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10.1172/JCI202867
Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype
Robert B. Lindell,1 Samir U. Sayed,2 Jose S. Campos Duran,2 Sydney A. Sheetz,3 Apoorva Babu,4 Montana S. Knight,4 Andrea A. Mauracher,2 Ceire A. Hay,2 Peyton E. Conrey,2 Julie C. Fitzgerald,1 Nadir Yehya,1 Stephen T. Famularo III,3 Teresa Arroyo,3 Richard Tustin III,2 Hossein Fazelinia,5 Edward M. Behrens,6 David T. Teachey,7 Lisa R. Forbes Satter,8 Alexandra F. Freeman,9 Jenna R.E. Bergerson,9 Steven M. Holland,9 Jennifer W. Leiding,10 Scott L. Weiss,11 Mark W. Hall,12 Deanne M. Taylor,13 Rui Feng,14 E. John Wherry,15 Nuala J. Meyer,15 and Sarah E. Henrickson16
1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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Behrens, E.
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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Teachey, D.
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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Forbes Satter, L.
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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Holland, S.
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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Feng, R.
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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Meyer, N.
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1Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States of America
3Division of Critical Care Medicine, Department of Anesthesia and Critical C, Children's Hospital of Philadelphia, Philadelphia, United States of America
4Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, United States of America
5Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, United States of America
6Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
8Division of Immunology, Allergy, and Retrovirology, Department of Pediatric, Texas Children's Hospital and Baylor College of Medicine, Houston, United States of America
9Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States of America
10Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, United States of America
11Division of Critical Care, Department of Pediatrics, Nemours Children's Health and Sidney Kimmel Medical College at Thomas Jefferson University, Wilmington, United States of America
12Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, United States of America
13Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
14Department of Biostatistics, Center for Clinical Epidemiology and Biostatis, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
15Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
16Institute for Immunology and Immune Health, Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
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Published June 9, 2026 - More info
Copyright © 2026, Lindell et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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