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Usage Information

Caspases: pharmacological manipulation of cell death
Inna N. Lavrik, … , Alexander Golks, Peter H. Krammer
Inna N. Lavrik, … , Alexander Golks, Peter H. Krammer
Published October 3, 2005
Citation Information: J Clin Invest. 2005;115(10):2665-2672. https://doi.org/10.1172/JCI26252.
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Review Series Article has an altmetric score of 9

Caspases: pharmacological manipulation of cell death

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Abstract

Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last decade, major progress has been made to further understand caspase structure and function, providing a unique basis for drug design. This Review gives an overview of caspases and their classification, structure, and substrate specificity. We also describe the current knowledge of how interference with caspase signaling can be used to pharmacologically manipulate cell death.

Authors

Inna N. Lavrik, Alexander Golks, Peter H. Krammer

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 1,686 480
PDF 94 59
Figure 247 0
Table 51 0
Citation downloads 75 0
Totals 2,153 539
Total Views 2,692
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Referenced in 5 patents
Referenced in 5 Wikipedia pages
381 readers on Mendeley
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