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Citations to this article

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
Wen Jiang, … , Guang Bai, Xia Zhang
Wen Jiang, … , Guang Bai, Xia Zhang
Published November 1, 2005
Citation Information: J Clin Invest. 2005;115(11):3104-3116. https://doi.org/10.1172/JCI25509.
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Research Article Neuroscience Article has an altmetric score of 805

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

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Abstract

The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. This study aimed at investigating the potential regulatory capacity of the potent synthetic cannabinoid HU210 on hippocampal neurogenesis and its possible correlation with behavioral change. We show that both embryonic and adult rat hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids could act on CB1 receptors to regulate neurogenesis. This hypothesis is supported by further findings that HU210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal NS/PCs likely via a sequential activation of CB1 receptors, Gi/o proteins, and ERK signaling. Chronic, but not acute, HU210 treatment promoted neurogenesis in the hippocampal dentate gyrus of adult rats and exerted anxiolytic- and antidepressant-like effects. X-irradiation of the hippocampus blocked both the neurogenic and behavioral effects of chronic HU210 treatment, suggesting that chronic HU210 treatment produces anxiolytic- and antidepressant-like effects likely via promotion of hippocampal neurogenesis.

Authors

Wen Jiang, Yun Zhang, Lan Xiao, Jamie Van Cleemput, Shao-Ping Ji, Guang Bai, Xia Zhang

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 1 10 5 7 15 13 6 7 10 10 8 23 13 13 15 15 10 9 10 4 1 205
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2009 (10)

Title and authors Publication Year
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine
J Liu, JC Garza, J Bronner, CS Kim, W Zhang, XY Lu
Psychopharmacology 2009
Seizures increase cell proliferation in the dentate gyrus by shortening progenitor cell-cycle length
FP Varodayan, XJ Zhu, XN Cui, BE Porter
Epilepsia 2009
Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus
MN Hill, AK Titterness, AC Morrish, EJ Carrier, TT Lee, J Gil-Mohapel, BB Gorzalka, CJ Hillard, BR Christie
Hippocampus 2009
Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of chronic antidepressant treatments
DT Balu, GE Hodes, BT Anderson, I Lucki
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009
Antiaversive effects of cannabinoids: is the periaqueductal gray involved?
FA Moreira, DC Aguiar, AC Campos, SF Lisboa, AL Terzian, LB Resstel, FS Guimarães
Neural plasticity 2009
Neuropeptides in depression: role of VGF
S Thakker-Varia, J Alder
Behavioural Brain Research 2009
The endocannabinoid system as a target for the treatment of cannabis dependence
JR Clapper, RA Mangieri, D Piomelli
Neuropharmacology 2009
The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders
I Galve-Roperh, J Palazuelos, T Aguado, M Guzmán
European Archives of Psychiatry and Clinical Neuroscience 2009
The Use of a Synthetic Cannabinoid in the Management of Treatment-Resistant Nightmares in Posttraumatic Stress Disorder (PTSD)
GA Fraser
CNS Neuroscience & Therapeutics 2009

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