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Citations to this article

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
Wen Jiang, … , Guang Bai, Xia Zhang
Wen Jiang, … , Guang Bai, Xia Zhang
Published November 1, 2005
Citation Information: J Clin Invest. 2005;115(11):3104-3116. https://doi.org/10.1172/JCI25509.
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Research Article Neuroscience Article has an altmetric score of 805

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

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Abstract

The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. This study aimed at investigating the potential regulatory capacity of the potent synthetic cannabinoid HU210 on hippocampal neurogenesis and its possible correlation with behavioral change. We show that both embryonic and adult rat hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids could act on CB1 receptors to regulate neurogenesis. This hypothesis is supported by further findings that HU210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal NS/PCs likely via a sequential activation of CB1 receptors, Gi/o proteins, and ERK signaling. Chronic, but not acute, HU210 treatment promoted neurogenesis in the hippocampal dentate gyrus of adult rats and exerted anxiolytic- and antidepressant-like effects. X-irradiation of the hippocampus blocked both the neurogenic and behavioral effects of chronic HU210 treatment, suggesting that chronic HU210 treatment produces anxiolytic- and antidepressant-like effects likely via promotion of hippocampal neurogenesis.

Authors

Wen Jiang, Yun Zhang, Lan Xiao, Jamie Van Cleemput, Shao-Ping Ji, Guang Bai, Xia Zhang

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 2 10 5 7 15 13 6 7 10 10 8 23 13 13 15 15 10 9 10 4 1 206
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2020 (13)

Title and authors Publication Year
Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies
V Reddy, D Grogan, M Ahluwalia, ÉL Salles, P Ahluwalia, H Khodadadi, K Alverson, A Nguyen, SP Raju, P Gaur, M Braun, FL Vale, V Costigliola, K Dhandapani, B Baban, K Vaibhav
The EPMA Journal 2020
Cannabinoid Receptors: An Update on Cell Signaling, Pathophysiological Roles and Therapeutic Opportunities in Neurological, Cardiovascular, and Inflammatory Diseases
D Haspula, MA Clark
International journal of molecular sciences 2020
Beyond the Hippocampus and the SVZ: Adult Neurogenesis Throughout the Brain
MP Jurkowski, L Bettio, EK Woo, A Patten, SY Yau, J Gil-Mohapel
Frontiers in cellular neuroscience 2020
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
G Chevalier, E Siopi, L Guenin-Macé, M Pascal, T Laval, A Rifflet, IG Boneca, C Demangel, B Colsch, A Pruvost, E Chu-Van, A Messager, F Leulier, G Lepousez, G Eberl, PM Lledo
Nature Communications 2020
Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms
DF Engel, VC Bobbo, CS Solon, GA Nogueira, A Moura-Assis, NF Mendes, AM Zanesco, A Papangelis, T Ulven, LA Velloso
Scientific Reports 2020
Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB 1 Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster
G Tortoriello, J Beiersdorf, S Romani, G Williams, GA Cameron, K Mackie, MJ Williams, VD Marzo, E Keimpema, P Doherty, T Harkany
Cannabis and Cannabinoid Research 2020
Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases—focusing on FAAH/MAGL inhibitors
S Ren, Z Wang, Y Zhang, N Chen
Acta Pharmacologica Sinica 2020
The Synthetic Cannabinoids THJ-2201 and 5F-PB22 Enhance In Vitro CB1 Receptor-Mediated Neuronal Differentiation at Biologically Relevant Concentrations
J Alexandre, R Malheiro, DD da Silva, H Carmo, F Carvalho, JP Silva
International journal of molecular sciences 2020
Cannabinoid receptor subtype influence on neuritogenesis in human SH-SY5Y cells
EL Lyons, S Leone-Kabler, AL Kovach, BF Thomas, AC Howlett
Molecular and cellular neurosciences 2020
Learning and memory retention deficits in prepubertal guinea pigs prenatally exposed to low levels of the organophosphorus insecticide malathion
EW Lumsden, L McCowan, JD Pescrille, WP Fawcett, H Chen, EX Albuquerque, J Mamczarz, EF Pereira
Neurotoxicology and Teratology 2020
Dual pharmacological inhibitor of endocannabinoid degrading enzymes reduces depressive-like behavior in female rats
B Dong, BM Shilpa, R Shah, A Goyal, S Xie, MJ Bakalian, RF Suckow, TB Cooper, JJ Mann, V Arango, KY Vinod
Journal of Psychiatric Research 2020
Gestational exposures to organophosphorus insecticides: From acute poisoning to developmental neurotoxicity
SW Todd, EW Lumsden, Y Aracava, J Mamczarz, EX Albuquerque, EF Pereira
Neuropharmacology 2020
Neurobiology of cannabinoid receptor signaling
.
Lutz B
Dialogues in clinical neuroscience 2020

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