Research Article
R Wang, S J Shattil, D R Ambruso, P J Newman
Title and authors | Publication | Year |
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Profiling the Genetic and Molecular Characteristics of Glanzmann Thrombasthenia: Can It Guide Current and Future Therapies?
A Nurden |
Journal of blood medicine | 2021 |
A novel frameshift mutation in the ITGB3 gene leading to Glanzmann's thrombasthenia in a Saudi Arabian family
A Alharbi, JA Hashmi, E Alharby, AM Albalawi, K Ramzan, S Basit |
Hematology/Oncology and Stem Cell Therapy | 2021 |
Topological Adaptation of Transmembrane Domains to the Force-Modulated Lipid Bilayer Is a Basis of Sensing Mechanical Force
J Kim, J Lee, J Jang, F Ye, SJ Hong, BG Petrich, TS Ulmer, C Kim |
Current biology : CB | 2020 |
ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells
P Fuentes, M Sesé, PJ Guijarro, M Emperador, S Sánchez-Redondo, H Peinado, S Hümmer, SR y Cajal |
Nature Communications | 2020 |
Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors
YY Bernadskaya, S Brahmbhatt, SE Gline, W Wang, L Christiaen |
Nature Communications | 2019 |
Molecular Hematology 4e
D Provan, J Gribben |
2019 | |
Clinical And Molecular Insights into Glanzmann's Thrombasthenia in China
L Zhou, M Jiang, H Shen, T You, Z Ding, Q Cui, Z Ma, F Yang, Z Xie, H Shi, J Su, L Cao, J Lin, J Yin, L Dai, H Wang, Z Wang, Z Yu, C Ruan, L Xia |
Clinical Genetics | 2018 |
An intracytoplasmic β3 Leu718 deletion in a patient with a novel platelet phenotype
P Nurden, JC Bordet, X Pillois, AT Nurden |
Blood Advances | 2017 |
Platelets in Thrombotic and Non-Thrombotic Disorders
P Gresele, NS Kleiman, JA Lopez, CP Page |
Platelets in Thrombotic and Non-Thrombotic Disorders | 2017 |
Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α-granules
M Favier, JC Bordet, R Favier, V Gkalea, X Pillois, P Rameau, N Debili, MC Alessi, P Nurden, H Raslova, A Nurden |
American Journal of Hematology | 2017 |
The integrin adhesome: from genes and proteins to human disease
SE Winograd-Katz, R Fässler, B Geiger, KR Legate |
Nature Reviews Molecular Cell Biology | 2014 |
Talin and kindlin: the one-two punch in integrin activation
F Ye, AK Snider, MH Ginsberg |
Frontiers of Medicine | 2014 |
Glanzmann thrombasthenia: state of the art and future directions
AT Nurden, X Pillois, DA Wilcox |
Seminars in thrombosis and hemostasis | 2013 |
Regulation of integrin activation―the role of integrin activation in tumor metastasis
H KATO, Y TOMIYAMA |
Japanese Journal of Thrombosis and Hemostasis | 2013 |
Reconstruction of integrin activation
F Ye, C Kim, MH Ginsberg |
Blood | 2012 |
A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIbβ3 to an active state : Mutation in the β3 tail locks αIIbβ3 in a resting state
H Hauschner, R Mor-Cohen, U Seligsohn, N Rosenberg |
Journal of Thrombosis and Haemostasis | 2012 |
Understanding the genetic basis of Glanzmann thrombasthenia: implications for treatment
AT Nurden, X Pillois, P Nurden |
Expert Review of Hematology | 2012 |
Integrin αIIb-mediated PI3K/Akt activation in platelets
H Niu, X Chen, RA Gruppo, D Li, Y Wang, L Zhang, K Wang, W Chai, Y Sun, Z Ding, TK Gartner, J Liu |
PloS one | 2012 |
Integrin αIIb-Mediated PI3K/Akt Activation in Platelets
H Niu, X Chen, RA Gruppo, D Li, Y Wang, L Zhang, K Wang, W Chai, Y Sun, Z Ding, TK Gartner, J Liu, EF Plow |
PloS one | 2012 |
Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models
AT Nurden, M Fiore, P Nurden, X Pillois |
Blood | 2011 |
Do Cell Junction Protein Mutations Cause an Airway Phenotype in Mice or Humans?
