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ResearchIn-Press PreviewInflammationMetabolismNephrology
Open Access | 
10.1172/JCI200755
Fumarate-induced succination of A-kinase anchor protein 12 exacerbates renal inflammation and fibrosis
Shuai Sun,1 Xu-yang Yan,2 Yu-hang Dong,3 Jian-min You,2 Zhen-yu Guo,2 Dong-xue Lv,3 Shuai-shuai Xie,3 Rui Hou,3 Xiang-yu Li,3 Ju-tao Yu,3 Xiao-yu Shen,3 Jie Wei,3 Zhen-yu Song,2 Zi-qi Chen,2 Yun-long Zhu,2 Xing-xin Xu,4 Juan Jin,3 Jia-gen Wen,3 Hao Wang,5 Xiao-ming Meng,3 and Wei Wang2
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Sun, S. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Yan, X. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Dong, Y. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by You, J. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Guo, Z. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Lv, D. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Xie, S. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Hou, R. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Li, X. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Yu, J. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Shen, X. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Wei, J. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Song, Z. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Chen, Z. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Zhu, Y. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Xu, X. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Jin, J. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Wen, J. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
Find articles by Wang, H. in: PubMed | Google Scholar
1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
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1Department of Urology, The Fifth Affiliated Hospital of Anhui Medical University, Fuyang, China
2Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
3Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China
4Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
5Department of Urology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, China
6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Heifei, China
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Published June 30, 2026 - More info
Copyright © 2026, Sun et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)