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ResearchIn-Press PreviewImmunologyReproductive biology
Open Access | 
10.1172/JCI202874
Decidua-accumulated effector-like memory CD8+ T cells orchestrate localized antimicrobial defense without compromising fetal tolerance
Lu Liu,1 Xixi Huang,1 Tingxuan Yin,1 Xianyang Hu,1 Hailin Yu,1 Guohua Zhu,1 Chunfang Xu,1 Jiajia Chen,2 Jiangyuan Du,1 Hongyan Wang,3 Qingyu Wu,4 Wei Zhang,1 Feng Wang,5 Huimei Wu,6 and Meirong Du1
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Liu, L. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Huang, X. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Yin, T. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Hu, X. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Yu, H. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Zhu, G. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Xu, C. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Chen, J. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Du, J. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Wang, H. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Wu, Q. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Zhang, W. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
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Wang, F.
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1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Wu, H. in: PubMed | Google Scholar
1Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Femal, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China
3Key Laboratory of RNA Science and Engineering, CAS Center for Excellence in, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
4Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine an, Soochow University, Suzhou, China
5Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6The Reproductive Medicine Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Find articles by Du, M. in: PubMed | Google Scholar
Published November 5, 2026 - More info
Copyright © 2026, Liu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)