The anemia of inflammation, commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until recently, we understood little about its pathogenesis. It now appears that the inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible for most or all of the features of this disorder.
Nancy C. Andrews
Title and authors | Publication | Year |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Inflammation and its impact on anaemia in chronic kidney disease: from haemoglobin variability to hyporesponsiveness
AL de Francisco, P Stenvinkel, S Vaulont |
NDT Plus | 2009 |
Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
G Ramey, JC Deschemin, S Vaulont |
Haematologica | 2009 |
STAT3 signaling within hepatocytes is required for anemia of inflammation in vivo
R Sakamori, T Takehara, T Tatsumi, M Shigekawa, H Hikita, N Hiramatsu, T Kanto, N Hayashi |
Journal of Gastroenterology | 2009 |
Expression of hepcidin and other iron-regulatory genes in human hepatocellular carcinoma and its clinical implications
HH Tseng, JG Chang, YH Hwang, KT Yeh, YL Chen, HS Yu |
Journal of Cancer Research and Clinical Oncology | 2009 |
Anemia and growth failure among HIV-infected children in India: a retrospective analysis
Shet A, Mehta S, Rajagopalan N, Dinakar C, Ramesh E, Samuel N, Indumathi C, Fawzi WW, Kurpad AV |
BMC Pediatrics | 2009 |