Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms
Kathryn G. Schuff, Shane T. Hentges, Michele A. Kelly, Nadine Binart, Paul A. Kelly, P. Michael Iuvone, Sylvia L. Asa, Malcolm J. Low
Kathryn G. Schuff, Shane T. Hentges, Michele A. Kelly, Nadine Binart, Paul A. Kelly, P. Michael Iuvone, Sylvia L. Asa, Malcolm J. Low
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Article Genetics

Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms

Abstract

Research Article

Authors

Kathryn G. Schuff, Shane T. Hentges, Michele A. Kelly, Nadine Binart, Paul A. Kelly, P. Michael Iuvone, Sylvia L. Asa, Malcolm J. Low

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Serum PRL responses to a dopamine D2R agonist and antagonist in 15-month...
Serum PRL responses to a dopamine D2R agonist and antagonist in 15-month-old male mice measured one hour after treatment. (a) Bromocriptine decreased PRL levels in Prlr–/– mice, but not the other mutant genotypes. (b) Haloperidol increased PRL levels in wild-type mice but in none of the other genotypes. Because of their low basal values, the wild-type responses are shown magnified in the insets. Statistical analyses were by one-tailed paired Student t test for each drug within genotype. *P < 0.05 compared with pretreatment; n = 5–8.