EH Chang, AA Pezzulo, J Zabner |
American journal of respiratory cell and molecular biology | 2011 |
Platelet Proteomics
MG Tomlinson |
Platelet Proteomics | 2011 |
L718P mutation in the membrane-proximal cytoplasmic tail of beta 3 promotes abnormal alpha IIb beta 3 clustering and lipid microdomain coalescence, and associates with a thrombasthenia-like phenotype
A Jayo, I Conde, P Lastres, C Martínez, J Rivera, V Vicente, C González-Manchón |
Haematologica | 2010 |
Variant type Glanzmann thrombasthenia caused by homozygous p.724R>X mutation in β3 integrin
Z Bagoly, F Fazakas, A Marosi, O Török, Z Bereczky, G Haramura, J Tóth, J Kappelmayer, L Muszbek |
Thrombosis Research | 2010 |
Obligatory involvement of FcgammaRIIa and the integrin beta3 cytoplasmic domain in eptifibatide-induced thrombocytopenia and thrombosis
Cunji Gao, Brian Boylan, Dan Bougie, Joan C. Gill, Jessica Birenbaum, Debra K. Newman, Richard H. Aster, and Peter J. Newman |
Journal of Clinical Investigation | 2009 |
Dominant inheritance of a novel integrin beta3 mutation associated with a hereditary macrothrombocytopenia and platelet dysfunction in two Italian families
P Gresele, E Falcinelli, S Giannini, P D'Adamo, A D'Eustacchio, T Corazzi, AM Mezzasoma, FD Bari, G Guglielmini, L Cecchetti, P Noris, CL Balduini, A Savoia |
Haematologica | 2009 |
Platelet integrin αIIbβ3 activation via integrin activation complex
S TADOKORO |
Japanese Journal of Thrombosis and Hemostasis | 2009 |
The β3 integrin cytoplasmic tail: protein scaffold and control freak
SJ Shattil |
Journal of Thrombosis and Haemostasis | 2009 |
The GPIIb/IIIa (integrin IIb 3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend
BS Coller, SJ Shattil |
Blood | 2008 |
Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets
AJ Ablooglu, J Kang, BG Petrich, MH Ginsberg, SJ Shattil |
Blood | 2008 |
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3
N Watanabe, L Bodin, M Pandey, M Krause, S Coughlin, VA Boussiotis, MH Ginsberg, SJ Shattil |
The Journal of Cell Biology | 2008 |
Identification of Fc RIIa as the ITAM-bearing receptor mediating IIb 3 outside-in integrin signaling in human platelets
B Boylan, C Gao, V Rathore, JC Gill, DK Newman, PJ Newman |
Blood | 2008 |
Inherited traits affecting platelet function
II Salles, HB Feys, BF Iserbyt, SF de Meyer, K Vanhoorelbeke, H Deckmyn |
Blood Reviews | 2008 |
Cooperative Role of the Membrane-proximal and -distal Residues of the Integrin β3 Cytoplasmic Domain in Regulation of Talin-mediated αIIbβ3 Activation
T Hato, J Yamanouchi, T Tamura, Y Yakushijin, I Sakai, M Yasukawa |
The Journal of biological chemistry | 2008 |
Recent Advances in Thrombosis and Hemostasis 2008
K Tanaka, EW Davie, Y Ikeda, S Iwanaga, H Saito, K Sueishi |
2008 | |
The anti-thrombotic potential of selective blockade of talin-dependent integrin alphaIIbbeta3 (Platelet GPIIb-IIIa) activation
Brian G. Petrich, Anthony W. Partridge, Nima Yousefi, Ararat J. Ablooglu Sanford J. Shattil, and Mark H. Ginsberg |
Journal of Clinical Investigation | 2007 |
Congenital and Acquired Disorders of Platelet Function and Number
S Jobe, JD Paola |
Consultative Hemostasis and Thrombosis | 2007 |
Consultative Hemostasis and Thrombosis
VJ Marder |
Consultative Hemostasis and Thrombosis | 2007 |
Glanzmann thrombasthenia
AT Nurden |
Orphanet Journal of Rare Diseases | 2006 |
Tyrosine Phosphorylation of the Integrin β 3 Subunit Regulates β 3 Cleavage by Calpain
X Xi, P Flevaris, A Stojanovic, A Chishti, DR Phillips, SC Lam, X Du |
The Journal of biological chemistry | 2006 |
Pathological shear stress directly regulates platelet α IIb β 3 signaling
S Feng, X Lu, JC Reséndiz, MH Kroll |
American journal of physiology. Cell physiology | 2006 |
Structure and function of the platelet integrin αIIbβ3
JS Bennett |
Journal of Clinical Investigation | 2005 |
A 13-bp deletion in alpha(IIb) gene is a founder mutation that predominates in Palestinian-Arab patients with Glanzmann thrombasthenia
