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Citations to this article

Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B.
S Rossol, … , R Williams, N V Naoumov
S Rossol, … , R Williams, N V Naoumov
Published June 15, 1997
Citation Information: J Clin Invest. 1997;99(12):3025-3033. https://doi.org/10.1172/JCI119498.
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Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B.

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Abstract

Interleukin-12, a cytokine with an important role against intracellular pathogens, promotes Th1 cell development, cellmediated cytotoxicity, and interferon-gamma production. We investigated the immunoregulatory role of IL-12 in 72 chronic hepatitis B virus (HBV) carriers, 33 of whom were monitored longitudinally during interferon-alpha treatment. Serum levels of IL-12 heterodimer, IL-12 p40 subunit, IL-4, and Th1 cytokines were determined by specific ELISAs, and hepatitis B core antigen-specific T cell response by a proliferation assay. Chronic HBV carriers had higher serum levels of IL-12 and IL-12 p40 in comparison with controls (P < 0.01), suggesting that IL-12 production is not impaired. The longitudinal analysis revealed a further substantial increase (> 2.5x baseline level) of bioactive IL-12 and Th1 cytokines in patients who cleared HBV and seroconverted to anti- hepatitis B e, unlike the 23 nonresponders with persistent HBV replication (P < 0.01). The IL-12 peak followed the peak of hepatocytolysis by 9.8+/-2.8 wk and occurred either before or simultaneously with hepatitis B e seroconversion. Hepatitis B core antigen-specific T cell proliferation closely correlated with hepatocytolysis and increased significantly in all patients (8 responders and 15 nonresponders) who developed hepatitis flare, irrespective of the virological outcome. These results provide in vivo evidence that IL-12 may have an important role for viral clearance in chronic HBV infection.

Authors

S Rossol, G Marinos, P Carucci, M V Singer, R Williams, N V Naoumov

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Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1967 Total
Citations: 2 5 5 5 2 3 3 1 7 10 9 9 4 7 4 4 10 7 15 6 9 7 8 9 5 7 3 1 167
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Citations to this article in year 2020 (5)

Title and authors Publication Year
Serum alanine aminotransferase flares in chronic hepatitis B infection: the good and the bad
MG Ghany, JJ Feld, KM Chang, HL Chan, AS Lok, K Visvanathan, HL Janssen
The Lancet Gastroenterology & Hepatology 2020
The Liver: Biology and Pathobiology
IM Arias, HJ Alter, JL Boyer, DE Cohen, DA Shafritz, SS Thorgeirsson, AW Wolkoff
2020
Single Nucleotide Polymorphisms in IFN- γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children
Y Zhuo, Y Yang, M Zhang, Y Xu, Z Chen, L Mu, X Tang, Z Zhong, J Chen, L Zhou
The Canadian Journal of Infectious Diseases & Medical Microbiology 2020
Transcriptome analysis based on RNA-seq of common innate immune responses of flounder cells to IHNV, VHSV, and HIRRV
KI Kim, UH Lee, M Cho, SH Jung, EY Min, JW Park, M del Mar Ortega-Villaizan
PloS one 2020
Carrot Pomace Polysaccharide (CPP) Improves Influenza Vaccine Efficacy in Immunosuppressed Mice via Dendritic Cell Activation
P Sun, Y Kim, H Lee, J Kim, BK Han, E Go, S Kwon, JG Kang, S You, J Kwon
Nutrients 2020

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