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Clinical Research and Public HealthIn-Press PreviewImmunologyOncology Open Access | 10.1172/JCI200135

IL-6 receptor blockade impedes proinflammatory atypical Treg subset associated with immune checkpoint inhibitor-induced inflammatory arthritis

Yifei Ma,1 Nianqi Liu,2 Yan Li,3 Denghan Zhang,1 Shaohui He,4 Jun Lv,5 Yongluo Jiang,6 Guangmin Jian,7 Jingyao Zhang,8 Pengfei Zhu,7 Yue Ma,9 Jiacai Lin,10 Jin Li,11 Tong Wu,12 Yiwei Xu,13 Xiajie Lyu,14 Youlong Wang,15 Yiming Li,16 Yu Si Niu,17 Zhenyun Guo,1 Churong Lin,18 Ningnan Fang,19 Wei Jiang,20 Lihong Wang,20 Mengqin Yuan,20 Shenyue Wang,21 Shulin Huang,22 Qi Huang,3 Jinjian Li,23 Jun Lu,23 Bocen Chen,24 Guanqing Zhong,3 Haizhou Liu,20 Fadian Ding,1 Shangeng Weng,1 Rui Li,21 and Ao Zhang3

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Ma, Y. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Liu, N. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Li, Y. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Zhang, D. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by He, S. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Lv, J. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Jiang, Y. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Jian, G. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Zhang, J. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Zhu, P. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Ma, Y. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Lin, J. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Li, J. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Wu, T. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Xu, Y. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Lyu, X. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Wang, Y. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Li, Y. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Niu, Y. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Guo, Z. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Lin, C. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Fang, N. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Jiang, W. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Wang, L. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Yuan, M. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Wang, S. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Huang, S. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Huang, Q. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Li, J. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Lu, J. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Chen, B. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Zhong, G. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Liu, H. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Ding, F. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Weng, S. in: PubMed | Google Scholar

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Li, R. in: PubMed | Google Scholar |

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

2Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China

3Department of Clinical Laboratory, State Key Laboratory of Oncology in Sout, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China

4Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China

5Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

6State Key Laboratory of Oncology in South China, Guangdong Key Laboratory o, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China

7Department of Clinical Laboratory & Key Clinical Laboratory of Henan Provin, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

8Department of Medicine, Nuvance Health Danbury Hospital, Danbury, United States of America

9Department of Laboratory Medicine, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, China

10Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

11Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China

12Department of Ophthalmology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

13Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China

14Internal Medicine Department, Jacobi Medical Center, New York, United States of America

15Department of General Surgery, Hainan Hospital of Chinese PLA General Hospital, Sanya, China

16Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

17Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, United States of America

18Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

19Department of Orthopedics and Spine Surgery, Cancer Hospital of Shantou University Medical College, Shantou, China

20Institute of Abdominal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

21Department of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China

22School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

23Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

24Key Laboratory of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China

Find articles by Zhang, A. in: PubMed | Google Scholar

Published May 12, 2026 - More info

J Clin Invest. https://doi.org/10.1172/JCI200135.
Copyright © 2026, Ma et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Published May 12, 2026 - Version history
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Abstract

Immune checkpoint inhibitor-induced inflammatory arthritis (ICI-IA) significantly impairs cancer therapy and patient quality of life, yet its pathogenic mechanisms remain unclear. Through integrated single-cell multi-omics analysis of paired peripheral blood, synovial fluid, and tumor samples from longitudinal ICI-IA cohorts and matched controls, we identified a unique regulatory T-cell (Treg) population co-expressing CD137 and IL-6R (AtpTreg). These cells exhibited reduced immunosuppressive capacity while aberrantly producing high level of IL-17 and promoting proinflammatory responses of synoviocytes. AtpTreg exhibits shared clonotypes and phenotypes across tissue compartments. Notably, AtpTreg frequency correlates with increased arthritis severity yet paradoxically associates with improved overall survival. Anti-IL6R therapy reduced AtpTreg levels, corresponding with improved arthritis outcomes and quality of life, without compromising anti-tumor immunity. Our findings define a pathogenic Treg subset in ICI-IA and validate IL-6R blockade as a mechanism-based therapeutic strategy, bridging mechanistic discovery to clinical translation. This study is registered at ClinicalTrials.gov (NCT07357636).

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Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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