Research Article
Akiyoshi Uemura, Minetaro Ogawa, Masanori Hirashima, Takashi Fujiwara, Shinji Koyama, Hitoshi Takagi, Yoshihito Honda, Stanley J. Wiegand, George D. Yancopoulos, Shin-Ichi Nishikawa
Title and authors | Publication | Year |
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Reduced chondroitin sulfate content prevents diabetic neuropathy through transforming growth factor-β signaling suppression.
Ishiguro H, Ushiki T, Honda A, Yoshimatsu Y, Ohashi R, Okuda S, Kawasaki A, Cho K, Tamura S, Suwabe T, Katagiri T, Ling Y, Iijima A, Mikami T, Kitagawa H, Uemura A, Sango K, Masuko M, Igarashi M, Sone H |
iScience | 2024 |
Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components
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Cell & Bioscience | 2024 |
The CLDN5 gene at the blood-brain barrier in health and disease.
Hashimoto Y, Greene C, Munnich A, Campbell M |
Fluids and barriers of the CNS | 2023 |
Biology of vascular mural cells
Siekmann AF |
Development (Cambridge, England) | 2023 |
Research advances in cochlear pericytes and hearing loss
Shi X |
Hearing Research | 2023 |
Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke
Fu J, Liang H, Yuan P, Wei Z, Zhong P |
Frontiers in cellular neuroscience | 2023 |
Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury.
He H, Yang W, Su N, Zhang C, Dai J, Han F, Singhal M, Bai W, Zhu X, Zhu J, Liu Z, Xia W, Liu X, Zhang C, Jiang K, Huang W, Chen D, Wang Z, He X, Kirchhoff F, Li Z, Liu C, Huan J, Wang X, Wei W, Wang J, Augustin HG, Hu J |
Journal of Experimental Medicine | 2022 |
VEGFR1 signaling in retinal angiogenesis and microinflammation
A Uemura, M Fruttiger, PA D'Amore, SD Falco, AM Joussen, F Sennlaub, LR Brunck, KT Johnson, GN Lambrou, KD Rittenhouse, T Langmann |
Progress in Retinal and Eye Research | 2021 |
Eph Receptors and Ephrins in Retinal Diseases
R Kaczmarek, P Gajdzis, M Gajdzis |
International journal of molecular sciences | 2021 |
An engineered tetra-valent antibody fully activates the Tie2 receptor with comparable potency to its natural ligand angiopoietin-1
Y Koya, H Nara, S Yagi, C Ueno, M Kamohara |
Scientific Reports | 2021 |
Pericyte morphology and function
Luis Alarcon-Martinez, Muge Yemisci, Turgay Dalkara |
Histology and histopathology | 2021 |
Embryonic Pericytes Promote Microglial Homeostasis and Their Effects on Neural Progenitors in the Developing Cerebral Cortex
Y Hattori, H Itoh, Y Tsugawa, Y Nishida, K Kurata, A Uemura, T Miyata |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2021 |
eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity.