N Rosenberg, H Hauschner, H Peretz, R Mor-Cohen, M Landau, B Shenkman, G Kenet, BS Coller, AA Awidi, U Seligsohn |
Journal of Thrombosis and Haemostasis | 2005 |
The Pro 33 Isoform of Integrin β 3 Enhances Outside-in Signaling in Human Platelets by Regulating the Activation of Serine/Threonine Phosphatases
KV Vijayan, Y Liu, W Sun, M Ito, PF Bray |
The Journal of biological chemistry | 2005 |
The β3 subunit of the integrin αIIbβ3 regulates αIIb-mediated outside-in signaling
J Liu, CW Jackson, RA Gruppo, LK Jennings, TK Gartner |
Blood | 2005 |
Integrin activation
DA Calderwood |
Journal of cell science | 2004 |
Mutations in the β3 gene giving rise to type I Glanzmann thrombasthenia in two families in Portugal
LC Garcia, C Breillat, M Lima, R Combrié, S Morais, MA Teixera, M Campos, B Justica, AT Nurden |
Platelets | 2004 |
Distinct roles of ligand affinity and cytoskeletal anchorage in α IIb β 3 (GP IIb/IIIa)-mediated cell aggregation and adhesion
K Peter, I Ahrens, M Schwarz, C Bode, J Ylänne |
Platelets | 2004 |
Lymphocyte Homing to the Skin: Immunology, Immunopathology, and Therapeutic Perspectives
A Schottelius, K Asadullah, T Zollner |
Lymphocyte Homing to the Skin: Immunology, Immunopathology, and Therapeutic Perspectives | 2004 |
Integrins: dynamic scaffolds for adhesion and signaling in platelets
SJ Shattil, PJ Newman |
Blood | 2004 |
Osteopetrosis and Glanzmann's thrombasthenia in a child
N Yaralı, T Fışgın, F Duru, A Kara |
Annals of Hematology | 2003 |
Gene therapy for platelet disorders: studies with Glanzmann's thrombasthenia
DA Wilcox, GC White |
Journal of Thrombosis and Haemostasis | 2003 |
Critical roles for the COOH-terminal NITY and RGT sequences of the integrin β 3 cytoplasmic domain in inside-out and outside-in signaling
X Xi, RJ Bodnar, Z Li, SC Lam, X Du |
The Journal of Cell Biology | 2003 |
Thrombin‐stimulated platelet aggregation is inhibited by kallikrein in a time‐ and concentration‐dependent manner
D Veloso |
Scandinavian Journal of Clinical & Laboratory Investigation | 2003 |
Disruption of the β3 663-687 disulfide bridge confers constitutive activity to β3 integrins
N Butta, EG Arias-Salgado, C González-Manchón, M Ferrer, S Larrucea, MS Ayuso, R Parrilla |
Blood | 2003 |
Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment
S Bellucci, J Caen |
Blood Reviews | 2002 |
Disruption of the long-range GPIIIa Cys5-Cys435 disulfide bond results in the production of constitutively active GPIIb-IIIa (alpha IIbbeta 3) integrin complexes
QH Sun |
Blood | 2002 |
Enhanced Activation of Mitogen-activated Protein Kinase and Myosin Light Chain Kinase by the Pro 33 Polymorphism of Integrin β 3
KV Vijayan, Y Liu, JF Dong, PF Bray |
The Journal of biological chemistry | 2002 |
INHERITED DEFECTS OF PLATELET FUNCTION
AT Nurden, P Nurden |
Reviews in Clinical and Experimental Hematology | 2001 |
A Val193Met mutation in GPIIIa results in a GPIIb/IIIa receptor with a constitutively high affinity for a small ligand
J Fullard, R Murphy, S O'Neill, N Moran, B Ottridge, DJ Fitzgerald |
British Journal of Haematology | 2001 |
Demystified...adhesion molecule deficiencies
D Inwald, EG Davies, N Klein |
Molecular pathology : MP | 2001 |
Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding
S Plançon, MC Morel-Kopp, E Schaffner-Reckinger, P Chen, N Kieffer |
Biochemical Journal | 2001 |
A Membrane-distal Segment of the Integrin α IIb Cytoplasmic Domain Regulates Integrin Activation
MH Ginsberg, B Yaspan, J Forsyth, TS Ulmer, ID Campbell, M Slepak |
The Journal of biological chemistry | 2001 |
A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (αIIbβ3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia–like phenotype
C Ruiz, CY Liu, QH Sun, M Sigaud-Fiks, E Fressinaud, JY Muller, P Nurden, AT Nurden, PJ Newman, N Valentin |
Blood | 2001 |
Combined defect in membrane expression and activation of platelet GPIIb-IIIa complex without primary sequence abnormalities in myeloproliferative disease
R Kaplan, J Gabbeta, L Sun, GF Mao, AK Rao |
British Journal of Haematology | 2000 |
