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Citations to this article

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
Wen Jiang, … , Guang Bai, Xia Zhang
Wen Jiang, … , Guang Bai, Xia Zhang
Published November 1, 2005
Citation Information: J Clin Invest. 2005;115(11):3104-3116. https://doi.org/10.1172/JCI25509.
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Research Article Neuroscience Article has an altmetric score of 805

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

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Abstract

The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. This study aimed at investigating the potential regulatory capacity of the potent synthetic cannabinoid HU210 on hippocampal neurogenesis and its possible correlation with behavioral change. We show that both embryonic and adult rat hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids could act on CB1 receptors to regulate neurogenesis. This hypothesis is supported by further findings that HU210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal NS/PCs likely via a sequential activation of CB1 receptors, Gi/o proteins, and ERK signaling. Chronic, but not acute, HU210 treatment promoted neurogenesis in the hippocampal dentate gyrus of adult rats and exerted anxiolytic- and antidepressant-like effects. X-irradiation of the hippocampus blocked both the neurogenic and behavioral effects of chronic HU210 treatment, suggesting that chronic HU210 treatment produces anxiolytic- and antidepressant-like effects likely via promotion of hippocampal neurogenesis.

Authors

Wen Jiang, Yun Zhang, Lan Xiao, Jamie Van Cleemput, Shao-Ping Ji, Guang Bai, Xia Zhang

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 1 10 5 7 15 13 6 7 10 10 8 23 13 13 15 15 10 9 10 4 1 205
Citation information
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Citations to this article in year 2010 (15)

Title and authors Publication Year
Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressant-like effects in adult rats
XH Zhu, HC Yan, J Zhang, HD Qu, XS Qiu, L Chen, SJ Li, X Cao, JC Bean, LH Chen, XH Qin, JH Liu, XC Bai, L Mei, TM Gao
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver
K Jagavelu, C Routray, U Shergill, SP O'Hara, W Faubion, VH Shah
Hepatology 2010
A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats
MV Solbrig, Y Fan, N Hermanowicz, MG Morgese, A Giuffrida
Experimental Neurology 2010
G-protein Coupled Receptors in Stem Cell Self-Renewal and Differentiation
NR Kobayashi, SM Hawes, JM Crook, A Pébay
Stem Cell Reviews and Reports 2010
Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia
G Bai, D Wei, S Zou, K Ren, R Dubner
Molecular Pain 2010
Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of acute and chronic antidepressant treatments
DT Balu
Experimental and Clinical Psychopharmacology 2010
The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain
MB Goncalves, EJ Williams, P Yip, RJ Yáñez-Muñoz, G Williams, P Doherty
British Journal of Pharmacology 2010
Open questions in current models of antidepressant action
A Tanti, C Belzung
British Journal of Pharmacology 2010
CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling
S Trazzi, M Steger, VM Mitrugno, R Bartesaghi, E Ciani
The Journal of biological chemistry 2010
Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress
W Wang, D Sun, B Pan, CJ Roberts, X Sun, CJ Hillard, Q Liu
Neuropsychopharmacology 2010
Intranasal Administration of Nerve Growth Factor Produces Antidepressant-Like Effects in Animals
C Shi, L Wang, Y Wu, P Wang, Z Gan, K Lin, L Jiang, Z Xu, M Fan
Neurochemical Research 2010
Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
M Roche, DP Finn
Pharmaceuticals (Basel, Switzerland) 2010
Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
SA Wolf, A Bick-Sander, K Fabel, P Leal-Galicia, S Tauber, G Ramirez-Rodriguez, A Müller, A Melnik, TP Waltinger, O Ullrich, G Kempermann
Cell Communication and Signaling 2010
Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice
Y Gao, DV Vasilyev, MB Goncalves, FV Howell, C Hobbs, M Reisenberg, R Shen, MY Zhang, BW Strassle, P Lu, L Mark, MJ Piesla, K Deng, EV Kouranova, RH Ring, GT Whiteside, B Bates, FS Walsh, G Williams, MN Pangalos, TA Samad, P Doherty
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
AT El-Alfy, K Ivey, K Robinson, S Ahmed, M Radwan, D Slade, I Khan, M ElSohly, S Ross
Pharmacology, biochemistry, and behavior 2010

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