Smith TL, Oubaha M, Cagnone G, Boscher C, Kim JS, El Bakkouri Y, Zhang Y, Chidiac R, Corriveau J, Delisle C, Andelfinger GU, Sapieha P, Joyal JS, Gratton JP |
Cellular and molecular life sciences : CMLS | 2021 |
A new perfusion culture method with a self-organized capillary network
K Sugihara, Y Yamaguchi, S Usui, Y Nashimoto, S Hanada, E Kiyokawa, A Uemura, R Yokokawa, K Nishiyama, T Miura, RM Merks |
PloS one | 2020 |
Low mortality oxidative stress murine chronic wound model
AC Panayi, Y Endo, M Karvar, P Sensharma, V Haug, S Fu, B Mi, Y An, DP Orgill |
BMJ Open Diabetes Research & Care | 2020 |
Transcriptomics analysis of pericytes from retinas of diabetic animals reveals novel genes and molecular pathways relevant to blood-retinal barrier alterations in diabetic retinopathy
S Rangasamy, F Monickaraj, C Legendre, AP Cabrera, L Llaci, C Bilagody, P McGuire, A Das |
Experimental Eye Research | 2020 |
Remodeling mechanisms determine size distributions in developing retinal vasculature
O Iizuka, S Kawamura, A Tero, A Uemura, T Miura, AS Lewin |
PloS one | 2020 |
VEGFR2 signaling drives meningeal vascular regeneration upon head injury
BI Koh, HJ Lee, PA Kwak, MJ Yang, JH Kim, HS Kim, GY Koh, I Kim |
Nature Communications | 2020 |
Shared changes in angiogenic factors across gastrointestinal vascular conditions: A pilot study
AR Douglas, G Holleran, SM Smith, D McNamara |
World journal of gastrointestinal pharmacology and therapeutics | 2020 |
Ursodeoxycholic Acid Attenuates the Retinal Vascular Abnormalities in Anti-PDGFR-β Antibody-Induced Pericyte Depletion Mouse Models
T Shiraya, F Araki, T Ueta, H Fukunaga, K Totsuka, T Arai, A Uemura, K Moriya, S Kato |
Scientific Reports | 2020 |
Observation of Corneal Wound Healing and Angiogenesis Using Low-Vacuum Scanning Electron Microscopy
T Arima, M Uchiyama, A Shimizu, H Takahashi |
Translational Vision Science & Technology | 2020 |
Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential
M Whitehead, A Osborne, PS Widdowson, P Yu-Wai-Man, KR Martin |
Journal of Diabetes Research | 2019 |
Pericytes in Microvessels: From “Mural” Function to Brain and Retina Regeneration
N Caporarello, F DAngeli, MT Cambria, S Candido, C Giallongo, M Salmeri, C Lombardo, A Longo, G Giurdanella, CD Anfuso, G Lupo |
International journal of molecular sciences | 2019 |
Pericytes: Problems and Promises for CNS Repair
F Laredo, J Plebanski, A Tedeschi |
Frontiers in cellular neuroscience | 2019 |
Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas
Keisuke Omori, Nanae Nagata, Kaori Kurata, Yoko Fukushima, Erika Sekihachi, Nobutaka Fujii, Tomoko Namba, Yoshitsugu Takabatake, Marcus Fruttiger, Takashi Nagasawa, Akiyoshi Uemura, Takahisa Murata |
JCI Insight | 2018 |
Pathophysiology of Diabetic Retinopathy: The Old and the New
S Kusuhara, Y Fukushima, S Ogura, N Inoue, A Uemura |
Diabetes & Metabolism Journal | 2018 |
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown
Shuntaro Ogura, Kaori Kurata, Yuki Hattori, Hiroshi Takase, Toshina Ishiguro-Oonuma, Yoonha Hwang, Soyeon Ahn, Inwon Park, Wataru Ikeda, Sentaro Kusuhara, Yoko Fukushima, Hiromi Nara, Hideto Sakai, Takashi Fujiwara, Jun Matsushita, Masatsugu Ema, Masanori Hirashima, Takashi Minami, Masabumi Shibuya, Nobuyuki Takakura, Pilhan Kim, Takaki Miyata, Yuichiro Ogura, Akiyoshi Uemura |
JCI Insight | 2017 |
Plastic roles of pericytes in the blood–retinal barrier
DY Park, J Lee, J Kim, K Kim, S Hong, S Han, Y Kubota, HG Augustin, L Ding, JW Kim, H Kim, Y He, RH Adams, GY Koh |
Nature Communications | 2017 |
The inner blood-retinal barrier: Cellular basis and development
M Díaz-Coránguez, C Ramos, DA Antonetti |
Vision research | 2017 |
The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability
AV Shah, GM Birdsey, C Peghaire, ME Pitulescu, NP Dufton, Y Yang, I Weinberg, LO Almagro, L Payne, JC Mason, H Gerhardt, RH Adams, AM Randi |
Nature Communications | 2017 |
Crosstalk between Stem and Progenitor Cellular Mediators with Special Emphasis on Vasculogenesis
R Rohban, B Prietl, TR Pieber |
Transfusion Medicine and Hemotherapy | 2017 |
