Unequivocal direct observations have established that the bacteria that cause device-related and other chronic infections grow in matrix-enclosed biofilms. The diagnostic and therapeutic strategies that have served us so well in the partial eradication of acute epidemic bacterial diseases have not yielded accurate data or favorable outcomes when applied to these biofilm diseases. We discuss the potential benefits of the application of the new methods and concepts developed by biofilm science and engineering to the clinical management of infectious diseases.
William Costerton, Richard Veeh, Mark Shirtliff, Mark Pasmore, Christopher Post, Garth Ehrlich
Title and authors | Publication | Year |
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Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease
A Swidsinski, J Weber, V Loening-Baucke, LP Hale, H Lochs |
Journal of clinical microbiology | 2005 |
Pseudomonas aeruginosa: the potential to immunise against infection
E Sedlak-Weinstein, AW Cripps, JM Kyd, AR Foxwell |
Expert Opinion on Biological Therapy | 2005 |
Effect of pH on an in vitro model of gastric microbiota in enteral nutrition patients
GA O'May, N Reynolds, GT Macfarlane |
Applied and environmental microbiology | 2005 |
Codon usage comparison of novel genes in clinical isolates of Haemophilus influenzae
J Gladitz, K Shen, P Antalis, FZ Hu, JC Post, GD Ehrlich |
Nucleic Acids Research | 2005 |
Identification, distribution, and expression of novel genes in 10 clinical isolates of nontypeable Haemophilus influenzae
K Shen, P Antalis, J Gladitz, S Sayeed, A Ahmed, S Yu, J Hayes, S Johnson, B Dice, R Dopico, R Keefe, B Janto, W Chong, J Goodwin, RM Wadowsky, G Erdos, JC Post, GD Ehrlich, FZ Hu |
Infection and immunity | 2005 |
Bacterial biofilm within diseased pancreatic and biliary tracts
A Swidsinski, P Schlien, A Pernthaler, U Gottschalk, E Bärlehner, G Decker, S Swidsinski, J Strassburg, V Loening-Baucke, U Hoffmann, D Seehofer, LP Hale, H Lochs |
Gut | 2005 |
Engineering approaches for the detection and control of orthopaedic biofilm infections
GD Ehrlich, P Stoodley, S Kathju, Y Zhao, BR McLeod, N Balaban, FZ Hu, NG Sotereanos, JW Costerton, PS Stewart, JC Post, Q Lin |
Clinical Orthopaedics and Related Research | 2005 |
Role of biofilms in neurosurgical device-related infections
EE Braxton, GD Ehrlich, L Hall-Stoodley, P Stoodley, R Veeh, C Fux, FZ Hu, M Quigley, JC Post |
Neurosurgical Review | 2005 |
Effect of intravenous iron on haemodialysis catheter microbial colonization and blood-borne infection
UC Brewster, SG Coca, RF Reilly, MA Perazella |
Nephrology | 2005 |
Engineering Approaches for the Detection and Control of Orthopaedic Biofilm Infections:
GD Ehrlich, P Stoodley, S Kathju, Y Zhao, BR McLeod, N Balaban, FZ Hu, NG Sotereanos, JW Costerton, PS Stewart, JC Post, Q Lin |
Clinical Orthopaedics and Related Research | 2005 |
Local Antibiotic Delivery Systems: Where Are We and Where Are We Going?
AD Hanssen, DR Osmon, R Patel |
Clinical Orthopaedics and Related Research | 2005 |
Is biofilm a cause of silent chronic inflammation in haemodialysis patients? A fascinating working hypothesis
G Cappelli, C Tetta, B Canaud |
Nephrology Dialysis Transplantation | 2005 |
Physiopathologie des infections sur matériel orthopédique
F Ader, L Bernard |
La Presse Médicale | 2005 |
Surfaces and Interfaces for Biomaterials
M Millar |
Surfaces and interfaces for biomaterials | 2005 |
Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: a randomised, double-blind, controlled clinical trial
SD Aaron, KL Vandemheen, W Ferris, D Fergusson, E Tullis, D Haase, Y Berthiaume, N Brown, P Wilcox, V Yozghatlian, P Bye, S Bell, F Chan, B Rose, A Jeanneret, A Stephenson, M Noseworthy, A Freitag, N Paterson, S Doucette, C Harbour, M Ruel, N MacDonald |
The Lancet | 2005 |
Prevention of Pneumonia in the Hospital Setting
SB Osmon, MH Kollef |
Clinics in Chest Medicine | 2005 |
Expression of a peroxiredoxinâglutaredoxin by Haemophilus influenzae in biofilms and during human respiratory tract infection
TF Murphy, C Kirkham, S Sethi, AJ Lesse |
FEMS Immunology & Medical Microbiology | 2005 |
Characterization of Bordetella pertussis growing as biofilm by chemical analysis and FT-IR spectroscopy
A Bosch, D Serra, C Prieto, J Schmitt, D Naumann, O Yantorno |
Applied Microbiology and Biotechnology | 2005 |
Bacterial Biofilms: Do They Play a Role in Chronic Sinusitis?
JN Palmer |
Otolaryngologic Clinics of North America | 2005 |
Microbial status of apical root canal system of human mandibular first molars with primary apical periodontitis after “one-visit” endodontic treatment
PN Nair, S Henry, V Cano, J Vera |
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2005 |
Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice
Alexander Swidsinski, Vera Loening-Baucke, Herbert Lochs, Laura-P Hale |
World journal of gastroenterology : WJG | 2005 |
Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescence in situ hybridization study in mice
A Swidsinski |
World journal of gastroenterology : WJG | 2005 |
Prostaglandin production during growth of Candida albicans biofilms
MA Alem, LJ Douglas |
Journal of Medical Microbiology | 2005 |
Colonization of Mucosal Surfaces
JP Nataro, PS Cohen, HL Mobley, JN Weiser |
2005 | |
Peritonitis and Automated Peritoneal Dialysis: A Therapeutic Conundrum?
L Troidle, FO Finkelstein |
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis | 2005 |