Unequivocal direct observations have established that the bacteria that cause device-related and other chronic infections grow in matrix-enclosed biofilms. The diagnostic and therapeutic strategies that have served us so well in the partial eradication of acute epidemic bacterial diseases have not yielded accurate data or favorable outcomes when applied to these biofilm diseases. We discuss the potential benefits of the application of the new methods and concepts developed by biofilm science and engineering to the clinical management of infectious diseases.
William Costerton, Richard Veeh, Mark Shirtliff, Mark Pasmore, Christopher Post, Garth Ehrlich
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J AM PODIAT MED ASSN | 2010 |
Gram-Positive Marine Bacteria as a Potential Resource for the Discovery of Quorum Sensing Inhibitors
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Marine Biotechnology | 2010 |
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G Bonkat, M Rieken, CA Rentsch, S Wyler, A Feike, J Schäfer, T Gasser, A Trampuz, A Bachmann, AF Widmer |
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A Meißner, C Mamoulakis, N Laube |
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CA Walsh, KH Moore |
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Injury | 2010 |
Differences between Pseudomonas aeruginosa in a clinical sample and in a colony isolated from it: Comparison of virulence capacity and susceptibility of biofilm to inhibitors
AN Ramos, MC Peral, JC Valdez |
Comparative Immunology, Microbiology and Infectious Diseases | 2010 |
Antibiotic resistance of bacterial biofilms
N Høiby, T Bjarnsholt, M Givskov, S Molin, O Ciofu |
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Débridement of the noninfected wound
RS Cornell, AJ Meyr, JS Steinberg, CE Attinger |
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Infectious Complications in Patients With Left Ventricular Assist Device: Etiology and Outcomes in the Continuous-Flow Era
VK Topkara, S Kondareddy, F Malik, IW Wang, DL Mann, GA Ewald, N Moazami |
The Annals of Thoracic Surgery | 2010 |
Advanced Techniques for Detecting Lesions in Bone
E Cotti |
Dental clinics of North America | 2010 |
(iv) Osteomyelitis
M McNally, K Nagarajah |
Orthopaedics and Trauma | 2010 |
A Mouse Model of Post-Arthroplasty Staphylococcus aureus Joint Infection to Evaluate In Vivo the Efficacy of Antimicrobial Implant Coatings
NM Bernthal, AI Stavrakis, F Billi, JS Cho, TJ Kremen, SI Simon, AL Cheung, GA Finerman, JR Lieberman, JS Adams, LS Miller, PJ Planet |
PloS one | 2010 |
Destructive and Protective Roles of Cytokines in Periodontitis: A Re-appraisal from Host Defense and Tissue Destruction Viewpoints
GP Garlet |
Journal of dental research | 2010 |
Chronic wounds and the medical biofilm paradigm
RD Wolcott, DD Rhoads, ME Bennett, BM Wolcott, L Gogokhia, JW Costerton, SE Dowd |
Journal of wound care | 2010 |
Comparison of methods for the detection of biofilm production in coagulase-negative staphylococci
A Oliveira, M de Lourdes RS Cunha |
BMC Research Notes | 2010 |
Regulation of pga Operon Expression and Biofilm Formation in Actinobacillus pleuropneumoniae by σE and H-NS
JT Bossé, S Sinha, MS Li, CA O'Dwyer, JH Nash, AN Rycroft, JS Kroll, PR Langford |
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Escherichia coli Variants in Periprosthetic Joint Infection: Diagnostic Challenges with Sessile Bacteria and Sonication
P Sendi, R Frei, TB Maurer, A Trampuz, W Zimmerli, P Graber |
Journal of clinical microbiology | 2010 |