The anemia of inflammation, commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until recently, we understood little about its pathogenesis. It now appears that the inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible for most or all of the features of this disorder.
Nancy C. Andrews
Title and authors | Publication | Year |
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Identification of Guanosine 5′-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway
S Angmo, N Tripathi, S Abbat, S Sharma, SS Singh, A Halder, K Yadav, G Shukla, R Sandhir, V Rishi, PV Bharatam, H Yadav, NK Singhal |
Scientific Reports | 2017 |
Vitamin D Status Is Associated with Hepcidin and Hemoglobin Concentrations in Children with Inflammatory Bowel Disease:
S Syed, ES Michalski, V Tangpricha, S Chesdachai, A Kumar, J Prince, TR Ziegler, PS Suchdev, S Kugathasan |
Inflammatory Bowel Diseases | 2017 |
Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types
JV Neves, MF Ramos, AC Moreira, T Silva, MS Gomes, PN Rodrigues |
Scientific Reports | 2017 |