The anemia of inflammation, commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until recently, we understood little about its pathogenesis. It now appears that the inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible for most or all of the features of this disorder.
Nancy C. Andrews
Title and authors | Publication | Year |
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Vitamin D: beyond bone: Vitamin D: beyond bone
S Christakos, M Hewison, DG Gardner, CL Wagner, IN Sergeev, E Rutten, AG Pittas, R Boland, L Ferrucci, DD Bikle |
Annals of the New York Academy of Sciences | 2013 |
Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus
S Gardenghi, TM Renaud, A Meloni, C Casu, BJ Crielaard, LM Bystrom, N Greenberg-Kushnir, BJ Sasu, KS Cooke, S Rivella |
Blood | 2013 |
A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease
T Fujiwara, T Ikeda, Y Nagasaka, Y Okitsu, Y Katsuoka, N Fukuhara, Y Onishi, K Ishizawa, R Ichinohasama, N Tomosugi, H Harigae |
PloS one | 2013 |
Identification of trans-sialidases as a common mediator of endothelial cell activation by African trypanosomes
Z Ammar, N Plazolles, T Baltz, V Coustou |
PLoS pathogens | 2013 |
Redox control of inflammation in macrophages
B Brüne, N Dehne, N Grossmann, M Jung, D Namgaladze, T Schmid, A Knethen, A Weigert |
Antioxidants & Redox Signaling | 2013 |
Suppression of Iron-Regulatory Hepcidin by Vitamin D
Bacchetta J, Zaritsky JJ, Sea JL, Chun RF, Lisse TS, Zavala K, Nayak A, Wesseling-Perry K, Westerman M, Hollis BW, Salusky IB, Hewison M |
Journal of the American Society of Nephrology : JASN | 2013 |
Mycobacterium avium Infection Induces H-Ferritin Expression in Mouse Primary Macrophages by Activating Toll-Like Receptor 2
Silva-Gomes S, Bouton C, Silva T, Santambrogio P, Rodrigues P, Appelberg R, Gomes MS |
PloS one | 2013 |
Intravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study
Abdel-Razeq H, Abbasi S, Saadi I, Jaber R, Abdelelah H |
Drug design, development and therapy | 2013 |
The role of interleukin-6 in the evolution of ovarian cancer: clinical and prognostic implications--a review.
Macciò A, Madeddu C |
Journal of Molecular Medicine | 2013 |