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Citations to this article

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
Giovanna Gallina, … , Silvio Bicciato, Vincenzo Bronte
Giovanna Gallina, … , Silvio Bicciato, Vincenzo Bronte
Published October 2, 2006
Citation Information: J Clin Invest. 2006;116(10):2777-2790. https://doi.org/10.1172/JCI28828.
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Research Article Oncology Article has an altmetric score of 6

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

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Abstract

Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b+IL-4 receptor α+ (CD11b+IL-4Rα+), inflammatory-type monocytes that is elicited by growing tumors and activated by IFN-γ released from T lymphocytes. CD11b+IL-4Rα+ cells produced IL-13 and IFN-γ and integrated the downstream signals of these cytokines to trigger the molecular pathways suppressing antigen-activated CD8+ T lymphocytes. Analogous immunosuppressive circuits were active in CD11b+ cells present within the tumor microenvironment. These suppressor cells challenge the current idea that tumor-conditioned immunosuppressive monocytes/macrophages are alternatively activated. Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions.

Authors

Giovanna Gallina, Luigi Dolcetti, Paolo Serafini, Carmela De Santo, Ilaria Marigo, Mario P. Colombo, Giuseppe Basso, Frank Brombacher, Ivan Borrello, Paola Zanovello, Silvio Bicciato, Vincenzo Bronte

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
Citations: 2 12 11 13 22 11 15 22 16 24 30 29 28 34 33 30 34 26 8 2 402
Citation information
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Citations to this article in year 2011 (33)

