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Citations to this article

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
Wen Jiang, … , Guang Bai, Xia Zhang
Wen Jiang, … , Guang Bai, Xia Zhang
Published November 1, 2005
Citation Information: J Clin Invest. 2005;115(11):3104-3116. https://doi.org/10.1172/JCI25509.
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Research Article Neuroscience Article has an altmetric score of 805

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

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Abstract

The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. This study aimed at investigating the potential regulatory capacity of the potent synthetic cannabinoid HU210 on hippocampal neurogenesis and its possible correlation with behavioral change. We show that both embryonic and adult rat hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids could act on CB1 receptors to regulate neurogenesis. This hypothesis is supported by further findings that HU210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal NS/PCs likely via a sequential activation of CB1 receptors, Gi/o proteins, and ERK signaling. Chronic, but not acute, HU210 treatment promoted neurogenesis in the hippocampal dentate gyrus of adult rats and exerted anxiolytic- and antidepressant-like effects. X-irradiation of the hippocampus blocked both the neurogenic and behavioral effects of chronic HU210 treatment, suggesting that chronic HU210 treatment produces anxiolytic- and antidepressant-like effects likely via promotion of hippocampal neurogenesis.

Authors

Wen Jiang, Yun Zhang, Lan Xiao, Jamie Van Cleemput, Shao-Ping Ji, Guang Bai, Xia Zhang

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 1 10 5 7 15 13 6 7 10 10 8 23 13 13 15 15 10 9 10 4 1 205
Citation information
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Citations to this article in year 2014 (23)

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Human Molecular Genetics 2014
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E Vendel, EC de Lange
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E Blanco-Calvo, P Rivera, S Arrabal, A Vargas, FJ Pavón, A Serrano, E Castilla-Ortega, P Galeano, L Rubio, J Suárez, FR de Fonseca
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Z Zhang, W Wang, P Zhong, SJ Liu, JZ Long, L Zhao, H Gao, BF Cravatt, Q Liu
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Interleukin-1 beta guides the migration of cortical neurons
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Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies
M Maccarrone, M Guzmán, K Mackie, P Doherty, T Harkany
Nature Reviews Neuroscience 2014
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TJ Schoenfeld, HA Cameron
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M Borsotto, J Veyssiere, HM Maati, C Devader, J Mazella, C Heurteaux
British Journal of Pharmacology 2014
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Molecular Psychiatry 2014
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Nature Reviews Neuroscience 2014
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Medical Marijuana Laws and Suicides by Gender and Age
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American journal of public health 2014
Endocannabinoid signaling in the etiology and treatment of major depressive illness.
Hillard CJ, Liu QS
Current pharmaceutical design 2014

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