Genetic analysis of integrin function in man: LAD-1 and other syndromes
N Hogg, PA Bates |
Matrix Biology | 2000 |
Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors
BA Judd, PS Myung, L Leng, A Obergfell, WS Pear, SJ Shattil, GA Koretzky |
Proceedings of the National Academy of Sciences | 2000 |
Platelets
JN George |
The Lancet | 2000 |
Nischarin, a Novel Protein That Interacts with the Integrin α5 Subunit and Inhibits Cell Migration
SK Alahari, JW Lee, RL Juliano |
The Journal of Cell Biology | 2000 |
The Leukocyte Integrins
ES Harris, TM McIntyre, SM Prescott, GA Zimmerman |
The Journal of biological chemistry | 2000 |
Signal-transducing Mechanisms Involved in Activation of the Platelet Collagen Receptor Integrin α 2 β 1
SM Jung, M Moroi |
The Journal of biological chemistry | 2000 |
Platelet Glycoprotein IIb/IIIa Receptors and Glanzmann’s Thrombasthenia
DL French, U Seligsohn |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
A naturally occurring mutation near the amino terminus of αIIb defines a new region involved in ligand binding to αIIbβ3
RB Basani, DL French, G Vilaire, DL Brown, F Chen, BS Coller, JM Derrick, TK Gartner, JS Bennett, M Poncz |
Blood | 2000 |
A Leu262Pro mutation in the integrin β3 subunit results in an αIIb-β3 complex that binds fibrin but not fibrinogen
CM Ward, AS Kestin, PJ Newman |
Blood | 2000 |
Megakaryocyte-targeted synthesis of the integrin β3-subunit results in the phenotypic correction of Glanzmann thrombasthenia
DA Wilcox, JC Olsen, L Ishizawa, PF Bray, DL French, DA Steeber, WR Bell, M Griffith, GC White |
Blood | 2000 |
A novel leukocyte adhesion deficiency caused by expressed but nonfunctional β2 integrins Mac-1 and LFA-1
N Hogg, MP Stewart, SL Scarth, R Newton, JM Shaw, SK Law, N Klein |
Journal of Clinical Investigation | 1999 |
Integrin-dependent control of translation: engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets
R Pabla, AS Weyrich, DA Dixon, PF Bray, TM McIntyre, SM Prescott, GA Zimmerman |
The Journal of Cell Biology | 1999 |
Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells
DA Wilcox, JC Olsen, L Ishizawa, M Griffith, GC 2nd |
Proceedings of the National Academy of Sciences | 1999 |
Integrin alpha IIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells
DA Wilcox, JC Olsen, L Ishizawa, M Griffith, GC White |
Proceedings of the National Academy of Sciences | 1999 |
Integrin-dependent Control of Translation: Engagement of Integrin α IIb β 3 Regulates Synthesis of Proteins in Activated Human Platelets
R Pabla, AS Weyrich, DA Dixon, PF Bray, TM McIntyre, SM Prescott, GA Zimmerman |
The Journal of Cell Biology | 1999 |
Enhancement of Endothelial Cell Migration and in Vitro Tube Formation by Tap20, a Novel β5 Integrin–Modulating, Pkcθ-Dependent Protein
S Tang, Y Gao, JA Ware |
The Journal of Cell Biology | 1999 |
Divalent Cations Differentially Regulate Integrin α IIb Cytoplasmic Tail Binding to β 3 and to Calcium- and Integrin-binding Protein
L Vallar, C Melchior, S Plançon, H Drobecq, G Lippens, V Regnault, N Kieffer |
The Journal of biological chemistry | 1999 |
Low Density Lipoprotein Phosphorylates the Focal Adhesion-associated Kinase p125 FAK in Human Platelets Independent of Integrin α IIb β 3
CM Hackeng, MW Pladet, JW Akkerman, HJ van Rijn |
The Journal of biological chemistry | 1999 |
Handbook of Platelet Physiology and Pharmacology
GH Rao |
1999 | |
Integrin affinity modulation
PE Hughes, M Pfaff |
Trends in Cell Biology | 1998 |
Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3
T Hato, N Pampori, SJ Shattil |
The Journal of Cell Biology | 1998 |
Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin α IIb β 3
T Hato, N Pampori, SJ Shattil |
The Journal of Cell Biology | 1998 |
Integrin Signaling: The Platelet Paradigm
SJ Shattil, H Kashiwagi, N Pampori |
Blood | 1998 |
Adhesive and Signaling Properties of a Naturally Occurring Allele of Glycoprotein IIIa With an Amino Acid Substitution Within the Ligand Binding Domain—The Pena/PenbPlatelet Alloantigenic Epitopes
R Wang, PJ Newman |
Blood | 1998 |