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Citations to this article

Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B.
S Rossol, … , R Williams, N V Naoumov
S Rossol, … , R Williams, N V Naoumov
Published June 15, 1997
Citation Information: J Clin Invest. 1997;99(12):3025-3033. https://doi.org/10.1172/JCI119498.
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Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B.

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Abstract

Interleukin-12, a cytokine with an important role against intracellular pathogens, promotes Th1 cell development, cellmediated cytotoxicity, and interferon-gamma production. We investigated the immunoregulatory role of IL-12 in 72 chronic hepatitis B virus (HBV) carriers, 33 of whom were monitored longitudinally during interferon-alpha treatment. Serum levels of IL-12 heterodimer, IL-12 p40 subunit, IL-4, and Th1 cytokines were determined by specific ELISAs, and hepatitis B core antigen-specific T cell response by a proliferation assay. Chronic HBV carriers had higher serum levels of IL-12 and IL-12 p40 in comparison with controls (P < 0.01), suggesting that IL-12 production is not impaired. The longitudinal analysis revealed a further substantial increase (> 2.5x baseline level) of bioactive IL-12 and Th1 cytokines in patients who cleared HBV and seroconverted to anti- hepatitis B e, unlike the 23 nonresponders with persistent HBV replication (P < 0.01). The IL-12 peak followed the peak of hepatocytolysis by 9.8+/-2.8 wk and occurred either before or simultaneously with hepatitis B e seroconversion. Hepatitis B core antigen-specific T cell proliferation closely correlated with hepatocytolysis and increased significantly in all patients (8 responders and 15 nonresponders) who developed hepatitis flare, irrespective of the virological outcome. These results provide in vivo evidence that IL-12 may have an important role for viral clearance in chronic HBV infection.

Authors

S Rossol, G Marinos, P Carucci, M V Singer, R Williams, N V Naoumov

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Total citations by year

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Citations: 2 5 5 5 2 3 3 1 7 10 9 9 4 7 4 4 10 7 15 6 9 7 8 9 5 7 3 1 167
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Citations to this article in year 2018 (3)

Title and authors Publication Year
Insights From Antiviral Therapy Into Immune Responses to Hepatitis B and C Virus Infection
B Rehermann, R Thimme
Gastroenterology 2018
Risk of Hepatitis B Reactivation in Patients with Psoriasis on Ustekinumab
SW Ting, YC Chen, YH Huang
Clinical Drug Investigation 2018
Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
FM Teo, M Nyo, AA Wong, NW Tan, MT Koh, YF Chan, CY Chong, JJ Chu
Scientific Reports 2018

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