhang
Pathology oncology research : POR 2009
Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells
P Ge, J Zhang, X Wang, F Meng, W Li, Y Luan, F Ling, Y Luo
Acta Pharmacologica Sinica 2009
The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy
L Ellis, M Bots, RK Lindemann, JE Bolden, A Newbold, LA Cluse, CL Scott, A Strasser, P Atadja, SW Lowe, RW Johnstone
Blood 2009
Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation
JS Carew, EC Medina, JA 2nd, D Mahalingam, R Swords, K Kelly, H Zhang, P Huang, AC Mita, MM Mita, FJ Giles, ST Nawrocki
Journal of Cellular and Molecular Medicine 2009
High Throughput Screening for Inhibitors of Mycobacterium tuberculosis H37Rv
S Ananthan, ER Faaleolea, RC Goldman, JV Hobrath, CD Kwong, BE Laughon, JA Maddry, A Mehta, L Rasmussen, RC Reynolds, JA 3rd, N Shindo, DN Showe, MI Sosa, WJ Suling, EL White
Tuberculosis (Edinburgh, Scotland) 2009
Autophagy in tumour suppression and promotion
A Brech, T Ahlquist, RA Lothe, H Stenmark
Molecular Oncology 2009
Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux
M Rossi, ER Munarriz, S Bartesaghi, M Milanese, D Dinsdale, MA Guerra-Martin, ET Bampton, P Glynn, G Bonanno, RA Knight, P Nicotera, G Melino
Journal of cell science 2009
Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling
C Yang, J Sudderth, T Dang, RG Bachoo, JG McDonald, RJ DeBerardinis
Cancer research 2009
A combination of indole-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy
Y Nakamura, S Yogosawa, Y Izutani, H Watanabe, E Otsuji, T Sakai
Molecular Cancer 2009
Atg5 Regulates Phenethyl Isothiocyanate–Induced Autophagic and Apoptotic Cell Death in Human Prostate Cancer Cells
A Bommareddy, ER Hahm, D Xiao, AA Powolny, AL Fisher, Y Jiang, SV Singh
Cancer research 2009
Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice.
Baerga R, Zhang Y, Chen PH, Goldman S, Jin S
Autophagy 2009
ARF, autophagy and tumor suppression
Pimkina J, Murphy ME
Autophagy 2009
An executioner caspase regulates autophagy
Hou YC, Hannigan AM, Gorski SM
Autophagy 2009

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