Negative pressure wound therapy: Regulating blood flow perfusion and microvessel maturation through microvascular pericytes
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International journal of molecular medicine | 2017 |
Hold Me, but Not Too Tight—Endothelial Cell–Cell Junctions in Angiogenesis
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Cold Spring Harbor perspectives in biology | 2017 |
Tubular Overexpression of Angiopoietin-1 Attenuates Renal Fibrosis
S Singh, SR Manson, H Lee, Y Kim, T Liu, Q Guo, JJ Geminiani, PF Austin, YM Chen, JA Joles |
PloS one | 2016 |
Fit for the Eye: Aptamers in Ocular Disorders
DW Drolet, LS Green, L Gold, N Janjic |
Nucleic Acid Therapeutics (Formerly Oligonucleotides) | 2016 |
Long-term safety and stability of angiogenesis induced by balanced single-vector co-expression of PDGF-BB and VEGF164 in skeletal muscle
R Gianni-Barrera, M Burger, T Wolff, M Heberer, DJ Schaefer, L Gürke, E Mujagic, A Banfi |
Scientific Reports | 2016 |
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JM Ha, SH Baek, YH Kim, SY Jin, HS Lee, SJ Kim, HK Shin, DH Lee, SH Song, CD Kim, SS Bae |
Experimental & molecular medicine | 2016 |
Skeletal and cardiac muscle pericytes: Functions and therapeutic potential
IR Murray, JE Baily, WC Chen, A Dar, ZN Gonzalez, AR Jensen, FA Petrigliano, A Deb, NC Henderson |
Pharmacology & Therapeutics | 2016 |
Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy
M Vähätupa, S Prince, S Vataja, T Mertimo, M Kataja, K Kinnunen, V Marjomäki, H Uusitalo, M Komatsu, TA Järvinen, H UusitaloJärvinen |
Investigative ophthalmology & visual science | 2016 |
Glipizide suppresses prostate cancer progression in the TRAMP model by inhibiting angiogenesis
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Pericytes of the neurovascular unit: key functions and signaling pathways
MD Sweeney, S Ayyadurai, BV Zlokovic |
Nature Neuroscience | 2016 |
Angiopoietin-1 and Angiopoietin-2 in metabolic disorders: therapeutic strategies to restore the highs and lows of angiogenesis in diabetes
AM Isidori, MA Venneri, D Fiore |
Journal of Endocrinological Investigation | 2016 |
Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema
PA Campochiaro, KG Peters |
Current Diabetes Reports | 2016 |
From Pathobiology to the Targeting of Pericytes for the Treatment of Diabetic Retinopathy
JF Arboleda-Velasquez, CN Valdez, CK Marko, PA D’Amore |
Current Diabetes Reports | 2015 |
Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes
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Neuron | 2015 |
PTK7 + Mononuclear Cells Express VEGFR2 and Contribute to Vascular Stabilization by Upregulating Angiopoietin-1Significance
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Intravitreal AAV2.COMP-Ang1 prevents neurovascular degeneration in a murine model of diabetic retinopathy
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Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2014 |
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Egfl7 Is Differentially Expressed in Arteries and Veins during Retinal Vascular Development
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Identification of novel drug targets for the treatment of diabetic retinopathy
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NG2 proteoglycan promotes tumor vascularization via integrin-dependent effects on pericyte function
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Angiogenesis | 2013 |
A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy
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Investigative ophthalmology & visual science | 2013 |
Engineering of In Vitro 3D Capillary Beds by Self-Directed Angiogenic Sprouting
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PloS one | 2012 |
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Angiopoietin-1 is Essential in Vasculature during Development and Disease in Mice
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Journal of Clinical Investigation | 2011 |
Pericyte-Derived Sphinogosine 1-Phosphate Induces the Expression of Adhesion Proteins and Modulates the Retinal Endothelial Cell Barrier
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Arteriosclerosis, thrombosis, and vascular biology | 2011 |