Title and authors Publication Year
T cells contribute to tumor progression by favoring pro-tumoral properties of intra-tumoral myeloid cells in a mouse model for spontaneous melanoma
R Lengagne, A Pommier, J Caron, L Douguet, M Garcette, M Kato, MF Avril, JP Abastado, N Bercovici, B Lucas, A Prévost-Blondel
PloS one 2011
Deletion of p120-Catenin Results in a Tumor Microenvironment with Inflammation and Cancer that Establishes It as a Tumor Suppressor Gene
DB Stairs, LJ Bayne, B Rhoades, ME Vega, TJ Waldron, J Kalabis, A Klein-Szanto, JS Lee, JP Katz, JA Diehl, AB Reynolds, RH Vonderheide, AK Rustgi
Cancer Cell 2011
Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth
SZ Manrique, MA Correa, DB Hoelzinger, AL Dominguez, N Mirza, HH Lin, J Stein-Streilein, S Gordon, J Lustgarten
Journal of Experimental Medicine 2011
Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice
BL Mundy-Bosse, GB Lesinski, AC Jaime-Ramirez, K Benninger, M Khan, P Kuppusamy, K Guenterberg, SV Kondadasula, AR Chaudhury, KM Perle, M Kreiner, G Young, DC Guttridge, WE Carson
Cancer research 2011
The immunological contribution of NF-κB within the tumor microenvironment: a potential protective role of zinc as an anti-tumor agent
B Bao, A Thakur, Y Li, A Ahmad, AS Azmi, S Banerjee, D Kong, S Ali, LG Lum, FH Sarkar
Biochimica et Biophysica Acta 2011
A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells
S Solito, E Falisi, CM Diaz-Montero, A Doni, L Pinton, A Rosato, S Francescato, G Basso, P Zanovello, G Onicescu, E Garrett-Mayer, AJ Montero, V Bronte, S Mandruzzato
Blood 2011
The parallel lives of angiogenesis and immunosuppression: cancer and other tales
GT Motz, G Coukos
Nature Reviews Immunology 2011
Tolerogenic pDCs: spotlight on Foxo3
V Bronte
Journal of Clinical Investigation 2011
Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients
BL Mundy-Bosse, LM Thornton, HC Yang, BL Andersen, WE Carson
Cellular Immunology 2011
TGF-β Signaling in Breast Cancer Cell Invasion and Bone Metastasis
Y Drabsch, P Dijke
Journal of Mammary Gland Biology and Neoplasia 2011
Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype
S Bhatia, M Fei, M Yarlagadda, Z Qi, S Akira, S Saijo, Y Iwakura, N Rooijen, GA Gibson, CM st Croix, A Ray, P Ray
PloS one 2011
Origin and Functions of Tumor-Associated Myeloid Cells (TAMCs)
A Sica, C Porta, S Morlacchi, S Banfi, L Strauss, M Rimoldi, MG Totaro, E Riboldi
Cancer Microenvironment 2011
Transcriptional regulation of macrophage polarization: enabling diversity with identity
T Lawrence, G Natoli
Nature Reviews Immunology 2011
Macrophage Polarization in Health and Disease
L Cassetta, E Cassol, G Poli
TheScientificWorldJournal 2011
The Immune Microenvironment of Myeloma
K Noonan, I Borrello
Cancer Microenvironment 2011
Chemokines in health and disease
D Raman, T Sobolik-Delmaire, A Richmond
Experimental Cell Research 2011
Hematopoietic Cytokine-Induced Transcriptional Regulation and Notch Signaling as Modulators of MDSC Expansion
SJ Saleem, DH Conrad
International Immunopharmacology 2011
Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model
C Meyer, A Sevko, M Ramacher, AV Bazhin, CS Falk, W Osen, I Borrello, M Kato, D Schadendorf, M Baniyash, V Umansky
Proceedings of the National Academy of Sciences 2011
Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13
RF Gabitass, NE Annels, DD Stocken, HA Pandha, GW Middleton
Cancer Immunology, Immunotherapy 2011
Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism
JD Waight, Q Hu, A Miller, S Liu, SI Abrams
PloS one 2011
Hepatic Stellate Cells Regulate Immune Response via Induction of Myeloid Suppressor Cells
HS Chou, CC Hsieh, HR Yang, L Wang, Y Arakawa, K Brown, Q Wu, F Lin, M Peters, JJ Fung, L Lu, S Qian
Hepatology 2011
In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site
JM Haverkamp, SA Crist, BD Elzey, C Cimen, TL Ratliff
European Journal of Immunology 2011
Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis
V Moliné-Velázquez, H Cuervo, VV Sol, MC Ortega, D Clemente, F Castro
Brain Pathology 2011
Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment
AM Lesokhin, TM Hohl, S Kitano, C Cortez, D Hirschhorn-Cymerman, F Avogadri, GA Rizzuto, JJ Lazarus, EG Pamer, AN Houghton, T Merghoub, JD Wolchok
Cancer research 2011
Targeting myeloid regulatory cells in cancer by chemotherapeutic agents
H Naiditch, MR Shurin, GV Shurin
Immunologic Research 2011
A Th1 cytokine-enriched microenvironment enhances tumor killing by activated T cells armed with bispecific antibodies and inhibits the development of myeloid-derived suppressor cells
A Thakur, D Schalk, SH Sarkar, Z Al-Khadimi, FH Sarkar, LG Lum
Cancer Immunology, Immunotherapy 2011
Myeloid derived suppressor cells in human diseases
TF Greten, MP Manns, F Korangy
International Immunopharmacology 2011
A Novel Combination Immunotherapy for Cancer by IL-13Rα2–Targeted DNA Vaccine and Immunotoxin in Murine Tumor Models
H Nakashima, M Terabe, JA Berzofsky, SR Husain, RK Puri
Journal of immunology (Baltimore, Md. : 1950) 2011
Sonoporation Delivery of Interleukin-27 Gene Therapy Efficiently Reduces Prostate Tumor Cell Growth In Vivo
O Zolochevska, X Xia, BJ Williams, A Ramsay, S Li, ML Figueiredo
Human Gene Therapy 2011
Phagocytosis, a Potential Mechanism for Myeloid-Derived Suppressor Cell Regulation of CD8 + T Cell Function Mediated through Programmed Cell Death-1 and Programmed Cell Death-1 Ligand Interaction
YJ Kim, SJ Park, HE Broxmeyer
Journal of immunology (Baltimore, Md. : 1950) 2011
Myeloid-derived suppressor cells: general characteristics and relevance to clinical management of pancreatic cancer.
Goedegebuure P, Mitchem JB, Porembka MR, Tan MC, Belt BA, Wang-Gillam A, Gillanders WE, Hawkins WG, Linehan DC
Current cancer drug targets 2011
Camouflage and sabotage: tumor escape from the immune system
Poschke I, Mougiakakos D, Kiessling R
Cancer Immunology, Immunotherapy 2011
Serum inhibits the immunosuppressive function of myeloid-derived suppressor cells isolated from 4T1 tumor-bearing mice
Hamilton MJ, Banáth JP, Lam V, LePard NE, Krystal G, Bennewith KL
Cancer Immunology, Immunotherapy 2011

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