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Citations to this article

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
Giovanna Gallina, … , Silvio Bicciato, Vincenzo Bronte
Giovanna Gallina, … , Silvio Bicciato, Vincenzo Bronte
Published October 2, 2006
Citation Information: J Clin Invest. 2006;116(10):2777-2790. https://doi.org/10.1172/JCI28828.
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Research Article Oncology Article has an altmetric score of 6

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

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Abstract

Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b+IL-4 receptor α+ (CD11b+IL-4Rα+), inflammatory-type monocytes that is elicited by growing tumors and activated by IFN-γ released from T lymphocytes. CD11b+IL-4Rα+ cells produced IL-13 and IFN-γ and integrated the downstream signals of these cytokines to trigger the molecular pathways suppressing antigen-activated CD8+ T lymphocytes. Analogous immunosuppressive circuits were active in CD11b+ cells present within the tumor microenvironment. These suppressor cells challenge the current idea that tumor-conditioned immunosuppressive monocytes/macrophages are alternatively activated. Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions.

Authors

Giovanna Gallina, Luigi Dolcetti, Paolo Serafini, Carmela De Santo, Ilaria Marigo, Mario P. Colombo, Giuseppe Basso, Frank Brombacher, Ivan Borrello, Paola Zanovello, Silvio Bicciato, Vincenzo Bronte

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
Citations: 2 12 11 13 22 11 15 22 16 24 30 29 28 34 33 30 34 26 8 2 402
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Citations to this article in year 2020 (11)

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Aptamers against mouse and human tumor-infiltrating myeloid cells as reagents for targeted chemotherapy
AD Fuente, S Zilio, J Caroli, DV Simaeys, EM Mazza, TA Ince, V Bronte, S Bicciato, DT Weed, P Serafini
Science Translational Medicine 2020
Breast cancer models: Engineering the tumor microenvironment
G Bahcecioglu, G Basara, BW Ellis, X Ren, P Zorlutuna
Acta Biomaterialia 2020

Effect and Molecular Mechanisms of Traditional Chinese Medicine on Tumor Targeting Tumor-Associated Macrophages


J He, P Yin, K Xu
Drug design, development and therapy 2020
Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
AM Law, F Valdes-Mora, D Gallego-Ortega
Cells 2020
Overcoming Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutated Tumours
EL Paton, JA Turner, IR Schlaepfer
Journal of Oncology 2020
Explicating the Pivotal Pathogenic, Diagnostic, and Therapeutic Biomarker Potentials of Myeloid-Derived Suppressor Cells in Glioblastoma
SA Richard, WJ Tu
Disease Markers 2020
Dysregulated Immune Responses by ASK1 Deficiency Alter Epithelial Progenitor Cell Fate and Accelerate Metaplasia Development during H. pylori Infection
Y Hayakawa, Y Hirata, M Hata, M Tsuboi, Y Oya, K Kurokawa, S Abe, J Arai, N Suzuki, H Nakagawa, H Fujiwara, K Tateishi, S Maeda, K Koike
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A DNA Hypomethylating Drug Alters the Tumor Microenvironment and Improves the Effectiveness of Immune Checkpoint Inhibitors in a Mouse Model of Pancreatic Cancer
TA Gonda, J Fang, M Salas, C Do, E Hsu, A Zhukovskaya, A Siegel, R Takahashi, ZA Lopez-Bujanda, CG Drake, GA Manji, TC Wang, KP Olive, B Tycko
Cancer research 2020
Myeloid-Derived Suppressor Cells: A New and Pivotal Player in Colorectal Cancer Progression
K Yin, X Xia, K Rui, T Wang, S Wang
Frontiers in Oncology 2020
CD200 promotes immunosuppression in the pancreatic tumor microenvironment
F Choueiry, M Torok, R Shakya, K Agrawal, A Deems, B Benner, A Hinton, J Shaffer, BW Blaser, AM Noonan, TM Williams, M Dillhoff, DL Conwell, PA Hart, Z Cruz-Monserrate, XF Bai, WE Carson, TA Mace
Journal for ImmunoTherapy of Cancer 2020
Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration
J Xu, Y Luo, C Yuan, L Han, Q Wu, L Xu, Y Gao, Y Sun, S Ma, G Tang, S Li, W Sun, Y Gong, C Xie
International journal of biological sciences 2020

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