FAP-targeting CAR T cells with constitutive IL-10 expression reduce kidney fibrosis in mice

Blake D. Jardin; Feiyan Liu; Li Li; Cheryl L. Smith; Jonathan A. Epstein

doi:10.1172/JCI210355

¹Departments of Medicine and of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, United States of America

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¹Departments of Medicine and of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, United States of America

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J Clin Invest. https://doi.org/10.1172/JCI210355.
Copyright © 2026, Jardin et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Published October 20, 2026 - Version history

FAP-targeting CAR T cells with constitutive IL-10 expression reduce kidney fibrosis in mice

Blake D. Jardin,¹ Feiyan Liu,¹ Li Li,¹ Cheryl L. Smith,¹ and Jonathan A. Epstein¹

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FAP-targeting CAR T cells with constitutive IL-10 expression reduce kidney fibrosis in mice

Blake D. Jardin,1 Feiyan Liu,1 Li Li,1 Cheryl L. Smith,1 and Jonathan A. Epstein1

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Blake D. Jardin,¹ Feiyan Liu,¹ Li Li,¹ Cheryl L. Smith,¹ and Jonathan A. Epstein¹