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Citations to this article

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
Giovanna Gallina, … , Silvio Bicciato, Vincenzo Bronte
Giovanna Gallina, … , Silvio Bicciato, Vincenzo Bronte
Published October 2, 2006
Citation Information: J Clin Invest. 2006;116(10):2777-2790. https://doi.org/10.1172/JCI28828.
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Research Article Oncology Article has an altmetric score of 6

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

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Abstract

Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b+IL-4 receptor α+ (CD11b+IL-4Rα+), inflammatory-type monocytes that is elicited by growing tumors and activated by IFN-γ released from T lymphocytes. CD11b+IL-4Rα+ cells produced IL-13 and IFN-γ and integrated the downstream signals of these cytokines to trigger the molecular pathways suppressing antigen-activated CD8+ T lymphocytes. Analogous immunosuppressive circuits were active in CD11b+ cells present within the tumor microenvironment. These suppressor cells challenge the current idea that tumor-conditioned immunosuppressive monocytes/macrophages are alternatively activated. Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions.

Authors

Giovanna Gallina, Luigi Dolcetti, Paolo Serafini, Carmela De Santo, Ilaria Marigo, Mario P. Colombo, Giuseppe Basso, Frank Brombacher, Ivan Borrello, Paola Zanovello, Silvio Bicciato, Vincenzo Bronte

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
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Citations to this article in year 2019 (15)

Title and authors Publication Year
Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3
R Trovato, A Fiore, S Sartori, S Canè, R Giugno, L Cascione, S Paiella, R Salvia, FD Sanctis, O Poffe, C Anselmi, F Hofer, S Sartoris, G Piro, C Carbone, V Corbo, R Lawlor, S Solito, L Pinton, S Mandruzzato, C Bassi, A Scarpa, V Bronte, S Ugel
Journal for ImmunoTherapy of Cancer 2019
Myeloid-Derived Suppressor Cells Promote Metastasis in Breast Cancer After the Stress of Operative Removal of the Primary Cancer
X Ma, M Wang, T Yin, Y Zhao, X Wei
Frontiers in Oncology 2019
CCR2 Chemokine Receptors Enhance Growth and Cell-Cycle Progression of Breast Cancer Cells through SRC and PKC Activation
M Yao, W Fang, C Smart, Q Hu, S Huang, N Alvarez, P Fields, N Cheng
Molecular cancer research : MCR 2019
Synergetic Functional Nanocomposites Enhance Immunotherapy in Solid Tumors by Remodeling the Immunoenvironment
L Yang, J Sun, Q Liu, R Zhu, Q Yang, J Hua, L Zheng, K Li, S Wang, A Li
Advanced Science 2019
Myeloid Cell Crosstalk Regulates the Efficacy of the DNA/ALVAC/gp120 HIV Vaccine Candidate
M Vaccari, S Fourati, DR Brown, IS de Castro, M Bissa, L Schifanella, MN Doster, KE Foulds, M Roederer, RA Koup, Y Sui, JA Berzofsky, RP Sekaly, G Franchini
Frontiers in immunology 2019
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SK Esher, PL Fidel, MC Noverr
Journal of Fungi 2019
Sculpting tumor microenvironment with immune system: from immunometabolism to immunoediting
YR Yu, PC Ho
Clinical & Experimental Immunology 2019
Dissecting intratumoral myeloid cell plasticity by single cell RNA‐seq
Q Song, GA Hawkins, L Wudel, PC Chou, E Forbes, AK Pullikuth, L Liu, G Jin, L Craddock, U Topaloglu, G Kucera, S ONeill, EA Levine, P Sun, K Watabe, Y Lu, MA AlexanderMiller, B Pasche, LD Miller, W Zhang
Cancer Medicine 2019
Autologous Hematopoietic Stem Cells Are a Preferred Source to Generate Dendritic Cells for Immunotherapy in Multiple Myeloma Patients
P Shinde, S Melinkeri, MK Santra, V Kale, L Limaye
Frontiers in immunology 2019
Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer
A Jayakumar, AL Bothwell
Journal of immunology (Baltimore, Md. : 1950) 2019
CCR5 status and metastatic progression in colorectal cancer
M Suarez-Carmona, P Chaorentong, JN Kather, R Rothenheber, A Ahmed, A Berthel, A Heinzelmann, R Moraleda, NA Valous, Z Kosaloglu, R Eurich, J Wolf, S Grauling-Halama, M Hundemer, F Lasitschka, F Klupp, C Kahlert, A Ulrich, M Schneider, C Falk, D Jäger, I Zoernig, N Halama
OncoImmunology 2019
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms
IS Kim, Y Gao, T Welte, H Wang, J Liu, M Janghorban, K Sheng, Y Niu, A Goldstein, N Zhao, I Bado, HC Lo, MJ Toneff, T Nguyen, W Bu, W Jiang, J Arnold, F Gu, J He, D Jebakumar, K Walker, Y Li, Q Mo, TF Westbrook, C Zong, A Rao, A Sreekumar, JM Rosen, XH Zhang
Nature Cell Biology 2019
Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite
KJ Filbey, F Varyani, Y Harcus, JP Hewitson, DJ Smyth, HJ McSorley, A Ivens, S Nylén, M Rottenberg, S Löser, RM Maizels
Frontiers in immunology 2019
Sustained Delivery of Carfilzomib by Tannic Acid-Based Nanocapsules Helps Develop Antitumor Immunity
MS Taha, GM Cresswell, J Park, W Lee, TL Ratliff, Y Yeo
Nano letters 2019
Lactoferrin deficiency induces a pro-metastatic tumor microenvironment through recruiting myeloid-derived suppressor cells in mice
L Wei, X Zhang, J Wang, Q Ye, X Zheng, Q Peng, Y Zheng, P Liu, X Zhang, Z Li, C Liu, Q Yan, G Li, J Ma
Oncogene 2019

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