Targeting Microvasculature for Neuroprotection after SCI
JM Fassbender, SR Whittemore, T Hagg |
Neurotherapeutics | 2011 |
Pericyte Requirement for Anti-Leak Action of Angiopoietin-1 and Vascular Remodeling in Sustained Inflammation
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The American Journal of Pathology | 2011 |
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Journal of Tissue Engineering and Regenerative Medicine | 2011 |
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Proceedings of the National Academy of Sciences | 2010 |
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Proceedings of the National Academy of Sciences | 2010 |
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Stimulation of in vivo angiogenesis by in situ crosslinked, dual growth factor-loaded, glycosaminoglycan hydrogels
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Brain : a journal of neurology | 2010 |
Angiogenic factors stimulate growth of adult neural stem cells
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Proceedings of the National Academy of Sciences | 2009 |
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Nature Reviews Molecular Cell Biology | 2009 |
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Proceedings of the National Academy of Sciences | 2008 |
Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors
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PloS one | 2008 |
Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney
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The American Journal of Pathology | 2008 |
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Theoretical Biology and Medical Modelling | 2008 |
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Journal of Molecular Medicine | 2007 |
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World Journal of Gastroenterology | 2007 |
Tlx acts as a pro-angiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes
Akiyoshi Uemura, Sentaro Kusuhara, Stanley J. Wiegand, Ruth T. Yu, and Shin-Ichi Nishikawa |
Journal of Clinical Investigation | 2006 |
Rapid vascular regrowth in tumors after reversal of VEGF inhibition
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Journal of Clinical Investigation | 2006 |
Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization
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The American Journal of Pathology | 2006 |
Stimulation of in vivo angiogenesis using dual growth factor-loaded crosslinked glycosaminoglycan hydrogels
CM Riley, PW Fuegy, MA Firpo, XZ Shu, GD Prestwich, RA Peattie |
Biomaterials | 2006 |
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B Frerich, K Zückmantel, A Hemprich |
Head & face medicine | 2006 |
Genetic and epigenetic mechanisms in the early development of the vascular system
D Ribatti |
Journal of Anatomy | 2006 |
Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma
Y Kitadai, T Sasaki, T Kuwai, T Nakamura, CD Bucana, IJ Fidler |
The American Journal of Pathology | 2006 |
Hepatic Tumor Growth: Target for Angiogenesis Inhibition?
S Sarraf-Yazdi, J Mi, BM Clary |
World Journal of Surgery | 2005 |
Critical role of microenvironmental factors in angiogenesis
A Banfi, G von Degenfeld, HM Blau |
Current Atherosclerosis Reports | 2005 |
The role of pericytes in blood-vessel formation and maintenance
G Bergers, S Song |
Neuro-oncology | 2005 |
Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1
I Cascone, L Napione, F Maniero, G Serini, F Bussolino |
The Journal of Cell Biology | 2005 |
Endothelial and non-endothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
Alexandra Abramsson, Per Lindblom, Christer Betsholtz |
Journal of Clinical Investigation | 2003 |
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
P Lindblom, H Gerhardt, S Liebner, A Abramsson, M Enge, M Hellstrom, G Backstrom, S Fredriksson, U Landegren, HC Nystrom, G Bergstrom, E Dejana, A Ostman, P Lindahl, C Betsholtz |
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Getting Tie(2)d up in angiogenesis
M Ramsauer, PA DAmore |
Journal of Clinical Investigation | 2002 |